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Items: 1 to 50 of 153

1.

Legacy of Multiple Stressors: Responses of Gastropod Larvae and Juveniles to Ocean Acidification and Nutrition.

Bogan SN, McMahon JB, Pechenik JA, Pires A.

Biol Bull. 2019 Jun;236(3):159-173. doi: 10.1086/702993. Epub 2019 Apr 29.

PMID:
31167086
2.

Synthesis and Biological Evaluation of New Madecassic Acid Derivatives Targeting ERK Cascade Signaling.

Valdeira ASC, Ritt DA, Morrison DK, McMahon JB, Gustafson KR, Salvador JAR.

Front Chem. 2018 Sep 28;6:434. doi: 10.3389/fchem.2018.00434. eCollection 2018.

3.

Unequivocal determination of caulamidines A and B: application and validation of new tools in the structure elucidation tool box.

Milanowski DJ, Oku N, Cartner LK, Bokesch HR, Williamson RT, Saurí J, Liu Y, Blinov KA, Ding Y, Li XC, Ferreira D, Walker LA, Khan S, Davies-Coleman MT, Kelley JA, McMahon JB, Martin GE, Gustafson KR.

Chem Sci. 2017 Nov 6;9(2):307-314. doi: 10.1039/c7sc01996c. eCollection 2018 Jan 14.

4.

Macrophilone A: Structure Elucidation, Total Synthesis, and Functional Evaluation of a Biologically Active Iminoquinone from the Marine Hydroid Macrorhynchia philippina.

Zlotkowski K, Hewitt WM, Yan P, Bokesch HR, Peach ML, Nicklaus MC, O'Keefe BR, McMahon JB, Gustafson KR, Schneekloth JS Jr.

Org Lett. 2017 Apr 7;19(7):1726-1729. doi: 10.1021/acs.orglett.7b00496. Epub 2017 Mar 27.

5.

Characterization and Synthesis of Eudistidine C, a Bioactive Marine Alkaloid with an Intriguing Molecular Scaffold.

Chan ST, Nani RR, Schauer EA, Martin GE, Williamson RT, Saurí J, Buevich AV, Schafer WA, Joyce LA, Goey AK, Figg WD, Ransom TT, Henrich CJ, McKee TC, Moser A, MacDonald SA, Khan S, McMahon JB, Schnermann MJ, Gustafson KR.

J Org Chem. 2016 Nov 18;81(22):10631-10640. Epub 2016 Nov 10.

6.

Screening and Biological Effects of Marine Pyrroloiminoquinone Alkaloids: Potential Inhibitors of the HIF-1α/p300 Interaction.

Goey AK, Chau CH, Sissung TM, Cook KM, Venzon DJ, Castro A, Ransom TR, Henrich CJ, McKee TC, McMahon JB, Grkovic T, Cadelis MM, Copp BR, Gustafson KR, Figg WD.

J Nat Prod. 2016 May 27;79(5):1267-75. doi: 10.1021/acs.jnatprod.5b00846. Epub 2016 May 3.

7.

Englerin A Inhibits EWS-FLI1 DNA Binding in Ewing Sarcoma Cells.

Caropreso V, Darvishi E, Turbyville TJ, Ratnayake R, Grohar PJ, McMahon JB, Woldemichael GM.

J Biol Chem. 2016 May 6;291(19):10058-66. doi: 10.1074/jbc.M115.701375. Epub 2016 Mar 9.

8.

Stelliosphaerols A and B, Sesquiterpene-Polyol Conjugates from an Ecuadorian Fungal Endophyte.

Forcina GC, Castro A, Bokesch HR, Spakowicz DJ, Legaspi ME, Kucera K, Villota S, Narváez-Trujillo A, McMahon JB, Gustafson KR, Strobel SA.

J Nat Prod. 2015 Dec 24;78(12):3005-10. doi: 10.1021/acs.jnatprod.5b00749. Epub 2015 Dec 14.

9.

Deguelins, Natural Product Modulators of NF1-Defective Astrocytoma Cell Growth Identified by High-Throughput Screening of Partially Purified Natural Product Extracts.

Henrich CJ, Cartner LK, Wilson JA, Fuller RW, Rizzo AE, Reilly KM, McMahon JB, Gustafson KR.

J Nat Prod. 2015 Nov 25;78(11):2776-81. doi: 10.1021/acs.jnatprod.5b00753. Epub 2015 Oct 15.

10.

Stellettapeptins A and B, HIV-inhibitory cyclic depsipeptides from the marine sponge Stelletta sp.

Shin HJ, Rashid MA, Cartner LK, Bokesch HR, Wilson JA, McMahon JB, Gustafson KR.

Tetrahedron Lett. 2015 Jul 8;56(28):4215-4219.

11.

Structural Elucidation and Synthesis of Eudistidine A: An Unusual Polycyclic Marine Alkaloid that Blocks Interaction of the Protein Binding Domains of p300 and HIF-1α.

Chan ST, Patel PR, Ransom TR, Henrich CJ, McKee TC, Goey AK, Cook KM, Figg WD, McMahon JB, Schnermann MJ, Gustafson KR.

J Am Chem Soc. 2015 Apr 29;137(16):5569-75. doi: 10.1021/jacs.5b02156. Epub 2015 Apr 20.

12.

Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation.

Henrich CJ, Brooks AD, Erickson KL, Thomas CL, Bokesch HR, Tewary P, Thompson CR, Pompei RJ, Gustafson KR, McMahon JB, Sayers TJ.

Cell Death Dis. 2015 Feb 26;6:e1666. doi: 10.1038/cddis.2015.38.

13.

Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus.

Moulaei T, Alexandre KB, Shenoy SR, Meyerson JR, Krumpe LR, Constantine B, Wilson J, Buckheit RW Jr, McMahon JB, Subramaniam S, Wlodawer A, O'Keefe BR.

Retrovirology. 2015 Jan 23;12:6. doi: 10.1186/s12977-014-0127-3.

14.

Engineering soya bean seeds as a scalable platform to produce cyanovirin-N, a non-ARV microbicide against HIV.

O'Keefe BR, Murad AM, Vianna GR, Ramessar K, Saucedo CJ, Wilson J, Buckheit KW, da Cunha NB, Araújo AC, Lacorte CC, Madeira L, McMahon JB, Rech EL.

Plant Biotechnol J. 2015 Sep;13(7):884-92. doi: 10.1111/pbi.12309. Epub 2015 Jan 9.

15.

Steroidal alkaloids from the marine sponge Corticium niger that inhibit growth of human colon carcinoma cells.

Sunassee SN, Ransom T, Henrich CJ, Beutler JA, Covell DG, McMahon JB, Gustafson KR.

J Nat Prod. 2014 Nov 26;77(11):2475-80. doi: 10.1021/np500556t. Epub 2014 Oct 22.

16.

The cyanobacterial lectin scytovirin displays potent in vitro and in vivo activity against Zaire Ebola virus.

Garrison AR, Giomarelli BG, Lear-Rooney CM, Saucedo CJ, Yellayi S, Krumpe LR, Rose M, Paragas J, Bray M, Olinger GG Jr, McMahon JB, Huggins J, O'Keefe BR.

Antiviral Res. 2014 Dec;112:1-7. doi: 10.1016/j.antiviral.2014.09.012. Epub 2014 Oct 5.

17.

Tricyclic guanidine alkaloids from the marine sponge Acanthella cavernosa that stabilize the tumor suppressor PDCD4.

Grkovic T, Blees JS, Bayer MM, Colburn NH, Thomas CL, Henrich CJ, Peach ML, McMahon JB, Schmid T, Gustafson KR.

Mar Drugs. 2014 Aug 21;12(8):4593-601. doi: 10.3390/md12084593.

18.

Inhibition of the HIF1α-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II).

Jayatunga MK, Thompson S, McKee TC, Chan MC, Reece KM, Hardy AP, Sekirnik R, Seden PT, Cook KM, McMahon JB, Figg WD, Schofield CJ, Hamilton AD.

Eur J Med Chem. 2015 Apr 13;94:509-16. doi: 10.1016/j.ejmech.2014.06.006. Epub 2014 Jun 27.

19.

Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor.

Bajer MM, Kunze MM, Blees JS, Bokesch HR, Chen H, Brauss TF, Dong Z, Gustafson KR, Biondi RM, Henrich CJ, McMahon JB, Colburn NH, Schmid T, Brüne B.

Biochem Pharmacol. 2014 Apr 1;88(3):313-21. doi: 10.1016/j.bcp.2014.01.034. Epub 2014 Feb 7.

20.

Compounds from Simarouba berteroana which inhibit proliferation of NF1-defective cancer cells.

Devkota KP, Wilson JA, Henrich CJ, McMahon JB, Reilly KM, Beutler JA.

Phytochem Lett. 2014 Feb 1;7:42-45.

21.

Mechanisms of HIV-1 subtype C resistance to GRFT, CV-N and SVN.

Alexandre KB, Moore PL, Nonyane M, Gray ES, Ranchobe N, Chakauya E, McMahon JB, O'Keefe BR, Chikwamba R, Morris L.

Virology. 2013 Nov;446(1-2):66-76. doi: 10.1016/j.virol.2013.07.019. Epub 2013 Aug 15.

22.

Identification of compounds by high-content screening that induce cytoplasmic to nuclear localization of a fluorescent estrogen receptor α chimera and exhibit agonist or antagonist activity in vitro.

Dull AB, George AA, Goncharova EI, Evans JR, Wamiru A, Cartner LK, Hager GL, McMahon JB.

J Biomol Screen. 2014 Feb;19(2):242-52. doi: 10.1177/1087057113504136. Epub 2013 Sep 19.

23.

High-throughput screening for identification of inhibitors of EpCAM-dependent growth of hepatocellular carcinoma cells.

Henrich CJ, Budhu A, Yu Z, Evans JR, Goncharova EI, Ransom TT, Wang XW, McMahon JB.

Chem Biol Drug Des. 2013 Aug;82(2):131-9. doi: 10.1111/cbdd.12146.

24.

Antiviral lectins from red and blue-green algae show potent in vitro and in vivo activity against hepatitis C virus.

Takebe Y, Saucedo CJ, Lund G, Uenishi R, Hase S, Tsuchiura T, Kneteman N, Ramessar K, Tyrrell DL, Shirakura M, Wakita T, McMahon JB, O'Keefe BR.

PLoS One. 2013 May 21;8(5):e64449. doi: 10.1371/journal.pone.0064449. Print 2013.

25.

Growth inhibition of human colon carcinoma cells by sesquiterpenoids and tetralones of Zygogynum calothyrsum.

Devkota KP, Covell D, Ransom T, McMahon JB, Beutler JA.

J Nat Prod. 2013 Apr 26;76(4):710-4. doi: 10.1021/np400042q. Epub 2013 Mar 21.

26.

Isobutylhydroxyamides from the pericarp of Nepalese Zanthoxylum armatum inhibit NF1-defective tumor cell line growth.

Devkota KP, Wilson J, Henrich CJ, McMahon JB, Reilly KM, Beutler JA.

J Nat Prod. 2013 Jan 25;76(1):59-63. doi: 10.1021/np300696g. Epub 2012 Dec 26.

27.

Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase β-TrCP1.

Blees JS, Bokesch HR, Rübsamen D, Schulz K, Milke L, Bajer MM, Gustafson KR, Henrich CJ, McMahon JB, Colburn NH, Schmid T, Brüne B.

PLoS One. 2012;7(10):e46567. doi: 10.1371/journal.pone.0046567. Epub 2012 Oct 2.

28.
29.

Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.

McKee TC, Rabe D, Bokesch HR, Grkovic T, Whitson EL, Diyabalanage T, Van Wyk AW, Marcum SR, Gardella RS, Gustafson KR, Linehan WM, McMahon JB, Bottaro DP.

J Nat Prod. 2012 Sep 28;75(9):1632-6. Epub 2012 Aug 28.

30.

Flabelliferins A and B, sesterterpenoids from the South Pacific sponge Carteriospongia flabellifera.

Diyabalanage T, Ratnayake R, Bokesch HR, Ransom TT, Henrich CJ, Beutler JA, McMahon JB, Gustafson KR.

J Nat Prod. 2012 Aug 24;75(8):1490-4. doi: 10.1021/np3003518. Epub 2012 Jul 26.

31.

Synergistic TRAIL sensitizers from Barleria alluaudii and Diospyros maritima.

Whitson EL, Sun H, Thomas CL, Henrich CJ, Sayers TJ, McMahon JB, Griesinger C, McKee TC.

J Nat Prod. 2012 Mar 23;75(3):394-9. doi: 10.1021/np200805z. Epub 2012 Feb 7.

32.

Chlorinated englerins with selective inhibition of renal cancer cell growth.

Akee RK, Ransom T, Ratnayake R, McMahon JB, Beutler JA.

J Nat Prod. 2012 Mar 23;75(3):459-63. doi: 10.1021/np200905u. Epub 2012 Jan 26.

33.

The lectins griffithsin, cyanovirin-N and scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4(+) cells.

Alexandre KB, Gray ES, Mufhandu H, McMahon JB, Chakauya E, O'Keefe BR, Chikwamba R, Morris L.

Virology. 2012 Feb 20;423(2):175-86. doi: 10.1016/j.virol.2011.12.001. Epub 2011 Dec 29.

34.

Effects of cucurbitacins on cell morphology are associated with sensitization of renal carcinoma cells to TRAIL-induced apoptosis.

Henrich CJ, Thomas CL, Brooks AD, Booth NL, Lowery EM, Pompei RJ, McMahon JB, Sayers TJ.

Apoptosis. 2012 Jan;17(1):79-89. doi: 10.1007/s10495-011-0652-7.

35.

A new hypoxia inducible factor-2 inhibitory pyrrolinone alkaloid from roots and stems of Piper sarmentosum.

Bokesch HR, Gardella RS, Rabe DC, Bottaro DP, Linehan WM, McMahon JB, McKee TC.

Chem Pharm Bull (Tokyo). 2011;59(9):1178-9.

36.

Actinopolysporins A-C and tubercidin as a Pdcd4 stabilizer from the halophilic actinomycete Actinopolyspora erythraea YIM 90600.

Zhao LX, Huang SX, Tang SK, Jiang CL, Duan Y, Beutler JA, Henrich CJ, McMahon JB, Schmid T, Blees JS, Colburn NH, Rajski SR, Shen B.

J Nat Prod. 2011 Sep 23;74(9):1990-5. doi: 10.1021/np200603g. Epub 2011 Aug 26.

37.

Grassypeptolides F and G, cyanobacterial peptides from Lyngbya majuscula.

Popplewell WL, Ratnayake R, Wilson JA, Beutler JA, Colburn NH, Henrich CJ, McMahon JB, McKee TC.

J Nat Prod. 2011 Aug 26;74(8):1686-91. doi: 10.1021/np2005083. Epub 2011 Aug 1.

38.

Nothospondin, a new AP-1 inhibitory quassinoid from the Cameroonian plant Nothospondias staudtii.

Diyabalanage T, Ratnayake R, Wilson JA, Henrich CJ, Beutler JA, Colburn NH, McMahon JB, Gustafson KR.

Bioorg Med Chem Lett. 2011 Aug 1;21(15):4397-9. doi: 10.1016/j.bmcl.2011.06.044. Epub 2011 Jun 17.

39.

Binding of the mannose-specific lectin, griffithsin, to HIV-1 gp120 exposes the CD4-binding site.

Alexandre KB, Gray ES, Pantophlet R, Moore PL, McMahon JB, Chakauya E, O'Keefe BR, Chikwamba R, Morris L.

J Virol. 2011 Sep;85(17):9039-50. doi: 10.1128/JVI.02675-10. Epub 2011 Jun 22.

40.

Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening.

Grohar PJ, Woldemichael GM, Griffin LB, Mendoza A, Chen QR, Yeung C, Currier DG, Davis S, Khanna C, Khan J, McMahon JB, Helman LJ.

J Natl Cancer Inst. 2011 Jun 22;103(12):962-78. doi: 10.1093/jnci/djr156. Epub 2011 Jun 8.

41.

New candidaspongiolides, tedanolide analogues that selectively inhibit melanoma cell growth.

Whitson EL, Pluchino KM, Hall MD, McMahon JB, McKee TC.

Org Lett. 2011 Jul 1;13(13):3518-21. doi: 10.1021/ol201329p. Epub 2011 Jun 6. Erratum in: Org Lett. 2011 Aug 19;13(16):4477.

42.

Cryptocaryols A-H, α-pyrone-containing 1,3-polyols from Cryptocarya sp. implicated in stabilizing the tumor suppressor Pdcd4.

Grkovic T, Blees JS, Colburn NH, Schmid T, Thomas CL, Henrich CJ, McMahon JB, Gustafson KR.

J Nat Prod. 2011 May 27;74(5):1015-20. doi: 10.1021/np100918z. Epub 2011 May 3.

43.

New monoterpene glycosides and phenolic compounds from Distylium racemosum and their inhibitory activity against ribonuclease H.

Kim JA, Yang SY, Wamiru A, McMahon JB, Le Grice SF, Beutler JA, Kim YH.

Bioorg Med Chem Lett. 2011 May 15;21(10):2840-4. doi: 10.1016/j.bmcl.2011.03.091. Epub 2011 Mar 30.

PMID:
21489793
44.

Identification and evaluation of soft coral diterpenes as inhibitors of HIF-2α induced gene expression.

Grkovic T, Whitson EL, Rabe DC, Gardella RS, Bottaro DP, Linehan WM, McMahon JB, Gustafson KR, McKee TC.

Bioorg Med Chem Lett. 2011 Apr 1;21(7):2113-5. doi: 10.1016/j.bmcl.2011.01.127. Epub 2011 Feb 23.

45.

Inhibitors of the oncogenic transcription factor AP-1 from Podocarpus latifolius.

Devkota KP, Ratnayake R, Colburn NH, Wilson JA, Henrich CJ, McMahon JB, Beutler JA.

J Nat Prod. 2011 Mar 25;74(3):374-7. doi: 10.1021/np100736y. Epub 2011 Feb 9.

46.

Flavonoids from eight tropical plant species that inhibit the multidrug resistance transporter ABCG2.

Versiani MA, Diyabalanage T, Ratnayake R, Henrich CJ, Bates SE, McMahon JB, Gustafson KR.

J Nat Prod. 2011 Feb 25;74(2):262-6. doi: 10.1021/np100797y. Epub 2011 Jan 28.

47.

Carminomycin I is an apoptosis inducer that targets the Golgi complex in clear cell renal carcinoma cells.

Woldemichael GM, Turbyville TJ, Linehan WM, McMahon JB.

Cancer Res. 2011 Jan 1;71(1):134-42. doi: 10.1158/0008-5472.CAN-10-0757.

48.

Clerodane diterpenes from Casearia arguta that act as synergistic TRAIL sensitizers.

Whitson EL, Thomas CL, Henrich CJ, Sayers TJ, McMahon JB, McKee TC.

J Nat Prod. 2010 Dec 27;73(12):2013-8. doi: 10.1021/np1004455. Epub 2010 Nov 10.

49.

Monomerization of viral entry inhibitor griffithsin elucidates the relationship between multivalent binding to carbohydrates and anti-HIV activity.

Moulaei T, Shenoy SR, Giomarelli B, Thomas C, McMahon JB, Dauter Z, O'Keefe BR, Wlodawer A.

Structure. 2010 Sep 8;18(9):1104-15. doi: 10.1016/j.str.2010.05.016.

50.

Development of an image analysis screen for estrogen receptor alpha (ERα) ligands through measurement of nuclear translocation dynamics.

Dull A, Goncharova E, Hager G, McMahon JB.

J Steroid Biochem Mol Biol. 2010 Nov;122(5):341-51. doi: 10.1016/j.jsbmb.2010.08.009. Epub 2010 Sep 17.

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