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Items: 1 to 50 of 334

1.

Gli3 controls the onset of cortical neurogenesis by regulating the radial glial cell cycle through Cdk6 expression.

Hasenpusch-Theil K, West S, Kelman A, Kozic Z, Horrocks S, McMahon AP, Price DJ, Mason JO, Theil T.

Development. 2018 Aug 20;145(17). pii: dev163147. doi: 10.1242/dev.163147.

2.

A Simple Bioreactor-Based Method to Generate Kidney Organoids from Pluripotent Stem Cells.

Przepiorski A, Sander V, Tran T, Hollywood JA, Sorrenson B, Shih JH, Wolvetang EJ, McMahon AP, Holm TM, Davidson AJ.

Stem Cell Reports. 2018 Aug 14;11(2):470-484. doi: 10.1016/j.stemcr.2018.06.018. Epub 2018 Jul 19.

3.

Progressive Recruitment of Mesenchymal Progenitors Reveals a Time-Dependent Process of Cell Fate Acquisition in Mouse and Human Nephrogenesis.

Lindström NO, De Sena Brandine G, Tran T, Ransick A, Suh G, Guo J, Kim AD, Parvez RK, Ruffins SW, Rutledge EA, Thornton ME, Grubbs B, McMahon JA, Smith AD, McMahon AP.

Dev Cell. 2018 Jun 4;45(5):651-660.e4. doi: 10.1016/j.devcel.2018.05.010.

PMID:
29870722
4.

Disparate levels of beta-catenin activity determine nephron progenitor cell fate.

Ramalingam H, Fessler AR, Das A, Valerius MT, Basta J, Robbins L, Brown AC, Oxburgh L, McMahon AP, Rauchman M, Carroll TJ.

Dev Biol. 2018 Aug 1;440(1):13-21. doi: 10.1016/j.ydbio.2018.04.020. Epub 2018 Apr 26.

PMID:
29705331
5.

Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions.

Tan Z, Niu B, Tsang KY, Melhado IG, Ohba S, He X, Huang Y, Wang C, McMahon AP, Jauch R, Chan D, Zhang MQ, Cheah KSE.

PLoS Genet. 2018 Apr 16;14(4):e1007346. doi: 10.1371/journal.pgen.1007346. eCollection 2018 Apr.

6.

Conserved and Divergent Features of Human and Mouse Kidney Organogenesis.

Lindström NO, McMahon JA, Guo J, Tran T, Guo Q, Rutledge E, Parvez RK, Saribekyan G, Schuler RE, Liao C, Kim AD, Abdelhalim A, Ruffins SW, Thornton ME, Baskin L, Grubbs B, Kesselman C, McMahon AP.

J Am Soc Nephrol. 2018 Mar;29(3):785-805. doi: 10.1681/ASN.2017080887. Epub 2018 Feb 15.

PMID:
29449453
7.

Conserved and Divergent Molecular and Anatomic Features of Human and Mouse Nephron Patterning.

Lindström NO, Tran T, Guo J, Rutledge E, Parvez RK, Thornton ME, Grubbs B, McMahon JA, McMahon AP.

J Am Soc Nephrol. 2018 Mar;29(3):825-840. doi: 10.1681/ASN.2017091036. Epub 2018 Feb 15.

PMID:
29449451
8.

Conserved and Divergent Features of Mesenchymal Progenitor Cell Types within the Cortical Nephrogenic Niche of the Human and Mouse Kidney.

Lindström NO, Guo J, Kim AD, Tran T, Guo Q, De Sena Brandine G, Ransick A, Parvez RK, Thornton ME, Baskin L, Grubbs B, McMahon JA, Smith AD, McMahon AP.

J Am Soc Nephrol. 2018 Mar;29(3):806-824. doi: 10.1681/ASN.2017080890. Epub 2018 Feb 15.

PMID:
29449449
9.

Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies.

O'Brien LL, Guo Q, Bahrami-Samani E, Park JS, Hasso SM, Lee YJ, Fang A, Kim AD, Guo J, Hong TM, Peterson KA, Lozanoff S, Raviram R, Ren B, Fogelgren B, Smith AD, Valouev A, McMahon AP.

PLoS Genet. 2018 Jan 29;14(1):e1007181. doi: 10.1371/journal.pgen.1007181. eCollection 2018 Jan.

10.

Development of the Human Fetal Kidney from Mid to Late Gestation in Male and Female Infants.

Ryan D, Sutherland MR, Flores TJ, Kent AL, Dahlstrom JE, Puelles VG, Bertram JF, McMahon AP, Little MH, Moore L, Black MJ.

EBioMedicine. 2018 Jan;27:275-283. doi: 10.1016/j.ebiom.2017.12.016. Epub 2017 Dec 20.

11.

An immunohistochemical identification key for cell types in adult mouse prostatic and urethral tissue sections.

Wegner KA, Cadena MT, Trevena R, Turco AE, Gottschalk A, Halberg RB, Guo J, McMahon JA, McMahon AP, Vezina CM.

PLoS One. 2017 Nov 16;12(11):e0188413. doi: 10.1371/journal.pone.0188413. eCollection 2017.

12.

Molecular characterization of the transition from acute to chronic kidney injury following ischemia/reperfusion.

Liu J, Kumar S, Dolzhenko E, Alvarado GF, Guo J, Lu C, Chen Y, Li M, Dessing MC, Parvez RK, Cippà PE, Krautzberger AM, Saribekyan G, Smith AD, McMahon AP.

JCI Insight. 2017 Sep 21;2(18). pii: 94716. doi: 10.1172/jci.insight.94716. [Epub ahead of print]

13.

Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.

Rutledge EA, Benazet JD, McMahon AP.

Development. 2017 Sep 1;144(17):3177-3188. doi: 10.1242/dev.149112. Epub 2017 Jul 13.

14.

Sox9 positive periosteal cells in fracture repair of the adult mammalian long bone.

He X, Bougioukli S, Ortega B, Arevalo E, Lieberman JR, McMahon AP.

Bone. 2017 Oct;103:12-19. doi: 10.1016/j.bone.2017.06.008. Epub 2017 Jun 13.

PMID:
28627474
15.

Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.

Naiman N, Fujioka K, Fujino M, Valerius MT, Potter SS, McMahon AP, Kobayashi A.

Dev Cell. 2017 May 22;41(4):349-365.e3. doi: 10.1016/j.devcel.2017.04.022.

16.

A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking.

Minegishi K, Hashimoto M, Ajima R, Takaoka K, Shinohara K, Ikawa Y, Nishimura H, McMahon AP, Willert K, Okada Y, Sasaki H, Shi D, Fujimori T, Ohtsuka T, Igarashi Y, Yamaguchi TP, Shimono A, Shiratori H, Hamada H.

Dev Cell. 2017 Mar 13;40(5):439-452.e4. doi: 10.1016/j.devcel.2017.02.010.

17.

Hedgehog Signaling: From Basic Biology to Cancer Therapy.

Wu F, Zhang Y, Sun B, McMahon AP, Wang Y.

Cell Chem Biol. 2017 Mar 16;24(3):252-280. doi: 10.1016/j.chembiol.2017.02.010. Epub 2017 Mar 9. Review.

18.

(Re)Building a Kidney.

Oxburgh L, Carroll TJ, Cleaver O, Gossett DR, Hoshizaki DK, Hubbell JA, Humphreys BD, Jain S, Jensen J, Kaplan DL, Kesselman C, Ketchum CJ, Little MH, McMahon AP, Shankland SJ, Spence JR, Valerius MT, Wertheim JA, Wessely O, Zheng Y, Drummond IA.

J Am Soc Nephrol. 2017 May;28(5):1370-1378. doi: 10.1681/ASN.2016101077. Epub 2017 Jan 17.

19.

Correction: Foxf Genes Integrate Tbx5 and Hedgehog Pathways in the Second Heart Field for Cardiac Septation.

Hoffmann AD, Yang XH, Burnicka-Turek O, Bosman JD, Ren X, Xie L, Steimle JD, Vokes SA, McMahon AP, Kalinichenko VV, Moskowitz IP.

PLoS Genet. 2016 Dec 29;12(12):e1006533. doi: 10.1371/journal.pgen.1006533. eCollection 2016 Dec.

20.

An Emerging Regulatory Landscape for Skeletal Development.

Hojo H, McMahon AP, Ohba S.

Trends Genet. 2016 Dec;32(12):774-787. doi: 10.1016/j.tig.2016.10.001. Epub 2016 Nov 1. Review.

21.

AP-1 family members act with Sox9 to promote chondrocyte hypertrophy.

He X, Ohba S, Hojo H, McMahon AP.

Development. 2016 Aug 15;143(16):3012-23. doi: 10.1242/dev.134502. Epub 2016 Jul 28.

22.

Stem cells for all ages, yet hostage to aging.

Finch CE, McMahon AP.

Stem Cell Investig. 2016 Apr 14;3:11. doi: 10.21037/sci.2016.04.02. eCollection 2016. No abstract available.

23.

An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1.

Lorberbaum DS, Ramos AI, Peterson KA, Carpenter BS, Parker DS, De S, Hillers LE, Blake VM, Nishi Y, McFarlane MR, Chiang AC, Kassis JA, Allen BL, McMahon AP, Barolo S.

Elife. 2016 May 5;5. pii: e13550. doi: 10.7554/eLife.13550.

24.

Sp7/Osterix Is Restricted to Bone-Forming Vertebrates where It Acts as a Dlx Co-factor in Osteoblast Specification.

Hojo H, Ohba S, He X, Lai LP, McMahon AP.

Dev Cell. 2016 May 9;37(3):238-53. doi: 10.1016/j.devcel.2016.04.002. Epub 2016 Apr 28.

25.

Development of the Mammalian Kidney.

McMahon AP.

Curr Top Dev Biol. 2016;117:31-64. doi: 10.1016/bs.ctdb.2015.10.010. Epub 2016 Jan 23. Review.

26.

Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators.

O'Brien LL, Guo Q, Lee Y, Tran T, Benazet JD, Whitney PH, Valouev A, McMahon AP.

Development. 2016 Feb 15;143(4):595-608. doi: 10.1242/dev.127175.

27.

Iroquois Proteins Promote Skeletal Joint Formation by Maintaining Chondrocytes in an Immature State.

Askary A, Mork L, Paul S, He X, Izuhara AK, Gopalakrishnan S, Ichida JK, McMahon AP, Dabizljevic S, Dale R, Mariani FV, Crump JG.

Dev Cell. 2015 Nov 9;35(3):358-65. doi: 10.1016/j.devcel.2015.10.004.

28.

Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity.

Hettmer S, Lin MM, Tchessalova D, Tortorici SJ, Castiglioni A, Desai T, Mao J, McMahon AP, Wagers AJ.

Exp Cell Res. 2016 Jan 1;340(1):43-52. doi: 10.1016/j.yexcr.2015.10.008. Epub 2015 Oct 13.

29.

A direct fate exclusion mechanism by Sonic hedgehog-regulated transcriptional repressors.

Nishi Y, Zhang X, Jeong J, Peterson KA, Vedenko A, Bulyk ML, Hide WA, McMahon AP.

Development. 2015 Oct 1;142(19):3286-93. doi: 10.1242/dev.124636. Epub 2015 Aug 20.

30.

Sox9 Activation Highlights a Cellular Pathway of Renal Repair in the Acutely Injured Mammalian Kidney.

Kumar S, Liu J, Pang P, Krautzberger AM, Reginensi A, Akiyama H, Schedl A, Humphreys BD, McMahon AP.

Cell Rep. 2015 Aug 25;12(8):1325-38. doi: 10.1016/j.celrep.2015.07.034. Epub 2015 Aug 13.

31.

Corrigendum: The dynamics of methylammonium ions in hybrid organic-inorganic perovskite solar cells.

Leguy AM, Frost JM, McMahon AP, Sakai VG, Kockelmann W, Law C, Li X, Foglia F, Walsh A, O'Regan BC, Nelson J, Cabral JT, Barnes PR.

Nat Commun. 2015 Jul 20;6:7780. doi: 10.1038/ncomms8780. No abstract available.

32.

Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte.

Ohba S, He X, Hojo H, McMahon AP.

Cell Rep. 2015 Jul 14;12(2):229-43. doi: 10.1016/j.celrep.2015.06.013. Epub 2015 Jul 2.

33.

The dynamics of methylammonium ions in hybrid organic-inorganic perovskite solar cells.

Leguy AM, Frost JM, McMahon AP, Sakai VG, Kochelmann W, Law C, Li X, Foglia F, Walsh A, O'Regan BC, Nelson J, Cabral JT, Barnes PR.

Nat Commun. 2015 May 29;6:7124. doi: 10.1038/ncomms8124. Erratum in: Nat Commun. 2015;6:7780. Kochelmann, W [Corrected to Kockelmann, W].

34.

A predictive model of bifunctional transcription factor signaling during embryonic tissue patterning.

Junker JP, Peterson KA, Nishi Y, Mao J, McMahon AP, van Oudenaarden A.

Dev Cell. 2014 Nov 24;31(4):448-60. doi: 10.1016/j.devcel.2014.10.017. Epub 2014 Nov 24.

35.

Genome-wide RNA Tomography in the zebrafish embryo.

Junker JP, Noël ES, Guryev V, Peterson KA, Shah G, Huisken J, McMahon AP, Berezikov E, Bakkers J, van Oudenaarden A.

Cell. 2014 Oct 23;159(3):662-75. doi: 10.1016/j.cell.2014.09.038.

36.

Identification of a multipotent self-renewing stromal progenitor population during mammalian kidney organogenesis.

Kobayashi A, Mugford JW, Krautzberger AM, Naiman N, Liao J, McMahon AP.

Stem Cell Reports. 2014 Oct 14;3(4):650-62. doi: 10.1016/j.stemcr.2014.08.008. Epub 2014 Sep 18.

37.

Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation.

Hoffmann AD, Yang XH, Burnicka-Turek O, Bosman JD, Ren X, Steimle JD, Vokes SA, McMahon AP, Kalinichenko VV, Moskowitz IP.

PLoS Genet. 2014 Oct 30;10(10):e1004604. doi: 10.1371/journal.pgen.1004604. eCollection 2014 Oct. Erratum in: PLoS Genet. 2016 Dec 29;12 (12 ):e1006533.

38.

Stk11 (Lkb1) deletion in the osteoblast lineage leads to high bone turnover, increased trabecular bone density and cortical porosity.

Lai LP, Lotinun S, Bouxsein ML, Baron R, McMahon AP.

Bone. 2014 Dec;69:98-108. doi: 10.1016/j.bone.2014.09.010. Epub 2014 Sep 18.

39.

Defining the acute kidney injury and repair transcriptome.

Kumar S, Liu J, McMahon AP.

Semin Nephrol. 2014 Jul;34(4):404-17. doi: 10.1016/j.semnephrol.2014.06.007. Epub 2014 Jun 13. Review.

40.

Induction and patterning of the metanephric nephron.

O'Brien LL, McMahon AP.

Semin Cell Dev Biol. 2014 Dec;36:31-8. doi: 10.1016/j.semcdb.2014.08.014. Epub 2014 Sep 3. Review.

41.

Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs.

Lopez-Rios J, Duchesne A, Speziale D, Andrey G, Peterson KA, Germann P, Unal E, Liu J, Floriot S, Barbey S, Gallard Y, Müller-Gerbl M, Courtney AD, Klopp C, Rodriguez S, Ivanek R, Beisel C, Wicking C, Iber D, Robert B, McMahon AP, Duboule D, Zeller R.

Nature. 2014 Jul 3;511(7507):46-51. doi: 10.1038/nature13289. Epub 2014 Jun 18.

PMID:
24990743
42.

Collecting duct-derived cells display mesenchymal stem cell properties and retain selective in vitro and in vivo epithelial capacity.

Li J, Ariunbold U, Suhaimi N, Sunn N, Guo J, McMahon JA, McMahon AP, Little M.

J Am Soc Nephrol. 2015 Jan;26(1):81-94. doi: 10.1681/ASN.2013050517. Epub 2014 Jun 5.

43.

Global quantification of tissue dynamics in the developing mouse kidney.

Short KM, Combes AN, Lefevre J, Ju AL, Georgas KM, Lamberton T, Cairncross O, Rumballe BA, McMahon AP, Hamilton NA, Smyth IM, Little MH.

Dev Cell. 2014 Apr 28;29(2):188-202. doi: 10.1016/j.devcel.2014.02.017.

44.

Translational profiles of medullary myofibroblasts during kidney fibrosis.

Grgic I, Krautzberger AM, Hofmeister A, Lalli M, DiRocco DP, Fleig SV, Liu J, Duffield JS, McMahon AP, Aronow B, Humphreys BD.

J Am Soc Nephrol. 2014 Sep;25(9):1979-90. doi: 10.1681/ASN.2013101143. Epub 2014 Mar 20.

45.

Cell-specific translational profiling in acute kidney injury.

Liu J, Krautzberger AM, Sui SH, Hofmann OM, Chen Y, Baetscher M, Grgic I, Kumar S, Humphreys BD, Hide WA, McMahon AP.

J Clin Invest. 2014 Mar;124(3):1242-54. doi: 10.1172/JCI72126. Epub 2014 Feb 24. Erratum in: J Clin Invest. 2014 May 1;124(5):2288. Humphreys, Benjamin [corrected to Humphreys, Benjamin D].

46.

Defining kidney biology to understand renal disease.

Little MH, Brown D, Humphreys BD, McMahon AP, Miner JH, Sands JM, Weisz OA, Mullins C, Hoshizaki D; Kidney Research National Dialogue (KRND).

Clin J Am Soc Nephrol. 2014 Apr;9(4):809-11. doi: 10.2215/CJN.10851013. Epub 2013 Dec 26.

47.

A novel site comes into sight.

Wang Y, McMahon AP.

Elife. 2013 Dec 3;2:e01680. doi: 10.7554/eLife.01680.

48.

Distinct cellular origin and genetic requirement of Hedgehog-Gli in postnatal rhabdomyosarcoma genesis.

Rajurkar M, Huang H, Cotton JL, Brooks JK, Sicklick J, McMahon AP, Mao J.

Oncogene. 2014 Nov 13;33(46):5370-8. doi: 10.1038/onc.2013.480. Epub 2013 Nov 25.

49.

Lkb1/Stk11 regulation of mTOR signaling controls the transition of chondrocyte fates and suppresses skeletal tumor formation.

Lai LP, Lilley BN, Sanes JR, McMahon AP.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19450-5. doi: 10.1073/pnas.1309001110. Epub 2013 Nov 11.

50.

Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis.

Humphreys BD, Xu F, Sabbisetti V, Grgic I, Movahedi Naini S, Wang N, Chen G, Xiao S, Patel D, Henderson JM, Ichimura T, Mou S, Soeung S, McMahon AP, Kuchroo VK, Bonventre JV.

J Clin Invest. 2013 Sep;123(9):4023-35. doi: 10.1172/JCI45361. Epub 2013 Aug 27.

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