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Items: 7

1.

Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target.

Yuthavong Y, Tarnchompoo B, Vilaivan T, Chitnumsub P, Kamchonwongpaisan S, Charman SA, McLennan DN, White KL, Vivas L, Bongard E, Thongphanchang C, Taweechai S, Vanichtanankul J, Rattanajak R, Arwon U, Fantauzzi P, Yuvaniyama J, Charman WN, Matthews D.

Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16823-8. doi: 10.1073/pnas.1204556109. Epub 2012 Oct 3.

2.

Lymphatic absorption of subcutaneously administered proteins: influence of different injection sites on the absorption of darbepoetin alfa using a sheep model.

Kota J, Machavaram KK, McLennan DN, Edwards GA, Porter CJ, Charman SA.

Drug Metab Dispos. 2007 Dec;35(12):2211-7. Epub 2007 Sep 17.

PMID:
17875672
3.

The absorption of darbepoetin alfa occurs predominantly via the lymphatics following subcutaneous administration to sheep.

McLennan DN, Porter CJ, Edwards GA, Heatherington AC, Martin SW, Charman SA.

Pharm Res. 2006 Sep;23(9):2060-6. Epub 2006 Aug 9.

PMID:
16951999
4.

Subcutaneous drug delivery and the role of the lymphatics.

McLennan DN, Porter CJ, Charman SA.

Drug Discov Today Technol. 2005 Spring;2(1):89-96. doi: 10.1016/j.ddtec.2005.05.006.

PMID:
24981760
5.

Lymphatic absorption is the primary contributor to the systemic availability of epoetin Alfa following subcutaneous administration to sheep.

McLennan DN, Porter CJ, Edwards GA, Martin SW, Heatherington AC, Charman SA.

J Pharmacol Exp Ther. 2005 Apr;313(1):345-51. Epub 2004 Dec 3.

PMID:
15579493
6.

Pharmacokinetic model to describe the lymphatic absorption of r-metHu-leptin after subcutaneous injection to sheep.

McLennan DN, Porter CJ, Edwards GA, Brumm M, Martin SW, Charman SA.

Pharm Res. 2003 Aug;20(8):1156-62.

PMID:
12948012
7.

Lymphatic absorption is a significant contributor to the subcutaneous bioavailability of insulin in a sheep model.

Charman SA, McLennan DN, Edwards GA, Porter CJ.

Pharm Res. 2001 Nov;18(11):1620-6.

PMID:
11758772

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