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Dissociating STAT4 and STAT5 Signaling Inhibitory Functions of SOCS3: Effects on CD8 T Cell Responses.

Hwang JY, Holland JE, Valenteros KB, Sun Y, Usherwood YK, Verissimo AF, McLellan JS, Grigoryan G, Usherwood EJ.

Immunohorizons. 2019 Nov 20;3(11):547-558. doi: 10.4049/immunohorizons.1800075.


Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD.

Wang N, Rosen O, Wang L, Turner HL, Stevens LJ, Corbett KS, Bowman CA, Pallesen J, Shi W, Zhang Y, Leung K, Kirchdoerfer RN, Becker MM, Denison MR, Chappell JD, Ward AB, Graham BS, McLellan JS.

Cell Rep. 2019 Sep 24;28(13):3395-3405.e6. doi: 10.1016/j.celrep.2019.08.052.


Effects of antihypertensives, lipid-modifying drugs, glycaemic control drugs and sodium bicarbonate on the progression of stages 3 and 4 chronic kidney disease in adults: a systematic review and meta-analysis.

Taylor KS, Mclellan J, Verbakel JY, Aronson JK, Lasserson DS, Pidduck N, Roberts N, Fleming S, O'Callaghan CA, Bankhead CR, Banerjee A, Hobbs FR, Perera R.

BMJ Open. 2019 Sep 20;9(9):e030596. doi: 10.1136/bmjopen-2019-030596.


The 3.1-Angstrom Cryo-electron Microscopy Structure of the Porcine Epidemic Diarrhea Virus Spike Protein in the Prefusion Conformation.

Wrapp D, McLellan JS.

J Virol. 2019 Nov 13;93(23). pii: e00923-19. doi: 10.1128/JVI.00923-19. Print 2019 Dec 1.


Structure of the Respiratory Syncytial Virus Polymerase Complex.

Gilman MSA, Liu C, Fung A, Behera I, Jordan P, Rigaux P, Ysebaert N, Tcherniuk S, Sourimant J, Eléouët JF, Sutto-Ortiz P, Decroly E, Roymans D, Jin Z, McLellan JS.

Cell. 2019 Sep 19;179(1):193-204.e14. doi: 10.1016/j.cell.2019.08.014. Epub 2019 Sep 5.


A proof of concept for structure-based vaccine design targeting RSV in humans.

Crank MC, Ruckwardt TJ, Chen M, Morabito KM, Phung E, Costner PJ, Holman LA, Hickman SP, Berkowitz NM, Gordon IJ, Yamshchikov GV, Gaudinski MR, Kumar A, Chang LA, Moin SM, Hill JP, DiPiazza AT, Schwartz RM, Kueltzo L, Cooper JW, Chen P, Stein JA, Carlton K, Gall JG, Nason MC, Kwong PD, Chen GL, Mascola JR, McLellan JS, Ledgerwood JE, Graham BS; VRC 317 Study Team.

Science. 2019 Aug 2;365(6452):505-509. doi: 10.1126/science.aav9033.


Natriuretic peptide-guided treatment for heart failure: a systematic review and meta-analysis.

McLellan J, Bankhead CR, Oke JL, Hobbs FDR, Taylor CJ, Perera R.

BMJ Evid Based Med. 2019 Jul 20. pii: bmjebm-2019-111208. doi: 10.1136/bmjebm-2019-111208. [Epub ahead of print]


Alternative conformations of a major antigenic site on RSV F.

Jones HG, Battles MB, Lin CC, Bianchi S, Corti D, McLellan JS.

PLoS Pathog. 2019 Jul 15;15(7):e1007944. doi: 10.1371/journal.ppat.1007944. eCollection 2019 Jul.


Investigating midwives' barriers and facilitators to multiple health promotion practice behaviours: a qualitative study using the theoretical domains framework.

McLellan JM, O'Carroll RE, Cheyne H, Dombrowski SU.

Implement Sci. 2019 Jun 18;14(1):64. doi: 10.1186/s13012-019-0913-3.


Transient opening of trimeric prefusion RSV F proteins.

Gilman MSA, Furmanova-Hollenstein P, Pascual G, B van 't Wout A, Langedijk JPM, McLellan JS.

Nat Commun. 2019 May 8;10(1):2105. doi: 10.1038/s41467-019-09807-5.


Case - Recurrent incarcerated inguinal bladder hernia with small bowel obstruction.

McLellan J, Mir ZM, Di Lena M, Nanji S, Beiko D.

Can Urol Assoc J. 2019 Feb 26:E382-E384. doi: 10.5489/cuaj.5740. [Epub ahead of print] No abstract available.


Respiratory syncytial virus entry and how to block it.

Battles MB, McLellan JS.

Nat Rev Microbiol. 2019 Apr;17(4):233-245. doi: 10.1038/s41579-019-0149-x. Review.


Iterative screen optimization maximizes the efficiency of macromolecular crystallization.

Jones HG, Wrapp D, Gilman MSA, Battles MB, Wang N, Sacerdote S, Chuang GY, Kwong PD, McLellan JS.

Acta Crystallogr F Struct Biol Commun. 2019 Feb 1;75(Pt 2):123-131. doi: 10.1107/S2053230X18017338. Epub 2019 Jan 24.


Structure-Based Vaccine Antigen Design.

Graham BS, Gilman MSA, McLellan JS.

Annu Rev Med. 2019 Jan 27;70:91-104. doi: 10.1146/annurev-med-121217-094234.


Publisher Correction: Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis.

Kirchdoerfer RN, Wang N, Pallesen J, Wrapp D, Turner HL, Cottrell CA, Corbett KS, Graham BS, McLellan JS, Ward AB.

Sci Rep. 2018 Dec 10;8(1):17823. doi: 10.1038/s41598-018-36918-8.


A high-throughput inhibition assay to study MERS-CoV antibody interactions using image cytometry.

Rosen O, Chan LL, Abiona OM, Gough P, Wang L, Shi W, Zhang Y, Wang N, Kong WP, McLellan JS, Graham BS, Corbett KS.

J Virol Methods. 2019 Mar;265:77-83. doi: 10.1016/j.jviromet.2018.11.009. Epub 2018 Nov 20.


Essential components in natriuretic peptide-guided management of heart failure: an intervention synthesis.

Oke J, Clements A, McLellan J, Bankhead C, Taylor CJ, Spence G, Banerjee A, Perera R.

Open Heart. 2018 Oct 8;5(2):e000826. doi: 10.1136/openhrt-2018-000826. eCollection 2018.


Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis.

Kirchdoerfer RN, Wang N, Pallesen J, Wrapp D, Turner HL, Cottrell CA, Corbett KS, Graham BS, McLellan JS, Ward AB.

Sci Rep. 2018 Oct 24;8(1):15701. doi: 10.1038/s41598-018-34171-7. Erratum in: Sci Rep. 2018 Dec 10;8(1):17823.


Evaluation of videoendoscopic examinations of arytenoid function in the 2-year-old Thoroughbred: Can we all agree?

McLellan J, Plevin S.

Equine Vet J. 2019 May;51(3):364-369. doi: 10.1111/evj.13030. Epub 2018 Oct 27.


Ultrasound tissue characterisation of the superficial digital flexor tendons in juvenile Thoroughbred racehorses during early race training.

Plevin S, McLellan J, van Schie H, Parkin T.

Equine Vet J. 2019 May;51(3):349-355. doi: 10.1111/evj.13006. Epub 2018 Sep 18.


Managing clinical uncertainty: An ethnographic study of the impact of critical care outreach on end-of-life transitions in ward-based critically ill patients with a life-limiting illness.

Pattison N, Mclellan J, Roskelly L, McLeod K, Wiseman T.

J Clin Nurs. 2018 Nov;27(21-22):3900-3912. doi: 10.1111/jocn.14618. Epub 2018 Aug 2.


The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates.

Mazur NI, Higgins D, Nunes MC, Melero JA, Langedijk AC, Horsley N, Buchholz UJ, Openshaw PJ, McLellan JS, Englund JA, Mejias A, Karron RA, Simões EA, Knezevic I, Ramilo O, Piedra PA, Chu HY, Falsey AR, Nair H, Kragten-Tabatabaie L, Greenough A, Baraldi E, Papadopoulos NG, Vekemans J, Polack FP, Powell M, Satav A, Walsh EE, Stein RT, Graham BS, Bont LJ; Respiratory Syncytial Virus Network (ReSViNET) Foundation.

Lancet Infect Dis. 2018 Oct;18(10):e295-e311. doi: 10.1016/S1473-3099(18)30292-5. Epub 2018 Jun 18. Review. Erratum in: Lancet Infect Dis. 2018 Jul 25;:.


Five Residues in the Apical Loop of the Respiratory Syncytial Virus Fusion Protein F2 Subunit Are Critical for Its Fusion Activity.

Hicks SN, Chaiwatpongsakorn S, Costello HM, McLellan JS, Ray W, Peeples ME.

J Virol. 2018 Jul 17;92(15). pii: e00621-18. doi: 10.1128/JVI.00621-18. Print 2018 Aug 1.


Global site-specific analysis of glycoprotein N-glycan processing.

Cao L, Diedrich JK, Ma Y, Wang N, Pauthner M, Park SR, Delahunty CM, McLellan JS, Burton DR, Yates JR, Paulson JC.

Nat Protoc. 2018 Jun;13(6):1196-1212. doi: 10.1038/nprot.2018.024. Epub 2018 May 3.


Kidney age, not kidney disease.

Stevens RJ, Evans J, Oke J, Smart B, Hobbs FDR, Holloway E, Horwood J, Judd M, Locock L, McLellan J, Perera R.

CMAJ. 2018 Apr 3;190(13):E389-E393. doi: 10.1503/cmaj.170674. Review. No abstract available. Erratum in: CMAJ. 2019 Apr 1;191(13):E372.


Natriuretic peptide guided therapy for management of patients with heart failure does not show improvement compared with usual medical therapy alone.

McLellan J, Bankhead C.

BMJ Evid Based Med. 2018 Apr;23(2):74-75. doi: 10.1136/bmjebm-2017-110880. Epub 2018 Feb 22. Review. No abstract available.


Tracking intracellular uptake and localisation of alkyne tagged fatty acids using Raman spectroscopy.

Jamieson LE, Greaves J, McLellan JA, Munro KR, Tomkinson NCO, Chamberlain LH, Faulds K, Graham D.

Spectrochim Acta A Mol Biomol Spectrosc. 2018 May 15;197:30-36. doi: 10.1016/j.saa.2018.01.064. Epub 2018 Mar 7.


Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape.

Wang L, Shi W, Chappell JD, Joyce MG, Zhang Y, Kanekiyo M, Becker MM, van Doremalen N, Fischer R, Wang N, Corbett KS, Choe M, Mason RD, Van Galen JG, Zhou T, Saunders KO, Tatti KM, Haynes LM, Kwong PD, Modjarrad K, Kong WP, McLellan JS, Denison MR, Munster VJ, Mascola JR, Graham BS.

J Virol. 2018 Apr 27;92(10). pii: e02002-17. doi: 10.1128/JVI.02002-17. Print 2018 May 15.


Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies.

Jones HG, Ritschel T, Pascual G, Brakenhoff JPJ, Keogh E, Furmanova-Hollenstein P, Lanckacker E, Wadia JS, Gilman MSA, Williamson RA, Roymans D, van 't Wout AB, Langedijk JP, McLellan JS.

PLoS Pathog. 2018 Mar 6;14(3):e1006935. doi: 10.1371/journal.ppat.1006935. eCollection 2018 Mar.


Superbugs in the supermarket? Assessing the rate of contamination with third-generation cephalosporin-resistant gram-negative bacteria in fresh Australian pork and chicken.

McLellan JE, Pitcher JI, Ballard SA, Grabsch EA, Bell JM, Barton M, Grayson ML.

Antimicrob Resist Infect Control. 2018 Feb 23;7:30. doi: 10.1186/s13756-018-0322-4. eCollection 2018.


Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation.

Goodwin E, Gilman MSA, Wrapp D, Chen M, Ngwuta JO, Moin SM, Bai P, Sivasubramanian A, Connor RI, Wright PF, Graham BS, McLellan JS, Walker LM.

Immunity. 2018 Feb 20;48(2):339-349.e5. doi: 10.1016/j.immuni.2018.01.005. Epub 2018 Feb 3.


Regioselective Reaction of Heterocyclic N-Oxides, an Acyl Chloride, and Cyclic Thioethers.

Frei P, Jones DH, Kay ST, McLellan JA, Johnston BF, Kennedy AR, Tomkinson NCO.

J Org Chem. 2018 Feb 2;83(3):1510-1517. doi: 10.1021/acs.joc.7b02457. Epub 2018 Jan 18.


Extraction of unadjusted estimates of prognostic association for meta-analysis: simulation methods as good alternatives to trend and direct method estimation.

Pérez T, McLellan J, Perera R.

J Clin Epidemiol. 2018 Jul;99:153-163. doi: 10.1016/j.jclinepi.2017.12.017. Epub 2017 Dec 28.


Electroconvulsive Therapy: The Impact of a Brief Educational Intervention on Public Knowledge and Attitudes.

Hoffman GA, McLellan J, Hoogendoorn V, Beck AW.

Int Q Community Health Educ. 2018 Jan;38(2):129-136. doi: 10.1177/0272684X17749939. Epub 2017 Dec 25.


Chimeric Pneumoviridae fusion proteins as immunogens to induce cross-neutralizing antibody responses.

Olmedillas E, Cano O, Martínez I, Luque D, Terrón MC, McLellan JS, Melero JA, Más V.

EMBO Mol Med. 2018 Feb;10(2):175-187. doi: 10.15252/emmm.201708078.


Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein.

Tian D, Battles MB, Moin SM, Chen M, Modjarrad K, Kumar A, Kanekiyo M, Graepel KW, Taher NM, Hotard AL, Moore ML, Zhao M, Zheng ZZ, Xia NS, McLellan JS, Graham BS.

Nat Commun. 2017 Nov 30;8(1):1877. doi: 10.1038/s41467-017-01858-w.


Corrigendum: Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state.

Rossey I, Gilman MSA, Kabeche SC, Sedeyn K, Wrapp D, Kanekiyo M, Chen M, Mas V, Spitaels J, Melero JA, Graham BS, Schepens B, McLellan JS, Saelens X.

Nat Commun. 2017 Nov 29;8:16165. doi: 10.1038/ncomms16165.


Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoprotein.

Battles MB, Más V, Olmedillas E, Cano O, Vázquez M, Rodríguez L, Melero JA, McLellan JS.

Nat Commun. 2017 Nov 16;8(1):1528. doi: 10.1038/s41467-017-01708-9.


Clinical Potential of Prefusion RSV F-specific Antibodies.

Rossey I, McLellan JS, Saelens X, Schepens B.

Trends Microbiol. 2018 Mar;26(3):209-219. doi: 10.1016/j.tim.2017.09.009. Epub 2017 Oct 17. Review.


Systematic Review and Metaanalysis Comparing the Bias and Accuracy of the Modification of Diet in Renal Disease and Chronic Kidney Disease Epidemiology Collaboration Equations in Community-Based Populations.

McFadden EC, Hirst JA, Verbakel JY, McLellan JH, Hobbs FDR, Stevens RJ, O'Callaghan CA, Lasserson DS.

Clin Chem. 2018 Mar;64(3):475-485. doi: 10.1373/clinchem.2017.276683. Epub 2017 Oct 18.


Crystal Structures of Two Immune Complexes Identify Determinants for Viral Infectivity and Type-Specific Neutralization of Human Papillomavirus.

Li Z, Wang D, Gu Y, Song S, He M, Shi J, Liu X, Wei S, Li J, Yu H, Zheng Q, Yan X, Baker TS, Zhang J, McLellan JS, Li S, Xia N.

MBio. 2017 Sep 26;8(5). pii: e00787-17. doi: 10.1128/mBio.00787-17.


Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.

Pallesen J, Wang N, Corbett KS, Wrapp D, Kirchdoerfer RN, Turner HL, Cottrell CA, Becker MM, Wang L, Shi W, Kong WP, Andres EL, Kettenbach AN, Denison MR, Chappell JD, Graham BS, Ward AB, McLellan JS.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):E7348-E7357. doi: 10.1073/pnas.1707304114. Epub 2017 Aug 14.


Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor.

Roymans D, Alnajjar SS, Battles MB, Sitthicharoenchai P, Furmanova-Hollenstein P, Rigaux P, Berg JVD, Kwanten L, Ginderen MV, Verheyen N, Vranckx L, Jaensch S, Arnoult E, Voorzaat R, Gallup JM, Larios-Mora A, Crabbe M, Huntjens D, Raboisson P, Langedijk JP, Ackermann MR, McLellan JS, Vendeville S, Koul A.

Nat Commun. 2017 Aug 1;8(1):167. doi: 10.1038/s41467-017-00170-x.


Regioselective Three-Component Reaction of Pyridine N-Oxides, Acyl Chlorides, and Cyclic Ethers.

Jones DH, Kay ST, McLellan JA, Kennedy AR, Tomkinson NCO.

Org Lett. 2017 Jul 7;19(13):3512-3515. doi: 10.1021/acs.orglett.7b01481. Epub 2017 Jun 16.


Science-in-brief: Bisphosphonate use in the racehorse: Safe or unsafe?

McLellan J.

Equine Vet J. 2017 Jul;49(4):404-407. doi: 10.1111/evj.12682. No abstract available.


The Effect of Antibiotic Exposure and Specimen Volume on the Detection of Bacterial Pathogens in Children With Pneumonia.

Driscoll AJ, Deloria Knoll M, Hammitt LL, Baggett HC, Brooks WA, Feikin DR, Kotloff KL, Levine OS, Madhi SA, O'Brien KL, Scott JAG, Thea DM, Howie SRC, Adrian PV, Ahmed D, DeLuca AN, Ebruke BE, Gitahi C, Higdon MM, Kaewpan A, Karani A, Karron RA, Mazumder R, McLellan J, Moore DP, Mwananyanda L, Park DE, Prosperi C, Rhodes J, Saifullah M, Seidenberg P, Sow SO, Tamboura B, Zeger SL, Murdoch DR; PERCH Study Group .

Clin Infect Dis. 2017 Jun 15;64(suppl_3):S368-S377. doi: 10.1093/cid/cix101.


The Diagnostic Utility of Induced Sputum Microscopy and Culture in Childhood Pneumonia.

Murdoch DR, Morpeth SC, Hammitt LL, Driscoll AJ, Watson NL, Baggett HC, Brooks WA, Deloria Knoll M, Feikin DR, Kotloff KL, Levine OS, Madhi SA, O'Brien KL, Scott JAG, Thea DM, Adrian PV, Ahmed D, Alam M, Awori JO, DeLuca AN, Higdon MM, Karron RA, Kwenda G, Machuka EM, Makprasert S, McLellan J, Moore DP, Mwaba J, Mwarumba S, Park DE, Prosperi C, Sangwichian O, Sissoko S, Tapia MD, Zeger SL, Howie SRC; PERCH Study Group .

Clin Infect Dis. 2017 Jun 15;64(suppl_3):S280-S288. doi: 10.1093/cid/cix090.


Improved Prefusion Stability, Optimized Codon Usage, and Augmented Virion Packaging Enhance the Immunogenicity of Respiratory Syncytial Virus Fusion Protein in a Vectored-Vaccine Candidate.

Liang B, Ngwuta JO, Surman S, Kabatova B, Liu X, Lingemann M, Liu X, Yang L, Herbert R, Swerczek J, Chen M, Moin SM, Kumar A, McLellan JS, Kwong PD, Graham BS, Collins PL, Munir S.

J Virol. 2017 Jul 12;91(15). pii: e00189-17. doi: 10.1128/JVI.00189-17. Print 2017 Aug 1.

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