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Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1.

Kishk SM, McLean KJ, Sood S, Helal MA, Gomaa MS, Salama I, Mostafa SM, de Carvalho LPS, Munro AW, Simons C.

Bioorg Med Chem. 2019 Apr 15;27(8):1546-1561. doi: 10.1016/j.bmc.2019.02.051. Epub 2019 Feb 27.


Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs.

Jeffreys LN, Poddar H, Golovanova M, Levy CW, Girvan HM, McLean KJ, Voice MW, Leys D, Munro AW.

Sci Rep. 2019 Feb 7;9(1):1577. doi: 10.1038/s41598-018-37330-y.


Maternal nutrition and stage of early pregnancy in beef heifers: impacts on hexose and AA concentrations in maternal and fetal fluids1.

Crouse MS, Greseth NP, McLean KJ, Crosswhite MR, Pereira NN, Ward AK, Reynolds LP, Dahlen CR, Neville BW, Borowicz PP, Caton JS.

J Anim Sci. 2019 Mar 1;97(3):1296-1316. doi: 10.1093/jas/skz013.


Identification of Plasmodium GAPDH epitopes for generation of antibodies that inhibit malaria infection.

Cha SJ, McLean KJ, Jacobs-Lorena M.

Life Sci Alliance. 2018 Sep 18;1(5):e201800111. doi: 10.26508/lsa.201800111. eCollection 2018 Oct.


Characterization of Cytochrome P450 Enzymes and Their Applications in Synthetic Biology.

Jeffreys LN, Girvan HM, McLean KJ, Munro AW.

Methods Enzymol. 2018;608:189-261. doi: 10.1016/bs.mie.2018.06.013. Epub 2018 Aug 20.


Structural and catalytic properties of the peroxygenase P450 enzyme CYP152K6 from Bacillus methanolicus.

Girvan HM, Poddar H, McLean KJ, Nelson DR, Hollywood KA, Levy CW, Leys D, Munro AW.

J Inorg Biochem. 2018 Nov;188:18-28. doi: 10.1016/j.jinorgbio.2018.08.002. Epub 2018 Aug 3.


Expression, Purification, and Biochemical Characterization of the Flavocytochrome P450 CYP505A30 from Myceliophthora thermophila.

Baker GJ, Girvan HM, Matthews S, McLean KJ, Golovanova M, Waltham TN, Rigby SEJ, Nelson DR, Blankley RT, Munro AW.

ACS Omega. 2017 Aug 31;2(8):4705-4724. doi: 10.1021/acsomega.7b00450. Epub 2017 Aug 18.


Structure and function of the cytochrome P450 peroxygenase enzymes.

Munro AW, McLean KJ, Grant JL, Makris TM.

Biochem Soc Trans. 2018 Feb 19;46(1):183-196. doi: 10.1042/BST20170218. Epub 2018 Feb 6. Review.


The effects of nutrient restriction on mRNA expression of endogenous retroviruses, interferon-tau, and pregnancy-specific protein-B during the establishment of pregnancy in beef heifers.

McLean KJ, Crouse MS, Crosswhite MR, Negrin Pereira N, Dahlen CR, Borowicz PP, Reynolds LP, Ward AK, Neville BW, Caton JS.

J Anim Sci. 2018 Apr 3;96(3):950-963. doi: 10.1093/jas/skx001.


Maternal nutrition and stage of early pregnancy in beef heifers: Impacts on expression of glucose, fructose, and cationic amino acid transporters in utero-placental tissues.

Crouse MS, McLean KJ, Greseth NP, Crosswhite MR, Pereira NN, Ward AK, Reynolds LP, Dahlen CR, Neville BW, Borowicz PP, Caton JS.

J Anim Sci. 2017 Dec;95(12):5563-5572. doi: 10.2527/jas2017.1983.


Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation.

Taban IM, Elshihawy HEAE, Torun B, Zucchini B, Williamson CJ, Altuwairigi D, Ngu AST, McLean KJ, Levy CW, Sood S, Marino LB, Munro AW, de Carvalho LPS, Simons C.

J Med Chem. 2017 Dec 28;60(24):10257-10267. doi: 10.1021/acs.jmedchem.7b01562. Epub 2017 Dec 7.


Design, synthesis and evaluation against Mycobacterium tuberculosis of azole piperazine derivatives as dicyclotyrosine (cYY) mimics.

El-Wahab HAAA, Accietto M, Marino LB, McLean KJ, Levy CW, Abdel-Rahman HM, El-Gendy MA, Munro AW, Aboraia AS, Simons C.

Bioorg Med Chem. 2018 Jan 1;26(1):161-176. doi: 10.1016/j.bmc.2017.11.030. Epub 2017 Nov 21.


The effects of maternal nutrition on the messenger ribonucleic acid expression of neutral and acidic amino acid transporters in bovine uteroplacental tissues from day sixteen to fifty of gestation.

Greseth NP, Crouse MS, McLean KJ, Crosswhite MR, Pereira NN, Dahlen CR, Borowicz PP, Reynolds LP, Ward AK, Neville BW, Caton JS.

J Anim Sci. 2017 Oct;95(10):4668-4676. doi: 10.2527/jas2017.1713.


Effect of DMSO on Protein Structure and Interactions Assessed by Collision-Induced Dissociation and Unfolding.

Chan DS, Kavanagh ME, McLean KJ, Munro AW, Matak-Vinković D, Coyne AG, Abell C.

Anal Chem. 2017 Sep 19;89(18):9976-9983. doi: 10.1021/acs.analchem.7b02329. Epub 2017 Aug 25.


Plasmodium falciparum Maf1 Confers Survival upon Amino Acid Starvation.

McLean KJ, Jacobs-Lorena M.

MBio. 2017 Mar 28;8(2). pii: e02317-16. doi: 10.1128/mBio.02317-16.


Fragment Profiling Approach to Inhibitors of the Orphan M. tuberculosis P450 CYP144A1.

Kavanagh ME, Chenge J, Zoufir A, McLean KJ, Coyne AG, Bender A, Munro AW, Abell C.

Biochemistry. 2017 Mar 21;56(11):1559-1572. doi: 10.1021/acs.biochem.6b00954. Epub 2017 Mar 6.


Production of alkenes and novel secondary products by P450 OleTJE using novel H2 O2 -generating fusion protein systems.

Matthews S, Tee KL, Rattray NJ, McLean KJ, Leys D, Parker DA, Blankley RT, Munro AW.

FEBS Lett. 2017 Mar;591(5):737-750. doi: 10.1002/1873-3468.12581. Epub 2017 Feb 21.


Corrigendum: Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors.

Kavanagh ME, Gray JL, Gilbert SH, Coyne AG, McLean KJ, Davis HJ, Munro AW, Abell C.

ChemMedChem. 2017 Jan 20;12(2):194-195. doi: 10.1002/cmdc.201600619. Epub 2016 Dec 19. No abstract available.


Catalytic Determinants of Alkene Production by the Cytochrome P450 Peroxygenase OleTJE.

Matthews S, Belcher JD, Tee KL, Girvan HM, McLean KJ, Rigby SE, Levy CW, Leys D, Parker DA, Blankley RT, Munro AW.

J Biol Chem. 2017 Mar 24;292(12):5128-5143. doi: 10.1074/jbc.M116.762336. Epub 2017 Jan 4.


Technical note: A new surgical technique for ovariohysterectomy during early pregnancy in beef heifers.

McLean KJ, Dahlen CR, Borowicz PP, Reynolds LP, Crosswhite MR, Neville BW, Walden SD, Caton JS.

J Anim Sci. 2016 Dec;94(12):5089-5096. doi: 10.2527/jas.2016-0761.


Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1.

Chenge JT, Duyet LV, Swami S, McLean KJ, Kavanagh ME, Coyne AG, Rigby SE, Cheesman MR, Girvan HM, Levy CW, Rupp B, von Kries JP, Abell C, Leys D, Munro AW.

J Biol Chem. 2017 Jan 27;292(4):1310-1329. doi: 10.1074/jbc.M116.748822. Epub 2016 Dec 8.


Evaluation of the Biocompatibility of Polypyrrole Implanted Subdurally in GAERS.

Bauquier SH, McLean KJ, Jiang JL, Boston RC, Lai A, Yue Z, Moulton SE, Halliday AJ, Wallace G, Cook MJ.

Macromol Biosci. 2017 May;17(5). doi: 10.1002/mabi.201600334. Epub 2016 Dec 5.


Nutrient transporters in bovine uteroplacental tissues on days sixteen to fifty of gestation.

Crouse MS, McLean KJ, Crosswhite MR, Reynolds LP, Dahlen CR, Neville BW, Borowicz PP, Caton JS.

J Anim Sci. 2016 Nov;94(11):4738-4747. doi: 10.2527/jas.2016-0857.


RAPID COMMUNICATION: Expression of an endogenous retroviral element, during early gestation in beef heifers.

McLean KJ, Crouse MS, Crosswhite MR, Black DN, Dahlen CR, Borowicz PP, Reynolds LP, Ward AK, Neville BW, Caton JS.

J Anim Sci. 2016 Oct;94(10):4452-4456. doi: 10.2527/jas.2016-0793.


RAPID COMMUNICATION: Isolation of glucose transporters and in bovine uteroplacental tissues from days 16 to 50 of gestation.

Crouse MS, Caton JS, McLean KJ, Borowicz PP, Reynolds LP, Dahlen CR, Neville BW, Ward AK.

J Anim Sci. 2016 Oct;94(10):4463-4469. doi: 10.2527/jas.2016-0808.


The Implementation of Bring Your Own Device (BYOD) in Primary [Elementary] Schools.

McLean KJ.

Front Psychol. 2016 Nov 15;7:1739. eCollection 2016. No abstract available.


Drug targeting of heme proteins in Mycobacterium tuberculosis.

McLean KJ, Munro AW.

Drug Discov Today. 2017 Mar;22(3):566-575. doi: 10.1016/j.drudis.2016.11.004. Epub 2016 Nov 14. Review.


Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors.

Kavanagh ME, Gray JL, Gilbert SH, Coyne AG, McLean KJ, Davis HJ, Munro AW, Abell C.

ChemMedChem. 2016 Sep 6;11(17):1924-35. doi: 10.1002/cmdc.201600248. Epub 2016 Jul 19. Erratum in: ChemMedChem. 2017 Jan 20;12 (2):194-195.


Structural characterization of CYP144A1 - a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis.

Chenge J, Kavanagh ME, Driscoll MD, McLean KJ, Young DB, Cortes T, Matak-Vinkovic D, Levy CW, Rigby SE, Leys D, Abell C, Munro AW.

Sci Rep. 2016 May 26;6:26628. doi: 10.1038/srep26628.


Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors.

Kavanagh ME, Coyne AG, McLean KJ, James GG, Levy CW, Marino LB, de Carvalho LP, Chan DS, Hudson SA, Surade S, Leys D, Munro AW, Abell C.

J Med Chem. 2016 Apr 14;59(7):3272-302. doi: 10.1021/acs.jmedchem.6b00007. Epub 2016 Mar 22.


Genetic Control Of Malaria Mosquitoes.

McLean KJ, Jacobs-Lorena M.

Trends Parasitol. 2016 Mar;32(3):174-176. doi: 10.1016/ Epub 2016 Jan 19.


Injectable phenytoin loaded polymeric microspheres for the control of temporal lobe epilepsy in rats.

Jiang JL, Yue Z, Bauquier SH, Lai A, Chen Y, McLean KJ, Halliday AJ, Sui Y, Moulton S, Wallace GG, Cook MJ.

Restor Neurol Neurosci. 2015;33(6):823-34. doi: 10.3233/RNN-150520.


Biological diversity of cytochrome P450 redox partner systems.

McLean KJ, Luciakova D, Belcher J, Tee KL, Munro AW.

Adv Exp Med Biol. 2015;851:299-317. doi: 10.1007/978-3-319-16009-2_11. Review.


Genetic investigation of tricarboxylic acid metabolism during the Plasmodium falciparum life cycle.

Ke H, Lewis IA, Morrisey JM, McLean KJ, Ganesan SM, Painter HJ, Mather MW, Jacobs-Lorena M, Llinás M, Vaidya AB.

Cell Rep. 2015 Apr 7;11(1):164-74. doi: 10.1016/j.celrep.2015.03.011. Epub 2015 Apr 2.


Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum.

McLean KJ, Hans M, Meijrink B, van Scheppingen WB, Vollebregt A, Tee KL, van der Laan JM, Leys D, Munro AW, van den Berg MA.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2847-52. doi: 10.1073/pnas.1419028112. Epub 2015 Feb 17.


Isoprenoid precursor biosynthesis is the essential metabolic role of the apicoplast during gametocytogenesis in Plasmodium falciparum.

Wiley JD, Merino EF, Krai PM, McLean KJ, Tripathi AK, Vega-Rodríguez J, Jacobs-Lorena M, Klemba M, Cassera MB.

Eukaryot Cell. 2015 Feb;14(2):128-39. doi: 10.1128/EC.00198-14. Epub 2014 Dec 1.


The structure, function and properties of sirohaem decarboxylase--an enzyme with structural homology to a transcription factor family that is part of the alternative haem biosynthesis pathway.

Palmer DJ, Schroeder S, Lawrence AD, Deery E, Lobo SA, Saraiva LM, McLean KJ, Munro AW, Ferguson SJ, Pickersgill RW, Brown DG, Warren MJ.

Mol Microbiol. 2014 Jul;93(2):247-61. doi: 10.1111/mmi.12656. Epub 2014 Jun 18.


Human P450-like oxidation of diverse proton pump inhibitor drugs by 'gatekeeper' mutants of flavocytochrome P450 BM3.

Butler CF, Peet C, McLean KJ, Baynham MT, Blankley RT, Fisher K, Rigby SE, Leys D, Voice MW, Munro AW.

Biochem J. 2014 Jun 1;460(2):247-59. doi: 10.1042/BJ20140030.


Strength of axial water ligation in substrate-free cytochrome P450s is isoform dependent.

Conner KP, Schimpf AM, Cruce AA, McLean KJ, Munro AW, Frank DJ, Krzyaniak MD, Ortiz de Montellano P, Bowman MK, Atkins WM.

Biochemistry. 2014 Mar 11;53(9):1428-34. doi: 10.1021/bi401547j. Epub 2014 Feb 27.


Structure and biochemical properties of the alkene producing cytochrome P450 OleTJE (CYP152L1) from the Jeotgalicoccus sp. 8456 bacterium.

Belcher J, McLean KJ, Matthews S, Woodward LS, Fisher K, Rigby SE, Nelson DR, Potts D, Baynham MT, Parker DA, Leys D, Munro AW.

J Biol Chem. 2014 Mar 7;289(10):6535-50. doi: 10.1074/jbc.M113.527325. Epub 2014 Jan 18.


Overcoming the limitations of fragment merging: rescuing a strained merged fragment series targeting Mycobacterium tuberculosis CYP121.

Hudson SA, Surade S, Coyne AG, McLean KJ, Leys D, Munro AW, Abell C.

ChemMedChem. 2013 Sep;8(9):1451-6. doi: 10.1002/cmdc.201300219. Epub 2013 Jun 20. No abstract available.


Nanoelectrospray ionization mass spectrometric study of Mycobacterium tuberculosis CYP121-ligand interactions.

Duffell KM, Hudson SA, McLean KJ, Munro AW, Abell C, Matak-Vinković D.

Anal Chem. 2013 Jun 18;85(12):5707-14. doi: 10.1021/ac400236z. Epub 2013 May 29.


Transposon mutagenesis identifies genes essential for Plasmodium falciparum gametocytogenesis.

Ikadai H, Shaw Saliba K, Kanzok SM, McLean KJ, Tanaka TQ, Cao J, Williamson KC, Jacobs-Lorena M.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):E1676-84. doi: 10.1073/pnas.1217712110. Epub 2013 Apr 9.


Bacillus megaterium has both a functional BluB protein required for DMB synthesis and a related flavoprotein that forms a stable radical species.

Collins HF, Biedendieck R, Leech HK, Gray M, Escalante-Semerena JC, McLean KJ, Munro AW, Rigby SE, Warren MJ, Lawrence AD.

PLoS One. 2013;8(2):e55708. doi: 10.1371/journal.pone.0055708. Epub 2013 Feb 14.


What makes a P450 tick?

Munro AW, Girvan HM, Mason AE, Dunford AJ, McLean KJ.

Trends Biochem Sci. 2013 Mar;38(3):140-50. doi: 10.1016/j.tibs.2012.11.006. Epub 2013 Jan 26. Review.


Levetiracetam-loaded biodegradable polymer implants in the tetanus toxin model of temporal lobe epilepsy in rats.

Halliday AJ, Campbell TE, Nelson TS, McLean KJ, Wallace GG, Cook MJ.

J Clin Neurosci. 2013 Jan;20(1):148-52. doi: 10.1016/j.jocn.2012.05.017. Epub 2012 Oct 16.


Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121.

Hudson SA, McLean KJ, Surade S, Yang YQ, Leys D, Ciulli A, Munro AW, Abell C.

Angew Chem Int Ed Engl. 2012 Sep 10;51(37):9311-6. doi: 10.1002/anie.201202544. Epub 2012 Aug 13. No abstract available.


Cholesterol, an essential molecule: diverse roles involving cytochrome P450 enzymes.

McLean KJ, Hans M, Munro AW.

Biochem Soc Trans. 2012 Jun 1;40(3):587-93. doi: 10.1042/BST20120077. Review.


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