Sort by
Items per page

Send to

Choose Destination

Search results

Items: 48


A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases.

Kiss L, Zeng J, Dickson CF, Mallery DL, Yang JC, McLaughlin SH, Boland A, Neuhaus D, James LC.

Nat Commun. 2019 Oct 3;10(1):4502. doi: 10.1038/s41467-019-12388-y.


Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome.

Yan K, Yang J, Zhang Z, McLaughlin SH, Chang L, Fasci D, Ehrenhofer-Murray AE, Heck AJR, Barford D.

Nature. 2019 Oct;574(7777):278-282. doi: 10.1038/s41586-019-1609-1. Epub 2019 Oct 2.


An oligomeric state-dependent switch in the ER enzyme FICD regulates AMPylation and deAMPylation of BiP.

Perera LA, Rato C, Yan Y, Neidhardt L, McLaughlin SH, Read RJ, Preissler S, Ron D.

EMBO J. 2019 Oct 4;38(21):e102177. doi: 10.15252/embj.2019102177. Epub 2019 Sep 18.


The structure of bactofilin filaments reveals their mode of membrane binding and lack of polarity.

Deng X, Gonzalez Llamazares A, Wagstaff JM, Hale VL, Cannone G, McLaughlin SH, Kureisaite-Ciziene D, Löwe J.

Nat Microbiol. 2019 Dec;4(12):2357-2368. doi: 10.1038/s41564-019-0544-0. Epub 2019 Sep 9.


Structure of KAP1 tripartite motif identifies molecular interfaces required for retroelement silencing.

Stoll GA, Oda SI, Chong ZS, Yu M, McLaughlin SH, Modis Y.

Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15042-15051. doi: 10.1073/pnas.1901318116. Epub 2019 Jul 9.


Activation of GCN2 by the ribosomal P-stalk.

Inglis AJ, Masson GR, Shao S, Perisic O, McLaughlin SH, Hegde RS, Williams RL.

Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):4946-4954. doi: 10.1073/pnas.1813352116. Epub 2019 Feb 25.


Architecture of the CBF3-centromere complex of the budding yeast kinetochore.

Yan K, Zhang Z, Yang J, McLaughlin SH, Barford D.

Nat Struct Mol Biol. 2018 Dec;25(12):1103-1110. doi: 10.1038/s41594-018-0154-1. Epub 2018 Nov 26.


Structural Analysis of the Interaction between the Bacterial Cell Division Proteins FtsQ and FtsB.

Kureisaite-Ciziene D, Varadajan A, McLaughlin SH, Glas M, Montón Silva A, Luirink R, Mueller C, den Blaauwen T, Grossmann TN, Luirink J, Löwe J.

mBio. 2018 Sep 11;9(5). pii: e01346-18. doi: 10.1128/mBio.01346-18.


RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs.

McClintock MA, Dix CI, Johnson CM, McLaughlin SH, Maizels RJ, Hoang HT, Bullock SL.

Elife. 2018 Jun 26;7. pii: e36312. doi: 10.7554/eLife.36312.


Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly.

Liu Y, Gupta GD, Barnabas DD, Agircan FG, Mehmood S, Wu D, Coyaud E, Johnson CM, McLaughlin SH, Andreeva A, Freund SMV, Robinson CV, Cheung SWT, Raught B, Pelletier L, van Breugel M.

Nat Commun. 2018 Apr 30;9(1):1731. doi: 10.1038/s41467-018-04122-x.


A low-complexity region in the YTH domain protein Mmi1 enhances RNA binding.

Stowell JAW, Wagstaff JL, Hill CH, Yu M, McLaughlin SH, Freund SMV, Passmore LA.

J Biol Chem. 2018 Jun 15;293(24):9210-9222. doi: 10.1074/jbc.RA118.002291. Epub 2018 Apr 25.


Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21.

Dickson C, Fletcher AJ, Vaysburd M, Yang JC, Mallery DL, Zeng J, Johnson CM, McLaughlin SH, Skehel M, Maslen S, Cruickshank J, Huguenin-Dezot N, Chin JW, Neuhaus D, James LC.

Elife. 2018 Apr 18;7. pii: e32660. doi: 10.7554/eLife.32660.


The Ciliopathy-Associated Cep104 Protein Interacts with Tubulin and Nek1 Kinase.

Al-Jassar C, Andreeva A, Barnabas DD, McLaughlin SH, Johnson CM, Yu M, van Breugel M.

Structure. 2017 Jan 3;25(1):146-156. doi: 10.1016/j.str.2016.11.014. Epub 2016 Dec 22.


Crenactin forms actin-like double helical filaments regulated by arcadin-2.

Izoré T, Kureisaite-Ciziene D, McLaughlin SH, Löwe J.

Elife. 2016 Nov 17;5. pii: e21600. doi: 10.7554/eLife.21600.


SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.

Elliott PR, Leske D, Hrdinka M, Bagola K, Fiil BK, McLaughlin SH, Wagstaff J, Volkmar N, Christianson JC, Kessler BM, Freund SM, Komander D, Gyrd-Hansen M.

Mol Cell. 2016 Sep 15;63(6):990-1005. doi: 10.1016/j.molcel.2016.08.001. Epub 2016 Aug 30.


Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi.

Galindo A, Soler N, McLaughlin SH, Yu M, Williams RL, Munro S.

Cell Rep. 2016 Jul 19;16(3):839-50. doi: 10.1016/j.celrep.2016.06.022. Epub 2016 Jun 30.


Crystal structure of the Z-ring associated cell division protein ZapC from Escherichia coli.

Ortiz C, Kureisaite-Ciziene D, Schmitz F, McLaughlin SH, Vicente M, Löwe J.

FEBS Lett. 2015 Dec 21;589(24 Pt B):3822-8. doi: 10.1016/j.febslet.2015.11.030. Epub 2015 Nov 30.


The Soluble Periplasmic Domains of Escherichia coli Cell Division Proteins FtsQ/FtsB/FtsL Form a Trimeric Complex with Submicromolar Affinity.

Glas M, van den Berg van Saparoea HB, McLaughlin SH, Roseboom W, Liu F, Koningstein GM, Fish A, den Blaauwen T, Heck AJ, de Jong L, Bitter W, de Esch IJ, Luirink J.

J Biol Chem. 2015 Aug 28;290(35):21498-509. doi: 10.1074/jbc.M115.654756. Epub 2015 Jul 9.


Atomic structure of the APC/C and its mechanism of protein ubiquitination.

Chang L, Zhang Z, Yang J, McLaughlin SH, Barford D.

Nature. 2015 Jun 25;522(7557):450-454. doi: 10.1038/nature14471. Epub 2015 Jun 15.


Structural Characterization of the Chaetomium thermophilum TREX-2 Complex and its Interaction with the mRNA Nuclear Export Factor Mex67:Mtr2.

Dimitrova L, Valkov E, Aibara S, Flemming D, McLaughlin SH, Hurt E, Stewart M.

Structure. 2015 Jul 7;23(7):1246-57. doi: 10.1016/j.str.2015.05.002. Epub 2015 Jun 4.


Evolution of oligomeric state through allosteric pathways that mimic ligand binding.

Perica T, Kondo Y, Tiwari SP, McLaughlin SH, Kemplen KR, Zhang X, Steward A, Reuter N, Clarke J, Teichmann SA.

Science. 2014 Dec 19;346(6216):1254346. doi: 10.1126/science.1254346.


Molecular architecture and mechanism of the anaphase-promoting complex.

Chang LF, Zhang Z, Yang J, McLaughlin SH, Barford D.

Nature. 2014 Sep 18;513(7518):388-393. doi: 10.1038/nature13543. Epub 2014 Jul 20.


Structures of PI4KIIIβ complexes show simultaneous recruitment of Rab11 and its effectors.

Burke JE, Inglis AJ, Perisic O, Masson GR, McLaughlin SH, Rutaganira F, Shokat KM, Williams RL.

Science. 2014 May 30;344(6187):1035-8. doi: 10.1126/science.1253397.


Structural basis for Pan3 binding to Pan2 and its function in mRNA recruitment and deadenylation.

Wolf J, Valkov E, Allen MD, Meineke B, Gordiyenko Y, McLaughlin SH, Olsen TM, Robinson CV, Bycroft M, Stewart M, Passmore LA.

EMBO J. 2014 Jul 17;33(14):1514-26. doi: 10.15252/embj.201488373. Epub 2014 May 28.


Structure of the SAS-6 cartwheel hub from Leishmania major.

van Breugel M, Wilcken R, McLaughlin SH, Rutherford TJ, Johnson CM.

Elife. 2014 Jan 1;3:e01812. doi: 10.7554/eLife.01812.


Diffuse transition state structure for the unfolding of a leucine-rich repeat protein.

Kelly SE, Meisl G, Rowling PJ, McLaughlin SH, Knowles T, Itzhaki LS.

Phys Chem Chem Phys. 2014 Apr 14;16(14):6448-59. doi: 10.1039/c3cp54818j. Epub 2014 Feb 18.


Differential binding of RhoA, RhoB, and RhoC to protein kinase C-related kinase (PRK) isoforms PRK1, PRK2, and PRK3: PRKs have the highest affinity for RhoB.

Hutchinson CL, Lowe PN, McLaughlin SH, Mott HR, Owen D.

Biochemistry. 2013 Nov 12;52(45):7999-8011. doi: 10.1021/bi401216w. Epub 2013 Oct 31.


The N-terminal acetylation of Sir3 stabilizes its binding to the nucleosome core particle.

Arnaudo N, Fernández IS, McLaughlin SH, Peak-Chew SY, Rhodes D, Martino F.

Nat Struct Mol Biol. 2013 Sep;20(9):1119-21. doi: 10.1038/nsmb.2641. Epub 2013 Aug 11.


Synthetic genetic polymers capable of heredity and evolution.

Pinheiro VB, Taylor AI, Cozens C, Abramov M, Renders M, Zhang S, Chaput JC, Wengel J, Peak-Chew SY, McLaughlin SH, Herdewijn P, Holliger P.

Science. 2012 Apr 20;336(6079):341-4. doi: 10.1126/science.1217622.


Electrostatic interactions involving the extreme C terminus of nuclear export factor CRM1 modulate its affinity for cargo.

Fox AM, Ciziene D, McLaughlin SH, Stewart M.

J Biol Chem. 2011 Aug 19;286(33):29325-35. doi: 10.1074/jbc.M111.245092. Epub 2011 Jun 27.


Mutational analysis reveals a single binding interface between RhoA and its effector, PRK1.

Hutchinson CL, Lowe PN, McLaughlin SH, Mott HR, Owen D.

Biochemistry. 2011 Apr 12;50(14):2860-9. doi: 10.1021/bi200039u. Epub 2011 Mar 16.


The chromosome passenger complex is required for fidelity of chromosome transmission and cytokinesis in meiosis of mouse oocytes.

Sharif B, Na J, Lykke-Hartmann K, McLaughlin SH, Laue E, Glover DM, Zernicka-Goetz M.

J Cell Sci. 2010 Dec 15;123(Pt 24):4292-300. doi: 10.1242/jcs.067447.


Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46.

Murzina NV, Pei XY, Zhang W, Sparkes M, Vicente-Garcia J, Pratap JV, McLaughlin SH, Ben-Shahar TR, Verreault A, Luisi BF, Laue ED.

Structure. 2008 Jul;16(7):1077-85. doi: 10.1016/j.str.2008.05.006. Epub 2008 Jun 19.


Mechanistic studies on Hsp90 inhibition by ansamycin derivatives.

Onuoha SC, Mukund SR, Coulstock ET, Sengerovà B, Shaw J, McLaughlin SH, Jackson SE.

J Mol Biol. 2007 Sep 14;372(2):287-97. Epub 2007 Jun 29.


The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins.

McLaughlin SH, Sobott F, Yao ZP, Zhang W, Nielsen PR, Grossmann JG, Laue ED, Robinson CV, Jackson SE.

J Mol Biol. 2006 Feb 24;356(3):746-58. Epub 2005 Dec 15.


Independent ATPase activity of Hsp90 subunits creates a flexible assembly platform.

McLaughlin SH, Ventouras LA, Lobbezoo B, Jackson SE.

J Mol Biol. 2004 Nov 26;344(3):813-26.


Biochemical and structural studies of the interaction of Cdc37 with Hsp90.

Zhang W, Hirshberg M, McLaughlin SH, Lazar GA, Grossmann JG, Nielsen PR, Sobott F, Robinson CV, Jackson SE, Laue ED.

J Mol Biol. 2004 Jul 16;340(4):891-907.


Folding and stability of the ligand-binding domain of the glucocorticoid receptor.

McLaughlin SH, Jackson SE.

Protein Sci. 2002 Aug;11(8):1926-36.


Stimulation of the weak ATPase activity of human hsp90 by a client protein.

McLaughlin SH, Smith HW, Jackson SE.

J Mol Biol. 2002 Jan 25;315(4):787-98.


Experimental and theoretical analyses of the domain architecture of mammalian protein disulphide-isomerase.

Freedman RB, Gane PJ, Hawkins HC, Hlodan R, McLaughlin SH, Parry JW.

Biol Chem. 1998 Mar;379(3):321-8.


Molecular recognition in procollagen chain assembly.

McLaughlin SH, Bulleid NJ.

Matrix Biol. 1998 Feb;16(7):369-77. Review.


Cloning and expression of active domains of human protein disulphide isomerase.

McLaughlin SH, Freedman RB.

Biochem Soc Trans. 1995 Feb;23(1):69S. No abstract available.


Protein disulfide-isomerase.

Freedman RB, Hawkins HC, McLaughlin SH.

Methods Enzymol. 1995;251:397-406. No abstract available.


Supplemental Content

Loading ...
Support Center