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Items: 1 to 50 of 102

1.

Development of a Novel Loop-Mediated Isothermal Amplification Method to Detect Guiana Extended-Spectrum (GES) β-Lactamase Genes in Pseudomonas aeruginosa.

Takano C, Seki M, Kim DW, Gardner H, McLaughlin RE, Kilgore PE, Kumasaka K, Hayakawa S.

Front Microbiol. 2019 Feb 4;10:25. doi: 10.3389/fmicb.2019.00025. eCollection 2019.

2.

Pseudomonas aeruginosa PcrV and Psl, the Molecular Targets of Bispecific Antibody MEDI3902, Are Conserved Among Diverse Global Clinical Isolates.

Tabor DE, Oganesyan V, Keller AE, Yu L, McLaughlin RE, Song E, Warrener P, Rosenthal K, Esser M, Qi Y, Ruzin A, Stover CK, DiGiandomenico A.

J Infect Dis. 2018 Nov 5;218(12):1983-1994. doi: 10.1093/infdis/jiy438.

PMID:
30016475
3.

Frequency and Mechanism of Spontaneous Resistance to Sulbactam Combined with the Novel β-Lactamase Inhibitor ETX2514 in Clinical Isolates of Acinetobacter baumannii.

McLeod SM, Shapiro AB, Moussa SH, Johnstone M, McLaughlin RE, de Jonge BLM, Miller AA.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01576-17. doi: 10.1128/AAC.01576-17. Print 2018 Feb.

4.

Discovery of Imidazo[1,2-a]pyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis.

Tantry SJ, Markad SD, Shinde V, Bhat J, Balakrishnan G, Gupta AK, Ambady A, Raichurkar A, Kedari C, Sharma S, Mudugal NV, Narayan A, Naveen Kumar CN, Nanduri R, Bharath S, Reddy J, Panduga V, Prabhakar KR, Kandaswamy K, Saralaya R, Kaur P, Dinesh N, Guptha S, Rich K, Murray D, Plant H, Preston M, Ashton H, Plant D, Walsh J, Alcock P, Naylor K, Collier M, Whiteaker J, McLaughlin RE, Mallya M, Panda M, Rudrapatna S, Ramachandran V, Shandil R, Sambandamurthy VK, Mdluli K, Cooper CB, Rubin H, Yano T, Iyer P, Narayanan S, Kavanagh S, Mukherjee K, Balasubramanian V, Hosagrahara VP, Solapure S, Ravishankar S, Hameed P S.

J Med Chem. 2017 Feb 23;60(4):1379-1399. doi: 10.1021/acs.jmedchem.6b01358. Epub 2017 Feb 3.

PMID:
28075132
5.

Homologous Recombination within Large Chromosomal Regions Facilitates Acquisition of β-Lactam and Vancomycin Resistance in Enterococcus faecium.

García-Solache M, Lebreton F, McLaughlin RE, Whiteaker JD, Gilmore MS, Rice LB.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):5777-86. doi: 10.1128/AAC.00488-16. Print 2016 Oct.

6.

Identification of unique in-frame deletions in OprD among clinical isolates of Pseudomonas aeruginosa.

Kos VN, McLaughlin RE, Gardner HA.

Pathog Dis. 2016 Jun;74(4):ftw031. doi: 10.1093/femspd/ftw031. Epub 2016 Apr 11.

PMID:
27073254
7.

Elucidation of Mechanisms of Ceftazidime Resistance among Clinical Isolates of Pseudomonas aeruginosa by Using Genomic Data.

Kos VN, McLaughlin RE, Gardner HA.

Antimicrob Agents Chemother. 2016 May 23;60(6):3856-61. doi: 10.1128/AAC.03113-15. Print 2016 Jun.

8.

Multiyear, Multinational Survey of the Incidence and Global Distribution of Metallo-β-Lactamase-Producing Enterobacteriaceae and Pseudomonas aeruginosa.

Kazmierczak KM, Rabine S, Hackel M, McLaughlin RE, Biedenbach DJ, Bouchillon SK, Sahm DF, Bradford PA.

Antimicrob Agents Chemother. 2015 Dec 7;60(2):1067-78. doi: 10.1128/AAC.02379-15. Print 2016 Feb.

9.

Pharmacodynamic Profiling of a Siderophore-Conjugated Monocarbam in Pseudomonas aeruginosa: Assessing the Risk for Resistance and Attenuated Efficacy.

Kim A, Kutschke A, Ehmann DE, Patey SA, Crandon JL, Gorseth E, Miller AA, McLaughlin RE, Blinn CM, Chen A, Nayar AS, Dangel B, Tsai AS, Rooney MT, Murphy-Benenato KE, Eakin AE, Nicolau DP.

Antimicrob Agents Chemother. 2015 Dec;59(12):7743-52. doi: 10.1128/AAC.00831-15. Epub 2015 Oct 5.

10.

Markerless Escherichia coli rrn Deletion Strains for Genetic Determination of Ribosomal Binding Sites.

Quan S, Skovgaard O, McLaughlin RE, Buurman ET, Squires CL.

G3 (Bethesda). 2015 Oct 4;5(12):2555-7. doi: 10.1534/g3.115.022301.

11.

Molecular characterization of MRSA isolates bracketing the current EUCAST ceftaroline-susceptible breakpoint for Staphylococcus aureus: the role of PBP2a in the activity of ceftaroline.

Lahiri SD, McLaughlin RE, Whiteaker JD, Ambler JE, Alm RA.

J Antimicrob Chemother. 2015 Sep;70(9):2488-98. doi: 10.1093/jac/dkv131. Epub 2015 Jun 4.

PMID:
26045529
12.

Pharmacokinetics/pharmacodynamics of a β-lactam and β-lactamase inhibitor combination: a novel approach for aztreonam/avibactam.

Singh R, Kim A, Tanudra MA, Harris JJ, McLaughlin RE, Patey S, O'Donnell JP, Bradford PA, Eakin AE.

J Antimicrob Chemother. 2015 Sep;70(9):2618-26. doi: 10.1093/jac/dkv132. Epub 2015 May 29.

PMID:
26024868
13.

Illicit Transport via Dipeptide Transporter Dpp is Irrelevant to the Efficacy of Negamycin in Mouse Thigh Models of Escherichia coli Infection.

McKinney DC, Bezdenejnih-Snyder N, Farrington K, Guo J, McLaughlin RE, Ruvinsky AM, Singh R, Basarab GS, Narayan S, Buurman ET.

ACS Infect Dis. 2015 May 8;1(5):222-30. doi: 10.1021/acsinfecdis.5b00027. Epub 2015 Apr 7.

PMID:
27622650
14.

Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate.

Hameed P S, Solapure S, Patil V, Henrich PP, Magistrado PA, Bharath S, Murugan K, Viswanath P, Puttur J, Srivastava A, Bellale E, Panduga V, Shanbag G, Awasthy D, Landge S, Morayya S, Koushik K, Saralaya R, Raichurkar A, Rautela N, Roy Choudhury N, Ambady A, Nandishaiah R, Reddy J, Prabhakar KR, Menasinakai S, Rudrapatna S, Chatterji M, Jiménez-Díaz MB, Martínez MS, Sanz LM, Coburn-Flynn O, Fidock DA, Lukens AK, Wirth DF, Bandodkar B, Mukherjee K, McLaughlin RE, Waterson D, Rosenbrier-Ribeiro L, Hickling K, Balasubramanian V, Warner P, Hosagrahara V, Dudley A, Iyer PS, Narayanan S, Kavanagh S, Sambandamurthy VK.

Nat Commun. 2015 Mar 31;6:6715. doi: 10.1038/ncomms7715.

15.

Selection and molecular characterization of ceftazidime/avibactam-resistant mutants in Pseudomonas aeruginosa strains containing derepressed AmpC.

Lahiri SD, Walkup GK, Whiteaker JD, Palmer T, McCormack K, Tanudra MA, Nash TJ, Thresher J, Johnstone MR, Hajec L, Livchak S, McLaughlin RE, Alm RA.

J Antimicrob Chemother. 2015;70(6):1650-8. doi: 10.1093/jac/dkv004. Epub 2015 Feb 1.

PMID:
25645206
16.

Small-molecule inhibitors of gram-negative lipoprotein trafficking discovered by phenotypic screening.

McLeod SM, Fleming PR, MacCormack K, McLaughlin RE, Whiteaker JD, Narita S, Mori M, Tokuda H, Miller AA.

J Bacteriol. 2015 Mar;197(6):1075-82. doi: 10.1128/JB.02352-14. Epub 2015 Jan 12.

17.

Molecular mechanisms of sulbactam antibacterial activity and resistance determinants in Acinetobacter baumannii.

Penwell WF, Shapiro AB, Giacobbe RA, Gu RF, Gao N, Thresher J, McLaughlin RE, Huband MD, DeJonge BL, Ehmann DE, Miller AA.

Antimicrob Agents Chemother. 2015 Mar;59(3):1680-9. doi: 10.1128/AAC.04808-14. Epub 2015 Jan 5.

18.

Characterization of novel respiratory syncytial virus inhibitors identified by high throughput screen.

Laganas VA, Dunn EF, McLaughlin RE, Tiong-Yip CL, Yuzhakov O, Isabella VM, Hill P, Yu Q.

Antiviral Res. 2015 Mar;115:71-4. doi: 10.1016/j.antiviral.2014.12.012. Epub 2014 Dec 24.

PMID:
25542974
19.

Characterization of the novel DNA gyrase inhibitor AZD0914: low resistance potential and lack of cross-resistance in Neisseria gonorrhoeae.

Alm RA, Lahiri SD, Kutschke A, Otterson LG, McLaughlin RE, Whiteaker JD, Lewis LA, Su X, Huband MD, Gardner H, Mueller JP.

Antimicrob Agents Chemother. 2015 Mar;59(3):1478-86. doi: 10.1128/AAC.04456-14. Epub 2014 Dec 22.

20.

The resistome of Pseudomonas aeruginosa in relationship to phenotypic susceptibility.

Kos VN, Déraspe M, McLaughlin RE, Whiteaker JD, Roy PH, Alm RA, Corbeil J, Gardner H.

Antimicrob Agents Chemother. 2015 Jan;59(1):427-36. doi: 10.1128/AAC.03954-14. Epub 2014 Nov 3.

21.

A novel high-throughput cell-based assay aimed at identifying inhibitors of DNA metabolism in bacteria.

Fan J, de Jonge BL, MacCormack K, Sriram S, McLaughlin RE, Plant H, Preston M, Fleming PR, Albert R, Foulk M, Mills SD.

Antimicrob Agents Chemother. 2014 Dec;58(12):7264-72. doi: 10.1128/AAC.03475-14. Epub 2014 Sep 22.

22.

Avibactam and class C β-lactamases: mechanism of inhibition, conservation of the binding pocket, and implications for resistance.

Lahiri SD, Johnstone MR, Ross PL, McLaughlin RE, Olivier NB, Alm RA.

Antimicrob Agents Chemother. 2014 Oct;58(10):5704-13. doi: 10.1128/AAC.03057-14. Epub 2014 Jul 14.

23.

Lead optimization of 1,4-azaindoles as antimycobacterial agents.

Shirude PS, Shandil RK, Manjunatha MR, Sadler C, Panda M, Panduga V, Reddy J, Saralaya R, Nanduri R, Ambady A, Ravishankar S, Sambandamurthy VK, Humnabadkar V, Jena LK, Suresh RS, Srivastava A, Prabhakar KR, Whiteaker J, McLaughlin RE, Sharma S, Cooper CB, Mdluli K, Butler S, Iyer PS, Narayanan S, Chatterji M.

J Med Chem. 2014 Jul 10;57(13):5728-37. doi: 10.1021/jm500571f. Epub 2014 Jun 20.

PMID:
24874895
24.

Analysis of Staphylococcus aureus clinical isolates with reduced susceptibility to ceftaroline: an epidemiological and structural perspective.

Alm RA, McLaughlin RE, Kos VN, Sader HS, Iaconis JP, Lahiri SD.

J Antimicrob Chemother. 2014 Aug;69(8):2065-75. doi: 10.1093/jac/dku114. Epub 2014 Apr 28.

PMID:
24777906
25.

Characterization of a respiratory syncytial virus L protein inhibitor.

Tiong-Yip CL, Aschenbrenner L, Johnson KD, McLaughlin RE, Fan J, Challa S, Xiong H, Yu Q.

Antimicrob Agents Chemother. 2014 Jul;58(7):3867-73. doi: 10.1128/AAC.02540-14. Epub 2014 Apr 28.

26.

Azaindoles: noncovalent DprE1 inhibitors from scaffold morphing efforts, kill Mycobacterium tuberculosis and are efficacious in vivo.

Shirude PS, Shandil R, Sadler C, Naik M, Hosagrahara V, Hameed S, Shinde V, Bathula C, Humnabadkar V, Kumar N, Reddy J, Panduga V, Sharma S, Ambady A, Hegde N, Whiteaker J, McLaughlin RE, Gardner H, Madhavapeddi P, Ramachandran V, Kaur P, Narayan A, Guptha S, Awasthy D, Narayan C, Mahadevaswamy J, Vishwas KG, Ahuja V, Srivastava A, Prabhakar KR, Bharath S, Kale R, Ramaiah M, Choudhury NR, Sambandamurthy VK, Solapure S, Iyer PS, Narayanan S, Chatterji M.

J Med Chem. 2013 Dec 12;56(23):9701-8. doi: 10.1021/jm401382v. Epub 2013 Nov 21.

PMID:
24215368
27.

Molecular determinants of AcrB-mediated bacterial efflux implications for drug discovery.

Manchester JI, Buurman ET, Bisacchi GS, McLaughlin RE.

J Med Chem. 2012 Mar 22;55(6):2532-7. doi: 10.1021/jm201275d. Epub 2012 Jan 27. No abstract available.

PMID:
22224562
28.

Arthroscopic treatment of the arthritic elbow due to primary radiocapitellar arthritis.

McLaughlin RE 2nd, Savoie FH 3rd, Field LD, Ramsey JR.

Arthroscopy. 2006 Jan;22(1):63-9.

PMID:
16399463
29.

Relationship between Trendelenburg tilt and internal jugular vein diameter.

Clenaghan S, McLaughlin RE, Martyn C, McGovern S, Bowra J.

Emerg Med J. 2005 Dec;22(12):867-8.

30.

Survey of attitudes of senior emergency physicians towards the introduction of emergency department ultrasound.

McLaughlin RE, Lee A, Clenaghan S, McGovern S, Martyn C, Bowra J.

Emerg Med J. 2005 Aug;22(8):553-5.

31.

Needle handling should be avoided while suturing.

McLaughlin RE.

Emerg Med J. 2005 Jan;22(1):78. No abstract available.

32.
33.

Colloidal gold: a novel nanoparticle vector for tumor directed drug delivery.

Paciotti GF, Myer L, Weinreich D, Goia D, Pavel N, McLaughlin RE, Tamarkin L.

Drug Deliv. 2004 May-Jun;11(3):169-83.

PMID:
15204636
34.

Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen.

Ajdić D, McShan WM, McLaughlin RE, Savić G, Chang J, Carson MB, Primeaux C, Tian R, Kenton S, Jia H, Lin S, Qian Y, Li S, Zhu H, Najar F, Lai H, White J, Roe BA, Ferretti JJ.

Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14434-9. Epub 2002 Oct 23.

35.

New doctors in emergency medicine: can they suture?

McAdam TK, McLaughlin RE, McNicholl BP.

Ann R Coll Surg Engl. 2002 Jul;84(4):279-80. No abstract available.

36.

Are we getting the point? Needlestick injuries-an ongoing problem.

McAdam TK, McLaughlin RE, McNicholl B.

Int J STD AIDS. 2002 Jul;13(7):453-5.

PMID:
12171663
37.

Two cases of near asphyxiation in children, using non-releasing plastic garden ties.

McLaughlin RE, Stewart A.

Emerg Med J. 2002 Mar;19(2):184; author reply 184. No abstract available.

39.

Palmitoylation of GAP-43 by the ER-Golgi intermediate compartment and Golgi apparatus.

McLaughlin RE, Denny JB.

Biochim Biophys Acta. 1999 Aug 12;1451(1):82-92.

40.
41.

Effect of inactivation of gtf genes on adherence of Streptococcus downei.

Colby SM, McLaughlin RE, Ferretti JJ, Russell RR.

Oral Microbiol Immunol. 1999 Feb;14(1):27-32.

PMID:
10204477
42.

Molecular approaches to the identification of streptococci.

McLaughlin RE, Ferretti JJ.

Methods Mol Med. 1998;15:117-38. doi: 10.1385/0-89603-498-4:117.

PMID:
21390746
43.

The multiple-sugar metabolism (msm) gene cluster of Streptococcus mutans is transcribed as a single operon.

McLaughlin RE, Ferretti JJ.

FEMS Microbiol Lett. 1996 Jul 1;140(2-3):261-4.

PMID:
8764489
44.

Femoral neck fractures in the elderly patient: a preventable injury.

Nguyen ND, Oesterling BR, McLaughlin RE, Edlich RF.

Am J Emerg Med. 1996 May;14(3):288-90.

PMID:
8639205
45.

Electrotransformation of Streptococci.

McLaughlin RE, Ferretti JJ.

Methods Mol Biol. 1995;47:185-93. No abstract available.

PMID:
7550734
46.

Demineralized bone matrix in the stabilization of porous-coated implants in bone defects in rabbits.

Shen WJ, Chung KC, Wang GJ, Balian G, McLaughlin RE.

Clin Orthop Relat Res. 1993 Aug;(293):346-52.

PMID:
8339502
47.

Transfibular compression arthrodesis of the ankle joint.

Wang GJ, Shen WJ, McLaughlin RE, Stamp WG.

Clin Orthop Relat Res. 1993 Apr;(289):223-7.

PMID:
8472421
48.

Cloning and analysis of lipooligosaccharide synthesis genes of Haemophilus influenzae type b that assemble or expose a 2-keto-3-deoxyoctulosonic acid epitope in Escherichia coli.

Abul Kwaik Y, McLaughlin RE, Apicella MA, Spinola SM.

J Infect Dis. 1992 Jun;165 Suppl 1:S195-6. No abstract available.

PMID:
1375254
49.

Mechanical failure of hydroxyapatite- and polysulfone-coated titanium rods in a weight-bearing canine model.

Shen WJ, Chung KC, Wang GJ, McLaughlin RE.

J Arthroplasty. 1992 Mar;7(1):43-9.

PMID:
1314288
50.

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