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Items: 29

1.

T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids.

Wun KS, Reijneveld JF, Cheng TY, Ladell K, Uldrich AP, Le Nours J, Miners KL, McLaren JE, Grant EJ, Haigh OL, Watkins TS, Suliman S, Iwany S, Jimenez J, Calderon R, Tamara KL, Leon SR, Murray MB, Mayfield JA, Altman JD, Purcell AW, Miles JJ, Godfrey DI, Gras S, Price DA, Van Rhijn I, Moody DB, Rossjohn J.

Nat Immunol. 2018 Apr;19(4):397-406. doi: 10.1038/s41590-018-0065-7. Epub 2018 Mar 12.

PMID:
29531339
2.

Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors.

Culina S, Lalanne AI, Afonso G, Cerosaletti K, Pinto S, Sebastiani G, Kuranda K, Nigi L, Eugster A, Østerbye T, Maugein A, McLaren JE, Ladell K, Larger E, Beressi JP, Lissina A, Appay V, Davidson HW, Buus S, Price DA, Kuhn M, Bonifacio E, Battaglia M, Caillat-Zucman S, Dotta F, Scharfmann R, Kyewski B, Mallone R; ImMaDiab Study Group, Carel JC, Tubiana-Rufi N, Martinerie L, Poidvin A, JacqzAigrain E, Corvez L, Berruer V, Gautier JF, Baz B, Haddadi N, Andreelli F, Amouyal C, Jaqueminet S, Bourron O, Dasque E, Hartemann A, Lemoine-Yazigi A, Dubois-Laforgue D, Travert F, Feron M, Rolland P, Vignali V, Marre M, Chanson P, Briet C, Guillausseau PJ, Ait-Bachir L, Collet C, Beziaud F, Desforges-Bullet V, Petit-Aubert G, Christin-Maitre S, Fève B, Vatier C, Bourcigaux N, Lautridou C, Lahlou N, Bakouboula P, Elie C, Morel H, Treluyer JM, Gagnerault MC, Maillard C, Jones A.

Sci Immunol. 2018 Feb 2;3(20). pii: eaao4013. doi: 10.1126/sciimmunol.aao4013.

PMID:
29429978
3.

Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8+ TCR-Vβ+ expansions.

Lissina A, McLaren JE, Ilander M, Andersson EI, Lewis CS, Clement M, Herman A, Ladell K, Llewellyn-Lacey S, Miners KL, Gostick E, Melenhorst JJ, Barrett AJ, Price DA, Mustjoki S, Wooldridge L.

Sci Rep. 2018 Feb 7;8(1):2534. doi: 10.1038/s41598-017-18062-x.

4.

VDJdb: a curated database of T-cell receptor sequences with known antigen specificity.

Shugay M, Bagaev DV, Zvyagin IV, Vroomans RM, Crawford JC, Dolton G, Komech EA, Sycheva AL, Koneva AE, Egorov ES, Eliseev AV, Van Dyk E, Dash P, Attaf M, Rius C, Ladell K, McLaren JE, Matthews KK, Clemens EB, Douek DC, Luciani F, van Baarle D, Kedzierska K, Kesmir C, Thomas PG, Price DA, Sewell AK, Chudakov DM.

Nucleic Acids Res. 2018 Jan 4;46(D1):D419-D427. doi: 10.1093/nar/gkx760.

5.

Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8+ T cell response.

Culshaw A, Ladell K, Gras S, McLaren JE, Miners KL, Farenc C, van den Heuvel H, Gostick E, Dejnirattisai W, Wangteeraprasert A, Duangchinda T, Chotiyarnwong P, Limpitikul W, Vasanawathana S, Malasit P, Dong T, Rossjohn J, Mongkolsapaya J, Price DA, Screaton GR.

Nat Immunol. 2017 Nov;18(11):1228-1237. doi: 10.1038/ni.3850. Epub 2017 Sep 25.

6.

Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance.

Davey MS, Willcox CR, Joyce SP, Ladell K, Kasatskaya SA, McLaren JE, Hunter S, Salim M, Mohammed F, Price DA, Chudakov DM, Willcox BE.

Nat Commun. 2017 Mar 1;8:14760. doi: 10.1038/ncomms14760.

7.

Targeted suppression of autoreactive CD8+ T-cell activation using blocking anti-CD8 antibodies.

Clement M, Pearson JA, Gras S, van den Berg HA, Lissina A, Llewellyn-Lacey S, Willis MD, Dockree T, McLaren JE, Ekeruche-Makinde J, Gostick E, Robertson NP, Rossjohn J, Burrows SR, Price DA, Wong FS, Peakman M, Skowera A, Wooldridge L.

Sci Rep. 2016 Oct 17;6:35332. doi: 10.1038/srep35332.

8.

CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold.

Dockree T, Holland CJ, Clement M, Ladell K, McLaren JE, van den Berg HA, Gostick E, L Miners K, Llewellyn-Lacey S, Bridgeman JS, Man S, Bailey M, Burrows SR, Price DA, Wooldridge L.

Immunol Cell Biol. 2017 Jan;95(1):68-76. doi: 10.1038/icb.2016.85. Epub 2016 Nov 8.

9.

Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8+ T Cells.

Pearson JA, Thayer TC, McLaren JE, Ladell K, De Leenheer E, Phillips A, Davies J, Kakabadse D, Miners K, Morgan P, Wen L, Price DA, Wong FS.

Diabetes. 2016 Jun;65(6):1679-89. doi: 10.2337/db15-1498. Epub 2016 Mar 7.

10.

Early innate responses to pathogens: pattern recognition by unconventional human T-cells.

Liuzzi AR, McLaren JE, Price DA, Eberl M.

Curr Opin Immunol. 2015 Oct;36:31-7. doi: 10.1016/j.coi.2015.06.002. Epub 2015 Jul 13. Review.

11.

Determinants of gliadin-specific T cell selection in celiac disease.

Petersen J, van Bergen J, Loh KL, Kooy-Winkelaar Y, Beringer DX, Thompson A, Bakker SF, Mulder CJ, Ladell K, McLaren JE, Price DA, Rossjohn J, Reid HH, Koning F.

J Immunol. 2015 Jun 15;194(12):6112-22. doi: 10.4049/jimmunol.1500161. Epub 2015 May 6.

12.

CD8+ TCR Bias and Immunodominance in HIV-1 Infection.

Kløverpris HN, McGregor R, McLaren JE, Ladell K, Harndahl M, Stryhn A, Carlson JM, Koofhethile C, Gerritsen B, Keşmir C, Chen F, Riddell L, Luzzi G, Leslie A, Walker BD, Ndung'u T, Buus S, Price DA, Goulder PJ.

J Immunol. 2015 Jun 1;194(11):5329-45. doi: 10.4049/jimmunol.1400854. Epub 2015 Apr 24.

13.

Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics.

Neller MA, Ladell K, McLaren JE, Matthews KK, Gostick E, Pentier JM, Dolton G, Schauenburg AJ, Koning D, Fontaine Costa AI, Watkins TS, Venturi V, Smith C, Khanna R, Miners K, Clement M, Wooldridge L, Cole DK, van Baarle D, Sewell AK, Burrows SR, Price DA, Miles JJ.

Immunol Cell Biol. 2015 Aug;93(7):625-33. doi: 10.1038/icb.2015.17. Epub 2015 Mar 24.

14.

Role of naive-derived T memory stem cells in T-cell reconstitution following allogeneic transplantation.

Roberto A, Castagna L, Zanon V, Bramanti S, Crocchiolo R, McLaren JE, Gandolfi S, Tentorio P, Sarina B, Timofeeva I, Santoro A, Carlo-Stella C, Bruno B, Carniti C, Corradini P, Gostick E, Ladell K, Price DA, Roederer M, Mavilio D, Lugli E.

Blood. 2015 Apr 30;125(18):2855-64. doi: 10.1182/blood-2014-11-608406. Epub 2015 Mar 5.

15.

Complex T-cell receptor repertoire dynamics underlie the CD8+ T-cell response to HIV-1.

Costa AI, Koning D, Ladell K, McLaren JE, Grady BP, Schellens IM, van Ham P, Nijhuis M, Borghans JA, Keşmir C, Price DA, van Baarle D.

J Virol. 2015 Jan;89(1):110-9. doi: 10.1128/JVI.01765-14. Epub 2014 Oct 15.

16.

β-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure.

Skowera A, Ladell K, McLaren JE, Dolton G, Matthews KK, Gostick E, Kronenberg-Versteeg D, Eichmann M, Knight RR, Heck S, Powrie J, Bingley PJ, Dayan CM, Miles JJ, Sewell AK, Price DA, Peakman M.

Diabetes. 2015 Mar;64(3):916-925. doi: 10.2337/db14-0332. Epub 2014 Sep 23.

17.

MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage.

Gold MC, McLaren JE, Reistetter JA, Smyk-Pearson S, Ladell K, Swarbrick GM, Yu YY, Hansen TH, Lund O, Nielsen M, Gerritsen B, Kesmir C, Miles JJ, Lewinsohn DA, Price DA, Lewinsohn DM.

J Exp Med. 2014 Jul 28;211(8):1601-10. doi: 10.1084/jem.20140507. Epub 2014 Jul 21.

18.

Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load.

Kløverpris HN, McGregor R, McLaren JE, Ladell K, Stryhn A, Koofhethile C, Brener J, Chen F, Riddell L, Graziano L, Klenerman P, Leslie A, Buus S, Price DA, Goulder P.

AIDS. 2014 Sep 10;28(14):2007-21.

19.

The link between CD8⁺ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate.

Lissina A, Fastenackels S, Inglesias MC, Ladell K, McLaren JE, Briceño O, Gostick E, Papagno L, Autran B, Sauce D, Price DA, Saez-Cirion A, Appay V.

AIDS. 2014 Feb 20;28(4):477-86. doi: 10.1097/QAD.0000000000000175.

20.

A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells.

Ladell K, Hashimoto M, Iglesias MC, Wilmann PG, McLaren JE, Gras S, Chikata T, Kuse N, Fastenackels S, Gostick E, Bridgeman JS, Venturi V, Arkoub ZA, Agut H, van Bockel DJ, Almeida JR, Douek DC, Meyer L, Venet A, Takiguchi M, Rossjohn J, Price DA, Appay V.

Immunity. 2013 Mar 21;38(3):425-36. doi: 10.1016/j.immuni.2012.11.021.

21.

A T cell-inducing influenza vaccine for the elderly: safety and immunogenicity of MVA-NP+M1 in adults aged over 50 years.

Antrobus RD, Lillie PJ, Berthoud TK, Spencer AJ, McLaren JE, Ladell K, Lambe T, Milicic A, Price DA, Hill AV, Gilbert SC.

PLoS One. 2012;7(10):e48322. doi: 10.1371/journal.pone.0048322. Epub 2012 Oct 31.

22.

Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity.

Humphreys IR, Clement M, Marsden M, Ladell K, McLaren JE, Smart K, Hindley JP, Bridgeman HM, van den Berg HA, Price DA, Ager A, Wooldridge L, Godkin A, Gallimore AM.

Eur J Immunol. 2012 Dec;42(12):3235-42. doi: 10.1002/eji.201242575. Epub 2012 Oct 16.

23.

Eicosapentaenoic acid and docosahexaenoic acid regulate modified LDL uptake and macropinocytosis in human macrophages.

McLaren JE, Michael DR, Guschina IA, Harwood JL, Ramji DP.

Lipids. 2011 Nov;46(11):1053-61. doi: 10.1007/s11745-011-3598-1. Epub 2011 Aug 7.

PMID:
21822944
24.

Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy.

McLaren JE, Michael DR, Ashlin TG, Ramji DP.

Prog Lipid Res. 2011 Oct;50(4):331-47. doi: 10.1016/j.plipres.2011.04.002. Epub 2011 May 13. Review.

PMID:
21601592
25.

ERK is integral to the IFN-γ-mediated activation of STAT1, the expression of key genes implicated in atherosclerosis, and the uptake of modified lipoproteins by human macrophages.

Li N, McLaren JE, Michael DR, Clement M, Fielding CA, Ramji DP.

J Immunol. 2010 Sep 1;185(5):3041-8. doi: 10.4049/jimmunol.1000993. Epub 2010 Jul 30.

26.

IL-33 reduces macrophage foam cell formation.

McLaren JE, Michael DR, Salter RC, Ashlin TG, Calder CJ, Miller AM, Liew FY, Ramji DP.

J Immunol. 2010 Jul 15;185(2):1222-9. doi: 10.4049/jimmunol.1000520. Epub 2010 Jun 11.

27.

The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro.

McLaren JE, Calder CJ, McSharry BP, Sexton K, Salter RC, Singh NN, Wilkinson GW, Wang EC, Ramji DP.

J Immunol. 2010 May 15;184(10):5827-34. doi: 10.4049/jimmunol.0903782. Epub 2010 Apr 21.

28.

STAT1 contributes to the maintenance of the latency III viral programme observed in Epstein-Barr virus-transformed B cells and their recognition by CD8+ T cells.

McLaren JE, Zuo J, Grimstead J, Poghosyan Z, Bell AI, Rowe M, Brennan P.

J Gen Virol. 2009 Sep;90(Pt 9):2239-50. doi: 10.1099/vir.0.011627-0. Epub 2009 May 13.

PMID:
19439556
29.

Interferon gamma: a master regulator of atherosclerosis.

McLaren JE, Ramji DP.

Cytokine Growth Factor Rev. 2009 Apr;20(2):125-35. doi: 10.1016/j.cytogfr.2008.11.003. Epub 2008 Nov 28. Review.

PMID:
19041276

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