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Items: 1 to 50 of 119

1.

DGAT2 Inhibition Alters Aspects of Triglyceride Metabolism in Rodents but Not in Non-human Primates.

McLaren DG, Han S, Murphy BA, Wilsie L, Stout SJ, Zhou H, Roddy TP, Gorski JN, Metzger DE, Shin MK, Reilly DF, Zhou HH, Tadin-Strapps M, Bartz SR, Cumiskey AM, Graham TH, Shen DM, Akinsanya KO, Previs SF, Imbriglio JE, Pinto S.

Cell Metab. 2018 Jun 5;27(6):1236-1248.e6. doi: 10.1016/j.cmet.2018.04.004. Epub 2018 Apr 26.

PMID:
29706567
2.

Quantifying ceramide kinetics in vivo using stable isotope tracers and LC-MS/MS.

Chen Y, Berejnaia O, Liu J, Wang SP, Daurio NA, Yin W, Mayoral R, Petrov A, Kasumov T, Zhang GF, Previs SF, Kelley DE, McLaren DG.

Am J Physiol Endocrinol Metab. 2018 Mar 6. doi: 10.1152/ajpendo.00457.2017. [Epub ahead of print]

PMID:
29509438
3.

Automatic spinal cord localization, robust to MRI contrasts using global curve optimization.

Gros C, De Leener B, Dupont SM, Martin AR, Fehlings MG, Bakshi R, Tummala S, Auclair V, McLaren DG, Callot V, Cohen-Adad J, Sdika M.

Med Image Anal. 2018 Feb;44:215-227. doi: 10.1016/j.media.2017.12.001. Epub 2017 Dec 6.

PMID:
29288983
4.

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease.

Harrison TM, McLaren DG, Moody TD, Feusner JD, Bookheimer SY.

J Vis Exp. 2017 Nov 14;(129). doi: 10.3791/55394.

PMID:
29286444
5.

Glucagon like receptor 1/ glucagon dual agonist acutely enhanced hepatic lipid clearance and suppressed de novo lipogenesis in mice.

More VR, Lao J, McLaren DG, Cumiskey AM, Murphy BA, Chen Y, Previs S, Stout S, Patel R, Satapati S, Li W, Kowalik E, Szeto D, Nawrocki A, Pocai A, Wang L, Carrington P.

PLoS One. 2017 Oct 24;12(10):e0186586. doi: 10.1371/journal.pone.0186586. eCollection 2017.

6.

Label-Free, LC-MS-Based Assays to Quantitate Small-Molecule Antagonist Binding to the Mammalian BLT1 Receptor.

Chen X, Stout S, Mueller U, Boykow G, Visconti R, Siliphaivanh P, Spencer K, Presland J, Kavana M, Basso AD, McLaren DG, Myers RW.

SLAS Discov. 2017 Aug 1:2472555217719748. doi: 10.1177/2472555217719748. [Epub ahead of print]

PMID:
28763622
7.

Enhancing Studies of Pharmacodynamic Mechanisms via Measurements of Metabolic Flux: Fundamental Concepts and Guiding Principles for Using Stable Isotope Tracers.

Daurio NA, Wang SP, Chen Y, Zhou H, McLaren DG, Roddy TP, Johns DG, Milot D, Kasumov T, Erion MD, Kelley DE, Previs SF.

J Pharmacol Exp Ther. 2017 Oct;363(1):80-91. doi: 10.1124/jpet.117.241091. Epub 2017 Jul 19. Review.

PMID:
28724692
8.

Inter-Rater Reliability of Preprocessing EEG Data: Impact of Subjective Artifact Removal on Associative Memory Task ERP Results.

Shirk SD, McLaren DG, Bloomfield JS, Powers A, Duffy A, Mitchell MB, Ezzati A, Ally BA, Atri A.

Front Neurosci. 2017 Jun 16;11:322. doi: 10.3389/fnins.2017.00322. eCollection 2017.

9.

siRNA-mediated inhibition of SREBP cleavage-activating protein reduces dyslipidemia in spontaneously dysmetabolic rhesus monkeys.

Murphy BA, Tadin-Strapps M, Jensen K, Mogg R, Liaw A, Herath K, Bhat G, McLaren DG, Previs SF, Pinto S.

Metabolism. 2017 Jun;71:202-212. doi: 10.1016/j.metabol.2017.02.015. Epub 2017 Mar 6.

PMID:
28521874
10.

APOEε4 Genotype and Hypertension Modify 8-year Cortical Thinning: Five Occasion Evidence from the Seattle Longitudinal Study.

Rast P, Kennedy KM, Rodrigue KM, Robinson PRAW, Gross AL, McLaren DG, Grabowski T, Schaie KW, Willis SL.

Cereb Cortex. 2018 Jun 1;28(6):1934-1945. doi: 10.1093/cercor/bhx099.

11.

Memory self-awareness in the preclinical and prodromal stages of Alzheimer's disease.

Vannini P, Amariglio R, Hanseeuw B, Johnson KA, McLaren DG, Chhatwal J, Pascual-Leone A, Rentz D, Sperling RA.

Neuropsychologia. 2017 May;99:343-349. doi: 10.1016/j.neuropsychologia.2017.04.002. Epub 2017 Apr 3.

12.

Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor.

Mandal M, Tan Z, Madsen-Duggan C, Buevich AV, Caldwell JP, Dejesus R, Flattery A, Garlisi CG, Gill C, Ha SN, Ho G, Koseoglu S, Labroli M, Basu K, Lee SH, Liang L, Liu J, Mayhood T, McGuinness D, McLaren DG, Wen X, Parmee E, Rindgen D, Roemer T, Sheth P, Tawa P, Tata J, Yang C, Yang SW, Xiao L, Wang H, Tan C, Tang H, Walsh P, Walsh E, Wu J, Su J.

J Med Chem. 2017 May 11;60(9):3851-3865. doi: 10.1021/acs.jmedchem.7b00113. Epub 2017 Mar 29.

PMID:
28322556
13.

Asymptomatic Alzheimer disease: Defining resilience.

Hohman TJ, McLaren DG, Mormino EC, Gifford KA, Libon DJ, Jefferson AL; Alzheimer's Disease Neuroimaging Initiative.

Neurology. 2016 Dec 6;87(23):2443-2450. Epub 2016 Nov 4.

14.

Quantitation of wall teichoic acid in Staphylococcus aureus by direct measurement of monomeric units using LC-MS/MS.

Berejnaia O, Wang H, Labroli M, Yang C, Gill C, Xiao J, Hesk D, DeJesus R, Su J, Tan CM, Sheth PR, Kavana M, McLaren DG.

Anal Biochem. 2017 Feb 1;518:9-15. doi: 10.1016/j.ab.2016.10.027. Epub 2016 Nov 2.

PMID:
27815077
15.

Dose-dependent effects of siRNA-mediated inhibition of SCAP on PCSK9, LDLR, and plasma lipids in mouse and rhesus monkey.

Jensen KK, Tadin-Strapps M, Wang SP, Hubert J, Kan Y, Ma Y, McLaren DG, Previs SF, Herath KB, Mahsut A, Liaw A, Wang S, Stout SJ, Keohan C, Forrest G, Coelho D, Yendluri S, Williams S, Koser M, Bartz S, Akinsanya KO, Pinto S.

J Lipid Res. 2016 Dec;57(12):2150-2162. Epub 2016 Oct 5.

16.

Modulation of glucose metabolism and metabolic connectivity by β-amyloid.

Carbonell F, Zijdenbos AP, McLaren DG, Iturria-Medina Y, Bedell BJ; Alzheimer’s Disease Neuroimaging Initiative.

J Cereb Blood Flow Metab. 2016 Dec;36(12):2058-2071. Epub 2016 Jun 14.

17.

An LC-MRM method for measuring intestinal triglyceride assembly using an oral stable isotope-labeled fat challenge.

Li X, Parks EJ, McLaren DG, Lambert JE, Cardasis HL, Chappell DL, McAvoy T, Salituro G, Alon A, Dennie J, Chakravarthy M, Shankar SS, Laterza OF, Lassman ME.

Bioanalysis. 2016 Jun;8(12):1265-77. doi: 10.4155/bio-2016-0024. Epub 2016 May 26.

PMID:
27225968
18.

Potential mechanism of enhanced postprandial glucagon-like peptide-1 release following treatment with a diacylglycerol acyltransferase 1 inhibitor.

Liu J, McLaren DG, Chen D, Kan Y, Stout SJ, Shen X, Murphy BA, Forrest G, Karanam B, Sonatore L, He S, Roddy TP, Pinto S.

Pharmacol Res Perspect. 2015 Nov 30;3(6):e00193. eCollection 2015 Dec.

19.

Mammalian interspecies substitution of immune modulatory alleles by genome editing.

Lillico SG, Proudfoot C, King TJ, Tan W, Zhang L, Mardjuki R, Paschon DE, Rebar EJ, Urnov FD, Mileham AJ, McLaren DG, Whitelaw CB.

Sci Rep. 2016 Feb 22;6:21645. doi: 10.1038/srep21645.

20.

Evaluation of CETP activity in vivo under non-steady-state conditions: influence of anacetrapib on HDL-TG flux.

McLaren DG, Previs SF, Phair RD, Stout SJ, Xie D, Chen Y, Salituro GM, Xu SS, Castro-Perez JM, Opiteck GJ, Akinsanya KO, Cleary MA, Dansky HM, Johns DG, Roddy TP.

J Lipid Res. 2016 Mar;57(3):398-409. doi: 10.1194/jlr.M063842. Epub 2015 Dec 9.

21.

Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus.

Whitworth KM, Rowland RR, Ewen CL, Trible BR, Kerrigan MA, Cino-Ozuna AG, Samuel MS, Lightner JE, McLaren DG, Mileham AJ, Wells KD, Prather RS.

Nat Biotechnol. 2016 Jan;34(1):20-2. doi: 10.1038/nbt.3434. Epub 2015 Dec 7. No abstract available.

PMID:
26641533
22.

Discovery and Pharmacology of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors.

Imbriglio JE, Shen DM, Liang R, Marby K, You M, Youm HW, Feng Z, London C, Xiong Y, Tata J, Verras A, Garcia-Calvo M, Song X, Addona GH, McLaren DG, He T, Murphy B, Metzger DE, Salituro G, Deckman D, Chen Q, Jin X, Stout SJ, Wang SP, Wilsie L, Palyha O, Han S, Hubbard BK, Previs SF, Pinto S, Taggart A.

J Med Chem. 2015 Dec 10;58(23):9345-53. doi: 10.1021/acs.jmedchem.5b01345. Epub 2015 Nov 20.

PMID:
26561979
23.

Quantitative profiling of oxylipins in plasma and atherosclerotic plaques of hypercholesterolemic rabbits.

Bojic LA, McLaren DG, Harms AC, Hankemeier T, Dane A, Wang SP, Rosa R, Previs SF, Johns DG, Castro-Perez JM.

Anal Bioanal Chem. 2016 Jan;408(1):97-105. doi: 10.1007/s00216-015-9105-4. Epub 2015 Oct 28.

PMID:
26511226
24.

Identification of DGAT2 Inhibitors Using Mass Spectrometry.

Song XS, Zhang J, Chen X, Palyha O, Chung C, Sonatore LM, Wilsie L, Stout S, McLaren DG, Taggart A, Imbriglio JE, Pinto S, Garcia-Calvo M, Addona GH.

J Biomol Screen. 2016 Feb;21(2):117-26. doi: 10.1177/1087057115607463. Epub 2015 Sep 24.

PMID:
26403520
25.

Effect of Error Propagation in Stable Isotope Tracer Studies: An Approach for Estimating Impact on Apparent Biochemical Flux.

Previs SF, Herath K, Castro-Perez J, Mahsut A, Zhou H, McLaren DG, Shah V, Rohm RJ, Stout SJ, Zhong W, Wang SP, Johns DG, Hubbard BK, Cleary MA, Roddy TP.

Methods Enzymol. 2015;561:331-58. doi: 10.1016/bs.mie.2015.06.021. Epub 2015 Aug 19. Review.

PMID:
26358910
26.

Shaped by the Past: The Default Mode Network Supports Cognition that Is Independent of Immediate Perceptual Input.

Konishi M, McLaren DG, Engen H, Smallwood J.

PLoS One. 2015 Jun 30;10(6):e0132209. doi: 10.1371/journal.pone.0132209. eCollection 2015.

27.

Recognition of faces and names: multimodal physiological correlates of memory and executive function.

Mitchell MB, Shirk SD, McLaren DG, Dodd JS, Ezzati A, Ally BA, Atri A.

Brain Imaging Behav. 2016 Jun;10(2):408-23. doi: 10.1007/s11682-015-9420-6.

PMID:
26116280
28.

Harvard Aging Brain Study: Dataset and accessibility.

Dagley A, LaPoint M, Huijbers W, Hedden T, McLaren DG, Chatwal JP, Papp KV, Amariglio RE, Blacker D, Rentz DM, Johnson KA, Sperling RA, Schultz AP.

Neuroimage. 2017 Jan;144(Pt B):255-258. doi: 10.1016/j.neuroimage.2015.03.069. Epub 2015 Apr 3.

29.

Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors.

Sun S, Zhang Z, Pokrovskaia N, Chowdhury S, Jia Q, Chang E, Khakh K, Kwan R, McLaren DG, Radomski CC, Ratkay LG, Fu J, Dales NA, Winther MD.

Bioorg Med Chem. 2015 Feb 1;23(3):455-65. doi: 10.1016/j.bmc.2014.12.014. Epub 2014 Dec 19.

PMID:
25555732
30.

Lipidome of atherosclerotic plaques from hypercholesterolemic rabbits.

Bojic LA, McLaren DG, Shah V, Previs SF, Johns DG, Castro-Perez JM.

Int J Mol Sci. 2014 Dec 15;15(12):23283-93. doi: 10.3390/ijms151223283.

31.

Highly efficient targeted chromosome deletions using CRISPR/Cas9.

He Z, Proudfoot C, Mileham AJ, McLaren DG, Whitelaw CB, Lillico SG.

Biotechnol Bioeng. 2015 May;112(5):1060-4. doi: 10.1002/bit.25490. Epub 2014 Dec 23.

PMID:
25362885
32.

Genome edited sheep and cattle.

Proudfoot C, Carlson DF, Huddart R, Long CR, Pryor JH, King TJ, Lillico SG, Mileham AJ, McLaren DG, Whitelaw CB, Fahrenkrug SC.

Transgenic Res. 2015 Feb;24(1):147-53. doi: 10.1007/s11248-014-9832-x. Epub 2014 Sep 10.

33.

Template based rotation: a method for functional connectivity analysis with a priori templates.

Schultz AP, Chhatwal JP, Huijbers W, Hedden T, van Dijk KR, McLaren DG, Ward AM, Wigman S, Sperling RA.

Neuroimage. 2014 Nov 15;102 Pt 2:620-36. doi: 10.1016/j.neuroimage.2014.08.022. Epub 2014 Aug 21.

34.

Flexible modulation of network connectivity related to cognition in Alzheimer's disease.

McLaren DG, Sperling RA, Atri A.

Neuroimage. 2014 Oct 15;100:544-57. doi: 10.1016/j.neuroimage.2014.05.032. Epub 2014 May 20.

35.

Effects of anacetrapib on plasma lipids, apolipoproteins and PCSK9 in healthy, lean rhesus macaques.

Roddy TP, McLaren DG, Chen Y, Xie D, Dunn K, Kulick A, Szeto D, Forrest G, Albanese K, Donnelly M, Gai C, Gewain A, Lederman H, Jensen KK, Ai X, Vachal P, Akinsanya KO, Cleary MA, Previs SF, Dansky HM, Johns DG.

Eur J Pharmacol. 2014 Oct 5;740:410-6. doi: 10.1016/j.ejphar.2014.04.015. Epub 2014 Apr 21.

PMID:
24769414
36.

Differential psychophysiological interactions of insular subdivisions during varied oropharyngeal swallowing tasks.

Humbert IA, McLaren DG.

Physiol Rep. 2014 Mar 27;2(3):e00239. doi: 10.1002/phy2.239. Print 2014.

37.

Amyloid deposition is linked to aberrant entorhinal activity among cognitively normal older adults.

Huijbers W, Mormino EC, Wigman SE, Ward AM, Vannini P, McLaren DG, Becker JA, Schultz AP, Hedden T, Johnson KA, Sperling RA.

J Neurosci. 2014 Apr 9;34(15):5200-10. doi: 10.1523/JNEUROSCI.3579-13.2014.

38.

Functional neuroimaging of personally-relevant stimuli in a paediatric case of impaired awareness.

Nicholas CR, McLaren DG, Gawrysiak MJ, Rogers BP, Dougherty JH, Nash MR.

Brain Inj. 2014;28(8):1135-8. doi: 10.3109/02699052.2014.890745. Epub 2014 Mar 21.

PMID:
24655307
39.

The effects of methylphenidate on cognitive control in active methamphetamine dependence using functional magnetic resonance imaging.

Jan RK, Lin JC, McLaren DG, Kirk IJ, Kydd RR, Russell BR.

Front Psychiatry. 2014 Mar 6;5:20. doi: 10.3389/fpsyt.2014.00020. eCollection 2014.

40.

Systematic evaluation of amide bioisosteres leading to the discovery of novel and potent thiazolylimidazolidinone inhibitors of SCD1 for the treatment of metabolic diseases.

Sun S, Zhang Z, Kodumuru V, Pokrovskaia N, Fonarev J, Jia Q, Leung PY, Tran J, Ratkay LG, McLaren DG, Radomski C, Chowdhury S, Fu J, Hubbard B, Winther MD, Dales NA.

Bioorg Med Chem Lett. 2014 Jan 15;24(2):520-5. doi: 10.1016/j.bmcl.2013.12.036. Epub 2013 Dec 16.

PMID:
24374272
41.

Discovery of thiazolylpyridinone SCD1 inhibitors with preferential liver distribution and reduced mechanism-based adverse effects.

Sun S, Zhang Z, Raina V, Pokrovskaia N, Hou D, Namdari R, Khakh K, Ratkay LG, McLaren DG, Mork M, Fu J, Ferreira S, Hubbard B, Winther MD, Dales N.

Bioorg Med Chem Lett. 2014 Jan 15;24(2):526-31. doi: 10.1016/j.bmcl.2013.12.035. Epub 2013 Dec 16.

PMID:
24370012
42.

Daytime sleepiness is associated with decreased default mode network connectivity in both young and cognitively intact elderly subjects.

Ward AM, McLaren DG, Schultz AP, Chhatwal J, Boot BP, Hedden T, Sperling RA.

Sleep. 2013 Nov 1;36(11):1609-15. doi: 10.5665/sleep.3108.

43.

Live pigs produced from genome edited zygotes.

Lillico SG, Proudfoot C, Carlson DF, Stverakova D, Neil C, Blain C, King TJ, Ritchie WA, Tan W, Mileham AJ, McLaren DG, Fahrenkrug SC, Whitelaw CB.

Sci Rep. 2013 Oct 10;3:2847. doi: 10.1038/srep02847.

44.

Enhanced data-independent analysis of lipids using ion mobility-TOFMSE to unravel quantitative and qualitative information in human plasma.

Shah V, Castro-Perez JM, McLaren DG, Herath KB, Previs SF, Roddy TP.

Rapid Commun Mass Spectrom. 2013 Oct 15;27(19):2195-200. doi: 10.1002/rcm.6675.

PMID:
23996393
45.

Midlife measurements of white matter microstructure predict subsequent regional white matter atrophy in healthy adults.

Ly M, Canu E, Xu G, Oh J, McLaren DG, Dowling NM, Alexander AL, Sager MA, Johnson SC, Bendlin BB.

Hum Brain Mapp. 2014 May;35(5):2044-54. doi: 10.1002/hbm.22311. Epub 2013 Jul 17.

46.

New methodologies for studying lipid synthesis and turnover: looking backwards to enable moving forwards.

Previs SF, McLaren DG, Wang SP, Stout SJ, Zhou H, Herath K, Shah V, Miller PL, Wilsie L, Castro-Perez J, Johns DG, Cleary MA, Roddy TP.

Biochim Biophys Acta. 2014 Mar;1842(3):402-13. doi: 10.1016/j.bbadis.2013.05.019. Epub 2013 May 22. Review.

47.

Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release--potential insight into mechanism of action.

Liu J, Gorski JN, Gold SJ, Chen D, Chen S, Forrest G, Itoh Y, Marsh DJ, McLaren DG, Shen Z, Sonatore L, Carballo-Jane E, Craw S, Guan X, Karanam B, Sakaki J, Szeto D, Tong X, Xiao J, Yoshimoto R, Yu H, Roddy TP, Balkovec J, Pinto S.

Obesity (Silver Spring). 2013 Jul;21(7):1406-15. doi: 10.1002/oby.20193. Epub 2013 May 13.

48.

Use of [13C18] oleic acid and mass isotopomer distribution analysis to study synthesis of plasma triglycerides in vivo: analytical and experimental considerations.

McLaren DG, Cardasis HL, Stout SJ, Wang SP, Mendoza V, Castro-Perez JM, Miller PL, Murphy BA, Cumiskey AM, Cleary MA, Johns DG, Previs SF, Roddy TP.

Anal Chem. 2013 Jul 2;85(13):6287-94. doi: 10.1021/ac400363k. Epub 2013 Jun 10.

PMID:
23668715
49.

The encoding/retrieval flip: interactions between memory performance and memory stage and relationship to intrinsic cortical networks.

Huijbers W, Schultz AP, Vannini P, McLaren DG, Wigman SE, Ward AM, Hedden T, Sperling RA.

J Cogn Neurosci. 2013 Jul;25(7):1163-79. doi: 10.1162/jocn_a_00366. Epub 2013 Feb 5.

50.

Discovery of piperazin-1-ylpyridazine-based potent and selective stearoyl-CoA desaturase-1 inhibitors for the treatment of obesity and metabolic syndrome.

Zhang Z, Sun S, Kodumuru V, Hou D, Liu S, Chakka N, Sviridov S, Chowdhury S, McLaren DG, Ratkay LG, Khakh K, Cheng X, Gschwend HW, Kamboj R, Fu J, Winther MD.

J Med Chem. 2013 Jan 24;56(2):568-83. doi: 10.1021/jm301661h. Epub 2013 Jan 7.

PMID:
23245208

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