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Items: 18


An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials.

Henderson CJ, Kapelyukh Y, Scheer N, Rode A, McLaren AW, MacLeod AK, Lin D, Wright J, Stanley LA, Wolf CR.

Drug Metab Dispos. 2019 Jun;47(6):601-615. doi: 10.1124/dmd.119.086397. Epub 2019 Mar 25.


Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability.

Henderson CJ, McLaughlin LA, Osuna-Cabello M, Taylor M, Gilbert I, McLaren AW, Wolf CR.

Biochem J. 2015 Feb 1;465(3):479-88. doi: 10.1042/BJ20140582.


In vivo regulation of human glutathione transferase GSTP by chemopreventive agents.

Henderson CJ, McLaren AW, Wolf CR.

Cancer Res. 2014 Aug 15;74(16):4378-87. doi: 10.1158/0008-5472.CAN-14-0792. Epub 2014 Jun 16.


Conditional deletion of cytochrome P450 oxidoreductase in the liver and gastrointestinal tract: a new model for studying the functions of the P450 system.

Finn RD, McLaren AW, Carrie D, Henderson CJ, Wolf CR.

J Pharmacol Exp Ther. 2007 Jul;322(1):40-7. Epub 2007 Apr 13.


Knockout mice in xenobiotic metabolism.

Henderson CJ, Otto DM, McLaren AW, Carrie D, Wolf CR.

Drug Metab Rev. 2003 Nov;35(4):385-92. No abstract available.


Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

Henderson CJ, Otto DM, Carrie D, Magnuson MA, McLaren AW, Rosewell I, Wolf CR.

J Biol Chem. 2003 Apr 11;278(15):13480-6. Epub 2003 Feb 3.


Pi-class glutathione S-transferase: regulation and function.

Henderson CJ, McLaren AW, Moffat GJ, Bacon EJ, Wolf CR.

Chem Biol Interact. 1998 Apr 24;111-112:69-82. Review.


Sp1-mediated transcriptional activation of the human Pi class glutathione S-transferase promoter.

Moffat GJ, McLaren AW, Wolf CR.

J Biol Chem. 1996 Jan 12;271(2):1054-60.


Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics.

Forrester LM, Henderson CJ, Glancey MJ, Back DJ, Park BK, Ball SE, Kitteringham NR, McLaren AW, Miles JS, Skett P, et al.

Biochem J. 1992 Jan 15;281 ( Pt 2):359-68.


Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity.

Miles JS, McLaren AW, Forrester LM, Glancey MJ, Lang MA, Wolf CR.

Biochem J. 1990 Apr 15;267(2):365-71.


Alternative splicing in the human cytochrome P450IIB6 gene: use of a cryptic exon within intron 3 and splice acceptor site within exon 4.

Miles JS, McLaren AW, Gonzalez FJ, Wolf CR.

Nucleic Acids Res. 1990 Jan 11;18(1):189. No abstract available.


Alternative splicing in the human cytochrome P450IIB6 gene generates a high level of aberrant messages.

Miles JS, McLaren AW, Wolf CR.

Nucleic Acids Res. 1989 Oct 25;17(20):8241-55.


Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies: implications for the assignment of substrate specificity.

Miles JS, Bickmore W, Brook JD, McLaren AW, Meehan R, Wolf CR.

Nucleic Acids Res. 1989 Apr 25;17(8):2907-17.


A novel human cytochrome P450 gene (P450IIB): chromosomal localization and evidence for alternative splicing.

Miles JS, Spurr NK, Gough AC, Jowett T, McLaren AW, Brook JD, Wolf CR.

Nucleic Acids Res. 1988 Jul 11;16(13):5783-95.

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