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Items: 1 to 20 of 454

1.

Lead optimization of a pyrrole-based dihydroorotate dehydrogenase inhibitor series for the treatment of Malaria.

Kokkonda S, Deng X, White KL, El Mazouni F, White J, Shackleford DM, Katneni K, Chiu FCK, Barker H, McLaren J, Crighton E, Chen G, Angulo-Barturen I, Jimenez-Diaz MB, Ferrer S, Valentin LH, Martínez-Martínez MS, Lafuente-Monasterio MJ, Kumar CR, Shahi SP, Wittlin S, Waterson D, Burrows JN, Matthews D, Tomchick DR, Rathod PK, Palmer MJ, Charman SA, Phillips MA.

J Med Chem. 2020 Apr 6. doi: 10.1021/acs.jmedchem.0c00311. [Epub ahead of print]

PMID:
32248693
2.

Characterizing infection in anti-neutrophil cytoplasmic antibody-associated vasculitis: results from a longitudinal, matched-cohort data linkage study.

Sarica SH, Dhaun N, Sznajd J, Harvie J, McLaren J, McGeoch L, Kumar V, Amft N, Erwig L, Marks A, Black C, Basu N.

Rheumatology (Oxford). 2020 Mar 11. pii: keaa070. doi: 10.1093/rheumatology/keaa070. [Epub ahead of print]

PMID:
32159801
3.

A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans.

Edwards SC, Sutton CE, Ladell K, Grant EJ, McLaren JE, Roche F, Dash P, Apiwattanakul N, Awad W, Miners KL, Lalor SJ, Ribot JC, Baik S, Moran B, McGinley A, Pivorunas V, Dowding L, Macoritto M, Paez-Cortez J, Slavin A, Anderson G, Silva-Santos B, Hokamp K, Price DA, Thomas PG, McLoughlin RM, Mills KHG.

J Exp Med. 2020 May 4;217(5). pii: e20190834. doi: 10.1084/jem.20190834.

PMID:
32106283
4.

How well do we know Gradenigo? A comprehensive literature review and proposal for novel diagnostic categories of Gradenigo's syndrome.

McLaren J, Cohen MS, El Saleeby CM.

Int J Pediatr Otorhinolaryngol. 2020 Feb 8;132:109942. doi: 10.1016/j.ijporl.2020.109942. [Epub ahead of print] Review.

PMID:
32065876
5.

CD4+ T Follicular Helper Cells in Human Tonsils and Blood Are Clonally Convergent but Divergent from Non-Tfh CD4+ Cells.

Brenna E, Davydov AN, Ladell K, McLaren JE, Bonaiuti P, Metsger M, Ramsden JD, Gilbert SC, Lambe T, Price DA, Campion SL, Chudakov DM, Borrow P, McMichael AJ.

Cell Rep. 2020 Jan 7;30(1):137-152.e5. doi: 10.1016/j.celrep.2019.12.016.

6.

Deprescribing psychotropic medications in children: results of a national qualitative study.

Barnett ER, Trepman AZ, Fuson HA, Acquilano SC, McLaren JL, Woloshin S, Leyenaar JK.

BMJ Qual Saf. 2019 Dec 13. pii: bmjqs-2019-010033. doi: 10.1136/bmjqs-2019-010033. [Epub ahead of print]

PMID:
31836627
7.

SIV-specific CD8+ T cells are clonotypically distinct across lymphoid and mucosal tissues.

Starke CE, Vinton CL, Ladell K, McLaren JE, Ortiz AM, Mudd JC, Flynn JK, Lai SH, Wu F, Hirsch VM, Darko S, Douek DC, Price DA, Brenchley JM.

J Clin Invest. 2020 Feb 3;130(2):789-798. doi: 10.1172/JCI129161.

8.

A phase III study of triple therapy with budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler 320/18/9.6 μg and 160/18/9.6 μg using co-suspension delivery technology in moderate-to-very severe COPD: The ETHOS study protocol.

Rabe KF, Martinez FJ, Ferguson GT, Wang C, Singh D, Wedzicha JA, Trivedi R, St Rose E, Ballal S, McLaren J, Darken P, Reisner C, Dorinsky P.

Respir Med. 2019 Oct - Nov;158:59-66. doi: 10.1016/j.rmed.2019.08.010. Epub 2019 Aug 22.

PMID:
31605923
9.

Global change effects on plant communities are magnified by time and the number of global change factors imposed.

Komatsu KJ, Avolio ML, Lemoine NP, Isbell F, Grman E, Houseman GR, Koerner SE, Johnson DS, Wilcox KR, Alatalo JM, Anderson JP, Aerts R, Baer SG, Baldwin AH, Bates J, Beierkuhnlein C, Belote RT, Blair J, Bloor JMG, Bohlen PJ, Bork EW, Boughton EH, Bowman WD, Britton AJ, Cahill JF Jr, Chaneton E, Chiariello NR, Cheng J, Collins SL, Cornelissen JHC, Du G, Eskelinen A, Firn J, Foster B, Gough L, Gross K, Hallett LM, Han X, Harmens H, Hovenden MJ, Jagerbrand A, Jentsch A, Kern C, Klanderud K, Knapp AK, Kreyling J, Li W, Luo Y, McCulley RL, McLaren JR, Megonigal JP, Morgan JW, Onipchenko V, Pennings SC, Prevéy JS, Price JN, Reich PB, Robinson CH, Russell FL, Sala OE, Seabloom EW, Smith MD, Soudzilovskaia NA, Souza L, Suding K, Suttle KB, Svejcar T, Tilman D, Tognetti P, Turkington R, White S, Xu Z, Yahdjian L, Yu Q, Zhang P, Zhang Y.

Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17867-17873. doi: 10.1073/pnas.1819027116. Epub 2019 Aug 19.

10.

Primary EBV Infection Induces an Acute Wave of Activated Antigen-Specific Cytotoxic CD4+ T Cells.

Meckiff BJ, Ladell K, McLaren JE, Ryan GB, Leese AM, James EA, Price DA, Long HM.

J Immunol. 2019 Sep 1;203(5):1276-1287. doi: 10.4049/jimmunol.1900377. Epub 2019 Jul 15.

11.

Fatigue in primary Sjögren's syndrome (pSS) is associated with lower levels of proinflammatory cytokines: a validation study.

Davies K, Mirza K, Tarn J, Howard-Tripp N, Bowman SJ, Lendrem D; UK Primary Sjögren’s Syndrome Registry, Ng WF.

Rheumatol Int. 2019 Nov;39(11):1867-1873. doi: 10.1007/s00296-019-04354-0. Epub 2019 Jun 27.

12.

TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis.

Wong EB, Gold MC, Meermeier EW, Xulu BZ, Khuzwayo S, Sullivan ZA, Mahyari E, Rogers Z, Kløverpris H, Sharma PK, Worley AH, Lalloo U, Baijnath P, Ambaram A, Naidoo L, Suleman M, Madansein R, McLaren JE, Ladell K, Miners KL, Price DA, Behar SM, Nielsen M, Kasprowicz VO, Leslie A, Bishai WR, Ndung'u T, Lewinsohn DM.

Commun Biol. 2019 Jun 5;2:203. doi: 10.1038/s42003-019-0442-2. eCollection 2019.

13.

Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sjögren's syndrome.

Hackett KL, Davies K, Tarn J, Bragg R, Hargreaves B, Miyamoto S, McMeekin P, Mitchell S, Bowman S, Price EJ, Pease C, Emery P, Andrews J, Lanyon P, Hunter J, Gupta M, Bombardieri M, Sutcliffe N, Pitzalis C, McLaren J, Cooper A, Regan M, Giles I, Isenberg D, Vadivelu S, Coady D, Dasgupta B, McHugh N, Young-Min S, Moots R, Gendi N, Akil M, Griffiths B, Lendrem DW, Ng WF.

RMD Open. 2019 Apr 24;5(1):e000885. doi: 10.1136/rmdopen-2018-000885. eCollection 2019.

14.

Spatially-offset Raman spectroscopy for monitoring mineralization of bone tissue engineering scaffolds: feasibility study based on phantom samples.

Dooley M, Prasopthum A, Liao Z, Sinjab F, McLaren J, Rose FRAJ, Yang J, Notingher I.

Biomed Opt Express. 2019 Mar 6;10(4):1678-1690. doi: 10.1364/BOE.10.001678. eCollection 2019 Apr 1.

15.

Porous Phosphate-Based Glass Microspheres Show Biocompatibility, Tissue Infiltration, and Osteogenic Onset in an Ovine Bone Defect Model.

McLaren JS, Macri-Pellizzeri L, Hossain KMZ, Patel U, Grant DM, Scammell BE, Ahmed I, Sottile V.

ACS Appl Mater Interfaces. 2019 May 1;11(17):15436-15446. doi: 10.1021/acsami.9b04603. Epub 2019 Apr 16.

16.

Effect of Timolol on Aqueous Humor Outflow Facility in Healthy Human Eyes.

Kazemi A, McLaren JW, Trese MGJ, Toris CB, Gulati V, Fan S, Reed DM, Kristoff T, Gilbert J, Moroi SE, Sit AJ.

Am J Ophthalmol. 2019 Jun;202:126-132. doi: 10.1016/j.ajo.2019.02.014. Epub 2019 Feb 19.

PMID:
30794789
17.

Functional Connectivity in Term Neonates With Hypoxic-Ischemic Encephalopathy Undergoing Therapeutic Hypothermia.

McLaren J, Holmes GL, Berg MT.

Pediatr Neurol. 2019 May;94:74-79. doi: 10.1016/j.pediatrneurol.2019.01.006. Epub 2019 Jan 9.

PMID:
30792031
18.

Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease.

Mayassi T, Ladell K, Gudjonson H, McLaren JE, Shaw DG, Tran MT, Rokicka JJ, Lawrence I, Grenier JC, van Unen V, Ciszewski C, Dimaano M, Sayegh HE, Kumar V, Wijmenga C, Green PHR, Gokhale R, Jericho H, Semrad CE, Guandalini S, Dinner AR, Kupfer SS, Reid HH, Barreiro LB, Rossjohn J, Price DA, Jabri B.

Cell. 2019 Feb 21;176(5):967-981.e19. doi: 10.1016/j.cell.2018.12.039. Epub 2019 Feb 7.

19.

Memory CD4+ T cells are generated in the human fetal intestine.

Li N, van Unen V, Abdelaal T, Guo N, Kasatskaya SA, Ladell K, McLaren JE, Egorov ES, Izraelson M, Chuva de Sousa Lopes SM, Höllt T, Britanova OV, Eggermont J, de Miranda NFCC, Chudakov DM, Price DA, Lelieveldt BPF, Koning F.

Nat Immunol. 2019 Mar;20(3):301-312. doi: 10.1038/s41590-018-0294-9. Epub 2019 Jan 21.

20.

IL-33 Augments Virus-Specific Memory T Cell Inflation and Potentiates the Efficacy of an Attenuated Cytomegalovirus-Based Vaccine.

McLaren JE, Clement M, Marsden M, Miners KL, Llewellyn-Lacey S, Grant EJ, Rubina A, Gimeno Brias S, Gostick E, Stacey MA, Orr SJ, Stanton RJ, Ladell K, Price DA, Humphreys IR.

J Immunol. 2019 Feb 1;202(3):943-955. doi: 10.4049/jimmunol.1701757.

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