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Items: 1 to 50 of 76

1.

Aluminum in neurological disease - a 36 year multicenter study.

Lukiw WJ, Kruck TPA, Percy ME, Pogue AI, Alexandrov PN, Walsh WJ, Sharfman NM, Jaber VR, Zhao Y, Li W, Bergeron C, Culicchia F, Fang Z, McLachlan DRC.

J Alzheimers Dis Parkinsonism. 2019;8(6). pii: 457. doi: 10.4172/2161-0460.1000457. Epub 2018 Nov 29.

2.

Aluminum in Neurological and Neurodegenerative Disease.

McLachlan DRC, Bergeron C, Alexandrov PN, Walsh WJ, Pogue AI, Percy ME, Kruck TPA, Fang Z, Sharfman NM, Jaber V, Zhao Y, Li W, Lukiw WJ.

Mol Neurobiol. 2019 Feb;56(2):1531-1538. doi: 10.1007/s12035-018-1441-x. Epub 2019 Jan 31.

PMID:
30706368
3.

Ligand specific effects on aluminum incorporation and toxicity in neurons and astrocytes.

Lévesque L, Mizzen CA, McLachlan DR, Fraser PE.

Brain Res. 2000 Sep 22;877(2):191-202.

PMID:
10986332
4.

Resolution of allelic and non-allelic variants of histone H1 by cation-exchange-hydrophilic-interaction chromatography.

Mizzen CA, Alpert AJ, Lévesque L, Kruck TP, McLachlan DR.

J Chromatogr B Biomed Sci Appl. 2000 Jul 7;744(1):33-46.

PMID:
10985564
5.
6.

Run-on gene transcription in human neocortical nuclei. Inhibition by nanomolar aluminum and implications for neurodegenerative disease.

Lukiw WJ, LeBlanc HJ, Carver LA, McLachlan DR, Bazan NG.

J Mol Neurosci. 1998 Aug;11(1):67-78.

PMID:
9826787
7.

Can the controversy of the role of aluminum in Alzheimer's disease be resolved? What are the suggested approaches to this controversy and methodological issues to be considered?

Savory J, Exley C, Forbes WF, Huang Y, Joshi JG, Kruck T, McLachlan DR, Wakayama I.

J Toxicol Environ Health. 1996 Aug 30;48(6):615-35. Review.

PMID:
8772802
8.

Further thoughts on the aluminum-Alzheimer's disease link.

Forbes WF, McLachlan DR.

J Epidemiol Community Health. 1996 Aug;50(4):401-3.

9.

Sensitive detection of metallothioneins-1, -2 and -3 in tissue homogenates by immunoblotting: a method for enhanced membrane transfer and retention.

Mizzen CA, Cartel NJ, Yu WH, Fraser PE, McLachlan DR.

J Biochem Biophys Methods. 1996 May 14;32(2):77-83.

PMID:
8796480
10.
11.

A prospective study of the clinical utility of ApoE genotype in the prediction of outcome in patients with memory impairment.

Tierney MC, Szalai JP, Snow WG, Fisher RH, Tsuda T, Chi H, McLachlan DR, St George-Hyslop PH.

Neurology. 1996 Jan;46(1):149-54.

PMID:
8559365
12.

Localization of a new ferritin heavy chain sequence present in human brain mRNA to chromosome 11.

Percy ME, Bauer SJ, Rainey S, McLachlan DR, Dhar MS, Joshi JG.

Genome. 1995 Jun;38(3):450-7.

PMID:
7557358
13.

Conformation and fibrillogenesis of Alzheimer A beta peptides with selected substitution of charged residues.

Fraser PE, McLachlan DR, Surewicz WK, Mizzen CA, Snow AD, Nguyen JT, Kirschner DA.

J Mol Biol. 1994 Nov 18;244(1):64-73.

PMID:
7966323
14.

Analysis of the functional effects of a mutation in SOD1 associated with familial amyotrophic lateral sclerosis.

Tsuda T, Munthasser S, Fraser PE, Percy ME, Rainero I, Vaula G, Pinessi L, Bergamini L, Vignocchi G, McLachlan DR, et al.

Neuron. 1994 Sep;13(3):727-36.

PMID:
7917302
15.

Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium?

Tsuda T, Lopez R, Rogaeva EA, Freedman M, Rogaev E, Drachman D, Pollen D, Haines J, Liang Y, McLachlan DR, et al.

Ann Neurol. 1994 Jul;36(1):97-100.

PMID:
8024269
16.

Machado-Joseph disease in pedigrees of Azorean descent is linked to chromosome 14.

St George-Hyslop P, Rogaeva E, Huterer J, Tsuda T, Santos J, Haines JL, Schlumpf K, Rogaev EI, Liang Y, McLachlan DR, et al.

Am J Hum Genet. 1994 Jul;55(1):120-5.

17.

Generation and characterization of novel antibodies highly selective for phosphorylated linker histone H1 in Tetrahymena and HeLa cells.

Lu MJ, Dadd CA, Mizzen CA, Perry CA, McLachlan DR, Annunziato AT, Allis CD.

Chromosoma. 1994 Apr;103(2):111-21.

PMID:
7519974
18.

Alzheimer A beta amyloid forms an inhibitory neuronal substrate.

Fraser PE, Lévesque L, McLachlan DR.

J Neurochem. 1994 Mar;62(3):1227-30.

PMID:
8113806
19.

Protein-DNA interactions in the promoter region of the amyloid precursor protein (APP) gene in human neocortex.

Lukiw WJ, Rogaev EI, Wong L, Vaula G, McLachlan DR, St George Hyslop P.

Brain Res Mol Brain Res. 1994 Mar;22(1-4):121-31.

PMID:
8015372
20.

SOD1 missense mutation in an Italian family with ALS.

Rainero I, Pinessi L, Tsuda T, Vignocchi MG, Vaula G, Calvi L, Cerrato P, Rossi B, Bergamini L, McLachlan DR, et al.

Neurology. 1994 Feb;44(2):347-9.

PMID:
8309590
21.
22.

Biochemistry of Alzheimer's disease amyloid plaques.

Fraser PE, Lévesque L, McLachlan DR.

Clin Biochem. 1993 Oct;26(5):339-49. Review.

PMID:
8299204
23.

Family with 22-derived marker chromosome and late-onset dementia of the Alzheimer type: II. Further cytogenetic analysis of the marker and characterization of the high-level repeat sequences using fluorescence in situ hybridization.

Percy ME, Dearie TG, Jabs EW, Bauer SJ, Chodakowski B, Somerville MJ, Lennox A, McLachlan DR, Baldini A, Miller DA.

Am J Med Genet. 1993 Aug 1;47(1):14-9.

PMID:
7690182
24.

Alpha 1-antichymotrypsin binding to Alzheimer A beta peptides is sequence specific and induces fibril disaggregation in vitro.

Fraser PE, Nguyen JT, McLachlan DR, Abraham CR, Kirschner DA.

J Neurochem. 1993 Jul;61(1):298-305.

PMID:
8515277
25.

Reduction of calbindin-28k mRNA levels in Alzheimer as compared to Huntington hippocampus.

Sutherland MK, Wong L, Somerville MJ, Yoong LK, Bergeron C, Parmentier M, McLachlan DR.

Brain Res Mol Brain Res. 1993 Apr;18(1-2):32-42.

PMID:
8479289
26.

Age-associated chromosome 21 loss in Down syndrome: possible relevance to mosaicism and Alzheimer disease.

Percy ME, Markovic VD, Dalton AJ, McLachlan DR, Berg JM, Rusk AC, Somerville MJ, Chodakowski B, Andrews DF.

Am J Med Genet. 1993 Mar 1;45(5):584-8.

PMID:
8456829
27.

A predictor for side effects in patients with Alzheimer's disease treated with deferoxamine mesylate.

Kruck TP, Fisher EA, McLachlan DR.

Clin Pharmacol Ther. 1993 Jan;53(1):30-7.

PMID:
8422739
28.
29.

Aluminum-binding serum proteins: desferrioxamine alters serum aluminum speciation.

Favarato M, Mizzen CA, Sutherland MK, Krishnan B, Kruck TP, McLachlan DR.

Clin Chim Acta. 1992 Apr 30;207(1-2):41-55.

PMID:
1591866
30.

Reduction of vitamin D hormone receptor mRNA levels in Alzheimer as compared to Huntington hippocampus: correlation with calbindin-28k mRNA levels.

Sutherland MK, Somerville MJ, Yoong LK, Bergeron C, Haussler MR, McLachlan DR.

Brain Res Mol Brain Res. 1992 Apr;13(3):239-50.

PMID:
1317496
31.

Reduction of thyroid hormone receptor c-ERB A alpha mRNA levels in the hippocampus of Alzheimer as compared to Huntington brain.

Sutherland MK, Wong L, Somerville MJ, Handley P, Yoong L, Bergeron C, McLachlan DR.

Neurobiol Aging. 1992 Mar-Apr;13(2):301-12.

PMID:
1387923
32.

Aluminium and the pathogenesis of Alzheimer's disease: a summary of evidence.

McLachlan DR, Fraser PE, Dalton AJ.

Ciba Found Symp. 1992;169:87-98; discussion 99-108. Review.

PMID:
1490430
33.

Would decreased aluminum ingestion reduce the incidence of Alzheimer's disease?

McLachlan DR, Kruck TP, Lukiw WJ, Krishnan SS.

CMAJ. 1991 Oct 1;145(7):793-804. Review.

34.

Anomalous gene expression in Alzheimer disease: cause or effect.

McLachlan DR, Lukiw WJ, Mizzen C, Percy ME, Somerville MJ, Sutherland MK, Wong L.

Can J Neurol Sci. 1991 Aug;18(3 Suppl):414-8.

PMID:
1933691
35.

A correlation between gene transcriptional activity and cerebral glucose metabolism in Alzheimer's disease-affected neocortex: cause or effect?

Lukiw WJ, Handley P, Sutherland MK, Wong L, McLachlan DR.

Adv Exp Med Biol. 1991;291:249-56.

PMID:
1927687
36.

Localization and quantitation of 68 kDa neurofilament and superoxide dismutase-1 mRNA in Alzheimer brains.

Somerville MJ, Percy ME, Bergeron C, Yoong LK, Grima EA, McLachlan DR.

Brain Res Mol Brain Res. 1991 Jan;9(1-2):1-8.

PMID:
1850065
37.

Cytoskeletal messenger RNA stability in human neocortex: studies in normal aging and in Alzheimer's disease.

Lukiw WJ, Wong L, McLachlan DR.

Int J Neurosci. 1990 Dec;55(2-4):81-8.

PMID:
2084053
38.

Effect of exposure of miners to aluminium powder.

Rifat SL, Eastwood MR, McLachlan DR, Corey PN.

Lancet. 1990 Nov 10;336(8724):1162-5.

PMID:
1978033
39.

Brain amino acid contents are dissimilar in sporadic and Guamanian amyotrophic lateral sclerosis.

Perry TL, Bergeron C, Steele JC, McLachlan DR, Hansen S.

J Neurol Sci. 1990 Oct;99(1):3-8.

PMID:
2250169
41.

Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder.

St George-Hyslop PH, Haines JL, Farrer LA, Polinsky R, Van Broeckhoven C, Goate A, McLachlan DR, Orr H, Bruni AC, Sorbi S, Rainero I, Foncin JF, Pollen D, Cantu JM, Tupler R, Voskresenskaya N, Mayeux R, Growden J, Fried VA, Myers RH, Nee L, Backhovens H, Martin JJ, Rossor M, Owen MJ, Mullan M, Percy ME, Karlinsky H, Rich S, Heston L, Montesi M, Mortilla M, Nacmias N, Gusella JF, Hardy JA; FAD Collaborative Study Group, et al.

Nature. 1990 Sep 13;347(6289):194-7.

PMID:
2395471
42.

Red cell superoxide dismutase, glutathione peroxidase and catalase in Down syndrome patients with and without manifestations of Alzheimer disease.

Percy ME, Dalton AJ, Markovic VD, McLachlan DR, Hummel JT, Rusk AC, Andrews DF.

Am J Med Genet. 1990 Apr;35(4):459-67.

PMID:
2139757
44.

Issues of lead toxicity.

Nicholls DM, McLachlan DR.

Basic Life Sci. 1990;55:237-46. Review. No abstract available.

PMID:
2088274
45.

New evidence for an active role of aluminum in Alzheimer's disease.

McLachlan DR, Lukiw WJ, Kruck TP.

Can J Neurol Sci. 1989 Nov;16(4 Suppl):490-7. Review.

PMID:
2680008
46.
47.

Aluminum as a pathogenic factor in senile dementia of the Alzheimer type: ion specific chelation.

Kruck TP, McLachlan DR.

Prog Clin Biol Res. 1989;317:1155-67. Review. No abstract available.

PMID:
2690090
48.

Chromatin structure in Alzheimer's disease: effect on 5' leader sequence for NF-L gene and role of aluminum.

McLachlan DR, Lukiw WJ, Mizzen CA, Kruck TP.

Prog Clin Biol Res. 1989;317:1061-75. Review. No abstract available.

PMID:
2690086
49.

High-performance liquid chromatographic analysis of desferrioxamine. Pharmacokinetic and metabolic studies.

Kruck TP, Teichert-Kuliszewska K, Fisher E, Kalow W, McLachlan DR.

J Chromatogr. 1988 Dec 9;433:207-16.

PMID:
3235548
50.

Priming of semantic autobiographical knowledge: a case study of retrograde amnesia.

Tulving E, Schacter DL, McLachlan DR, Moscovitch M.

Brain Cogn. 1988 Aug;8(1):3-20.

PMID:
3166816

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