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Passing Through.

McKnight SL.

Trends Biochem Sci. 2019 Nov;44(11):899-901. doi: 10.1016/j.tibs.2019.09.004. Epub 2019 Oct 16.


Redox State Controls Phase Separation of the Yeast Ataxin-2 Protein via Reversible Oxidation of Its Methionine-Rich Low-Complexity Domain.

Kato M, Yang YS, Sutter BM, Wang Y, McKnight SL, Tu BP.

Cell. 2019 Apr 18;177(3):711-721.e8. doi: 10.1016/j.cell.2019.02.044. Epub 2019 Apr 11.


Benefits of Enhancing Nicotinamide Adenine Dinucleotide Levels in Damaged or Diseased Nerve Cells.

Pieper AA, McKnight SL.

Cold Spring Harb Symp Quant Biol. 2018;83:207-217. doi: 10.1101/sqb.2018.83.037622. Epub 2019 Feb 20.


Structural characterization of the D290V mutation site in hnRNPA2 low-complexity-domain polymers.

Murray DT, Zhou X, Kato M, Xiang S, Tycko R, McKnight SL.

Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):E9782-E9791. doi: 10.1073/pnas.1806174115. Epub 2018 Oct 2.


ACSS2 promotes systemic fat storage and utilization through selective regulation of genes involved in lipid metabolism.

Huang Z, Zhang M, Plec AA, Estill SJ, Cai L, Repa JJ, McKnight SL, Tu BP.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):E9499-E9506. doi: 10.1073/pnas.1806635115. Epub 2018 Sep 18.


A Solid-State Conceptualization of Information Transfer from Gene to Message to Protein.

Kato M, McKnight SL.

Annu Rev Biochem. 2018 Jun 20;87:351-390. doi: 10.1146/annurev-biochem-061516-044700. Epub 2017 Dec 1. Review.


Structure of FUS Protein Fibrils and Its Relevance to Self-Assembly and Phase Separation of Low-Complexity Domains.

Murray DT, Kato M, Lin Y, Thurber KR, Hung I, McKnight SL, Tycko R.

Cell. 2017 Oct 19;171(3):615-627.e16. doi: 10.1016/j.cell.2017.08.048. Epub 2017 Sep 21.


Cross-β polymerization and hydrogel formation by low-complexity sequence proteins.

Kato M, Lin Y, McKnight SL.

Methods. 2017 Aug 15;126:3-11. doi: 10.1016/j.ymeth.2017.06.011. Epub 2017 Jun 15.


Toxic PRn poly-dipeptides encoded by the C9orf72 repeat expansion block nuclear import and export.

Shi KY, Mori E, Nizami ZF, Lin Y, Kato M, Xiang S, Wu LC, Ding M, Yu Y, Gall JG, McKnight SL.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1111-E1117. doi: 10.1073/pnas.1620293114. Epub 2017 Jan 9.


Cross-β Polymerization of Low Complexity Sequence Domains.

Kato M, McKnight SL.

Cold Spring Harb Perspect Biol. 2017 Mar 1;9(3). pii: a023598. doi: 10.1101/cshperspect.a023598. Review.


Toxic PR Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers.

Lin Y, Mori E, Kato M, Xiang S, Wu L, Kwon I, McKnight SL.

Cell. 2016 Oct 20;167(3):789-802.e12. doi: 10.1016/j.cell.2016.10.003.


The LC Domain of hnRNPA2 Adopts Similar Conformations in Hydrogel Polymers, Liquid-like Droplets, and Nuclei.

Xiang S, Kato M, Wu LC, Lin Y, Ding M, Zhang Y, Yu Y, McKnight SL.

Cell. 2015 Nov 5;163(4):829-39. doi: 10.1016/j.cell.2015.10.040.


Acetate dependence of tumors.

Comerford SA, Huang Z, Du X, Wang Y, Cai L, Witkiewicz AK, Walters H, Tantawy MN, Fu A, Manning HC, Horton JD, Hammer RE, McKnight SL, Tu BP.

Cell. 2014 Dec 18;159(7):1591-602. doi: 10.1016/j.cell.2014.11.020.


P7C3 neuroprotective chemicals block axonal degeneration and preserve function after traumatic brain injury.

Yin TC, Britt JK, De Jesús-Cortés H, Lu Y, Genova RM, Khan MZ, Voorhees JR, Shao J, Katzman AC, Huntington PJ, Wassink C, McDaniel L, Newell EA, Dutca LM, Naidoo J, Cui H, Bassuk AG, Harper MM, McKnight SL, Ready JM, Pieper AA.

Cell Rep. 2014 Sep 25;8(6):1731-1740. doi: 10.1016/j.celrep.2014.08.030. Epub 2014 Sep 15.


P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage.

Wang G, Han T, Nijhawan D, Theodoropoulos P, Naidoo J, Yadavalli S, Mirzaei H, Pieper AA, Ready JM, McKnight SL.

Cell. 2014 Sep 11;158(6):1324-1334. doi: 10.1016/j.cell.2014.07.040.


Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells.

Kwon I, Xiang S, Kato M, Wu L, Theodoropoulos P, Wang T, Kim J, Yun J, Xie Y, McKnight SL.

Science. 2014 Sep 5;345(6201):1139-45. doi: 10.1126/science.1254917. Epub 2014 Jul 31.


Please keep me 2uned to PKM2.

McKnight SL.

Mol Cell. 2014 Mar 6;53(5):683-4. doi: 10.1016/j.molcel.2014.02.022.


P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases.

Pieper AA, McKnight SL, Ready JM.

Chem Soc Rev. 2014 Oct 7;43(19):6716-26. doi: 10.1039/c3cs60448a. Review.


Concerted effort: oscillations in global gene expression during nematode development.

Laxman S, Tu BP, McKnight SL.

Mol Cell. 2014 Feb 6;53(3):363-4. doi: 10.1016/j.molcel.2014.01.023.


Phosphorylation-regulated binding of RNA polymerase II to fibrous polymers of low-complexity domains.

Kwon I, Kato M, Xiang S, Wu L, Theodoropoulos P, Mirzaei H, Han T, Xie S, Corden JL, McKnight SL.

Cell. 2013 Nov 21;155(5):1049-1060. doi: 10.1016/j.cell.2013.10.033. Erratum in: Cell. 2014 Jan 16;156(1-2):374.


Influence of metabolism on epigenetics and disease.

Kaelin WG Jr, McKnight SL.

Cell. 2013 Mar 28;153(1):56-69. doi: 10.1016/j.cell.2013.03.004. Review.


Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease.

De Jesús-Cortés H, Xu P, Drawbridge J, Estill SJ, Huntington P, Tran S, Britt J, Tesla R, Morlock L, Naidoo J, Melito LM, Wang G, Williams NS, Ready JM, McKnight SL, Pieper AA.

Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17010-5. doi: 10.1073/pnas.1213956109. Epub 2012 Oct 1.


Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis.

Tesla R, Wolf HP, Xu P, Drawbridge J, Estill SJ, Huntington P, McDaniel L, Knobbe W, Burket A, Tran S, Starwalt R, Morlock L, Naidoo J, Williams NS, Ready JM, McKnight SL, Pieper AA.

Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17016-21. doi: 10.1073/pnas.1213960109. Epub 2012 Oct 1.


Pure genes, pure genius.

McKnight SL.

Cell. 2012 Sep 14;150(6):1100-2. doi: 10.1016/j.cell.2012.08.022.


Cell-free formation of RNA granules: bound RNAs identify features and components of cellular assemblies.

Han TW, Kato M, Xie S, Wu LC, Mirzaei H, Pei J, Chen M, Xie Y, Allen J, Xiao G, McKnight SL.

Cell. 2012 May 11;149(4):768-79. doi: 10.1016/j.cell.2012.04.016.


Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels.

Kato M, Han TW, Xie S, Shi K, Du X, Wu LC, Mirzaei H, Goldsmith EJ, Longgood J, Pei J, Grishin NV, Frantz DE, Schneider JW, Chen S, Li L, Sawaya MR, Eisenberg D, Tycko R, McKnight SL.

Cell. 2012 May 11;149(4):753-67. doi: 10.1016/j.cell.2012.04.017.


Back to the future: molecular biology meets metabolism.

McKnight SL.

Cold Spring Harb Symp Quant Biol. 2011;76:403-11. doi: 10.1101/sqb.2012.76.013722. Epub 2012 Apr 17. Review. No abstract available.


Metabolic specialization of mouse embryonic stem cells.

Wang J, Alexander P, McKnight SL.

Cold Spring Harb Symp Quant Biol. 2011;76:183-93. doi: 10.1101/sqb.2011.76.010835. Epub 2011 Nov 9.


Targeted killing of a mammalian cell based upon its specialized metabolic state.

Alexander PB, Wang J, McKnight SL.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15828-33. doi: 10.1073/pnas.1111312108. Epub 2011 Sep 6.


Development of proneurogenic, neuroprotective small molecules.

MacMillan KS, Naidoo J, Liang J, Melito L, Williams NS, Morlock L, Huntington PJ, Estill SJ, Longgood J, Becker GL, McKnight SL, Pieper AA, De Brabander JK, Ready JM.

J Am Chem Soc. 2011 Feb 9;133(5):1428-37. doi: 10.1021/ja108211m. Epub 2011 Jan 6.


On getting there from here.

McKnight SL.

Science. 2010 Dec 3;330(6009):1338-9. doi: 10.1126/science.1199908.


Discovery of a proneurogenic, neuroprotective chemical.

Pieper AA, Xie S, Capota E, Estill SJ, Zhong J, Long JM, Becker GL, Huntington P, Goldman SE, Shen CH, Capota M, Britt JK, Kotti T, Ure K, Brat DJ, Williams NS, MacMillan KS, Naidoo J, Melito L, Hsieh J, De Brabander J, Ready JM, McKnight SL.

Cell. 2010 Jul 9;142(1):39-51. doi: 10.1016/j.cell.2010.06.018.


Unconventional wisdom.

McKnight SL.

Cell. 2009 Sep 4;138(5):817-9. doi: 10.1016/j.cell.2009.08.016.


Evidence of carbon monoxide-mediated phase advancement of the yeast metabolic cycle.

Tu BP, McKnight SL.

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14293-6. doi: 10.1073/pnas.0907786106. Epub 2009 Aug 11.


Dependence of mouse embryonic stem cells on threonine catabolism.

Wang J, Alexander P, Wu L, Hammer R, Cleaver O, McKnight SL.

Science. 2009 Jul 24;325(5939):435-9. doi: 10.1126/science.1173288. Epub 2009 Jul 9.


The yeast metabolic cycle: insights into the life of a eukaryotic cell.

Tu BP, McKnight SL.

Cold Spring Harb Symp Quant Biol. 2007;72:339-43. doi: 10.1101/sqb.2007.72.019. Review.


Pseudomonas aeruginosa PqsA is an anthranilate-coenzyme A ligase.

Coleman JP, Hudson LL, McKnight SL, Farrow JM 3rd, Calfee MW, Lindsey CA, Pesci EC.

J Bacteriol. 2008 Feb;190(4):1247-55. Epub 2007 Dec 14.


A conserved DNA damage response pathway responsible for coupling the cell division cycle to the circadian and metabolic cycles.

Chen Z, McKnight SL.

Cell Cycle. 2007 Dec 1;6(23):2906-12. Epub 2007 Oct 8. Review.


Cyclic changes in metabolic state during the life of a yeast cell.

Tu BP, Mohler RE, Liu JC, Dombek KM, Young ET, Synovec RE, McKnight SL.

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16886-91. Epub 2007 Oct 16.


Restriction of DNA replication to the reductive phase of the metabolic cycle protects genome integrity.

Chen Z, Odstrcil EA, Tu BP, McKnight SL.

Science. 2007 Jun 29;316(5833):1916-9.


Therapeutic anticancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity.

Williams NS, Burgett AW, Atkins AS, Wang X, Harran PG, McKnight SL.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2074-9. Epub 2007 Feb 7.


Metabolic cycles as an underlying basis of biological oscillations.

Tu BP, McKnight SL.

Nat Rev Mol Cell Biol. 2006 Sep;7(9):696-701. Epub 2006 Jul 5. Review.


NPAS2 as a transcriptional regulator of non-rapid eye movement sleep: genotype and sex interactions.

Franken P, Dudley CA, Estill SJ, Barakat M, Thomason R, O'Hara BF, McKnight SL.

Proc Natl Acad Sci U S A. 2006 May 2;103(18):7118-23. Epub 2006 Apr 24.


Logic of the yeast metabolic cycle: temporal compartmentalization of cellular processes.

Tu BP, Kudlicki A, Rowicka M, McKnight SL.

Science. 2005 Nov 18;310(5751):1152-8. Epub 2005 Oct 27. Erratum in: Science. 2006 Feb 17;311(5763):954.


The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice.

Pieper AA, Wu X, Han TW, Estill SJ, Dang Q, Wu LC, Reece-Fincanon S, Dudley CA, Richardson JA, Brat DJ, McKnight SL.

Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14052-7. Epub 2005 Sep 19.


Mammalian sprouty proteins assemble into large monodisperse particles having the properties of intracellular nanobatteries.

Wu X, Alexander PB, He Y, Kikkawa M, Vogel PD, McKnight SL.

Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14058-62. Epub 2005 Sep 19.


Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors.

Erbel-Sieler C, Dudley C, Zhou Y, Wu X, Estill SJ, Han T, Diaz-Arrastia R, Brunskill EW, Potter SS, McKnight SL.

Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13648-53. Epub 2004 Sep 3.


Discovery of antivirals against smallpox.

Harrison SC, Alberts B, Ehrenfeld E, Enquist L, Fineberg H, McKnight SL, Moss B, O'Donnell M, Ploegh H, Schmid SL, Walter KP, Theriot J.

Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11178-92. Epub 2004 Jul 12. Review. No abstract available.


Cloning and characterization of the NAD-dependent 7alpha-Hydroxysteroid dehydrogenase from Bacteroides fragilis.

Bennett MJ, McKnight SL, Coleman JP.

Curr Microbiol. 2003 Dec;47(6):475-84.


Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice.

Dudley CA, Erbel-Sieler C, Estill SJ, Reick M, Franken P, Pitts S, McKnight SL.

Science. 2003 Jul 18;301(5631):379-83. Epub 2003 Jul 3.

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