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Items: 1 to 50 of 184

1.

Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape.

Baranowski C, Welsh MA, Sham LT, Eskandarian HA, Lim HC, Kieser KJ, Wagner JC, McKinney JD, Fantner GE, Ioerger TR, Walker S, Bernhardt TG, Rubin EJ, Rego EH.

Elife. 2018 Oct 16;7. pii: e37516. doi: 10.7554/eLife.37516.

2.

Fluorescent Benzothiazinone Analogues Efficiently and Selectively Label Dpre1 in Mycobacteria and Actinobacteria.

Sommer R, Neres J, Piton J, Dhar N, van der Sar A, Mukherjee R, Laroche T, Dyson PJ, McKinney JD, Bitter W, Makarov V, Cole ST.

ACS Chem Biol. 2018 Oct 25. doi: 10.1021/acschembio.8b00790. [Epub ahead of print]

PMID:
30289689
3.

Photothermal Off-Resonance Tapping for Rapid and Gentle Atomic Force Imaging of Live Cells.

Nievergelt AP, Brillard C, Eskandarian HA, McKinney JD, Fantner GE.

Int J Mol Sci. 2018 Sep 30;19(10). pii: E2984. doi: 10.3390/ijms19102984.

4.

A microfluidic cell-trapping device to study dynamic host-microbe interactions at the single-cell level.

Toniolo C, Delincé M, McKinney JD.

Methods Cell Biol. 2018;147:199-213. doi: 10.1016/bs.mcb.2018.06.008. Epub 2018 Aug 2.

PMID:
30165958
5.

Elucidating the role of (p)ppGpp in mycobacterial persistence against antibiotics.

Bhaskar A, De Piano C, Gelman E, McKinney JD, Dhar N.

IUBMB Life. 2018 Sep;70(9):836-844. doi: 10.1002/iub.1888. Epub 2018 Aug 9. Review.

PMID:
30092117
6.

Division site selection linked to inherited cell surface wave troughs in mycobacteria.

Eskandarian HA, Odermatt PD, Ven JXY, Hannebelle MTM, Nievergelt AP, Dhar N, McKinney JD, Fantner GE.

Nat Microbiol. 2017 Jun 26;2:17094. doi: 10.1038/nmicrobiol.2017.94.

PMID:
28650475
7.

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria.

Singh V, Dhar N, Pató J, Kolly GS, Korduláková J, Forbak M, Evans JC, Székely R, Rybniker J, Palčeková Z, Zemanová J, Santi I, Signorino-Gelo F, Rodrigues L, Vocat A, Covarrubias AS, Rengifo MG, Johnsson K, Mowbray S, Buechler J, Delorme V, Brodin P, Knott GW, Aínsa JA, Warner DF, Kéri G, Mikušová K, McKinney JD, Cole ST, Mizrahi V, Hartkoorn RC.

Mol Microbiol. 2017 Jan;103(1):13-25. doi: 10.1111/mmi.13535. Epub 2016 Oct 29.

8.

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis.

Singh V, Donini S, Pacitto A, Sala C, Hartkoorn RC, Dhar N, Keri G, Ascher DB, Mondésert G, Vocat A, Lupien A, Sommer R, Vermet H, Lagrange S, Buechler J, Warner DF, McKinney JD, Pato J, Cole ST, Blundell TL, Rizzi M, Mizrahi V.

ACS Infect Dis. 2017 Jan 13;3(1):5-17. doi: 10.1021/acsinfecdis.6b00102. Epub 2016 Sep 8.

9.

Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-β-d-ribose Oxidase.

Batt SM, Cacho Izquierdo M, Castro Pichel J, Stubbs CJ, Vela-Glez Del Peral L, Pérez-Herrán E, Dhar N, Mouzon B, Rees M, Hutchinson JP, Young RJ, McKinney JD, Barros Aguirre D, Ballell L, Besra GS, Argyrou A.

ACS Infect Dis. 2015 Dec 11;1(12):615-26. doi: 10.1021/acsinfecdis.5b00065. Epub 2015 Aug 25.

PMID:
27623058
10.

Mycobacterium tuberculosis Phosphate Uptake System Component PstA2 Is Not Required for Gene Regulation or Virulence.

Tischler AD, Leistikow RL, Ramakrishnan P, Voskuil MI, McKinney JD.

PLoS One. 2016 Aug 24;11(8):e0161467. doi: 10.1371/journal.pone.0161467. eCollection 2016.

11.

A rheostat mechanism governs the bifurcation of carbon flux in mycobacteria.

Murima P, Zimmermann M, Chopra T, Pojer F, Fonti G, Dal Peraro M, Alonso S, Sauer U, Pethe K, McKinney JD.

Nat Commun. 2016 Aug 24;7:12527. doi: 10.1038/ncomms12527.

12.

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor.

Martínez-Hoyos M, Perez-Herran E, Gulten G, Encinas L, Álvarez-Gómez D, Alvarez E, Ferrer-Bazaga S, García-Pérez A, Ortega F, Angulo-Barturen I, Rullas-Trincado J, Blanco Ruano D, Torres P, Castañeda P, Huss S, Fernández Menéndez R, González Del Valle S, Ballell L, Barros D, Modha S, Dhar N, Signorino-Gelo F, McKinney JD, García-Bustos JF, Lavandera JL, Sacchettini JC, Jimenez MS, Martín-Casabona N, Castro-Pichel J, Mendoza-Losana A.

EBioMedicine. 2016 Jun;8:291-301. doi: 10.1016/j.ebiom.2016.05.006. Epub 2016 May 8.

13.

A microfluidic cell-trapping device for single-cell tracking of host-microbe interactions.

Delincé MJ, Bureau JB, López-Jiménez AT, Cosson P, Soldati T, McKinney JD.

Lab Chip. 2016 Aug 16;16(17):3276-85. doi: 10.1039/c6lc00649c.

PMID:
27425421
14.

Mycobacterium tuberculosis Resists Stress by Regulating PE19 Expression.

Ramakrishnan P, Aagesen AM, McKinney JD, Tischler AD.

Infect Immun. 2015 Dec 28;84(3):735-46. doi: 10.1128/IAI.00942-15.

15.

Combinations of β-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection.

Rullas J, Dhar N, McKinney JD, García-Pérez A, Lelievre J, Diacon AH, Hugonnet JE, Arthur M, Angulo-Barturen I, Barros-Aguirre D, Ballell L.

Antimicrob Agents Chemother. 2015 Aug;59(8):4997-9. doi: 10.1128/AAC.01063-15. Epub 2015 May 18.

16.

Single-cell tracking reveals antibiotic-induced changes in mycobacterial energy metabolism.

Maglica Ž, Özdemir E, McKinney JD.

MBio. 2015 Feb 17;6(1):e02236-14. doi: 10.1128/mBio.02236-14.

17.

Chromosome organization and replisome dynamics in Mycobacterium smegmatis.

Santi I, McKinney JD.

MBio. 2015 Feb 17;6(1):e01999-14. doi: 10.1128/mBio.01999-14.

18.

Stress and host immunity amplify Mycobacterium tuberculosis phenotypic heterogeneity and induce nongrowing metabolically active forms.

Manina G, Dhar N, McKinney JD.

Cell Host Microbe. 2015 Jan 14;17(1):32-46. doi: 10.1016/j.chom.2014.11.016. Epub 2014 Dec 24.

19.

Targeting bacterial central metabolism for drug development.

Murima P, McKinney JD, Pethe K.

Chem Biol. 2014 Nov 20;21(11):1423-32. doi: 10.1016/j.chembiol.2014.08.020. Epub 2014 Oct 16. Review.

20.

Rapid cytolysis of Mycobacterium tuberculosis by faropenem, an orally bioavailable β-lactam antibiotic.

Dhar N, Dubée V, Ballell L, Cuinet G, Hugonnet JE, Signorino-Gelo F, Barros D, Arthur M, McKinney JD.

Antimicrob Agents Chemother. 2015 Feb;59(2):1308-19. doi: 10.1128/AAC.03461-14. Epub 2014 Nov 24.

21.

Broadband RF disambiguation in subsampled analog optical links via intentionally-introduced sampling jitter.

Harmon SR, McKinney JD.

Opt Express. 2014 Oct 6;22(20):23928-37. doi: 10.1364/OE.22.023928.

PMID:
25321970
22.

Quantitative mass spectrometry reveals plasticity of metabolic networks in Mycobacterium smegmatis.

Chopra T, Hamelin R, Armand F, Chiappe D, Moniatte M, McKinney JD.

Mol Cell Proteomics. 2014 Nov;13(11):3014-28. doi: 10.1074/mcp.M113.034082. Epub 2014 Jul 5.

23.

4-aminoquinolone piperidine amides: noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity.

Naik M, Humnabadkar V, Tantry SJ, Panda M, Narayan A, Guptha S, Panduga V, Manjrekar P, Jena LK, Koushik K, Shanbhag G, Jatheendranath S, Manjunatha MR, Gorai G, Bathula C, Rudrapatna S, Achar V, Sharma S, Ambady A, Hegde N, Mahadevaswamy J, Kaur P, Sambandamurthy VK, Awasthy D, Narayan C, Ravishankar S, Madhavapeddi P, Reddy J, Prabhakar K, Saralaya R, Chatterji M, Whiteaker J, McLaughlin B, Chiarelli LR, Riccardi G, Pasca MR, Binda C, Neres J, Dhar N, Signorino-Gelo F, McKinney JD, Ramachandran V, Shandil R, Tommasi R, Iyer PS, Narayanan S, Hosagrahara V, Kavanagh S, Dinesh N, Ghorpade SR.

J Med Chem. 2014 Jun 26;57(12):5419-34. doi: 10.1021/jm5005978. Epub 2014 Jun 11.

PMID:
24871036
24.

Dielectrophoresis-based purification of antibiotic-treated bacterial subpopulations.

Elitas M, Martinez-Duarte R, Dhar N, McKinney JD, Renaud P.

Lab Chip. 2014 Jun 7;14(11):1850-7. doi: 10.1039/c4lc00109e. Epub 2014 Apr 23.

PMID:
24756475
25.

Technology: Photonics illuminates the future of radar.

McKinney JD.

Nature. 2014 Mar 20;507(7492):310-1. doi: 10.1038/507310a. No abstract available.

PMID:
24646990
26.

Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism.

Koul A, Vranckx L, Dhar N, Göhlmann HW, Özdemir E, Neefs JM, Schulz M, Lu P, Mørtz E, McKinney JD, Andries K, Bald D.

Nat Commun. 2014 Feb 26;5:3369. doi: 10.1038/ncomms4369.

27.

Assessing the essentiality of the decaprenyl-phospho-d-arabinofuranose pathway in Mycobacterium tuberculosis using conditional mutants.

Kolly GS, Boldrin F, Sala C, Dhar N, Hartkoorn RC, Ventura M, Serafini A, McKinney JD, Manganelli R, Cole ST.

Mol Microbiol. 2014 Apr;92(1):194-211. doi: 10.1111/mmi.12546. Epub 2014 Mar 7.

28.

Bias-dependent distortion in optical comb-based analog optical links.

McKinney JD, Urick VJ, Hastings AS.

Opt Express. 2013 Oct 7;21(20):23695-705. doi: 10.1364/OE.21.023695.

PMID:
24104282
29.

Single-cell dynamics of the chromosome replication and cell division cycles in mycobacteria.

Santi I, Dhar N, Bousbaine D, Wakamoto Y, McKinney JD.

Nat Commun. 2013;4:2470. doi: 10.1038/ncomms3470. Erratum in: Nat Commun. 2013;4:3913.

PMID:
24036848
30.

A problem of persistence: still more questions than answers?

Balaban NQ, Gerdes K, Lewis K, McKinney JD.

Nat Rev Microbiol. 2013 Aug;11(8):587-91. Review.

PMID:
24020075
31.

A single-cell perspective on non-growing but metabolically active (NGMA) bacteria.

Manina G, McKinney JD.

Curr Top Microbiol Immunol. 2013;374:135-61. doi: 10.1007/82_2013_333.

PMID:
23793585
32.

Suppression of even-order photodiode distortions via predistortion linearization with a bias-shifted Mach-Zehnder modulator.

Urick VJ, Hutchinson MN, Singley JM, McKinney JD, Williams KJ.

Opt Express. 2013 Jun 17;21(12):14368-76. doi: 10.1364/OE.21.014368.

PMID:
23787625
33.

A vitamin B₁₂ transporter in Mycobacterium tuberculosis.

Gopinath K, Venclovas C, Ioerger TR, Sacchettini JC, McKinney JD, Mizrahi V, Warner DF.

Open Biol. 2013 Feb 13;3(2):120175. doi: 10.1098/rsob.120175.

34.

Dynamic persistence of antibiotic-stressed mycobacteria.

Wakamoto Y, Dhar N, Chait R, Schneider K, Signorino-Gelo F, Leibler S, McKinney JD.

Science. 2013 Jan 4;339(6115):91-5. doi: 10.1126/science.1229858.

35.

Mycobacterium tuberculosis requires phosphate-responsive gene regulation to resist host immunity.

Tischler AD, Leistikow RL, Kirksey MA, Voskuil MI, McKinney JD.

Infect Immun. 2013 Jan;81(1):317-28. doi: 10.1128/IAI.01136-12. Epub 2012 Nov 6.

36.

Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis.

Neres J, Pojer F, Molteni E, Chiarelli LR, Dhar N, Boy-Röttger S, Buroni S, Fullam E, Degiacomi G, Lucarelli AP, Read RJ, Zanoni G, Edmondson DE, De Rossi E, Pasca MR, McKinney JD, Dyson PJ, Riccardi G, Mattevi A, Cole ST, Binda C.

Sci Transl Med. 2012 Sep 5;4(150):150ra121. doi: 10.1126/scitranslmed.3004395.

37.

Malachite green interferes with postantibiotic recovery of mycobacteria.

Gelman E, McKinney JD, Dhar N.

Antimicrob Agents Chemother. 2012 Jul;56(7):3610-4. doi: 10.1128/AAC.00406-12. Epub 2012 Apr 23.

38.

Cholesterol catabolism by Mycobacterium tuberculosis requires transcriptional and metabolic adaptations.

Griffin JE, Pandey AK, Gilmore SA, Mizrahi V, McKinney JD, Bertozzi CR, Sassetti CM.

Chem Biol. 2012 Feb 24;19(2):218-27. doi: 10.1016/j.chembiol.2011.12.016. Erratum in: Chem Biol. 2012 Sep 21;19(9):1210.

39.

Expression of the leptin receptor outside of bone marrow-derived cells regulates tuberculosis control and lung macrophage MHC expression.

Lemos MP, Rhee KY, McKinney JD.

J Immunol. 2011 Oct 1;187(7):3776-84. doi: 10.4049/jimmunol.1003226. Epub 2011 Aug 22.

40.

Nanoparticle conjugation and pulmonary delivery enhance the protective efficacy of Ag85B and CpG against tuberculosis.

Ballester M, Nembrini C, Dhar N, de Titta A, de Piano C, Pasquier M, Simeoni E, van der Vlies AJ, McKinney JD, Hubbell JA, Swartz MA.

Vaccine. 2011 Sep 16;29(40):6959-66. doi: 10.1016/j.vaccine.2011.07.039. Epub 2011 Jul 23.

PMID:
21787826
41.

Spontaneous phthiocerol dimycocerosate-deficient variants of Mycobacterium tuberculosis are susceptible to gamma interferon-mediated immunity.

Kirksey MA, Tischler AD, Siméone R, Hisert KB, Uplekar S, Guilhot C, McKinney JD.

Infect Immun. 2011 Jul;79(7):2829-38. doi: 10.1128/IAI.00097-11. Epub 2011 May 16.

42.

Relationship between vitamin D status and ICU outcomes in veterans.

McKinney JD, Bailey BA, Garrett LH, Peiris P, Manning T, Peiris AN.

J Am Med Dir Assoc. 2011 Mar;12(3):208-11. doi: 10.1016/j.jamda.2010.04.004.

PMID:
21333923
43.

Mycobacterium tuberculosis persistence mutants identified by screening in isoniazid-treated mice.

Dhar N, McKinney JD.

Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12275-80. doi: 10.1073/pnas.1003219107. Epub 2010 Jun 21.

44.

Contrasting persistence strategies in Salmonella and Mycobacterium.

Tischler AD, McKinney JD.

Curr Opin Microbiol. 2010 Feb;13(1):93-9. doi: 10.1016/j.mib.2009.12.007. Epub 2010 Jan 6. Review.

45.

Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis.

Makarov V, Manina G, Mikusova K, Möllmann U, Ryabova O, Saint-Joanis B, Dhar N, Pasca MR, Buroni S, Lucarelli AP, Milano A, De Rossi E, Belanova M, Bobovska A, Dianiskova P, Kordulakova J, Sala C, Fullam E, Schneider P, McKinney JD, Brodin P, Christophe T, Waddell S, Butcher P, Albrethsen J, Rosenkrands I, Brosch R, Nandi V, Bharath S, Gaonkar S, Shandil RK, Balasubramanian V, Balganesh T, Tyagi S, Grosset J, Riccardi G, Cole ST.

Science. 2009 May 8;324(5928):801-4. doi: 10.1126/science.1171583. Epub 2009 Mar 19.

46.

Functional characterization of a vitamin B12-dependent methylmalonyl pathway in Mycobacterium tuberculosis: implications for propionate metabolism during growth on fatty acids.

Savvi S, Warner DF, Kana BD, McKinney JD, Mizrahi V, Dawes SS.

J Bacteriol. 2008 Jun;190(11):3886-95. doi: 10.1128/JB.01767-07. Epub 2008 Mar 28.

47.

Characterization and imaging in optically scattering media by use of laser speckle and a variable-coherence source.

McKinney JD, Webster MA, Webb KJ, Weiner AM.

Opt Lett. 2000 Jan 1;25(1):4-6.

PMID:
18059763
48.

Role of the methylcitrate cycle in propionate metabolism and detoxification in Mycobacterium smegmatis.

Upton AM, McKinney JD.

Microbiology. 2007 Dec;153(Pt 12):3973-82.

PMID:
18048912
49.

Millimeter-wave arbitrary waveform generation with a direct space-to-time pulse shaper.

McKinney JD, Leaird DE, Weiner AM.

Opt Lett. 2002 Aug 1;27(15):1345-7.

PMID:
18026445
50.

Microbial phenotypic heterogeneity and antibiotic tolerance.

Dhar N, McKinney JD.

Curr Opin Microbiol. 2007 Feb;10(1):30-8. Epub 2007 Jan 9. Review.

PMID:
17215163

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