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Effects of Exposure to Acetaminophen and Ibuprofen on Fetal Germ Cell Development in Both Sexes in Rodent and Human Using Multiple Experimental Systems.

Hurtado-Gonzalez P, Anderson RA, Macdonald J, van den Driesche S, Kilcoyne K, Jørgensen A, McKinnell C, Macpherson S, Sharpe RM, Mitchell RT.

Environ Health Perspect. 2018 Apr 16;126(4):047006. doi: 10.1289/EHP2307.


Experimentally induced testicular dysgenesis syndrome originates in the masculinization programming window.

van den Driesche S, Kilcoyne KR, Wagner I, Rebourcet D, Boyle A, Mitchell R, McKinnell C, Macpherson S, Donat R, Shukla CJ, Jorgensen A, Meyts ER, Skakkebaek NE, Sharpe RM.

JCI Insight. 2017 Mar 23;2(6):e91204. doi: 10.1172/jci.insight.91204.


Analgesic exposure in pregnant rats affects fetal germ cell development with inter-generational reproductive consequences.

Dean A, van den Driesche S, Wang Y, McKinnell C, Macpherson S, Eddie SL, Kinnell H, Hurtado-Gonzalez P, Chambers TJ, Stevenson K, Wolfinger E, Hrabalkova L, Calarrao A, Bayne RA, Hagen CP, Mitchell RT, Anderson RA, Sharpe RM.

Sci Rep. 2016 Jan 27;6:19789. doi: 10.1038/srep19789.


Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model.

van den Driesche S, Macdonald J, Anderson RA, Johnston ZC, Chetty T, Smith LB, Mckinnell C, Dean A, Homer NZ, Jorgensen A, Camacho-Moll ME, Sharpe RM, Mitchell RT.

Sci Transl Med. 2015 May 20;7(288):288ra80. doi: 10.1126/scitranslmed.aaa4097.


Comparative effects of di(n-butyl) phthalate exposure on fetal germ cell development in the rat and in human fetal testis xenografts.

van den Driesche S, McKinnell C, Calarrão A, Kennedy L, Hutchison GR, Hrabalkova L, Jobling MS, Macpherson S, Anderson RA, Sharpe RM, Mitchell RT.

Environ Health Perspect. 2015 Mar;123(3):223-30. doi: 10.1289/ehp.1408248. Epub 2014 Dec 16.


Anogenital distance plasticity in adulthood: implications for its use as a biomarker of fetal androgen action.

Mitchell RT, Mungall W, McKinnell C, Sharpe RM, Cruickshanks L, Milne L, Smith LB.

Endocrinology. 2015 Jan;156(1):24-31. doi: 10.1210/en.2014-1534.


Fetal programming of adult Leydig cell function by androgenic effects on stem/progenitor cells.

Kilcoyne KR, Smith LB, Atanassova N, Macpherson S, McKinnell C, van den Driesche S, Jobling MS, Chambers TJ, De Gendt K, Verhoeven G, O'Hara L, Platts S, Renato de Franca L, Lara NL, Anderson RA, Sharpe RM.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):E1924-32. doi: 10.1073/pnas.1320735111. Epub 2014 Apr 21.


Prostaglandins, masculinization and its disorders: effects of fetal exposure of the rat to the cyclooxygenase inhibitor- indomethacin.

Dean A, Mungall W, McKinnell C, Sharpe RM.

PLoS One. 2013 May 3;8(5):e62556. doi: 10.1371/journal.pone.0062556. Print 2013.


Diethylstilboestrol exposure does not reduce testosterone production in human fetal testis xenografts.

Mitchell RT, Sharpe RM, Anderson RA, McKinnell C, Macpherson S, Smith LB, Wallace WH, Kelnar CJ, van den Driesche S.

PLoS One. 2013 Apr 19;8(4):e61726. doi: 10.1371/journal.pone.0061726. Print 2013.


Perinatal germ cell development and differentiation in the male marmoset (Callithrix jacchus): similarities with the human and differences from the rat.

McKinnell C, Mitchell RT, Morris K, Anderson RA, Kelnar CJ, Wallace WH, Sharpe RM.

Hum Reprod. 2013 Apr;28(4):886-96. doi: 10.1093/humrep/des465. Epub 2013 Jan 15.


Proposed role for COUP-TFII in regulating fetal Leydig cell steroidogenesis, perturbation of which leads to masculinization disorders in rodents.

van den Driesche S, Walker M, McKinnell C, Scott HM, Eddie SL, Mitchell RT, Seckl JR, Drake AJ, Smith LB, Anderson RA, Sharpe RM.

PLoS One. 2012;7(5):e37064. doi: 10.1371/journal.pone.0037064. Epub 2012 May 17.


Do phthalates affect steroidogenesis by the human fetal testis? Exposure of human fetal testis xenografts to di-n-butyl phthalate.

Mitchell RT, Childs AJ, Anderson RA, van den Driesche S, Saunders PT, McKinnell C, Wallace WH, Kelnar CJ, Sharpe RM.

J Clin Endocrinol Metab. 2012 Mar;97(3):E341-8. doi: 10.1210/jc.2011-2411. Epub 2012 Jan 11.


Foetal and post-natal exposure of sheep to sewage sludge chemicals disrupts sperm production in adulthood in a subset of animals.

Bellingham M, McKinnell C, Fowler PA, Amezaga MR, Zhang Z, Rhind SM, Cotinot C, Mandon-Pepin B, Evans NP, Sharpe RM.

Int J Androl. 2012 Jun;35(3):317-29. doi: 10.1111/j.1365-2605.2011.01234.x. Epub 2011 Dec 13.


Prenatal plus postnatal exposure to Di(n-Butyl) phthalate and/or flutamide markedly reduces final sertoli cell number in the rat.

Auharek SA, de Franca LR, McKinnell C, Jobling MS, Scott HM, Sharpe RM.

Endocrinology. 2010 Jun;151(6):2868-75. doi: 10.1210/en.2010-0108. Epub 2010 Apr 14.


Organotypic cultures of prepubertal mouse testes: a method to study androgen action in sertoli cells while preserving their natural environment.

De Gendt K, McKinnell C, Willems A, Saunders PT, Sharpe RM, Atanassova N, Swinnen JV, Verhoeven G.

Biol Reprod. 2009 Dec;81(6):1083-92. doi: 10.1095/biolreprod.109.078360. Epub 2009 Jul 8.


Effect of fetal or neonatal exposure to monobutyl phthalate (MBP) on testicular development and function in the marmoset.

McKinnell C, Mitchell RT, Walker M, Morris K, Kelnar CJ, Wallace WH, Sharpe RM.

Hum Reprod. 2009 Sep;24(9):2244-54. doi: 10.1093/humrep/dep200. Epub 2009 Jun 2.


Relationship between androgen action in the "male programming window," fetal sertoli cell number, and adult testis size in the rat.

Scott HM, Hutchison GR, Jobling MS, McKinnell C, Drake AJ, Sharpe RM.

Endocrinology. 2008 Oct;149(10):5280-7. doi: 10.1210/en.2008-0413. Epub 2008 Jun 19.


Sertoli cell development and function in an animal model of testicular dysgenesis syndrome.

Hutchison GR, Scott HM, Walker M, McKinnell C, Ferrara D, Mahood IK, Sharpe RM.

Biol Reprod. 2008 Feb;78(2):352-60. Epub 2007 Oct 10.


The origins and time of appearance of focal testicular dysgenesis in an animal model of testicular dysgenesis syndrome: evidence for delayed testis development?

Hutchison GR, Sharpe RM, Mahood IK, Jobling M, Walker M, McKinnell C, Mason JI, Scott HM.

Int J Androl. 2008 Apr;31(2):103-11. Epub 2007 Sep 18.


Effects of monobutyl and di(n-butyl) phthalate in vitro on steroidogenesis and Leydig cell aggregation in fetal testis explants from the rat: comparison with effects in vivo in the fetal rat and neonatal marmoset and in vitro in the human.

Hallmark N, Walker M, McKinnell C, Mahood IK, Scott H, Bayne R, Coutts S, Anderson RA, Greig I, Morris K, Sharpe RM.

Environ Health Perspect. 2007 Mar;115(3):390-6. Epub 2006 Dec 19.


Acute and long-term effects of in utero exposure of rats to di(n-butyl) phthalate on testicular germ cell development and proliferation.

Ferrara D, Hallmark N, Scott H, Brown R, McKinnell C, Mahood IK, Sharpe RM.

Endocrinology. 2006 Nov;147(11):5352-62. Epub 2006 Aug 17.


Cellular origins of testicular dysgenesis in rats exposed in utero to di(n-butyl) phthalate.

Mahood IK, McKinnell C, Walker M, Hallmark N, Scott H, Fisher JS, Rivas A, Hartung S, Ivell R, Mason JI, Sharpe RM.

Int J Androl. 2006 Feb;29(1):148-54; discussion 181-5.


Mechanisms of action underlying the antiandrogenic effects of the fungicide prochloraz.

Laier P, Metzdorff SB, Borch J, Hagen ML, Hass U, Christiansen S, Axelstad M, Kledal T, Dalgaard M, McKinnell C, Brokken LJ, Vinggaard AM.

Toxicol Appl Pharmacol. 2006 Jun 1;213(2):160-71. Epub 2006 Jan 10.


Cellular and hormonal disruption of fetal testis development in sheep reared on pasture treated with sewage sludge.

Paul C, Rhind SM, Kyle CE, Scott H, McKinnell C, Sharpe RM.

Environ Health Perspect. 2005 Nov;113(11):1580-7.


Expression of insulin-like factor 3 protein in the rat testis during fetal and postnatal development and in relation to cryptorchidism induced by in utero exposure to di (n-Butyl) phthalate.

McKinnell C, Sharpe RM, Mahood K, Hallmark N, Scott H, Ivell R, Staub C, Jégou B, Haag F, Koch-Nolte F, Hartung S.

Endocrinology. 2005 Oct;146(10):4536-44. Epub 2005 Jul 21.


Development and function of the adult generation of Leydig cells in mice with Sertoli cell-selective or total ablation of the androgen receptor.

De Gendt K, Atanassova N, Tan KA, de França LR, Parreira GG, McKinnell C, Sharpe RM, Saunders PT, Mason JI, Hartung S, Ivell R, Denolet E, Verhoeven G.

Endocrinology. 2005 Sep;146(9):4117-26. Epub 2005 May 26.


Evidence that androgens and oestrogens, as well as follicle-stimulating hormone, can alter Sertoli cell number in the neonatal rat.

Atanassova NN, Walker M, McKinnell C, Fisher JS, Sharpe RM.

J Endocrinol. 2005 Jan;184(1):107-17.


Abnormal Leydig Cell aggregation in the fetal testis of rats exposed to di (n-butyl) phthalate and its possible role in testicular dysgenesis.

Mahood IK, Hallmark N, McKinnell C, Walker M, Fisher JS, Sharpe RM.

Endocrinology. 2005 Feb;146(2):613-23. Epub 2004 Nov 11.


Role of the neonatal period of pituitary-testicular activity in germ cell proliferation and differentiation in the primate testis.

Sharpe RM, Fraser HM, Brougham MF, McKinnell C, Morris KD, Kelnar CJ, Wallace WH, Walker M.

Hum Reprod. 2003 Oct;18(10):2110-7.


Differentiation-dependent expression of 17beta-hydroxysteroid dehydrogenase, type 10, in the rodent testis: effect of aging in Leydig cells.

Ivell R, Balvers M, Anand RJ, Paust HJ, McKinnell C, Sharpe R.

Endocrinology. 2003 Jul;144(7):3130-7.


Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood.

Sharpe RM, McKinnell C, Kivlin C, Fisher JS.

Reproduction. 2003 Jun;125(6):769-84. Review.


Infant feeding with soy formula milk: effects on the testis and on blood testosterone levels in marmoset monkeys during the period of neonatal testicular activity.

Sharpe RM, Martin B, Morris K, Greig I, McKinnell C, McNeilly AS, Walker M.

Hum Reprod. 2002 Jul;17(7):1692-703.


Testicular changes during infantile 'quiescence' in the marmoset and their gonadotrophin dependence: a model for investigating susceptibility of the prepubertal human testis to cancer therapy?

Kelnar CJ, McKinnell C, Walker M, Morris KD, Wallace WH, Saunders PT, Fraser HM, Sharpe RM.

Hum Reprod. 2002 May;17(5):1367-78.


Relationship between expression of sex steroid receptors and structure of the seminal vesicles after neonatal treatment of rats with potent or weak estrogens.

Williams K, Fisher JS, Turner KJ, McKinnell C, Saunders PT, Sharpe RM.

Environ Health Perspect. 2001 Dec;109(12):1227-35.


Neonatal exposure to potent and environmental oestrogens and abnormalities of the male reproductive system in the rat: evidence for importance of the androgen-oestrogen balance and assessment of the relevance to man.

Williams K, McKinnell C, Saunders PT, Walker M, Fisher JS, Turner KJ, Atanassova N, Sharpe M.

Hum Reprod Update. 2001 May-Jun;7(3):236-47. Review.


Suppression of androgen action and the induction of gross abnormalities of the reproductive tract in male rats treated neonatally with diethylstilbestrol.

McKinnell C, Atanassova N, Williams K, Fisher JS, Walker M, Turner KJ, Saunders TK, Sharpe RM.

J Androl. 2001 Mar-Apr;22(2):323-38.


Induction of progesterone receptor immunoexpression in stromal tissue throughout the male reproductive tract after neonatal oestrogen treatment of rats.

Williams K, Saunders PT, Atanassova N, Fisher JS, Turner KJ, Millar MR, McKinnell C, Sharpe RM.

Mol Cell Endocrinol. 2000 Jun;164(1-2):117-31.


Effect of neonatal gonadotropin-releasing hormone antagonist administration on sertoli cell number and testicular development in the marmoset: comparison with the rat.

Sharpe RM, Walker M, Millar MR, Atanassova N, Morris K, McKinnell C, Saunders PT, Fraser HM.

Biol Reprod. 2000 Jun;62(6):1685-93.


Permanent effects of neonatal estrogen exposure in rats on reproductive hormone levels, Sertoli cell number, and the efficiency of spermatogenesis in adulthood.

Atanassova N, McKinnell C, Walker M, Turner KJ, Fisher JS, Morley M, Millar MR, Groome NP, Sharpe RM.

Endocrinology. 1999 Nov;140(11):5364-73.


Inhibin B levels in plasma of the male rat from birth to adulthood: effect of experimental manipulation of Sertoli cell number.

Sharpe RM, Turner KJ, McKinnell C, Groome NP, Atanassova N, Millar MR, Buchanan DL, Cooke PS.

J Androl. 1999 Jan-Feb;20(1):94-101.


Abnormalities in functional development of the Sertoli cells in rats treated neonatally with diethylstilbestrol: a possible role for estrogens in Sertoli cell development.

Sharpe RM, Atanassova N, McKinnell C, Parte P, Turner KJ, Fisher JS, Kerr JB, Groome NP, Macpherson S, Millar MR, Saunders PT.

Biol Reprod. 1998 Nov;59(5):1084-94.


Detection of germ cell-derived proteins in testicular interstitial fluid: potential for monitoring spermatogenesis in vivo.

Turner KJ, McKinnell C, McLaren TT, Qureshi SJ, Saunders PT, Foster PM, Sharpe RM.

J Androl. 1996 Mar-Apr;17(2):127-36.

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