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Items: 7

1.

Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain.

McKerrall SJ, Nguyen T, Lai KW, Bergeron P, Deng L, DiPasquale A, Chang JH, Chen J, Chernov-Rogan T, Hackos DH, Maher J, Ortwine DF, Pang J, Payandeh J, Proctor WR, Shields SD, Vogt J, Ji P, Liu W, Ballini E, Schumann L, Tarozzo G, Bankar G, Chowdhury S, Hasan A, Johnson JP Jr, Khakh K, Lin S, Cohen CJ, Dehnhardt CM, Safina BS, Sutherlin DP.

J Med Chem. 2019 Apr 25;62(8):4091-4109. doi: 10.1021/acs.jmedchem.9b00141. Epub 2019 Apr 16.

PMID:
30943032
2.

Nav1.7 inhibitors for the treatment of chronic pain.

McKerrall SJ, Sutherlin DP.

Bioorg Med Chem Lett. 2018 Oct 15;28(19):3141-3149. doi: 10.1016/j.bmcl.2018.08.007. Epub 2018 Aug 12. Review.

PMID:
30139550
3.

Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors.

Chernov-Rogan T, Li T, Lu G, Verschoof H, Khakh K, Jones SW, Beresini MH, Liu C, Ortwine DF, McKerrall SJ, Hackos DH, Sutherlin D, Cohen CJ, Chen J.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E792-E801. doi: 10.1073/pnas.1713701115. Epub 2018 Jan 8.

4.

Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs.

Parker CG, Kuttruff CA, Galmozzi A, Jørgensen L, Yeh CH, Hermanson DJ, Wang Y, Artola M, McKerrall SJ, Josyln CM, Nørremark B, Dünstl G, Felding J, Saez E, Baran PS, Cravatt BF.

ACS Cent Sci. 2017 Dec 27;3(12):1276-1285. doi: 10.1021/acscentsci.7b00420. Epub 2017 Dec 6.

5.

Correction to "Development of a Concise Synthesis of (+)-Ingenol".

McKerrall SJ, Jørgensen L, Kuttruff CA, Ungeheuer F, Baran PS.

J Am Chem Soc. 2015 Nov 18;137(45):14545. doi: 10.1021/jacs.5b11112. Epub 2015 Nov 4. No abstract available.

PMID:
26535919
6.

Development of a concise synthesis of (+)-ingenol.

McKerrall SJ, Jørgensen L, Kuttruff CA, Ungeheuer F, Baran PS.

J Am Chem Soc. 2014 Apr 16;136(15):5799-810. doi: 10.1021/ja501881p. Epub 2014 Apr 8. Erratum in: J Am Chem Soc. 2015 Nov 18;137(45):14545.

PMID:
24712341
7.

14-step synthesis of (+)-ingenol from (+)-3-carene.

Jørgensen L, McKerrall SJ, Kuttruff CA, Ungeheuer F, Felding J, Baran PS.

Science. 2013 Aug 23;341(6148):878-82. doi: 10.1126/science.1241606. Epub 2013 Aug 1. Erratum in: Science. 2015 Nov 27;350(6264):aad8935.

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