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NitroSynapsin for the treatment of neurological manifestations of tuberous sclerosis complex in a rodent model.

Okamoto SI, Prikhodko O, Pina-Crespo J, Adame A, McKercher SR, Brill LM, Nakanishi N, Oh CK, Nakamura T, Masliah E, Lipton SA.

Neurobiol Dis. 2019 Jul;127:390-397. doi: 10.1016/j.nbd.2019.03.029. Epub 2019 Mar 27.


NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism.

Tu S, Akhtar MW, Escorihuela RM, Amador-Arjona A, Swarup V, Parker J, Zaremba JD, Holland T, Bansal N, Holohan DR, Lopez K, Ryan SD, Chan SF, Yan L, Zhang X, Huang X, Sultan A, McKercher SR, Ambasudhan R, Xu H, Wang Y, Geschwind DH, Roberts AJ, Terskikh AV, Rissman RA, Masliah E, Lipton SA, Nakanishi N.

Nat Commun. 2017 Nov 14;8(1):1488. doi: 10.1038/s41467-017-01563-8.


Molecular Pathway to Protection From Age-Dependent Photoreceptor Degeneration in Mef2 Deficiency.

Nagar S, Trudler D, McKercher SR, Piña-Crespo J, Nakanishi N, Okamoto SI, Lipton SA.

Invest Ophthalmol Vis Sci. 2017 Jul 1;58(9):3741-3749. doi: 10.1167/iovs.17-21767.


MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stress.

Nagar S, Noveral SM, Trudler D, Lopez KM, McKercher SR, Han X, Yates JR 3rd, Piña-Crespo JC, Nakanishi N, Satoh T, Okamoto SI, Lipton SA.

Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4048-E4056. doi: 10.1073/pnas.1613067114. Epub 2017 May 1.


Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer's disease models.

Lipton SA, Rezaie T, Nutter A, Lopez KM, Parker J, Kosaka K, Satoh T, McKercher SR, Masliah E, Nakanishi N.

Cell Death Dis. 2016 Dec 1;7(12):e2499. doi: 10.1038/cddis.2016.389.


Levetiracetam inhibits oligomeric Aβ-induced glutamate release from human astrocytes.

Sanz-Blasco S, Piña-Crespo JC, Zhang X, McKercher SR, Lipton SA.

Neuroreport. 2016 Jun 15;27(9):705-9. doi: 10.1097/WNR.0000000000000601.


Corrigendum: Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease.

Takahashi H, Xia P, Cui J, Talantova M, Bodhinathan K, Li W, Saleem S, Holland EA, Tong G, Piña-Crespo J, Zhang D, Nakanishi N, Larrick JW, McKercher SR, Nakamura T, Wang Y, Lipton SA.

Sci Rep. 2016 Feb 12;6:20750. doi: 10.1038/srep20750. No abstract available.


Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation.

Akhtar MW, Sanz-Blasco S, Dolatabadi N, Parker J, Chon K, Lee MS, Soussou W, McKercher SR, Ambasudhan R, Nakamura T, Lipton SA.

Nat Commun. 2016 Jan 8;7:10242. doi: 10.1038/ncomms10242.


Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease.

Takahashi H, Xia P, Cui J, Talantova M, Bodhinathan K, Li W, Saleem S, Holland EA, Tong G, Piña-Crespo J, Zhang D, Nakanishi N, Larrick JW, McKercher SR, Nakamura T, Wang Y, Lipton SA.

Sci Rep. 2015 Oct 19;5:14781. doi: 10.1038/srep14781. Erratum in: Sci Rep. 2016;6:20750. Saleem, Sofiyan [added].


Differential Effects of Pharmacologic and Genetic Modulation of NMDA Receptor Activity on HIV/gp120-Induced Neuronal Damage in an In Vivo Mouse Model.

Nakanishi N, Kang YJ, Tu S, McKercher SR, Masliah E, Lipton SA.

J Mol Neurosci. 2016 Jan;58(1):59-65. doi: 10.1007/s12031-015-0651-1. Epub 2015 Sep 15.


Nrf2 and HSF-1 Pathway Activation via Hydroquinone-Based Proelectrophilic Small Molecules is Regulated by Electrochemical Oxidation Potential.

Satoh T, Stalder R, McKercher SR, Williamson RE, Roth GP, Lipton SA.

ASN Neuro. 2015 Aug 3;7(4). pii: 1759091415593294. doi: 10.1177/1759091415593294. Print 2015 Jul-Aug.


Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases.

Nakamura T, Prikhodko OA, Pirie E, Nagar S, Akhtar MW, Oh CK, McKercher SR, Ambasudhan R, Okamoto S, Lipton SA.

Neurobiol Dis. 2015 Dec;84:99-108. doi: 10.1016/j.nbd.2015.03.017. Epub 2015 Mar 18. Review.


Protection from cyanide-induced brain injury by the Nrf2 transcriptional activator carnosic acid.

Zhang D, Lee B, Nutter A, Song P, Dolatabadi N, Parker J, Sanz-Blasco S, Newmeyer T, Ambasudhan R, McKercher SR, Masliah E, Lipton SA.

J Neurochem. 2015 Jun;133(6):898-908. doi: 10.1111/jnc.13074. Epub 2015 Mar 11.


Transcriptional profiling of MEF2-regulated genes in human neural progenitor cells derived from embryonic stem cells.

Chan SF, Huang X, McKercher SR, Zaidi R, Okamoto SI, Nakanishi N, Lipton SA.

Genom Data. 2015 Mar 1;3:24-27.


S-nitrosylation-mediated redox transcriptional switch modulates neurogenesis and neuronal cell death.

Okamoto S, Nakamura T, Cieplak P, Chan SF, Kalashnikova E, Liao L, Saleem S, Han X, Clemente A, Nutter A, Sances S, Brechtel C, Haus D, Haun F, Sanz-Blasco S, Huang X, Li H, Zaremba JD, Cui J, Gu Z, Nikzad R, Harrop A, McKercher SR, Godzik A, Yates JR 3rd, Lipton SA.

Cell Rep. 2014 Jul 10;8(1):217-28. doi: 10.1016/j.celrep.2014.06.005. Epub 2014 Jul 4.


Potential for cell therapy in Parkinson's disease using genetically programmed human embryonic stem cell-derived neural progenitor cells.

Ambasudhan R, Dolatabadi N, Nutter A, Masliah E, Mckercher SR, Lipton SA.

J Comp Neurol. 2014 Aug 15;522(12):2845-56. doi: 10.1002/cne.23617. Epub 2014 May 7. Review.


Differential effects of synaptic and extrasynaptic NMDA receptors on Aβ-induced nitric oxide production in cerebrocortical neurons.

Molokanova E, Akhtar MW, Sanz-Blasco S, Tu S, Piña-Crespo JC, McKercher SR, Lipton SA.

J Neurosci. 2014 Apr 2;34(14):5023-8. doi: 10.1523/JNEUROSCI.2907-13.2014.


ATM-dependent phosphorylation of MEF2D promotes neuronal survival after DNA damage.

Chan SF, Sances S, Brill LM, Okamoto S, Zaidi R, McKercher SR, Akhtar MW, Nakanishi N, Lipton SA.

J Neurosci. 2014 Mar 26;34(13):4640-53. doi: 10.1523/JNEUROSCI.2510-12.2014.


Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells.

Zhu S, Ambasudhan R, Sun W, Kim HJ, Talantova M, Wang X, Zhang M, Zhang Y, Laurent T, Parker J, Kim HS, Zaremba JD, Saleem S, Sanz-Blasco S, Masliah E, McKercher SR, Cho YS, Lipton SA, Kim J, Ding S.

Cell Res. 2014 Jan;24(1):126-9. doi: 10.1038/cr.2013.156. Epub 2013 Dec 3. No abstract available.


Reprint of: Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs.

Satoh T, McKercher SR, Lipton SA.

Free Radic Biol Med. 2014 Jan;66:45-57. doi: 10.1016/j.freeradbiomed.2013.11.002. Epub 2013 Nov 18.


Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs.

Satoh T, McKercher SR, Lipton SA.

Free Radic Biol Med. 2013 Dec;65:645-657. doi: 10.1016/j.freeradbiomed.2013.07.022. Epub 2013 Jul 25. Review.


Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss.

Talantova M, Sanz-Blasco S, Zhang X, Xia P, Akhtar MW, Okamoto S, Dziewczapolski G, Nakamura T, Cao G, Pratt AE, Kang YJ, Tu S, Molokanova E, McKercher SR, Hires SA, Sason H, Stouffer DG, Buczynski MW, Solomon JP, Michael S, Powers ET, Kelly JW, Roberts A, Tong G, Fang-Newmeyer T, Parker J, Holland EA, Zhang D, Nakanishi N, Chen HS, Wolosker H, Wang Y, Parsons LH, Ambasudhan R, Masliah E, Heinemann SF, Piña-Crespo JC, Lipton SA.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2518-27. doi: 10.1073/pnas.1306832110. Epub 2013 Jun 17. Erratum in: Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13691. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3630. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):E3751-2.


S-nitrosylated SHP-2 contributes to NMDA receptor-mediated excitotoxicity in acute ischemic stroke.

Shi ZQ, Sunico CR, McKercher SR, Cui J, Feng GS, Nakamura T, Lipton SA.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3137-42. doi: 10.1073/pnas.1215501110. Epub 2013 Feb 4.


Protective effect of carnosic acid, a pro-electrophilic compound, in models of oxidative stress and light-induced retinal degeneration.

Rezaie T, McKercher SR, Kosaka K, Seki M, Wheeler L, Viswanath V, Chun T, Joshi R, Valencia M, Sasaki S, Tozawa T, Satoh T, Lipton SA.

Invest Ophthalmol Vis Sci. 2012 Nov 27;53(12):7847-54. doi: 10.1167/iovs.12-10793.


S-nitrosylation of Cdk5: potential implications in amyloid-β-related neurotoxicity in Alzheimer disease.

Qu J, Nakamura T, Holland EA, McKercher SR, Lipton SA.

Prion. 2012 Sep-Oct;6(4):364-70. doi: 10.4161/pri.21250. Epub 2012 Aug 9.


Isobaric tagging-based quantification by mass spectrometry of differentially regulated proteins in synaptosomes of HIV/gp120 transgenic mice: implications for HIV-associated neurodegeneration.

Banerjee S, Liao L, Russo R, Nakamura T, McKercher SR, Okamoto S, Haun F, Nikzad R, Zaidi R, Holland E, Eroshkin A, Yates JR 3rd, Lipton SA.

Exp Neurol. 2012 Aug;236(2):298-306. doi: 10.1016/j.expneurol.2012.04.013. Epub 2012 May 1.


MEF2C enhances dopaminergic neuron differentiation of human embryonic stem cells in a parkinsonian rat model.

Cho EG, Zaremba JD, McKercher SR, Talantova M, Tu S, Masliah E, Chan SF, Nakanishi N, Terskikh A, Lipton SA.

PLoS One. 2011;6(8):e24027. doi: 10.1371/journal.pone.0024027. Epub 2011 Aug 25.


Dual neuroprotective pathways of a pro-electrophilic compound via HSF-1-activated heat-shock proteins and Nrf2-activated phase 2 antioxidant response enzymes.

Satoh T, Rezaie T, Seki M, Sunico CR, Tabuchi T, Kitagawa T, Yanagitai M, Senzaki M, Kosegawa C, Taira H, McKercher SR, Hoffman JK, Roth GP, Lipton SA.

J Neurochem. 2011 Nov;119(3):569-78. doi: 10.1111/j.1471-4159.2011.07449.x. Epub 2011 Sep 21.


S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptide.

Qu J, Nakamura T, Cao G, Holland EA, McKercher SR, Lipton SA.

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14330-5. doi: 10.1073/pnas.1105172108. Epub 2011 Aug 15.


Autistic phenotype from MEF2C knockout cells.

Lipton SA, Li H, Zaremba JD, McKercher SR, Cui J, Kang YJ, Nie Z, Soussou W, Talantova M, Okamoto S, Nakanishi N.

Science. 2009 Jan 9;323(5911):208. doi: 10.1126/science.323.5911.208b. No abstract available.


Pillars article: the macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. Cell, 1990. 61: 113-124.

Klemsz MJ, McKercher SR, Celada A, Van Beveren C, Maki RA.

J Immunol. 2008 Aug 1;181(3):1597-608. No abstract available.


Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo.

Li H, Radford JC, Ragusa MJ, Shea KL, McKercher SR, Zaremba JD, Soussou W, Nie Z, Kang YJ, Nakanishi N, Okamoto S, Roberts AJ, Schwarz JJ, Lipton SA.

Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9397-402. doi: 10.1073/pnas.0802876105. Epub 2008 Jul 1.


Myocyte enhancer factor 2C as a neurogenic and antiapoptotic transcription factor in murine embryonic stem cells.

Li Z, McKercher SR, Cui J, Nie Z, Soussou W, Roberts AJ, Sallmen T, Lipton JH, Talantova M, Okamoto S, Lipton SA.

J Neurosci. 2008 Jun 25;28(26):6557-68. doi: 10.1523/JNEUROSCI.0134-08.2008.


Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis.

Beers DR, Henkel JS, Xiao Q, Zhao W, Wang J, Yen AA, Siklos L, McKercher SR, Appel SH.

Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):16021-6. Epub 2006 Oct 16.


At the interface of the immune system and the nervous system: how neuroinflammation modulates the fate of neural progenitors in vivo.

Mueller FJ, McKercher SR, Imitola J, Loring JF, Yip S, Khoury SJ, Snyder EY.

Ernst Schering Res Found Workshop. 2005;(53):83-114. Review.


Transcriptional regulation of mouse mu opioid receptor gene by PU.1.

Hwang CK, Kim CS, Choi HS, McKercher SR, Loh HH.

J Biol Chem. 2004 May 7;279(19):19764-74. Epub 2004 Mar 3.


Wound healing in the PU.1 null mouse--tissue repair is not dependent on inflammatory cells.

Martin P, D'Souza D, Martin J, Grose R, Cooper L, Maki R, McKercher SR.

Curr Biol. 2003 Jul 1;13(13):1122-8.


Identification of a PU.1-IRF4 protein interaction surface predicted by chemical exchange line broadening.

McKercher SR, Lombardo CR, Bobkov A, Jia X, Assa-Munt N.

Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):511-6. Epub 2003 Jan 7.


Identification of three genes up-regulated in PU.1 rescued monocytic precursor cells.

Henkel GW, McKercher SR, Maki RA.

Int Immunol. 2002 Jul;14(7):723-32.


Regulation of the PU.1 gene by distal elements.

Li Y, Okuno Y, Zhang P, Radomska HS, Chen H, Iwasaki H, Akashi K, Klemsz MJ, McKercher SR, Maki RA, Tenen DG.

Blood. 2001 Nov 15;98(10):2958-65.


Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow.

Mezey E, Chandross KJ, Harta G, Maki RA, McKercher SR.

Science. 2000 Dec 1;290(5497):1779-82.


Mesenchymal cells engulf and clear apoptotic footplate cells in macrophageless PU.1 null mouse embryos.

Wood W, Turmaine M, Weber R, Camp V, Maki RA, McKercher SR, Martin P.

Development. 2000 Dec;127(24):5245-52.


The transcription factor PU.1 does not regulate lineage commitment but has lineage-specific effects.

McKercher SR, Henkel GW, Maki RA.

J Leukoc Biol. 1999 Nov;66(5):727-32. Review.


Differentiation of the mononuclear phagocyte system during mouse embryogenesis: the role of transcription factor PU.1.

Lichanska AM, Browne CM, Henkel GW, Murphy KM, Ostrowski MC, McKercher SR, Maki RA, Hume DA.

Blood. 1999 Jul 1;94(1):127-38.


Commitment to the monocytic lineage occurs in the absence of the transcription factor PU.1.

Henkel GW, McKercher SR, Leenen PJ, Maki RA.

Blood. 1999 May 1;93(9):2849-58.


Murine GBP-2: a new IFN-gamma-induced member of the GBP family of GTPases isolated from macrophages.

Vestal DJ, Buss JE, McKercher SR, Jenkins NA, Copeland NG, Kelner GS, Asundi VK, Maki RA.

J Interferon Cytokine Res. 1998 Nov;18(11):977-85.


Myeloid development is selectively disrupted in PU.1 null mice.

Anderson KL, Smith KA, Conners K, McKercher SR, Maki RA, Torbett BE.

Blood. 1998 May 15;91(10):3702-10.


Defective trophoblast function in mice with a targeted mutation of Ets2.

Yamamoto H, Flannery ML, Kupriyanov S, Pearce J, McKercher SR, Henkel GW, Maki RA, Werb Z, Oshima RG.

Genes Dev. 1998 May 1;12(9):1315-26.


Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPalpha.

Iwama A, Zhang P, Darlington GJ, McKercher SR, Maki R, Tenen DG.

Nucleic Acids Res. 1998 Jun 15;26(12):3034-43.


Osteopetrosis in mice lacking haematopoietic transcription factor PU.1.

Tondravi MM, McKercher SR, Anderson K, Erdmann JM, Quiroz M, Maki R, Teitelbaum SL.

Nature. 1997 Mar 6;386(6620):81-4.


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