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Items: 25


A morphological and molecular study of proposed early forms of traditional serrated adenoma.

Bettington M, Rosty C, Whitehall V, Leggett B, McKeone D, Pearson SA, Walker N.

Histopathology. 2018 Jul 14. doi: 10.1111/his.13714. [Epub ahead of print]


Sessile Serrated Adenomas in Young Patients may have Limited Risk of Malignant Progression.

Bettington M, Brown I, Rosty C, Walker N, Liu C, Croese J, Rahman T, Pearson SA, McKeone D, Leggett B, Whitehall V.

J Clin Gastroenterol. 2018 Mar 21. doi: 10.1097/MCG.0000000000001014. [Epub ahead of print]


Copy number profiles of paired primary and metastatic colorectal cancers.

Kawamata F, Patch AM, Nones K, Bond C, McKeone D, Pearson SA, Homma S, Liu C, Fennell L, Dumenil T, Hartel G, Kobayasi N, Yokoo H, Fukai M, Nishihara H, Kamiyama T, Burge ME, Karapetis CS, Taketomi A, Leggett B, Waddell N, Whitehall V.

Oncotarget. 2017 Dec 15;9(3):3394-3405. doi: 10.18632/oncotarget.23277. eCollection 2018 Jan 9.


MLH1-93 G/a polymorphism is associated with MLH1 promoter methylation and protein loss in dysplastic sessile serrated adenomas with BRAFV600E mutation.

Fennell LJ, Jamieson S, McKeone D, Corish T, Rohdmann M, Furner T, Bettington M, Liu C, Kawamata F, Bond C, Van De Pols J, Leggett B, Whitehall V.

BMC Cancer. 2018 Jan 5;18(1):35. doi: 10.1186/s12885-017-3946-5.


Oncogenic BRAF mutation induces DNA methylation changes in a murine model for human serrated colorectal neoplasia.

Bond CE, Liu C, Kawamata F, McKeone DM, Fernando W, Jamieson S, Pearson SA, Kane A, Woods SL, Lannagan TRM, Somashekar R, Lee Y, Dumenil T, Hartel G, Spring KJ, Borowsky J, Fennell L, Bettington M, Lee J, Worthley DL, Leggett BA, Whitehall VLJ.

Epigenetics. 2018;13(1):40-48. doi: 10.1080/15592294.2017.1411446. Epub 2018 Feb 19.


The role of APC in WNT pathway activation in serrated neoplasia.

Borowsky J, Dumenil T, Bettington M, Pearson SA, Bond C, Fennell L, Liu C, McKeone D, Rosty C, Brown I, Walker N, Leggett B, Whitehall V.

Mod Pathol. 2018 Mar;31(3):495-504. doi: 10.1038/modpathol.2017.150. Epub 2017 Nov 17.


RNF43 is mutated less frequently in Lynch Syndrome compared with sporadic microsatellite unstable colorectal cancers.

Fennell LJ, Clendenning M, McKeone DM, Jamieson SH, Balachandran S, Borowsky J, Liu J, Kawamata F, Bond CE, Rosty C, Burge ME, Buchanan DD, Leggett BA, Whitehall VLJ.

Fam Cancer. 2018 Jan;17(1):63-69. doi: 10.1007/s10689-017-0003-0.


GNAS mutations are present in colorectal traditional serrated adenomas, serrated tubulovillous adenomas and serrated adenocarcinomas with adverse prognostic features.

Liu C, McKeone DM, Walker NI, Bettington ML, Leggett BA, Whitehall VLJ.

Histopathology. 2017 Jun;70(7):1079-1088. doi: 10.1111/his.13180. Epub 2017 Mar 22.


RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis.

Bond CE, McKeone DM, Kalimutho M, Bettington ML, Pearson SA, Dumenil TD, Wockner LF, Burge M, Leggett BA, Whitehall VL.

Oncotarget. 2016 Oct 25;7(43):70589-70600. doi: 10.18632/oncotarget.12130.


Clinicopathological and molecular features of sessile serrated adenomas with dysplasia or carcinoma.

Bettington M, Walker N, Rosty C, Brown I, Clouston A, McKeone D, Pearson SA, Leggett B, Whitehall V.

Gut. 2017 Jan;66(1):97-106. doi: 10.1136/gutjnl-2015-310456. Epub 2015 Oct 15.


Serrated tubulovillous adenoma of the large intestine.

Bettington M, Walker N, Rosty C, Brown I, Clouston A, McKeone D, Pearson SA, Klein K, Leggett B, Whitehall V.

Histopathology. 2016 Mar;68(4):578-87. doi: 10.1111/his.12788. Epub 2015 Sep 17.


Methylation and expression of the tumour suppressor, PRDM5, in colorectal cancer and polyp subgroups.

Bond CE, Bettington ML, Pearson SA, McKeone DM, Leggett BA, Whitehall VL.

BMC Cancer. 2015 Jan 23;15:20. doi: 10.1186/s12885-015-1011-9.


Isocitrate dehydrogenase 1 R132C mutation occurs exclusively in microsatellite stable colorectal cancers with the CpG island methylator phenotype.

Whitehall VL, Dumenil TD, McKeone DM, Bond CE, Bettington ML, Buttenshaw RL, Bowdler L, Montgomery GW, Wockner LF, Leggett BA.

Epigenetics. 2014 Nov;9(11):1454-60. doi: 10.4161/15592294.2014.971624.


A clinicopathological and molecular analysis of 200 traditional serrated adenomas.

Bettington ML, Walker NI, Rosty C, Brown IS, Clouston AD, McKeone DM, Pearson SA, Klein K, Leggett BA, Whitehall VL.

Mod Pathol. 2015 Mar;28(3):414-27. doi: 10.1038/modpathol.2014.122. Epub 2014 Sep 12.


Genome-wide DNA methylation analysis of formalin-fixed paraffin embedded colorectal cancer tissue.

Dumenil TD, Wockner LF, Bettington M, McKeone DM, Klein K, Bowdler LM, Montgomery GW, Leggett BA, Whitehall VL.

Genes Chromosomes Cancer. 2014 Jul;53(7):537-48. doi: 10.1002/gcc.22164. Epub 2014 Mar 28.


Cancer risks for relatives of patients with serrated polyposis.

Win AK, Walters RJ, Buchanan DD, Jenkins MA, Sweet K, Frankel WL, de la Chapelle A, McKeone DM, Walsh MD, Clendenning M, Pearson SA, Pavluk E, Nagler B, Hopper JL, Gattas MR, Goldblatt J, George J, Suthers GK, Phillips KD, Woodall S, Arnold J, Tucker K, Field M, Greening S, Gallinger S, Aronson M, Perrier R, Woods MO, Green JS, Walker N, Rosty C, Parry S, Young JP.

Am J Gastroenterol. 2012 May;107(5):770-8. doi: 10.1038/ajg.2012.52. Epub 2012 Apr 24.


Oncogenic PIK3CA mutations in colorectal cancers and polyps.

Whitehall VL, Rickman C, Bond CE, Ramsnes I, Greco SA, Umapathy A, McKeone D, Faleiro RJ, Buttenshaw RL, Worthley DL, Nayler S, Zhao ZZ, Montgomery GW, Mallitt KA, Jass JR, Matsubara N, Notohara K, Ishii T, Leggett BA.

Int J Cancer. 2012 Aug 15;131(4):813-20. doi: 10.1002/ijc.26440. Epub 2011 Nov 19.


Linkage to chromosome 2q32.2-q33.3 in familial serrated neoplasia (Jass syndrome).

Roberts A, Nancarrow D, Clendenning M, Buchanan DD, Jenkins MA, Duggan D, Taverna D, McKeone D, Walters R, Walsh MD, Young BW, Jass JR, Rosty C, Gattas M, Pelzer E, Hopper JL, Goldblatt J, George J, Suthers GK, Phillips K, Parry S, Woodall S, Arnold J, Tucker K, Muir A, Drini M, Macrae F, Newcomb P, Potter JD, Pavluk E, Lindblom A, Young JP.

Fam Cancer. 2011 Jun;10(2):245-54. doi: 10.1007/s10689-010-9408-8.


Murine erythroid short-term radioprotection requires a BMP4-dependent, self-renewing population of stress erythroid progenitors.

Harandi OF, Hedge S, Wu DC, McKeone D, Paulson RF.

J Clin Invest. 2010 Dec;120(12):4507-19. doi: 10.1172/JCI41291. Epub 2010 Nov 8.


Risk factors for colorectal cancer in patients with multiple serrated polyps: a cross-sectional case series from genetics clinics.

Buchanan DD, Sweet K, Drini M, Jenkins MA, Win AK, English DR, Walsh MD, Clendenning M, McKeone DM, Walters RJ, Roberts A, Pearson SA, Pavluk E, Hopper JL, Gattas MR, Goldblatt J, George J, Suthers GK, Phillips KD, Woodall S, Arnold J, Tucker K, Muir A, Field M, Greening S, Gallinger S, Perrier R, Baron JA, Potter JD, Haile R, Frankel W, de la Chapelle A, Macrae F, Rosty C, Walker NI, Parry S, Young JP.

PLoS One. 2010 Jul 16;5(7):e11636. doi: 10.1371/journal.pone.0011636.


Lynch syndrome-associated breast cancers: clinicopathologic characteristics of a case series from the colon cancer family registry.

Walsh MD, Buchanan DD, Cummings MC, Pearson SA, Arnold ST, Clendenning M, Walters R, McKeone DM, Spurdle AB, Hopper JL, Jenkins MA, Phillips KD, Suthers GK, George J, Goldblatt J, Muir A, Tucker K, Pelzer E, Gattas MR, Woodall S, Parry S, Macrae FA, Haile RW, Baron JA, Potter JD, Le Marchand L, Bapat B, Thibodeau SN, Lindor NM, McGuckin MA, Young JP.

Clin Cancer Res. 2010 Apr 1;16(7):2214-24. doi: 10.1158/1078-0432.CCR-09-3058. Epub 2010 Mar 9.


Phenotypic diversity in patients with multiple serrated polyps: a genetics clinic study.

Buchanan DD, Sweet K, Drini M, Jenkins MA, Win AK, Gattas M, Walsh MD, Clendenning M, McKeone D, Walters R, Roberts A, Young A, Hampel H, Hopper JL, Goldblatt J, George J, Suthers GK, Phillips K, Young GP, Chow E, Parry S, Woodall S, Tucker K, Muir A, Field M, Greening S, Gallinger S, Green J, Woods MO, Spaetgens R, de la Chapelle A, Macrae F, Walker NI, Jass JR, Young JP.

Int J Colorectal Dis. 2010 Jun;25(6):703-12. doi: 10.1007/s00384-010-0907-8. Epub 2010 Mar 6. Erratum in: Int J Colorectal Dis. 2010 Dec;25(12):1513-5.


Analysis of families with Lynch syndrome complicated by advanced serrated neoplasia: the importance of pathology review and pedigree analysis.

Walsh MD, Buchanan DD, Walters R, Roberts A, Arnold S, McKeone D, Clendenning M, Ruszkiewicz AR, Jenkins MA, Hopper JL, Goldblatt J, George J, Suthers GK, Phillips K, Young GP, Macrae F, Drini M, Woods MO, Parry S, Jass JR, Young JP.

Fam Cancer. 2009;8(4):313-23. doi: 10.1007/s10689-009-9238-8. Epub 2009 Feb 25.


Molecular, pathologic, and clinical features of early-onset endometrial cancer: identifying presumptive Lynch syndrome patients.

Walsh MD, Cummings MC, Buchanan DD, Dambacher WM, Arnold S, McKeone D, Byrnes R, Barker MA, Leggett BA, Gattas M, Jass JR, Spurdle AB, Young J, Obermair A.

Clin Cancer Res. 2008 Mar 15;14(6):1692-700. doi: 10.1158/1078-0432.CCR-07-1849. Epub 2008 Feb 29.


Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: parallel pathways of tumorigenesis.

Young J, Simms LA, Biden KG, Wynter C, Whitehall V, Karamatic R, George J, Goldblatt J, Walpole I, Robin SA, Borten MM, Stitz R, Searle J, McKeone D, Fraser L, Purdie DR, Podger K, Price R, Buttenshaw R, Walsh MD, Barker M, Leggett BA, Jass JR.

Am J Pathol. 2001 Dec;159(6):2107-16.

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