Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 94


GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets.

Chen X, Gupta S, Cooper M, DeHelian D, Zhao X, Naik MU, Wurtzel JGT, Stalker TJ, Goldfinger LE, Benovic J, Brass LF, McKenzie SE, Naik UP, Ma P.

Blood Adv. 2020 Jan 14;4(1):76-86. doi: 10.1182/bloodadvances.2019000467.


TULA-2 Deficiency Enhances Platelet Functional Responses to CLEC-2 Agonists.

Kostyak JC, Mauri BR, Dangelmaier C, Patel A, Zhou Y, Eble JA, Tsygankov AY, McKenzie SE, Kunapuli SP.

TH Open. 2018 Dec 5;2(4):e411-e419. doi: 10.1055/s-0038-1676358. eCollection 2018 Oct.


Cleavage of anti-PF4/heparin IgG by a bacterial protease and potential benefit in heparin-induced thrombocytopenia.

Kizlik-Masson C, Deveuve Q, Zhou Y, Vayne C, Thibault G, McKenzie SE, Pouplard C, Loyau S, Gruel Y, Rollin J.

Blood. 2019 May 30;133(22):2427-2435. doi: 10.1182/blood.2019000437. Epub 2019 Mar 27.


The protease-activated receptor 4 Ala120Thr variant alters platelet responsiveness to low-dose thrombin and protease-activated receptor 4 desensitization, and is blocked by non-competitive P2Y12 inhibition.

Whitley MJ, Henke DM, Ghazi A, Nieman M, Stoller M, Simon LM, Chen E, Vesci J, Holinstat M, McKenzie SE, Shaw CA, Edelstein LC, Bray PF.

J Thromb Haemost. 2018 Dec;16(12):2501-2514. doi: 10.1111/jth.14318. Epub 2018 Nov 22.


Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration.

Cloutier N, Allaeys I, Marcoux G, Machlus KR, Mailhot B, Zufferey A, Levesque T, Becker Y, Tessandier N, Melki I, Zhi H, Poirier G, Rondina MT, Italiano JE, Flamand L, McKenzie SE, Cote F, Nieswandt B, Khan WI, Flick MJ, Newman PJ, Lacroix S, Fortin PR, Boilard E.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1550-E1559. doi: 10.1073/pnas.1720553115. Epub 2018 Jan 31.


5B9, a monoclonal antiplatelet factor 4/heparin IgG with a human Fc fragment that mimics heparin-induced thrombocytopenia antibodies.

Kizlik-Masson C, Vayne C, McKenzie SE, Poupon A, Zhou Y, Champier G, Pouplard C, Gruel Y, Rollin J.

J Thromb Haemost. 2017 Oct;15(10):2065-2075. doi: 10.1111/jth.13786. Epub 2017 Sep 4.


TULA-2 protein phosphatase suppresses activation of Syk through the GPVI platelet receptor for collagen by dephosphorylating Tyr(P)346, a regulatory site of Syk.

Reppschläger K, Gosselin J, Dangelmaier CA, Thomas DH, Carpino N, McKenzie SE, Kunapuli SP, Tsygankov AY.

J Biol Chem. 2017 Mar 10;292(10):4360. doi: 10.1074/jbc.A116.743732. No abstract available.


Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia.

Hayes V, Johnston I, Arepally GM, McKenzie SE, Cines DB, Rauova L, Poncz M.

J Clin Invest. 2017 Mar 1;127(3):1090-1098. doi: 10.1172/JCI90958. Epub 2017 Feb 20.


TULA-2 (T-Cell Ubiquitin Ligand-2) Inhibits the Platelet Fc Receptor for IgG IIA (FcγRIIA) Signaling Pathway and Heparin-Induced Thrombocytopenia in Mice.

Zhou Y, Abraham S, Renna S, Edelstein LC, Dangelmaier CA, Tsygankov AY, Kunapuli SP, Bray PF, McKenzie SE.

Arterioscler Thromb Vasc Biol. 2016 Dec;36(12):2315-2323. Epub 2016 Oct 20.


TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk.

Reppschläger K, Gosselin J, Dangelmaier CA, Thomas DH, Carpino N, McKenzie SE, Kunapuli SP, Tsygankov AY.

J Biol Chem. 2016 Oct 21;291(43):22427-22441. Epub 2016 Sep 8. Erratum in: J Biol Chem. 2017 Mar 10;292(10 ):4360.


Mice Expressing Low Levels of CalDAG-GEFI Exhibit Markedly Impaired Platelet Activation With Minor Impact on Hemostasis.

Piatt R, Paul DS, Lee RH, McKenzie SE, Parise LV, Cowley DO, Cooley BC, Bergmeier W.

Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1838-46. doi: 10.1161/ATVBAHA.116.307874. Epub 2016 Jul 14.


The antigenic complex in HIT binds to B cells via complement and complement receptor 2 (CD21).

Khandelwal S, Lee GM, Hester CG, Poncz M, McKenzie SE, Sachais BS, Rauova L, Kelsoe G, Cines DB, Frank M, Arepally GM.

Blood. 2016 Oct 6;128(14):1789-1799. doi: 10.1182/blood-2016-04-709634. Epub 2016 Jul 13.


Syk Inhibition in Ischemic Stroke.

McKenzie SE.

Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1054-5. doi: 10.1161/ATVBAHA.116.307709. No abstract available.


Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia.

Tutwiler V, Madeeva D, Ahn HS, Andrianova I, Hayes V, Zheng XL, Cines DB, McKenzie SE, Poncz M, Rauova L.

Blood. 2016 Jan 28;127(4):464-72. doi: 10.1182/blood-2013-11-539262. Epub 2015 Oct 30.


Anti-miR-148a regulates platelet FcγRIIA signaling and decreases thrombosis in vivo in mice.

Zhou Y, Abraham S, Andre P, Edelstein LC, Shaw CA, Dangelmaier CA, Tsygankov AY, Kunapuli SP, Bray PF, McKenzie SE.

Blood. 2015 Dec 24;126(26):2871-81. doi: 10.1182/blood-2015-02-631135. Epub 2015 Oct 29.


Food system policy, public health, and human rights in the United States.

Shannon KL, Kim BF, McKenzie SE, Lawrence RS.

Annu Rev Public Health. 2015 Mar 18;36:151-73. doi: 10.1146/annurev-publhealth-031914-122621. Review.


Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs.

Londin E, Loher P, Telonis AG, Quann K, Clark P, Jing Y, Hatzimichael E, Kirino Y, Honda S, Lally M, Ramratnam B, Comstock CE, Knudsen KE, Gomella L, Spaeth GL, Hark L, Katz LJ, Witkiewicz A, Rostami A, Jimenez SA, Hollingsworth MA, Yeh JJ, Shaw CA, McKenzie SE, Bray P, Nelson PT, Zupo S, Van Roosbroeck K, Keating MJ, Calin GA, Yeo C, Jimbo M, Cozzitorto J, Brody JR, Delgrosso K, Mattick JS, Fortina P, Rigoutsos I.

Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):E1106-15. doi: 10.1073/pnas.1420955112. Epub 2015 Feb 23.


Erythropoietin levels in patients with sickle cell disease do not correlate with known inducers of erythropoietin.

Pulte ED, McKenzie SE, Caro J, Ballas SK.

Hemoglobin. 2014;38(6):385-9. doi: 10.3109/03630269.2014.967868.


Protein kinase C δ deficiency enhances megakaryopoiesis and recovery from thrombocytopenia.

Kostyak JC, Bhavanasi D, Liverani E, McKenzie SE, Kunapuli SP.

Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2579-85. doi: 10.1161/ATVBAHA.114.304492. Epub 2014 Oct 30.


CalDAG-GEFI deficiency protects mice from FcγRIIa-mediated thrombotic thrombocytopenia induced by CD40L and β2GPI immune complexes.

Amirkhosravi A, Boulaftali Y, Robles-Carrillo L, Meyer T, McKenzie SE, Francis JL, Bergmeier W.

J Thromb Haemost. 2014 Dec;12(12):2113-9. doi: 10.1111/jth.12748. Epub 2014 Oct 30.


Cow allergen (Bos d2) and endotoxin concentrations are higher in the settled dust of homes proximate to industrial-scale dairy operations.

Williams DA, McCormack MC, Matsui EC, Diette GB, McKenzie SE, Geyh AS, Breysse PN.

J Expo Sci Environ Epidemiol. 2016 Jan-Feb;26(1):42-7. doi: 10.1038/jes.2014.57. Epub 2014 Aug 20.


Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation.

Yeung J, Tourdot BE, Fernandez-Perez P, Vesci J, Ren J, Smyrniotis CJ, Luci DK, Jadhav A, Simeonov A, Maloney DJ, Holman TR, McKenzie SE, Holinstat M.

Blood. 2014 Oct 2;124(14):2271-9. doi: 10.1182/blood-2014-05-575878. Epub 2014 Aug 6.


MicroRNA expression differences in human hematopoietic cell lineages enable regulated transgene expression.

Teruel-Montoya R, Kong X, Abraham S, Ma L, Kunapuli SP, Holinstat M, Shaw CA, McKenzie SE, Edelstein LC, Bray PF.

PLoS One. 2014 Jul 16;9(7):e102259. doi: 10.1371/journal.pone.0102259. eCollection 2014.


Advances in the pathophysiology and treatment of heparin-induced thrombocytopenia.

McKenzie SE, Sachais BS.

Curr Opin Hematol. 2014 Sep;21(5):380-7. doi: 10.1097/MOH.0000000000000066. Review.


Race, stigma, and mental health referrals among clients of aging services who screened positive for depression.

Sirey JA, Franklin AJ, McKenzie SE, Ghosh S, Raue PJ.

Psychiatr Serv. 2014 Apr 1;65(4):537-40. doi: 10.1176/


The human platelet: strong transcriptome correlations among individuals associate weakly with the platelet proteome.

Londin ER, Hatzimichael E, Loher P, Edelstein L, Shaw C, Delgrosso K, Fortina P, Bray PF, McKenzie SE, Rigoutsos I.

Biol Direct. 2014 Feb 14;9:3. doi: 10.1186/1745-6150-9-3.


Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics.

Simon LM, Edelstein LC, Nagalla S, Woodley AB, Chen ES, Kong X, Ma L, Fortina P, Kunapuli S, Holinstat M, McKenzie SE, Dong JF, Shaw CA, Bray PF.

Blood. 2014 Apr 17;123(16):e37-45. doi: 10.1182/blood-2013-12-544692. Epub 2014 Feb 12.


Tyrosine phosphorylation on spleen tyrosine kinase (Syk) is differentially regulated in human and murine platelets by protein kinase C isoforms.

Buitrago L, Bhavanasi D, Dangelmaier C, Manne BK, Badolia R, Borgognone A, Tsygankov AY, McKenzie SE, Kunapuli SP.

J Biol Chem. 2013 Oct 4;288(40):29160-9. doi: 10.1074/jbc.M113.464107. Epub 2013 Aug 19.


MicroRNAs in platelet production and activation.

Edelstein LC, McKenzie SE, Shaw C, Holinstat MA, Kunapuli SP, Bray PF.

J Thromb Haemost. 2013 Jun;11 Suppl 1:340-50. doi: 10.1111/jth.12214. Review.


The complex transcriptional landscape of the anucleate human platelet.

Bray PF, McKenzie SE, Edelstein LC, Nagalla S, Delgrosso K, Ertel A, Kupper J, Jing Y, Londin E, Loher P, Chen HW, Fortina P, Rigoutsos I.

BMC Genomics. 2013 Jan 16;14:1. doi: 10.1186/1471-2164-14-1.


Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo.

Zhi H, Rauova L, Hayes V, Gao C, Boylan B, Newman DK, McKenzie SE, Cooley BC, Poncz M, Newman PJ.

Blood. 2013 Mar 7;121(10):1858-67. doi: 10.1182/blood-2012-07-443325. Epub 2012 Dec 20.


Monocytes in HIT: an evolving story.

McKenzie SE.

Blood. 2012 May 31;119(22):5065-6. doi: 10.1182/blood-2012-04-417352. No abstract available.


Historical changes in the severity of dementia and accompanying neuropsychiatric symptoms in persons presenting for evaluation in a multiracial urban dementia center.

Cohen CI, McKenzie SE, Rahmani M, Singh J, Prospere E.

Alzheimer Dis Assoc Disord. 2012 Oct-Dec;26(4):352-7. doi: 10.1097/WAD.0b013e31823cfbdd.


CalDAG-GEFI deficiency protects mice in a novel model of Fcγ RIIA-mediated thrombosis and thrombocytopenia.

Stolla M, Stefanini L, André P, Ouellette TD, Reilly MP, McKenzie SE, Bergmeier W.

Blood. 2011 Jul 28;118(4):1113-20. doi: 10.1182/blood-2011-03-342352. Epub 2011 Jun 7.


'The end of treatment is not the end': parents' experiences of their child's transition from treatment for childhood cancer.

McKenzie SE, Curle C.

Psychooncology. 2012 Jun;21(6):647-54. doi: 10.1002/pon.1953. Epub 2011 Mar 10.


PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model.

Reilly MP, Sinha U, André P, Taylor SM, Pak Y, Deguzman FR, Nanda N, Pandey A, Stolla M, Bergmeier W, McKenzie SE.

Blood. 2011 Feb 17;117(7):2241-6. doi: 10.1182/blood-2010-03-274969. Epub 2010 Nov 18.


Amelioration of murine immune thrombocytopenia by CD44 antibodies: a potential therapy for ITP?

Crow AR, Song S, Suppa SJ, Ma S, Reilly MP, Andre P, McKenzie SE, Lazarus AH.

Blood. 2011 Jan 20;117(3):971-4. doi: 10.1182/blood-2010-05-280115. Epub 2010 Nov 2.


Dominant expression of the inhibitory FcgammaRIIB prevents antigen presentation by murine plasmacytoid dendritic cells.

Flores M, Desai DD, Downie M, Liang B, Reilly MP, McKenzie SE, Clynes R.

J Immunol. 2009 Dec 1;183(11):7129-39. doi: 10.4049/jimmunol.0901169. Epub 2009 Nov 16.


The clot thickens (or not).

McKenzie SE, Reilly MP.

Blood. 2009 Aug 27;114(9):1722-3. doi: 10.1182/blood-2009-06-226720.


Platelet and monocyte antigenic complexes in the pathogenesis of heparin-induced thrombocytopenia (HIT).

Rauova L, Arepally G, McKenzie SE, Konkle BA, Cines DB, Poncz M.

J Thromb Haemost. 2009 Jul;7 Suppl 1:249-52. doi: 10.1111/j.1538-7836.2009.03373.x. Review.


Food Systems and Public Health Disparities.

Neff RA, Palmer AM, McKenzie SE, Lawrence RS.

J Hunger Environ Nutr. 2009 Jul;4(3-4):282-314. Epub 2009 Dec 11.


Cognitive training for early-stage Alzheimer's disease and dementia.

Yu F, Rose KM, Burgener SC, Cunningham C, Buettner LL, Beattie E, Bossen AL, Buckwalter KC, Fick DM, Fitzsimmons S, Kolanowski A, Janet K, Specht P, Richeson NE, Testad I, McKenzie SE.

J Gerontol Nurs. 2009 Mar;35(3):23-9. Review.


Needs of people with early-stage Alzheimer's disease: reviewing the evidence.

Bossen AL, Specht JK, McKenzie SE.

J Gerontol Nurs. 2009 Mar;35(3):8-15. Review.


Thrombopoietin following transfusion of platelets in preterm neonates.

Kline A, Mackley A, Taylor SM, McKenzie SE, Paul DA.

Platelets. 2008 Sep;19(6):428-31. doi: 10.1080/09537100802220476.


Heparin-induced thrombocytopenia: an autoimmune disorder regulated through dynamic autoantigen assembly/disassembly.

Cines DB, Rauova L, Arepally G, Reilly MP, McKenzie SE, Sachais BS, Poncz M.

J Clin Apher. 2007 Feb;22(1):31-6. Review.


Cholesterol enrichment of human monocyte/macrophages induces surface exposure of phosphatidylserine and the release of biologically-active tissue factor-positive microvesicles.

Liu ML, Reilly MP, Casasanto P, McKenzie SE, Williams KJ.

Arterioscler Thromb Vasc Biol. 2007 Feb;27(2):430-5. Epub 2006 Dec 7.


Platelet FcgammaRIIA binds and internalizes IgG-containing complexes.

Worth RG, Chien CD, Chien P, Reilly MP, McKenzie SE, Schreiber AD.

Exp Hematol. 2006 Nov;34(11):1490-5.


Prothrombotic factors enhance heparin-induced thrombocytopenia and thrombosis in vivo in a mouse model.

Reilly MP, Taylor SM, Franklin C, Sachais BS, Cines DB, Williams KJ, McKenzie SE.

J Thromb Haemost. 2006 Dec;4(12):2687-94. Epub 2006 Sep 8.


Development of spontaneous multisystem autoimmune disease and hypersensitivity to antibody-induced inflammation in Fcgamma receptor IIa-transgenic mice.

Tan Sardjono C, Mottram PL, van de Velde NC, Powell MS, Power D, Slocombe RF, Wicks IP, Campbell IK, McKenzie SE, Brooks M, Stevenson AW, Hogarth PM.

Arthritis Rheum. 2005 Oct;52(10):3220-9.


A novel human CD32 mAb blocks experimental immune haemolytic anaemia in FcgammaRIIA transgenic mice.

van Royen-Kerkhof A, Sanders EA, Walraven V, Voorhorst-Ogink M, Saeland E, Teeling JL, Gerritsen A, van Dijk MA, Kuis W, Rijkers GT, Vitale L, Keler T, McKenzie SE, Leusen JH, van de Winkel JG.

Br J Haematol. 2005 Jul;130(1):130-7.


Supplemental Content

Loading ...
Support Center