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Items: 40

1.

RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases.

Patel S, Webster JD, Varfolomeev E, Kwon YC, Cheng JH, Zhang J, Dugger DL, Wickliffe KE, Maltzman A, Sujatha-Bhaskar S, Bir Kohli P, Ramaswamy S, Deshmukh G, Liederer BM, Fong R, Hamilton G, Lupardus P, Caplazi P, Lee WP, van Lookeren Campagne M, Johnson A, McKenzie BS, Junttila MR, Newton K, Vucic D.

Cell Death Differ. 2019 May 17. doi: 10.1038/s41418-019-0347-0. [Epub ahead of print]

PMID:
31101885
2.

Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors.

Bryan MC, Drobnick J, Gobbi A, Kolesnikov A, Chen Y, Rajapaksa N, Ndubaku C, Feng J, Chang W, Francis R, Yu C, Choo EF, DeMent K, Ran Y, An L, Emson C, Huang Z, Sujatha-Bhaskar S, Brightbill H, DiPasquale A, Maher J, Wai J, McKenzie BS, Lupardus PJ, Zarrin AA, Kiefer JR.

J Med Chem. 2019 Jul 11;62(13):6223-6240. doi: 10.1021/acs.jmedchem.9b00439. Epub 2019 May 24.

PMID:
31082230
3.

Inflammatory Bowel Disease Susceptibility Gene C1ORF106 Regulates Intestinal Epithelial Permeability.

Manzanillo P, Mouchess M, Ota N, Dai B, Ichikawa R, Wuster A, Haley B, Alvarado G, Kwon Y, Caothien R, Roose-Girma M, Warming S, McKenzie BS, Keir ME, Scherl A, Ouyang W, Yi T.

Immunohorizons. 2018 May 30;2(5):164-171. doi: 10.4049/immunohorizons.1800027.

PMID:
31022698
4.

Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma.

Dengler HS, Wu X, Peng I, Rinderknecht CH, Kwon Y, Suto E, Kohli PB, Liimatta M, Barrett K, Lloyd J, Cain G, Briggs M, Addo S, Salmon G, Ubhayakar S, Deshmukh G, Shahidi-Latham SK, Quiason-Huynh CM, Jackman J, Liu J, Ray NC, Goodacre SC, Johnson A, McKenzie BS, Lee WP, Zak M, Kenny JR, Ghilardi N.

Sci Transl Med. 2018 Nov 21;10(468). pii: eaao2151. doi: 10.1126/scitranslmed.aao2151.

PMID:
30463918
5.

Micro-CT imaging and structural analysis of glomeruli in a model of Adriamycin-induced nephropathy.

Xie L, Koukos G, Barck K, Foreman O, Lee WP, Brendza R, Eastham-Anderson J, McKenzie BS, Peterson A, Carano RAD.

Am J Physiol Renal Physiol. 2019 Jan 1;316(1):F76-F89. doi: 10.1152/ajprenal.00331.2018. Epub 2018 Sep 26.

PMID:
30256127
6.

Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development.

Crawford JJ, Johnson AR, Misner DL, Belmont LD, Castanedo G, Choy R, Coraggio M, Dong L, Eigenbrot C, Erickson R, Ghilardi N, Hau J, Katewa A, Kohli PB, Lee W, Lubach JW, McKenzie BS, Ortwine DF, Schutt L, Tay S, Wei B, Reif K, Liu L, Wong H, Young WB.

J Med Chem. 2018 Mar 22;61(6):2227-2245. doi: 10.1021/acs.jmedchem.7b01712. Epub 2018 Feb 23.

PMID:
29457982
7.

NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus.

Brightbill HD, Suto E, Blaquiere N, Ramamoorthi N, Sujatha-Bhaskar S, Gogol EB, Castanedo GM, Jackson BT, Kwon YC, Haller S, Lesch J, Bents K, Everett C, Kohli PB, Linge S, Christian L, Barrett K, Jaochico A, Berezhkovskiy LM, Fan PW, Modrusan Z, Veliz K, Townsend MJ, DeVoss J, Johnson AR, Godemann R, Lee WP, Austin CD, McKenzie BS, Hackney JA, Crawford JJ, Staben ST, Alaoui Ismaili MH, Wu LC, Ghilardi N.

Nat Commun. 2018 Jan 12;9(1):179. doi: 10.1038/s41467-017-02672-0.

8.

TPL2 kinase action and control of inflammation.

Xu D, Matsumoto ML, McKenzie BS, Zarrin AA.

Pharmacol Res. 2018 Mar;129:188-193. doi: 10.1016/j.phrs.2017.11.031. Epub 2017 Nov 26. Review.

9.

Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins.

Whiteley AM, Prado MA, Peng I, Abbas AR, Haley B, Paulo JA, Reichelt M, Katakam A, Sagolla M, Modrusan Z, Lee DY, Roose-Girma M, Kirkpatrick DS, McKenzie BS, Gygi SP, Finley D, Brown EJ.

Elife. 2017 Sep 21;6. pii: e26435. doi: 10.7554/eLife.26435.

10.

The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation.

Senger K, Pham VC, Varfolomeev E, Hackney JA, Corzo CA, Collier J, Lau VWC, Huang Z, Hamidzhadeh K, Caplazi P, Peng I, Setiadi AF, Francis R, Paler-Martinez A, Kwon YC, Ramirez-Carrozzi V, Sun Y, Grigg PW, Roose-Girma M, Jeet S, Barck KH, Pham A, Ota N, Ha C, Stinson J, Guillory J, Tam L, Modrusan Z, Emson C, McKenzie BS, Townsend MJ, Carano RAD, Warming S, Vucic D, DeVoss J, Lee WP, Lill JR, Zarrin AA.

Sci Signal. 2017 Apr 18;10(475). pii: eaah4273. doi: 10.1126/scisignal.aah4273.

PMID:
28420753
11.

Therapeutic Targeting of the G-CSF Receptor Reduces Neutrophil Trafficking and Joint Inflammation in Antibody-Mediated Inflammatory Arthritis.

Campbell IK, Leong D, Edwards KM, Rayzman V, Ng M, Goldberg GL, Wilson NJ, Scalzo-Inguanti K, Mackenzie-Kludas C, Lawlor KE, Wicks IP, Brown LE, Baz Morelli A, Panousis C, Wilson MJ, Nash AD, McKenzie BS, Andrews AE.

J Immunol. 2016 Dec 1;197(11):4392-4402. Epub 2016 Nov 2.

12.

GM-CSF primes cardiac inflammation in a mouse model of Kawasaki disease.

Stock AT, Hansen JA, Sleeman MA, McKenzie BS, Wicks IP.

J Exp Med. 2016 Sep 19;213(10):1983-98. doi: 10.1084/jem.20151853. Epub 2016 Sep 5.

13.

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury.

Newton K, Dugger DL, Maltzman A, Greve JM, Hedehus M, Martin-McNulty B, Carano RA, Cao TC, van Bruggen N, Bernstein L, Lee WP, Wu X, DeVoss J, Zhang J, Jeet S, Peng I, McKenzie BS, Roose-Girma M, Caplazi P, Diehl L, Webster JD, Vucic D.

Cell Death Differ. 2016 Sep 1;23(9):1565-76. doi: 10.1038/cdd.2016.46. Epub 2016 May 13.

14.

G-CSF and Neutrophils Are Nonredundant Mediators of Murine Experimental Autoimmune Uveoretinitis.

Goldberg GL, Cornish AL, Murphy J, Pang ES, Lim LL, Campbell IK, Scalzo-Inguanti K, Chen X, McMenamin PG, Maraskovsky E, McKenzie BS, Wicks IP.

Am J Pathol. 2016 Jan;186(1):172-84. doi: 10.1016/j.ajpath.2015.09.008.

PMID:
26718978
15.

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response.

Sun Y, Peng I, Webster JD, Suto E, Lesch J, Wu X, Senger K, Francis G, Barrett K, Collier JL, Burch JD, Zhou M, Chen Y, Chan C, Eastham-Anderson J, Ngu H, Li O, Staton T, Havnar C, Jaochico A, Jackman J, Jeet S, Riol-Blanco L, Wu LC, Choy DF, Arron JR, McKenzie BS, Ghilardi N, Ismaili MH, Pei Z, DeVoss J, Austin CD, Lee WP, Zarrin AA.

Sci Signal. 2015 Dec 1;8(405):ra122. doi: 10.1126/scisignal.aab0949.

PMID:
26628680
16.

Granulocyte Macrophage Colony-Stimulating Factor-Activated Eosinophils Promote Interleukin-23 Driven Chronic Colitis.

Griseri T, Arnold IC, Pearson C, Krausgruber T, Schiering C, Franchini F, Schulthess J, McKenzie BS, Crocker PR, Powrie F.

Immunity. 2015 Jul 21;43(1):187-99. doi: 10.1016/j.immuni.2015.07.008.

17.

Therapeutic effect of IVIG on inflammatory arthritis in mice is dependent on the Fc portion and independent of sialylation or basophils.

Campbell IK, Miescher S, Branch DR, Mott PJ, Lazarus AH, Han D, Maraskovsky E, Zuercher AW, Neschadim A, Leontyev D, McKenzie BS, Käsermann F.

J Immunol. 2014 Jun 1;192(11):5031-8. doi: 10.4049/jimmunol.1301611. Epub 2014 Apr 23.

18.

Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically.

Putoczki TL, Thiem S, Loving A, Busuttil RA, Wilson NJ, Ziegler PK, Nguyen PM, Preaudet A, Farid R, Edwards KM, Boglev Y, Luwor RB, Jarnicki A, Horst D, Boussioutas A, Heath JK, Sieber OM, Pleines I, Kile BT, Nash A, Greten FR, McKenzie BS, Ernst M.

Cancer Cell. 2013 Aug 12;24(2):257-71. doi: 10.1016/j.ccr.2013.06.017.

19.

Biomarkers of Therapeutic Response in the IL-23 Pathway in Inflammatory Bowel Disease.

Cayatte C, Joyce-Shaikh B, Vega F, Boniface K, Grein J, Murphy E, Blumenschein WM, Chen S, Malinao MC, Basham B, Pierce RH, Bowman EP, McKenzie BS, Elson CO, Faubion WA, Malefyt Rde W, Kastelein RA, Cua D, McClanahan TK, Beaumont M.

Clin Transl Gastroenterol. 2012 Feb 16;3:e10. doi: 10.1038/ctg.2012.2.

20.

Dysregulated hematopoietic stem and progenitor cell activity promotes interleukin-23-driven chronic intestinal inflammation.

Griseri T, McKenzie BS, Schiering C, Powrie F.

Immunity. 2012 Dec 14;37(6):1116-29. doi: 10.1016/j.immuni.2012.08.025. Epub 2012 Nov 29.

21.

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis.

O'Donoghue RJ, Knight DA, Richards CD, Prêle CM, Lau HL, Jarnicki AG, Jones J, Bozinovski S, Vlahos R, Thiem S, McKenzie BS, Wang B, Stumbles P, Laurent GJ, McAnulty RJ, Rose-John S, Zhu HJ, Anderson GP, Ernst MR, Mutsaers SE.

EMBO Mol Med. 2012 Sep;4(9):939-51. doi: 10.1002/emmm.201100604. Epub 2012 Jun 8.

22.

G-CSF and GM-CSF as therapeutic targets in rheumatoid arthritis.

Cornish AL, Campbell IK, McKenzie BS, Chatfield S, Wicks IP.

Nat Rev Rheumatol. 2009 Oct;5(10):554-9. doi: 10.1038/nrrheum.2009.178. Review.

PMID:
19798030
23.

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.

Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, McKenzie BS, Kastelein RA, Cua DJ, de Waal Malefyt R.

J Exp Med. 2009 Mar 16;206(3):535-48. doi: 10.1084/jem.20082293. Epub 2009 Mar 9.

24.

Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population.

Coquet JM, Chakravarti S, Kyparissoudis K, McNab FW, Pitt LA, McKenzie BS, Berzins SP, Smyth MJ, Godfrey DI.

Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11287-92. doi: 10.1073/pnas.0801631105. Epub 2008 Aug 6.

25.

Development, cytokine profile and function of human interleukin 17-producing helper T cells.

Wilson NJ, Boniface K, Chan JR, McKenzie BS, Blumenschein WM, Mattson JD, Basham B, Smith K, Chen T, Morel F, Lecron JC, Kastelein RA, Cua DJ, McClanahan TK, Bowman EP, de Waal Malefyt R.

Nat Immunol. 2007 Sep;8(9):950-7. Epub 2007 Aug 5.

PMID:
17676044
26.

Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1.

Kallies A, Hasbold J, Fairfax K, Pridans C, Emslie D, McKenzie BS, Lew AM, Corcoran LM, Hodgkin PD, Tarlinton DM, Nutt SL.

Immunity. 2007 May;26(5):555-66.

27.

Interleukin-23 drives innate and T cell-mediated intestinal inflammation.

Hue S, Ahern P, Buonocore S, Kullberg MC, Cua DJ, McKenzie BS, Powrie F, Maloy KJ.

J Exp Med. 2006 Oct 30;203(11):2473-83. Epub 2006 Oct 9.

28.

IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis.

Kullberg MC, Jankovic D, Feng CG, Hue S, Gorelick PL, McKenzie BS, Cua DJ, Powrie F, Cheever AW, Maloy KJ, Sher A.

J Exp Med. 2006 Oct 30;203(11):2485-94. Epub 2006 Oct 9.

29.

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.

Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, Cua DJ, Littman DR.

Cell. 2006 Sep 22;126(6):1121-33.

30.

Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology.

Uhlig HH, McKenzie BS, Hue S, Thompson C, Joyce-Shaikh B, Stepankova R, Robinson N, Buonocore S, Tlaskalova-Hogenova H, Cua DJ, Powrie F.

Immunity. 2006 Aug;25(2):309-18.

31.

Rapid specific amplification of rat antibody cDNA from nine hybridomas in the presence of myeloma light chains.

Brady JL, Corbett AJ, McKenzie BS, Lew AM.

J Immunol Methods. 2006 Aug 31;315(1-2):61-7. Epub 2006 Jul 31.

PMID:
16901500
32.

Understanding the IL-23-IL-17 immune pathway.

McKenzie BS, Kastelein RA, Cua DJ.

Trends Immunol. 2006 Jan;27(1):17-23. Epub 2005 Nov 14.

PMID:
16290228
33.

Antigen delivery via two molecules on the CD8- dendritic cell subset induces humoral immunity in the absence of conventional "danger".

Corbett AJ, Caminschi I, McKenzie BS, Brady JL, Wright MD, Mottram PL, Hogarth PM, Hodder AN, Zhan Y, Tarlinton DM, Shortman K, Lew AM.

Eur J Immunol. 2005 Oct;35(10):2815-25.

34.

Targeting lymphocyte Peyer's patch adhesion molecule-1: a relay approach to gut immunization.

McKenzie BS, Corbett AJ, Brady JL, Boyle JS, Rockman SP, Lew AM.

Vaccine. 2005 May 25;23(28):3668-78.

PMID:
15882527
35.

IL-12 and IL-23: master regulators of innate and adaptive immunity.

Langrish CL, McKenzie BS, Wilson NJ, de Waal Malefyt R, Kastelein RA, Cua DJ.

Immunol Rev. 2004 Dec;202:96-105. Review.

PMID:
15546388
36.

Bypassing luminal barriers, delivery to a gut addressin by parenteral targeting elicits local IgA responses.

McKenzie BS, Corbett AJ, Johnson S, Brady JL, Pleasance J, Kramer DR, Boyle JS, Jackson DC, Strugnell RA, Lew AM.

Int Immunol. 2004 Nov;16(11):1613-22. Epub 2004 Oct 5.

PMID:
15466913
37.

Mucosal immunity: overcoming the barrier for induction of proximal responses.

McKenzie BS, Brady JL, Lew AM.

Immunol Res. 2004;30(1):35-71. Review.

PMID:
15258310
38.

Anti-CD45RB antibody deters xenograft rejection by modulating T cell priming and homing.

Sutherland RM, McKenzie BS, Zhan Y, Corbett AJ, Fox-Marsh A, Georgiou HM, Harrison LC, Lew AM.

Int Immunol. 2002 Aug;14(8):953-62.

PMID:
12147632
39.

Nucleic acid vaccines: tasks and tactics.

McKenzie BS, Corbett AJ, Brady JL, Dyer CM, Strugnell RA, Kent SJ, Kramer DR, Boyle JS, Lew AM.

Immunol Res. 2001;24(3):225-44. Review.

PMID:
11817323
40.

Overcoming the poor immunogenicity of a protein by DNA immunization as a fusion construct.

Sutherland RM, McKenzie BS, Corbett AJ, Brady JL, Lew AM.

Immunol Cell Biol. 2001 Feb;79(1):49-53.

PMID:
11168623

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