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Items: 43


Developing a framework for digital objects in the Big Data to Knowledge (BD2K) commons: Report from the Commons Framework Pilots workshop.

Jagodnik KM, Koplev S, Jenkins SL, Ohno-Machado L, Paten B, Schurer SC, Dumontier M, Verborgh R, Bui A, Ping P, McKenna NJ, Madduri R, Pillai A, Ma'ayan A.

J Biomed Inform. 2017 Jul;71:49-57. doi: 10.1016/j.jbi.2017.05.006. Epub 2017 May 10.


Discovering relationships between nuclear receptor signaling pathways, genes, and tissues in Transcriptomine.

Becnel LB, Ochsner SA, Darlington YF, McOwiti A, Kankanamge WH, Dehart M, Naumov A, McKenna NJ.

Sci Signal. 2017 Apr 25;10(476). pii: eaah6275. doi: 10.1126/scisignal.aah6275.


Improving the discoverability, accessibility, and citability of omics datasets: a case report.

Darlington YF, Naumov A, McOwiti A, Kankanamge WH, Becnel LB, McKenna NJ.

J Am Med Inform Assoc. 2017 Mar 1;24(2):388-393. doi: 10.1093/jamia/ocw096.


Research Resource: A Reference Transcriptome for Constitutive Androstane Receptor and Pregnane X Receptor Xenobiotic Signaling.

Ochsner SA, Tsimelzon A, Dong J, Coarfa C, McKenna NJ.

Mol Endocrinol. 2016 Aug;30(8):937-48. doi: 10.1210/me.2016-1095. Epub 2016 Jul 13.


Research Resources for Nuclear Receptor Signaling Pathways.

McKenna NJ.

Mol Pharmacol. 2016 Aug;90(2):153-9. doi: 10.1124/mol.116.103713. Epub 2016 May 23. Review.


Nuclear Receptor Signaling Atlas: Opening Access to the Biology of Nuclear Receptor Signaling Pathways.

Becnel LB, Darlington YF, Ochsner SA, Easton-Marks JR, Watkins CM, McOwiti A, Kankanamge WH, Wise MW, DeHart M, Margolis RN, McKenna NJ.

PLoS One. 2015 Sep 1;10(9):e0135615. doi: 10.1371/journal.pone.0135615. eCollection 2015.


Nuclear Receptor Signaling: a home for nuclear receptor and coregulator signaling research.

McKenna NJ, Evans RM, O'Malley BW.

Nucl Recept Signal. 2014 Dec 15;12:e006. doi: 10.1621/nrs.12006. eCollection 2014. Review.


Androgen receptor agonism promotes an osteogenic gene program in preadipocytes.

Hartig SM, Feng Q, Ochsner SA, Xiao R, McKenna NJ, McGuire SE, He B.

Biochem Biophys Res Commun. 2013 May 3;434(2):357-62. doi: 10.1016/j.bbrc.2013.03.078. Epub 2013 Apr 6.


Feed-forward inhibition of androgen receptor activity by glucocorticoid action in human adipocytes.

Hartig SM, He B, Newberg JY, Ochsner SA, Loose DS, Lanz RB, McKenna NJ, Buehrer BM, McGuire SE, Marcelli M, Mancini MA.

Chem Biol. 2012 Sep 21;19(9):1126-41. doi: 10.1016/j.chembiol.2012.07.020.


Activation of NF-κB protein prevents the transition from juvenile ovary to testis and promotes ovarian development in zebrafish.

Pradhan A, Khalaf H, Ochsner SA, Sreenivasan R, Koskinen J, Karlsson M, Karlsson J, McKenna NJ, Orbán L, Olsson PE.

J Biol Chem. 2012 Nov 2;287(45):37926-38. doi: 10.1074/jbc.M112.386284. Epub 2012 Sep 17.


Minireview: progress and challenges in proteomics data management, sharing, and integration.

Becnel LB, McKenna NJ.

Mol Endocrinol. 2012 Oct;26(10):1660-74. Epub 2012 Aug 17. Review.


Transcriptomine, a web resource for nuclear receptor signaling transcriptomes.

Ochsner SA, Watkins CM, McOwiti A, Xu X, Darlington YF, Dehart MD, Cooney AJ, Steffen DL, Becnel LB, McKenna NJ.

Physiol Genomics. 2012 Sep 1;44(17):853-63. doi: 10.1152/physiolgenomics.00033.2012. Epub 2012 Jul 10.


Research resource: dkCOIN, the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) consortium interconnectivity network: a pilot program to aggregate research resources generated by multiple research consortia.

McKenna NJ, Howard CL, Aufiero M, Easton-Marks J, Steffen DL, Becnel LB, Magnuson MA, McIndoe RA, Cartailler JP.

Mol Endocrinol. 2012 Oct;26(10):1675-81. Epub 2012 Jun 25.


EMBO Retinoids 2011: Mechanisms, biology and pathology of signaling by retinoic acid and retinoic acid receptors.

McKenna NJ.

Nucl Recept Signal. 2012;10:e003. doi: 10.1621/nrs.10003. Epub 2012 Feb 27.


Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis.

Anakk S, Watanabe M, Ochsner SA, McKenna NJ, Finegold MJ, Moore DD.

J Clin Invest. 2011 Jan;121(1):86-95. doi: 10.1172/JCI42846. Epub 2010 Dec 1.


Discovery-driven research and bioinformatics in nuclear receptor and coregulator signaling.

McKenna NJ.

Biochim Biophys Acta. 2011 Aug;1812(8):808-17. doi: 10.1016/j.bbadis.2010.10.009. Epub 2010 Oct 26. Review.


SnapShot: NR coregulators.

McKenna NJ, O'Malley BW.

Cell. 2010 Oct 1;143(1):172-172.e1. doi: 10.1016/j.cell.2010.09.032. No abstract available.


SnapShot: Nuclear receptors II.

McKenna NJ, O'Malley BW.

Cell. 2010 Sep 17;142(6):986.e1. doi: 10.1016/j.cell.2010.08.041. No abstract available.


SnapShot: Nuclear receptors I.

McKenna NJ, O'Malley BW.

Cell. 2010 Sep 3;142(5):822-822.e1. doi: 10.1016/j.cell.2010.08.026. No abstract available.


Research resource: Tissue-specific transcriptomics and cistromics of nuclear receptor signaling: a web research resource.

Ochsner SA, Watkins CM, LaGrone BS, Steffen DL, McKenna NJ.

Mol Endocrinol. 2010 Oct;24(10):2065-9. doi: 10.1210/me.2010-0216. Epub 2010 Aug 4.


Signals from NURSA.

DeFranco DB, McKenna NJ.

Mol Endocrinol. 2009 Dec;23(12):1939. doi: 10.1210/me.2009-0447. No abstract available.


Molecular endocrinology: A portal for enhanced access and utility of the nuclear receptor signaling atlas (NURSA) web resource.

McKenna NJ, DeFranco DB.

Mol Endocrinol. 2009 Jun;23(6):739. doi: 10.1210/me.2009-0169. No abstract available.


Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas.

McKenna NJ, Cooney AJ, DeMayo FJ, Downes M, Glass CK, Lanz RB, Lazar MA, Mangelsdorf DJ, Moore DD, Qin J, Steffen DL, Tsai MJ, Tsai SY, Yu R, Margolis RN, Evans RM, O'Malley BW.

Mol Endocrinol. 2009 Jun;23(6):740-6. doi: 10.1210/me.2009-0135. Epub 2009 May 7. Review. Erratum in: Mol Endocrinol. 2009 Sep;23(9):1522.


Re-expression of GATA2 cooperates with peroxisome proliferator-activated receptor-gamma depletion to revert the adipocyte phenotype.

Schupp M, Cristancho AG, Lefterova MI, Hanniman EA, Briggs ER, Steger DJ, Qatanani M, Curtin JC, Schug J, Ochsner SA, McKenna NJ, Lazar MA.

J Biol Chem. 2009 Apr 3;284(14):9458-64. doi: 10.1074/jbc.M809498200. Epub 2009 Jan 9.


GEMS (Gene Expression MetaSignatures), a Web resource for querying meta-analysis of expression microarray datasets: 17beta-estradiol in MCF-7 cells.

Ochsner SA, Steffen DL, Hilsenbeck SG, Chen ES, Watkins C, McKenna NJ.

Cancer Res. 2009 Jan 1;69(1):23-6. doi: 10.1158/0008-5472.CAN-08-3492.


Much room for improvement in deposition rates of expression microarray datasets.

Ochsner SA, Steffen DL, Stoeckert CJ Jr, McKenna NJ.

Nat Methods. 2008 Dec;5(12):991. doi: 10.1038/nmeth1208-991. No abstract available. Erratum in: Nat Methods. 2009 Jan;6(1):109.


Coactivators and corepressors: what's in a name?

O'Malley BW, McKenna NJ.

Mol Endocrinol. 2008 Oct;22(10):2213-4. doi: 10.1210/me.2008-0201. Epub 2008 Aug 13.


Nuclear Receptor Signaling Atlas ( hyperlinking the nuclear receptor signaling community.

Lanz RB, Jericevic Z, Zuercher WJ, Watkins C, Steffen DL, Margolis R, McKenna NJ.

Nucleic Acids Res. 2006 Jan 1;34(Database issue):D221-6.


Hierarchical affinities and a bipartite interaction model for estrogen receptor isoforms and full-length steroid receptor coactivator (SRC/p160) family members.

Cheskis BJ, McKenna NJ, Wong CW, Wong J, Komm B, Lyttle CR, O'Malley BW.

J Biol Chem. 2003 Apr 11;278(15):13271-7. Epub 2003 Jan 22.


Minireview: nuclear receptor coactivators--an update.

McKenna NJ, O'Malley BW.

Endocrinology. 2002 Jul;143(7):2461-5. Review.


Combinatorial control of gene expression by nuclear receptors and coregulators.

McKenna NJ, O'Malley BW.

Cell. 2002 Feb 22;108(4):465-74. Review.


From ligand to response: generating diversity in nuclear receptor coregulator function.

McKenna NJ, O'Malley BW.

J Steroid Biochem Mol Biol. 2000 Nov 30;74(5):351-6. Review.


An issue of tissues: divining the split personalities of selective estrogen receptor modulators.

McKenna NJ, O'Malley BW.

Nat Med. 2000 Sep;6(9):960-2. No abstract available.


Nuclear receptor coactivators: multiple enzymes, multiple complexes, multiple functions.

McKenna NJ, Xu J, Nawaz Z, Tsai SY, Tsai MJ, O'Malley BW.

J Steroid Biochem Mol Biol. 1999 Apr-Jun;69(1-6):3-12. Review.


Nuclear receptor coregulators: cellular and molecular biology.

McKenna NJ, Lanz RB, O'Malley BW.

Endocr Rev. 1999 Jun;20(3):321-44. Review.


A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex.

Lanz RB, McKenna NJ, Onate SA, Albrecht U, Wong J, Tsai SY, Tsai MJ, O'Malley BW.

Cell. 1999 Apr 2;97(1):17-27.


Distinct steady-state nuclear receptor coregulator complexes exist in vivo.

McKenna NJ, Nawaz Z, Tsai SY, Tsai MJ, O'Malley BW.

Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11697-702.


Steroid receptor coactivator-1 is a histone acetyltransferase.

Spencer TE, Jenster G, Burcin MM, Allis CD, Zhou J, Mizzen CA, McKenna NJ, Onate SA, Tsai SY, Tsai MJ, O'Malley BW.

Nature. 1997 Sep 11;389(6647):194-8.


Ovarian carcinoma-associated TaqI restriction fragment length polymorphism in intron G of the progesterone receptor gene is due to an Alu sequence insertion.

Rowe SM, Coughlan SJ, McKenna NJ, Garrett E, Kieback DG, Carney DN, Headon DR.

Cancer Res. 1995 Jul 1;55(13):2743-5.


A germline TaqI restriction fragment length polymorphism in the progesterone receptor gene in ovarian carcinoma.

McKenna NJ, Kieback DG, Carney DN, Fanning M, McLinden J, Headon DR.

Br J Cancer. 1995 Mar;71(3):451-5.


Membrane-bound peptidases of Helix aspersa.

Ennis MP, McGrath-Linden SJ, McKenna NJ, McCann JJ, Irvine GB, Williams CH.

Biochem Soc Trans. 1991 Aug;19(3):295S. No abstract available.


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