Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 85


L-Type Cav 1.2 Calcium Channel-α-1C Regulates Response to Rituximab in Diffuse Large B-Cell Lymphoma.

Zhang JY, Zhang PP, Zhou WP, Yu JY, Yao ZH, Chu JF, Yao SN, Wang C, Lone W, Xia QX, Ma J, Yang SJ, Liu KD, Dong ZG, Guo YJ, Smith LM, McKeithan TW, Chan WC, Iqbal J, Liu YY.

Clin Cancer Res. 2019 Jul 1;25(13):4168-4178. doi: 10.1158/1078-0432.CCR-18-2146. Epub 2019 Mar 1.


Genetic drivers of oncogenic pathways in molecular subgroups of peripheral T-cell lymphoma.

Heavican TB, Bouska A, Yu J, Lone W, Amador C, Gong Q, Zhang W, Li Y, Dave BJ, Nairismägi ML, Greiner TC, Vose J, Weisenburger DD, Lachel C, Wang C, Fu K, Stevens JM, Lim ST, Ong CK, Gascoyne RD, Missiaglia E, Lemonnier F, Haioun C, Hartmann S, Pedersen MB, Laginestra MA, Wilcox RA, Teh BT, Yoshida N, Ohshima K, Seto M, Rosenwald A, Ott G, Campo E, Rimsza LM, Jaffe ES, Braziel RM, d'Amore F, Inghirami G, Bertoni F, de Leval L, Gaulard P, Staudt LM, McKeithan TW, Pileri S, Chan WC, Iqbal J.

Blood. 2019 Apr 11;133(15):1664-1676. doi: 10.1182/blood-2018-09-872549. Epub 2019 Feb 19.


Molecular and Genomic Landscape of Peripheral T-Cell Lymphoma.

Iqbal J, Amador C, McKeithan TW, Chan WC.

Cancer Treat Res. 2019;176:31-68. doi: 10.1007/978-3-319-99716-2_2.


The miR-17~92 cluster activates mTORC1 in mantle cell lymphoma by targeting multiple regulators in the STK11/AMPK/TSC/mTOR pathway.

Jiang C, Bi C, Jiang X, Tian T, Huang X, Wang C, Fernandez MR, Iqbal J, Chan WC, McKeithan TW, Lewis RE, Fu K.

Br J Haematol. 2019 May;185(3):616-620. doi: 10.1111/bjh.15591. Epub 2018 Sep 10. No abstract available.


Assessment of T-cell receptor repertoire and clonal expansion in peripheral T-cell lymphoma using RNA-seq data.

Gong Q, Wang C, Zhang W, Iqbal J, Hu Y, Greiner TC, Cornish A, Kim JH, Rabadan R, Abate F, Wang X, Inghirami GG, McKeithan TW, Chan WC.

Sci Rep. 2017 Sep 12;7(1):11301. doi: 10.1038/s41598-017-11310-0.


Adult high-grade B-cell lymphoma with Burkitt lymphoma signature: genomic features and potential therapeutic targets.

Bouska A, Bi C, Lone W, Zhang W, Kedwaii A, Heavican T, Lachel CM, Yu J, Ferro R, Eldorghamy N, Greiner TC, Vose J, Weisenburger DD, Gascoyne RD, Rosenwald A, Ott G, Campo E, Rimsza LM, Jaffe ES, Braziel RM, Siebert R, Miles RR, Dave S, Reddy A, Delabie J, Staudt LM, Song JY, McKeithan TW, Fu K, Green M, Chan WC, Iqbal J.

Blood. 2017 Oct 19;130(16):1819-1831. doi: 10.1182/blood-2017-02-767335. Epub 2017 Aug 11.


Flow cytometric sorting coupled with exon capture sequencing identifies somatic mutations in archival lymphoma tissues.

Jiang N, Chen C, Gong Q, Shields K, Li Y, Chen Y, Song J, McKeithan TW, Chan WC.

Lab Invest. 2017 Nov;97(11):1364-1374. doi: 10.1038/labinvest.2017.73. Epub 2017 Aug 7.


Inhibition of 4EBP phosphorylation mediates the cytotoxic effect of mechanistic target of rapamycin kinase inhibitors in aggressive B-cell lymphomas.

Bi C, Zhang X, Lu T, Zhang X, Wang X, Meng B, Zhang H, Wang P, Vose JM, Chan WC, McKeithan TW, Fu K.

Haematologica. 2017 Apr;102(4):755-764. doi: 10.3324/haematol.2016.159160. Epub 2017 Jan 19.


Combined copy number and mutation analysis identifies oncogenic pathways associated with transformation of follicular lymphoma.

Bouska A, Zhang W, Gong Q, Iqbal J, Scuto A, Vose J, Ludvigsen M, Fu K, Weisenburger DD, Greiner TC, Gascoyne RD, Rosenwald A, Ott G, Campo E, Rimsza LM, Delabie J, Jaffe ES, Braziel RM, Connors JM, Wu CI, Staudt LM, D'Amore F, McKeithan TW, Chan WC.

Leukemia. 2017 Jan;31(1):83-91. doi: 10.1038/leu.2016.175. Epub 2016 Jun 16.


Comment on: Frequent CTLA4-CD28 gene fusion in diverse types of T-cell lymphoma, by Yoo et al.

Gong Q, Wang C, Rohr J, Feldman AL, Chan WC, McKeithan TW.

Haematologica. 2016 Jun;101(6):e269-70. doi: 10.3324/haematol.2016.147074. Epub 2016 May 31. No abstract available.


IDH2R172 mutations define a unique subgroup of patients with angioimmunoblastic T-cell lymphoma.

Wang C, McKeithan TW, Gong Q, Zhang W, Bouska A, Rosenwald A, Gascoyne RD, Wu X, Wang J, Muhammad Z, Jiang B, Rohr J, Cannon A, Steidl C, Fu K, Li Y, Hung S, Weisenburger DD, Greiner TC, Smith L, Ott G, Rogan EG, Staudt LM, Vose J, Iqbal J, Chan WC.

Blood. 2015 Oct 8;126(15):1741-52. doi: 10.1182/blood-2015-05-644591. Epub 2015 Aug 12.


Global promoter methylation analysis reveals novel candidate tumor suppressor genes in natural killer cell lymphoma.

Küçük C, Hu X, Jiang B, Klinkebiel D, Geng H, Gong Q, Bouska A, Iqbal J, Gaulard P, McKeithan TW, Chan WC.

Clin Cancer Res. 2015 Apr 1;21(7):1699-711. doi: 10.1158/1078-0432.CCR-14-1216. Epub 2015 Jan 22.


Global microRNA expression profiling uncovers molecular markers for classification and prognosis in aggressive B-cell lymphoma.

Iqbal J, Shen Y, Huang X, Liu Y, Wake L, Liu C, Deffenbacher K, Lachel CM, Wang C, Rohr J, Guo S, Smith LM, Wright G, Bhagavathi S, Dybkaer K, Fu K, Greiner TC, Vose JM, Jaffe E, Rimsza L, Rosenwald A, Ott G, Delabie J, Campo E, Braziel RM, Cook JR, Tubbs RR, Armitage JO, Weisenburger DD, Staudt LM, Gascoyne RD, McKeithan TW, Chan WC.

Blood. 2015 Feb 12;125(7):1137-45. doi: 10.1182/blood-2014-04-566778. Epub 2014 Dec 10.


Activation of the STAT3 signaling pathway is associated with poor survival in diffuse large B-cell lymphoma treated with R-CHOP.

Huang X, Meng B, Iqbal J, Ding BB, Perry AM, Cao W, Smith LM, Bi C, Jiang C, Greiner TC, Weisenburger DD, Rimsza L, Rosenwald A, Ott G, Delabie J, Campo E, Braziel RM, Gascoyne RD, Cook JR, Tubbs RR, Jaffe ES, Armitage JO, Vose JM, Staudt LM, McKeithan TW, Chan WC, Ye BH, Fu K.

J Clin Oncol. 2013 Dec 20;31(36):4520-8. doi: 10.1200/JCO.2012.45.6004. Epub 2013 Nov 12.


Genome-wide copy-number analyses reveal genomic abnormalities involved in transformation of follicular lymphoma.

Bouska A, McKeithan TW, Deffenbacher KE, Lachel C, Wright GW, Iqbal J, Smith LM, Zhang W, Kucuk C, Rinaldi A, Bertoni F, Fitzgibbon J, Fu K, Weisenburger DD, Greiner TC, Dave BJ, Gascoyne RD, Rosenwald A, Ott G, Campo E, Rimsza LM, Delabie J, Jaffe ES, Braziel RM, Connors JM, Staudt LM, Chan WC.

Blood. 2014 Mar 13;123(11):1681-90. doi: 10.1182/blood-2013-05-500595. Epub 2013 Sep 13.


MicroRNA expression profiling identifies molecular signatures associated with anaplastic large cell lymphoma.

Liu C, Iqbal J, Teruya-Feldstein J, Shen Y, Dabrowska MJ, Dybkaer K, Lim MS, Piva R, Barreca A, Pellegrino E, Spaccarotella E, Lachel CM, Kucuk C, Jiang CS, Hu X, Bhagavathi S, Greiner TC, Weisenburger DD, Aoun P, Perkins SL, McKeithan TW, Inghirami G, Chan WC.

Blood. 2013 Sep 19;122(12):2083-92. doi: 10.1182/blood-2012-08-447375. Epub 2013 Jun 25.


Quantitative proteomics reveals that miR-155 regulates the PI3K-AKT pathway in diffuse large B-cell lymphoma.

Huang X, Shen Y, Liu M, Bi C, Jiang C, Iqbal J, McKeithan TW, Chan WC, Ding SJ, Fu K.

Am J Pathol. 2012 Jul;181(1):26-33. doi: 10.1016/j.ajpath.2012.03.013. Epub 2012 May 18.


Genome-wide miRNA profiling of mantle cell lymphoma reveals a distinct subgroup with poor prognosis.

Iqbal J, Shen Y, Liu Y, Fu K, Jaffe ES, Liu C, Liu Z, Lachel CM, Deffenbacher K, Greiner TC, Vose JM, Bhagavathi S, Staudt LM, Rimsza L, Rosenwald A, Ott G, Delabie J, Campo E, Braziel RM, Cook JR, Tubbs RR, Gascoyne RD, Armitage JO, Weisenburger DD, McKeithan TW, Chan WC.

Blood. 2012 May 24;119(21):4939-48. doi: 10.1182/blood-2011-07-370122. Epub 2012 Apr 5.


Inhibition of poly(ADP-ribose) polymerase (PARP) and ataxia telangiectasia mutated (ATM) on the chemosensitivity of mantle cell lymphoma to agents that induce DNA strand breaks.

Golla RM, Li M, Shen Y, Ji M, Yan Y, Fu K, Greiner TC, McKeithan TW, Chan WC.

Hematol Oncol. 2012 Dec;30(4):175-9. doi: 10.1002/hon.1020. Epub 2011 Dec 14.


PRDM1 is a tumor suppressor gene in natural killer cell malignancies.

Küçük C, Iqbal J, Hu X, Gaulard P, De Leval L, Srivastava G, Au WY, McKeithan TW, Chan WC.

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20119-24. doi: 10.1073/pnas.1115128108. Epub 2011 Dec 5.


The miRNA-17∼92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation.

Rao E, Jiang C, Ji M, Huang X, Iqbal J, Lenz G, Wright G, Staudt LM, Zhao Y, McKeithan TW, Chan WC, Fu K.

Leukemia. 2012 May;26(5):1064-72. doi: 10.1038/leu.2011.305. Epub 2011 Nov 25.


The miR-17-92 microRNA cluster is regulated by multiple mechanisms in B-cell malignancies.

Ji M, Rao E, Ramachandrareddy H, Shen Y, Jiang C, Chen J, Hu Y, Rizzino A, Chan WC, Fu K, McKeithan TW.

Am J Pathol. 2011 Oct;179(4):1645-56. doi: 10.1016/j.ajpath.2011.06.008. Epub 2011 Jul 30.


BCL6 promoter interacts with far upstream sequences with greatly enhanced activating histone modifications in germinal center B cells.

Ramachandrareddy H, Bouska A, Shen Y, Ji M, Rizzino A, Chan WC, McKeithan TW.

Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11930-5. doi: 10.1073/pnas.1004962107. Epub 2010 Jun 14.


Identification of DPPA4 and other genes as putative Sox2:Oct-3/4 target genes using a combination of in silico analysis and transcription-based assays.

Chakravarthy H, Boer B, Desler M, Mallanna SK, McKeithan TW, Rizzino A.

J Cell Physiol. 2008 Sep;216(3):651-62. doi: 10.1002/jcp.21440.


PCR-based generation of shRNA libraries from cDNAs.

Du C, Ge B, Liu Z, Fu K, Chan WC, McKeithan TW.

BMC Biotechnol. 2006 Jun 21;6:28.


BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription.

Brocke-Heidrich K, Ge B, Cvijic H, Pfeifer G, Löffler D, Henze C, McKeithan TW, Horn F.

Oncogene. 2006 Nov 23;25(55):7297-304. Epub 2006 May 29.


Generation of variable and fixed length siRNA from a novel siRNA expression vector.

Du C, Ge B, Feng X, Chan WC, McKeithan TW.

Biochem Biophys Res Commun. 2006 Jun 23;345(1):99-105. Epub 2006 Apr 25.


Surface display of recombinant proteins on Bacillus thuringiensis spores.

Du C, Chan WC, McKeithan TW, Nickerson KW.

Appl Environ Microbiol. 2005 Jun;71(6):3337-41.


The human BCL6 transgene promotes the development of lymphomas in the mouse.

Baron BW, Anastasi J, Montag A, Huo D, Baron RM, Karrison T, Thirman MJ, Subudhi SK, Chin RK, Felsher DW, Fu YX, McKeithan TW, Baron JM.

Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14198-203. Epub 2004 Sep 16.


Distinct gene expression profiles in different B-cell compartments in human peripheral lymphoid organs.

Shen Y, Iqbal J, Xiao L, Lynch RC, Rosenwald A, Staudt LM, Sherman S, Dybkaer K, Zhou G, Eudy JD, Delabie J, McKeithan TW, Chan WC.

BMC Immunol. 2004 Sep 15;5:20.


NF-kappa B regulates BCL3 transcription in T lymphocytes through an intronic enhancer.

Ge B, Li O, Wilder P, Rizzino A, McKeithan TW.

J Immunol. 2003 Oct 15;171(8):4210-8.


Minimal structural elements of an inhibitory anti-ATF1/CREB single-chain antibody fragment (scFv41.4).

Olsen RJ, Mazlo J, Koepsell SA, McKeithan TW, Hinrichs SH.

Hybrid Hybridomics. 2003 Apr;22(2):65-77.


Two newly characterized germinal center B-cell-associated genes, GCET1 and GCET2, have differential expression in normal and neoplastic B cells.

Pan Z, Shen Y, Du C, Zhou G, Rosenwald A, Staudt LM, Greiner TC, McKeithan TW, Chan WC.

Am J Pathol. 2003 Jul;163(1):135-44.


Live-cell dynamics and the role of costimulation in immunological synapse formation.

Wetzel SA, McKeithan TW, Parker DC.

J Immunol. 2002 Dec 1;169(11):6092-101.


The human programmed cell death-2 (PDCD2) gene is a target of BCL6 repression: implications for a role of BCL6 in the down-regulation of apoptosis.

Baron BW, Anastasi J, Thirman MJ, Furukawa Y, Fears S, Kim DC, Simone F, Birkenbach M, Montag A, Sadhu A, Zeleznik-Le N, McKeithan TW.

Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2860-5. Epub 2002 Feb 19.


Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice.

Ong ST, Hackbarth ML, Degenstein LC, Baunoch DA, Anastasi J, McKeithan TW.

Oncogene. 1998 May 7;16(18):2333-43.


Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: implications for the mechanism of fragile site induction.

Le Beau MM, Rassool FV, Neilly ME, Espinosa R 3rd, Glover TW, Smith DI, McKeithan TW.

Hum Mol Genet. 1998 Apr;7(4):755-61.


An FHIT tumor suppressor gene?

Le Beau MM, Drabkin H, Glover TW, Gemmill R, Rassool FV, McKeithan TW, Smith DI.

Genes Chromosomes Cancer. 1998 Apr;21(4):281-9. Review.


Molecular analysis of the t(8;14)(q24;q11) chromosomal breakpoint junctions in the T-cell leukemia line MOLT-16.

Shima-Rich EA, Harden AM, McKeithan TW, Rowley JD, Diaz MO.

Genes Chromosomes Cancer. 1997 Dec;20(4):363-71.


BCL3 rearrangements and t(14;19) in chronic lymphocytic leukemia and other B-cell malignancies: a molecular and cytogenetic study.

McKeithan TW, Takimoto GS, Ohno H, Bjorling VS, Morgan R, Hecht BK, Dubé I, Sandberg AA, Rowley JD.

Genes Chromosomes Cancer. 1997 Sep;20(1):64-72. Review.


BCL6 can repress transcription from the human immunodeficiency virus type I promoter/enhancer region.

Baron BW, Desai M, Baber LJ, Paras L, Zhang Q, Sadhu A, Duguay S, Nucifora G, McKeithan TW, Zeleznik-Le N.

Genes Chromosomes Cancer. 1997 May;19(1):14-21.


CpG-rich sequences close to the site of duplication within the human IGH constant region.

Sadhu A, Shen ML, Hackbarth M, Hume E, McKeithan TW.

Immunogenetics. 1997;45(6):365-70.


Complete lymphoid chimerism and chronic graft-versus-host disease in an infant recipient of a hepatic allograft from an HLA-homozygous parental living donor.

Whitington PF, Rubin CM, Alonso EM, McKeithan TW, Anastasi J, Hart J, Thistlethwaite JR.

Transplantation. 1996 Nov 27;62(10):1516-9.


Direct cloning of DNA sequences from the common fragile site region at chromosome band 3p14.2.

Rassool FV, Le Beau MM, Shen ML, Neilly ME, Espinosa R 3rd, Ong ST, Boldog F, Drabkin H, McCarroll R, McKeithan TW.

Genomics. 1996 Jul 1;35(1):109-17.


Resolution of Helicobacter pylori-associated gastric lymphoproliferative disease in a child.

Blecker U, McKeithan TW, Hart J, Kirschner BS.

Gastroenterology. 1995 Sep;109(3):973-7.


Kinetic proofreading in T-cell receptor signal transduction.

McKeithan TW.

Proc Natl Acad Sci U S A. 1995 May 23;92(11):5042-6.

Supplemental Content

Loading ...
Support Center