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Aberrant FGFR Tyrosine Kinase Signaling Enhances the Warburg Effect by Reprogramming LDH Isoform Expression and Activity in Prostate Cancer.

Liu J, Chen G, Liu Z, Liu S, Cai Z, You P, Ke Y, Lai L, Huang Y, Gao H, Zhao L, Pelicano H, Huang P, McKeehan WL, Wu CL, Wang C, Zhong W, Wang F.

Cancer Res. 2018 Aug 15;78(16):4459-4470. doi: 10.1158/0008-5472.CAN-17-3226. Epub 2018 Jun 11.


A tribute to Dr. Gordon Hisashi Sato (December 24, 1927-March 31, 2017).

Sato JD, Okamoto T, Barnes D, Hayashi J, Serrero G, McKeehan WL.

In Vitro Cell Dev Biol Anim. 2018 Mar;54(3):177-193. doi: 10.1007/s11626-018-0230-1. Epub 2018 Feb 12.


Correction: Novel Role of NOX in Supporting Aerobic Glycolysis in Cancer Cells with Mitochondrial Dysfunction and as a Potential Target for Cancer Therapy.

Lu W, Hu Y, Chen G, Chen Z, Zhang H, Wang F, Feng L, Pelicano H, Wang H, Keating MJ, Liu J, McKeehan W, Wang H, Luo Y, Huang P.

PLoS Biol. 2017 Dec 11;15(12):e1002616. doi: 10.1371/journal.pbio.1002616. eCollection 2017 Dec.


Fibroblast growth factors, old kids on the new block.

Li X, Wang C, Xiao J, McKeehan WL, Wang F.

Semin Cell Dev Biol. 2016 May;53:155-67. doi: 10.1016/j.semcdb.2015.12.014. Epub 2016 Jan 6. Review.


Defects in MAP1S-mediated autophagy cause reduction in mouse lifespans especially when fibronectin is overexpressed.

Li W, Zou J, Yue F, Song K, Chen Q, McKeehan WL, Wang F, Xu G, Huang H, Yi J, Liu L.

Aging Cell. 2016 Apr;15(2):370-9. doi: 10.1111/acel.12441. Epub 2016 Jan 10.


MAP1S Protein Regulates the Phagocytosis of Bacteria and Toll-like Receptor (TLR) Signaling.

Shi M, Zhang Y, Liu L, Zhang T, Han F, Cleveland J, Wang F, McKeehan WL, Li Y, Zhang D.

J Biol Chem. 2016 Jan 15;291(3):1243-50. doi: 10.1074/jbc.M115.687376. Epub 2015 Nov 12.


Blocking the association of HDAC4 with MAP1S accelerates autophagy clearance of mutant Huntingtin.

Yue F, Li W, Zou J, Chen Q, Xu G, Huang H, Xu Z, Zhang S, Gallinari P, Wang F, McKeehan WL, Liu L.

Aging (Albany NY). 2015 Oct;7(10):839-53.


Overexpression of FGF9 in prostate epithelial cells augments reactive stroma formation and promotes prostate cancer progression.

Huang Y, Jin C, Hamana T, Liu J, Wang C, An L, McKeehan WL, Wang F.

Int J Biol Sci. 2015 Jun 11;11(8):948-60. doi: 10.7150/ijbs.12468. eCollection 2015.


Hyperactivated FRS2α-mediated signaling in prostate cancer cells promotes tumor angiogenesis and predicts poor clinical outcome of patients.

Liu J, You P, Chen G, Fu X, Zeng X, Wang C, Huang Y, An L, Wan X, Navone N, Wu CL, McKeehan WL, Zhang Z, Zhong W, Wang F.

Oncogene. 2016 Apr 7;35(14):1750-9. doi: 10.1038/onc.2015.239. Epub 2015 Jun 22.


Prostate Sphere-forming Stem Cells Are Derived from the P63-expressing Basal Compartment.

Huang Y, Hamana T, Liu J, Wang C, An L, You P, Chang JY, Xu J, McKeehan WL, Wang F.

J Biol Chem. 2015 Jul 17;290(29):17745-52. doi: 10.1074/jbc.M115.661033. Epub 2015 Jun 1.


Type 2 Fibroblast Growth Factor Receptor Signaling Preserves Stemness and Prevents Differentiation of Prostate Stem Cells from the Basal Compartment.

Huang Y, Hamana T, Liu J, Wang C, An L, You P, Chang JY, Xu J, Jin C, Zhang Z, McKeehan WL, Wang F.

J Biol Chem. 2015 Jul 17;290(29):17753-61. doi: 10.1074/jbc.M115.661066. Epub 2015 Jun 1.


Prostate cancer cell-stromal cell crosstalk via FGFR1 mediates antitumor activity of dovitinib in bone metastases.

Wan X, Corn PG, Yang J, Palanisamy N, Starbuck MW, Efstathiou E, Li Ning Tapia EM, Zurita AJ, Aparicio A, Ravoori MK, Vazquez ES, Robinson DR, Wu YM, Cao X, Iyer MK, McKeehan W, Kundra V, Wang F, Troncoso P, Chinnaiyan AM, Logothetis CJ, Navone NM.

Sci Transl Med. 2014 Sep 3;6(252):252ra122. doi: 10.1126/scitranslmed.3009332. Erratum in: Sci Transl Med. 2015 May 13;7(287):287er3. Tapia, Elsa M Li-Ning [corrected to Li Ning Tapia, Elsa M].


Hepatocyte FRS2α is essential for the endocrine fibroblast growth factor to limit the amplitude of bile acid production induced by prandial activity.

Wang C, Yang C, Chang JY, You P, Li Y, Jin C, Luo Y, Li X, McKeehan WL, Wang F.

Curr Mol Med. 2014;14(6):703-711.


Effects of obesity on transcriptomic changes and cancer hallmarks in estrogen receptor-positive breast cancer.

Fuentes-Mattei E, Velazquez-Torres G, Phan L, Zhang F, Chou PC, Shin JH, Choi HH, Chen JS, Zhao R, Chen J, Gully C, Carlock C, Qi Y, Zhang Y, Wu Y, Esteva FJ, Luo Y, McKeehan WL, Ensor J, Hortobagyi GN, Pusztai L, Fraser Symmans W, Lee MH, Yeung SC.

J Natl Cancer Inst. 2014 Jun 23;106(7). pii: dju158. doi: 10.1093/jnci/dju158. Print 2014 Jul.


Restoration of fibroblast growth factor receptor 2IIIb enhances the chemosensitivity of human prostate cancer cells.

Shoji K, Teishima J, Hayashi T, Ohara S, Mckeehan WL, Matsubara A.

Oncol Rep. 2014 Jul;32(1):65-70. doi: 10.3892/or.2014.3200. Epub 2014 May 20.


Stressed Liver and Muscle Call on Adipocytes with FGF21.

Luo Y, McKeehan WL.

Front Endocrinol (Lausanne). 2013 Dec 18;4:194. doi: 10.3389/fendo.2013.00194. Review.


Deficiency of metabolic regulator FGFR4 delays breast cancer progression through systemic and microenvironmental metabolic alterations.

Luo Y, Yang C, Ye M, Jin C, Abbruzzese JL, Lee MH, Yeung SC, McKeehan WL.

Cancer Metab. 2013 Nov 25;1(1):21. doi: 10.1186/2049-3002-1-21.


FXR-induced secretion of FGF15/19 inhibits CYP27 expression in cholangiocytes through p38 kinase pathway.

Jung D, York JP, Wang L, Yang C, Zhang A, Francis HL, Webb P, McKeehan WL, Alpini G, Lesage GD, Moore DD, Xia X.

Pflugers Arch. 2014 May;466(5):1011-9. doi: 10.1007/s00424-013-1364-3. Epub 2013 Sep 26.


Targeting fibroblast growth factor pathways in prostate cancer.

Corn PG, Wang F, McKeehan WL, Navone N.

Clin Cancer Res. 2013 Nov 1;19(21):5856-66. doi: 10.1158/1078-0432.CCR-13-1550. Epub 2013 Sep 19. Review.


Fibroblast growth factor signaling is essential for self-renewal of dental epithelial stem cells.

Chang JY, Wang C, Liu J, Huang Y, Jin C, Yang C, Hai B, Liu F, D'Souza RN, McKeehan WL, Wang F.

J Biol Chem. 2013 Oct 4;288(40):28952-61. doi: 10.1074/jbc.M113.506873. Epub 2013 Aug 26.


Self-renewal and multilineage differentiation of mouse dental epithelial stem cells.

Chang JY, Wang C, Jin C, Yang C, Huang Y, Liu J, McKeehan WL, D'Souza RN, Wang F.

Stem Cell Res. 2013 Nov;11(3):990-1002. doi: 10.1016/j.scr.2013.06.008. Epub 2013 Jul 1.


Type 1 fibroblast growth factor receptor in cranial neural crest cell-derived mesenchyme is required for palatogenesis.

Wang C, Chang JY, Yang C, Huang Y, Liu J, You P, McKeehan WL, Wang F, Li X.

J Biol Chem. 2013 Jul 26;288(30):22174-83. doi: 10.1074/jbc.M113.463620. Epub 2013 Jun 10.


Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress.

Yang C, Lu W, Lin T, You P, Ye M, Huang Y, Jiang X, Wang C, Wang F, Lee MH, Yeung SC, Johnson RL, Wei C, Tsai RY, Frazier ML, McKeehan WL, Luo Y.

BMC Gastroenterol. 2013 Apr 17;13:67. doi: 10.1186/1471-230X-13-67.


Treating diabetes and obesity with an FGF21-mimetic antibody activating the βKlotho/FGFR1c receptor complex.

Foltz IN, Hu S, King C, Wu X, Yang C, Wang W, Weiszmann J, Stevens J, Chen JS, Nuanmanee N, Gupte J, Komorowski R, Sekirov L, Hager T, Arora T, Ge H, Baribault H, Wang F, Sheng J, Karow M, Wang M, Luo Y, McKeehan W, Wang Z, Véniant MM, Li Y.

Sci Transl Med. 2012 Nov 28;4(162):162ra153. doi: 10.1126/scitranslmed.3004690.


Control of lipid metabolism by adipocyte FGFR1-mediated adipohepatic communication during hepatic stress.

Yang C, Wang C, Ye M, Jin C, He W, Wang F, McKeehan WL, Luo Y.

Nutr Metab (Lond). 2012 Oct 30;9(1):94. doi: 10.1186/1743-7075-9-94.


Distinct roles for fibroblast growth factor signaling in cerebellar development and medulloblastoma.

Emmenegger BA, Hwang EI, Moore C, Markant SL, Brun SN, Dutton JW, Read TA, Fogarty MP, Singh AR, Durden DL, Yang C, McKeehan WL, Wechsler-Reya RJ.

Oncogene. 2013 Aug 29;32(35):4181-8. doi: 10.1038/onc.2012.440. Epub 2012 Oct 8.


Structural basis of heparan sulfate-specific degradation by heparinase III.

Dong W, Lu W, McKeehan WL, Luo Y, Ye S.

Protein Cell. 2012 Dec;3(12):950-61. doi: 10.1007/s13238-012-2056-z. Epub 2012 Jul 21.


Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy.

Lu W, Hu Y, Chen G, Chen Z, Zhang H, Wang F, Feng L, Pelicano H, Wang H, Keating MJ, Liu J, McKeehan W, Wang H, Luo Y, Huang P.

PLoS Biol. 2012;10(5):e1001326. doi: 10.1371/journal.pbio.1001326. Epub 2012 May 8. Erratum in: PLoS Biol. 2017 Dec 11;15(12 ):e1002616.


A tribute to Richard G. Ham (1932-2011).

McKeehan WL.

In Vitro Cell Dev Biol Anim. 2012 May;48(5):259-70. doi: 10.1007/s11626-012-9509-9. Epub 2012 May 12. No abstract available.


Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB.

Yang C, Jin C, Li X, Wang F, McKeehan WL, Luo Y.

PLoS One. 2012;7(3):e33870. doi: 10.1371/journal.pone.0033870. Epub 2012 Mar 19.


The fibroblast growth factor signaling axis controls cardiac stem cell differentiation through regulating autophagy.

Zhang J, Liu J, Liu L, McKeehan WL, Wang F.

Autophagy. 2012 Apr;8(4):690-1. doi: 10.4161/auto.19290. Epub 2012 Apr 1.


MAP1S enhances autophagy to suppress tumorigenesis.

Liu L, McKeehan WL, Wang F, Xie R.

Autophagy. 2012 Feb 1;8(2):278-80. doi: 10.4161/auto.8.2.18939. Epub 2012 Feb 1.


Mechanism of fibrotic cardiomyopathy in mice expressing truncated Rho-associated coiled-coil protein kinase 1.

Yang X, Li Q, Lin X, Ma Y, Yue X, Tao Z, Wang F, Mckeehan WL, Wei L, Schwartz RJ, Chang J.

FASEB J. 2012 May;26(5):2105-16. doi: 10.1096/fj.11-201319. Epub 2012 Jan 25.


FRS2α-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity.

Zhang J, Liu J, Huang Y, Chang JY, Liu L, McKeehan WL, Martin JF, Wang F.

Circ Res. 2012 Feb 17;110(4):e29-39. doi: 10.1161/CIRCRESAHA.111.255950. Epub 2011 Dec 29.


Autophagy enhanced by microtubule- and mitochondrion-associated MAP1S suppresses genome instability and hepatocarcinogenesis.

Xie R, Wang F, McKeehan WL, Liu L.

Cancer Res. 2011 Dec 15;71(24):7537-46. doi: 10.1158/0008-5472.CAN-11-2170. Epub 2011 Oct 28.


FRS2α is essential for the fibroblast growth factor to regulate the mTOR pathway and autophagy in mouse embryonic fibroblasts.

Lin X, Zhang Y, Liu L, McKeehan WL, Shen Y, Song S, Wang F.

Int J Biol Sci. 2011;7(8):1114-21. Epub 2011 Sep 15.


FGFR3-expressing smooth muscle-like stromal cells differentiate in response to FGFR2IIIb-expressing prostate tumor cells and delay tumor progression.

Jin C, Yang C, Wu X, Wang F, McKeehan WL.

In Vitro Cell Dev Biol Anim. 2011 Aug;47(7):500-5. doi: 10.1007/s11626-011-9432-5. Epub 2011 Jun 21.


FGFR1 abrogates inhibitory effect of androgen receptor concurrent with induction of androgen-receptor variants in androgen receptor-negative prostate tumor epithelial cells.

Kobayashi M, Huang Y, Jin C, Luo Y, Okamoto T, Wang F, McKeehan WL.

Prostate. 2011 Nov;71(15):1691-700. doi: 10.1002/pros.21386. Epub 2011 Mar 28.


Microtubule-associated protein 1S (MAP1S) bridges autophagic components with microtubules and mitochondria to affect autophagosomal biogenesis and degradation.

Xie R, Nguyen S, McKeehan K, Wang F, McKeehan WL, Liu L.

J Biol Chem. 2011 Mar 25;286(12):10367-77. doi: 10.1074/jbc.M110.206532. Epub 2011 Jan 24.


Acetylated microtubules are required for fusion of autophagosomes with lysosomes.

Xie R, Nguyen S, McKeehan WL, Liu L.

BMC Cell Biol. 2010 Nov 22;11:89. doi: 10.1186/1471-2121-11-89.


Metabolic regulator betaKlotho interacts with fibroblast growth factor receptor 4 (FGFR4) to induce apoptosis and inhibit tumor cell proliferation.

Luo Y, Yang C, Lu W, Xie R, Jin C, Huang P, Wang F, McKeehan WL.

J Biol Chem. 2010 Sep 24;285(39):30069-78. doi: 10.1074/jbc.M110.148288. Epub 2010 Jul 23.


Tissue culture: the unlimited potential.

Sato GH, Sato JD, Okamoto T, McKeehan WL, Barnes DW.

In Vitro Cell Dev Biol Anim. 2010 Jul;46(7):590-4. doi: 10.1007/s11626-010-9315-1. Epub 2010 May 29.


Tbx1 regulates Vegfr3 and is required for lymphatic vessel development.

Chen L, Mupo A, Huynh T, Cioffi S, Woods M, Jin C, McKeehan W, Thompson-Snipes L, Baldini A, Illingworth E.

J Cell Biol. 2010 May 3;189(3):417-24. doi: 10.1083/jcb.200912037.


Dual function microtubule- and mitochondria-associated proteins mediate mitotic cell death.

Liu L, Xie R, Yang C, McKeehan WL.

Cell Oncol. 2009;31(5):393-405. doi: 10.3233/CLO-2009-0484.


Robust autophagy/mitophagy persists during mitosis.

Liu L, Xie R, Nguyen S, Ye M, McKeehan WL.

Cell Cycle. 2009 May 15;8(10):1616-20. Epub 2009 May 27.


Novel phosphotyrosine targets of FGFR2IIIb signaling.

Luo Y, Yang C, Jin C, Xie R, Wang F, McKeehan WL.

Cell Signal. 2009 Sep;21(9):1370-8. doi: 10.1016/j.cellsig.2009.04.004. Epub 2009 May 3.


Resident hepatocyte fibroblast growth factor receptor 4 limits hepatocarcinogenesis.

Huang X, Yang C, Jin C, Luo Y, Wang F, McKeehan WL.

Mol Carcinog. 2009 Jun;48(6):553-62. doi: 10.1002/mc.20494.


Restoration of FGF receptor type 2 enhances radiosensitivity of hormone-refractory human prostate carcinoma PC-3 cells.

Matsubara A, Teishima J, Mirkhat S, Yasumoto H, Mochizuki H, Seki M, Mutaguchi K, Mckeehan WL, Usui T.

Anticancer Res. 2008 Jul-Aug;28(4B):2141-6.


Role of epithelial cell fibroblast growth factor receptor substrate 2alpha in prostate development, regeneration and tumorigenesis.

Zhang Y, Zhang J, Lin Y, Lan Y, Lin C, Xuan JW, Shen MM, McKeehan WL, Greenberg NM, Wang F.

Development. 2008 Feb;135(4):775-84. doi: 10.1242/dev.009910. Epub 2008 Jan 9.


FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver.

Huang X, Yang C, Luo Y, Jin C, Wang F, McKeehan WL.

Diabetes. 2007 Oct;56(10):2501-10. Epub 2007 Jul 30.

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