Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 42

1.

Evaluation of optimal biopsy location for assessment of histological activity, transcriptomic and immunohistochemical analyses in patients with active Crohn's disease.

Novak G, Stevens T, Van Viegen T, Bossuyt P, Štabuc B, Jeyarajah J, Zou G, Gaemers IC, McKee TD, Fu F, Shackelton LM, Khanna R, van den Brink GR, Sandborn WJ, Feagan BG, Pai RK, Jairath V, Vande Casteele N, D'Haens G.

Aliment Pharmacol Ther. 2019 Jun;49(11):1401-1409. doi: 10.1111/apt.15250. Epub 2019 Apr 15.

PMID:
30983024
2.

CoREST Complex-Selective Histone Deacetylase Inhibitors Show Prosynaptic Effects and an Improved Safety Profile To Enable Treatment of Synaptopathies.

Fuller NO, Pirone A, Lynch BA, Hewitt MC, Quinton MS, McKee TD, Ivarsson M.

ACS Chem Neurosci. 2019 Mar 20;10(3):1729-1743. doi: 10.1021/acschemneuro.8b00620. Epub 2018 Dec 13.

3.

Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma.

Jamieson SM, Tsai P, Kondratyev MK, Budhani P, Liu A, Senzer NN, Chiorean EG, Jalal SI, Nemunaitis JJ, Kee D, Shome A, Wong WW, Li D, Poonawala-Lohani N, Kakadia PM, Knowlton NS, Lynch CR, Hong CR, Lee TW, Grénman RA, Caporiccio L, McKee TD, Zaidi M, Butt S, Macann AM, McIvor NP, Chaplin JM, Hicks KO, Bohlander SK, Wouters BG, Hart CP, Print CG, Wilson WR, Curran MA, Hunter FW.

JCI Insight. 2018 Aug 23;3(16). pii: 122204. doi: 10.1172/jci.insight.122204. eCollection 2018 Aug 23.

4.

Radiation and Heat Improve the Delivery and Efficacy of Nanotherapeutics by Modulating Intratumoral Fluid Dynamics.

Stapleton S, Dunne M, Milosevic M, Tran CW, Gold MJ, Vedadi A, Mckee TD, Ohashi PS, Allen C, Jaffray DA.

ACS Nano. 2018 Aug 28;12(8):7583-7600. doi: 10.1021/acsnano.7b06301. Epub 2018 Jul 20.

PMID:
30004666
5.

Nanoparticle Formulation Derived from Carboxymethyl Cellulose, Polyethylene Glycol, and Cabazitaxel for Chemotherapy Delivery to the Brain.

Bteich J, Ernsting MJ, Mohammed M, Kiyota T, McKee TD, Trikha M, Lowman HB, Sokoll KK.

Bioconjug Chem. 2018 Jun 20;29(6):2009-2020. doi: 10.1021/acs.bioconjchem.8b00220. Epub 2018 May 23.

PMID:
29734804
6.

Role of chemokines in metastatic niche: new insights along with a diagnostic and prognostic approach.

Rezaeeyan H, Shirzad R, McKee TD, Saki N.

APMIS. 2018 May;126(5):359-370. doi: 10.1111/apm.12818. Epub 2018 Apr 20. Review.

PMID:
29676815
7.

The expression of CD markers in solid tumors: Significance in metastasis and prognostic value.

Rezaeeyan H, Shahrabi S, McKee TD, Saki N.

Histol Histopathol. 2018 Oct;33(10):1005-1012. doi: 10.14670/HH-11-981. Epub 2018 Mar 6. Review.

PMID:
29508889
8.

Computationally-Guided Development of a Stromal Inflammation Histologic Biomarker in Lung Squamous Cell Carcinoma.

Xia D, Casanova R, Machiraju D, McKee TD, Weder W, Beck AH, Soltermann A.

Sci Rep. 2018 Mar 2;8(1):3941. doi: 10.1038/s41598-018-22254-4.

9.

Pentraxin 3 deficiency enhances features of chronic rejection in a mouse orthotopic lung transplantation model.

Yoshida M, Oishi H, Martinu T, Hwang DM, Takizawa H, Sugihara J, McKee TD, Bai X, Guana Z, Lua C, Cho HR, Juvet S, Cypel M, Keshavjee S, Liu M.

Oncotarget. 2018 Jan 3;9(9):8489-8501. doi: 10.18632/oncotarget.23902. eCollection 2018 Feb 2.

10.

Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer.

Haynes J, McKee TD, Haller A, Wang Y, Leung C, Gendoo DMA, Lima-Fernandes E, Kreso A, Wolman R, Szentgyorgyi E, Vines DC, Haibe-Kains B, Wouters BG, Metser U, Jaffray DA, Smith M, O'Brien CA.

Clin Cancer Res. 2018 May 1;24(9):2116-2127. doi: 10.1158/1078-0432.CCR-17-1715. Epub 2018 Feb 23.

11.

The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer.

Ding M, Van der Kwast TH, Vellanki RN, Foltz WD, McKee TD, Sonenberg N, Pandolfi PP, Koritzinsky M, Wouters BG.

Mol Cancer Res. 2018 Apr;16(4):682-695. doi: 10.1158/1541-7786.MCR-17-0696. Epub 2018 Feb 16.

12.

Variations in the Abundance of Lipid Biomarker Ions in Mass Spectrometry Images Correlate to Tissue Density.

Bilkey J, Tata A, McKee TD, Porcari AM, Bluemke E, Woolman M, Ventura M, Eberlin MN, Zarrine-Afsar A.

Anal Chem. 2016 Dec 20;88(24):12099-12107. doi: 10.1021/acs.analchem.6b02767. Epub 2016 Nov 28.

PMID:
28193010
13.

Isotopologous Organotellurium Probes Reveal Dynamic Hypoxia In Vivo with Cellular Resolution.

Edgar LJ, Vellanki RN, McKee TD, Hedley D, Wouters BG, Nitz M.

Angew Chem Int Ed Engl. 2016 Oct 10;55(42):13159-13163. doi: 10.1002/anie.201607483.

PMID:
27709819
14.

Identification of RSK and TTK as Modulators of Blood Vessel Morphogenesis Using an Embryonic Stem Cell-Based Vascular Differentiation Assay.

Hammoud L, Adams JR, Loch AJ, Marcellus RC, Uehling DE, Aman A, Fladd C, McKee TD, Jo CEB, Al-Awar R, Egan SE, Rossant J.

Stem Cell Reports. 2016 Oct 11;7(4):787-801. doi: 10.1016/j.stemcr.2016.08.004. Epub 2016 Sep 8.

15.

RANKL blockade prevents and treats aggressive osteosarcomas.

Chen Y, Di Grappa MA, Molyneux SD, McKee TD, Waterhouse P, Penninger JM, Khokha R.

Sci Transl Med. 2015 Dec 9;7(317):317ra197. doi: 10.1126/scitranslmed.aad0295. Erratum in: Sci Transl Med. 2016 Feb 3;8(324):324er2.

PMID:
26659571
16.

Natural Product and Natural Product-Derived Gamma Secretase Modulators from Actaea Racemosa Extracts.

Findeis MA, Schroeder FC, Creaser SP, McKee TD, Xia W.

Medicines (Basel). 2015 Jun 30;2(3):127-140. doi: 10.3390/medicines2030127. Review.

17.

A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland.

Shiah YJ, Tharmapalan P, Casey AE, Joshi PA, McKee TD, Jackson HW, Beristain AG, Chan-Seng-Yue MA, Bader GD, Lydon JP, Waterhouse PD, Boutros PC, Khokha R.

Stem Cell Reports. 2015 Mar 10;4(3):313-322. doi: 10.1016/j.stemcr.2015.01.011. Epub 2015 Feb 19.

18.

Minimization of drug-drug interaction risk and candidate selection in a natural product-based class of gamma-secretase modulators.

Hubbs JL, Fuller NO, Austin WF, Shen R, Ma J, Gong Z, Li J, McKee TD, Loureiro RM, Tate B, Dumin JA, Ives J, Bronk BS.

Bioorg Med Chem Lett. 2015 Apr 1;25(7):1621-6. doi: 10.1016/j.bmcl.2015.01.051. Epub 2015 Feb 10.

PMID:
25708617
19.

Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR.

Belmont PJ, Jiang P, McKee TD, Xie T, Isaacson J, Baryla NE, Roper J, Sinnamon MJ, Lee NV, Kan JL, Guicherit O, Wouters BG, O'Brien CA, Shields D, Olson P, VanArsdale T, Weinrich SL, Rejto P, Christensen JG, Fantin VR, Hung KE, Martin ES.

Sci Signal. 2014 Nov 11;7(351):ra107. doi: 10.1126/scisignal.2005516.

PMID:
25389372
20.

Reprogramming metabolism with metformin improves tumor oxygenation and radiotherapy response.

Zannella VE, Dal Pra A, Muaddi H, McKee TD, Stapleton S, Sykes J, Glicksman R, Chaib S, Zamiara P, Milosevic M, Wouters BG, Bristow RG, Koritzinsky M.

Clin Cancer Res. 2013 Dec 15;19(24):6741-50. doi: 10.1158/1078-0432.CCR-13-1787. Epub 2013 Oct 18.

21.

Efficacy of SPI-1865, a novel gamma-secretase modulator, in multiple rodent models.

Loureiro RM, Dumin JA, McKee TD, Austin WF, Fuller NO, Hubbs JL, Shen R, Jonker J, Ives J, Bronk BS, Tate B.

Alzheimers Res Ther. 2013 Apr 18;5(2):19. doi: 10.1186/alzrt173. eCollection 2013.

22.

Modulation of gamma-secretase for the treatment of Alzheimer's disease.

Tate B, McKee TD, Loureiro RM, Dumin JA, Xia W, Pojasek K, Austin WF, Fuller NO, Hubbs JL, Shen R, Jonker J, Ives J, Bronk BS.

Int J Alzheimers Dis. 2012;2012:210756. doi: 10.1155/2012/210756. Epub 2012 Dec 19.

23.

An improved cell-based method for determining the γ-secretase enzyme activity against both Notch and APP substrates.

McKee TD, Loureiro RM, Dumin JA, Zarayskiy V, Tate B.

J Neurosci Methods. 2013 Feb 15;213(1):14-21. doi: 10.1016/j.jneumeth.2012.11.011. Epub 2012 Dec 7.

PMID:
23219895
24.

Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa.

Findeis MA, Schroeder F, McKee TD, Yager D, Fraering PC, Creaser SP, Austin WF, Clardy J, Wang R, Selkoe D, Eckman CB.

ACS Chem Neurosci. 2012 Nov 21;3(11):941-51. doi: 10.1021/cn3000857. Epub 2012 Aug 28.

25.

Initial Optimization of a New Series of γ-Secretase Modulators Derived from a Triterpene Glycoside.

Fuller NO, Hubbs JL, Austin WF, Creaser SP, McKee TD, Loureiro RM, Tate B, Xia W, Ives JL, Findeis MA, Bronk BS.

ACS Med Chem Lett. 2012 Aug 29;3(11):908-13. doi: 10.1021/ml300256p. eCollection 2012 Nov 8.

26.

Optimization of a natural product-based class of γ-secretase modulators.

Hubbs JL, Fuller NO, Austin WF, Shen R, Creaser SP, McKee TD, Loureiro RM, Tate B, Xia W, Ives J, Bronk BS.

J Med Chem. 2012 Nov 8;55(21):9270-82. doi: 10.1021/jm300976b. Epub 2012 Oct 15.

PMID:
23030762
27.

QUANTIFYING NANOPARTICLE TRANSPORT IN VIVO USING HYPERSPECTRAL IMAGING WITH A DORSAL SKINFOLD WINDOW CHAMBER.

McKee TD, Chen J, Corbin I, Zheng G, Khokha R.

J Innov Opt Health Sci. 2012 Oct;5(4). pii: 1250023. doi: 10.1142/S179354581250023X. Epub 2012 Nov 26.

28.

Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice.

Molyneux SD, Di Grappa MA, Beristain AG, McKee TD, Wai DH, Paderova J, Kashyap M, Hu P, Maiuri T, Narala SR, Stambolic V, Squire J, Penninger J, Sanchez O, Triche TJ, Wood GA, Kirschner LS, Khokha R.

J Clin Invest. 2010 Sep;120(9):3310-25. doi: 10.1172/JCI42391. Epub 2010 Aug 9.

29.

Mice with tissue inhibitor of metalloproteinases 4 (Timp4) deletion succumb to induced myocardial infarction but not to cardiac pressure overload.

Koskivirta I, Kassiri Z, Rahkonen O, Kiviranta R, Oudit GY, McKee TD, Kytö V, Saraste A, Jokinen E, Liu PP, Vuorio E, Khokha R.

J Biol Chem. 2010 Aug 6;285(32):24487-93. doi: 10.1074/jbc.M110.136820. Epub 2010 Jun 1.

30.

In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts.

Perentes JY, McKee TD, Ley CD, Mathiew H, Dawson M, Padera TP, Munn LL, Jain RK, Boucher Y.

Nat Methods. 2009 Feb;6(2):143-5. doi: 10.1038/nmeth.1295. Epub 2009 Jan 18.

31.

Engineering a "steric doorstop" in rhodopsin: converting an inverse agonist to an agonist.

McKee TD, Lewis MR, Kono M.

Biochemistry. 2007 Oct 30;46(43):12248-52. Epub 2007 Oct 6.

PMID:
17918963
32.

Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector.

McKee TD, Grandi P, Mok W, Alexandrakis G, Insin N, Zimmer JP, Bawendi MG, Boucher Y, Breakefield XO, Jain RK.

Cancer Res. 2006 Mar 1;66(5):2509-13.

34.

Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors.

Alexandrakis G, Brown EB, Tong RT, McKee TD, Campbell RB, Boucher Y, Jain RK.

Nat Med. 2004 Feb;10(2):203-7. Epub 2004 Jan 11.

35.

Irradiation reduces interstitial fluid transport and increases the collagen content in tumors.

Znati CA, Rosenstein M, McKee TD, Brown E, Turner D, Bloomer WD, Watkins S, Jain RK, Boucher Y.

Clin Cancer Res. 2003 Nov 15;9(15):5508-13.

36.
37.

Diffusion and convection in collagen gels: implications for transport in the tumor interstitium.

Ramanujan S, Pluen A, McKee TD, Brown EB, Boucher Y, Jain RK.

Biophys J. 2002 Sep;83(3):1650-60.

38.

Solid stress facilitates spheroid formation: potential involvement of hyaluronan.

Koike C, McKee TD, Pluen A, Ramanujan S, Burton K, Munn LL, Boucher Y, Jain RK.

Br J Cancer. 2002 Mar 18;86(6):947-53.

39.

Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors.

Pluen A, Boucher Y, Ramanujan S, McKee TD, Gohongi T, di Tomaso E, Brown EB, Izumi Y, Campbell RB, Berk DA, Jain RK.

Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4628-33. Epub 2001 Mar 27.

40.

A general method for mapping tertiary contacts between amino acid residues in membrane-embedded proteins.

Yu H, Kono M, McKee TD, Oprian DD.

Biochemistry. 1995 Nov 21;34(46):14963-9.

PMID:
7578109
41.

Targeted delivery of DNA using YEE(GalNAcAH)3, a synthetic glycopeptide ligand for the asialoglycoprotein receptor.

Merwin JR, Noell GS, Thomas WL, Chiou HC, DeRome ME, McKee TD, Spitalny GL, Findeis MA.

Bioconjug Chem. 1994 Nov-Dec;5(6):612-20.

PMID:
7873664
42.

Preparation of asialoorosomucoid-polylysine conjugates.

McKee TD, DeRome ME, Wu GY, Findeis MA.

Bioconjug Chem. 1994 Jul-Aug;5(4):306-11.

PMID:
7948096

Supplemental Content

Loading ...
Support Center