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Items: 1 to 50 of 167


A Role for Sox2 in the Adult Cerebellum.

Mandalos NP, Karampelas I, Saridaki M, McKay RDG, Cohen ML, Remboutsika E.

J Stem Cell Res Ther. 2018;8(7). pii: 433. doi: 10.4172/2157-7633.1000433. Epub 2018 Jul 27.


Novel inhibitors of As(III) S-adenosylmethionine methyltransferase (AS3MT) identified by virtual screening.

Bürli RW, Wei H, Ernst G, Mariga A, Hardern IM, Herlihy K, Cross AJ, Wesolowski SS, Chen H, McKay RDG, Weinberger DR, Brandon NJ, Barrow JC.

Bioorg Med Chem Lett. 2018 Oct 15;28(19):3231-3235. doi: 10.1016/j.bmcl.2018.08.012. Epub 2018 Aug 14.


Pluripotent Stem Cell Platforms for Drug Discovery.

Chen KG, Mallon BS, Park K, Robey PG, McKay RDG, Gottesman MM, Zheng W.

Trends Mol Med. 2018 Sep;24(9):805-820. doi: 10.1016/j.molmed.2018.06.009. Epub 2018 Jul 11. Review.


Concise Review: Conceptualizing Paralogous Stem-Cell Niches and Unfolding Bone Marrow Progenitor Cell Identities.

Chen KG, Johnson KR, McKay RDG, Robey PG.

Stem Cells. 2018 Jan;36(1):11-21. doi: 10.1002/stem.2711. Epub 2017 Oct 12. Review.


PatternMarkers & GWCoGAPS for novel data-driven biomarkers via whole transcriptome NMF.

Stein-O'Brien GL, Carey JL, Lee WS, Considine M, Favorov AV, Flam E, Guo T, Li S, Marchionni L, Sherman T, Sivy S, Gaykalova DA, McKay RD, Ochs MF, Colantuoni C, Fertig EJ.

Bioinformatics. 2017 Jun 15;33(12):1892-1894. doi: 10.1093/bioinformatics/btx058.


Erratum to: Practical impacts of genomic data "cleaning" on biological discovery using surrogate variable analysis.

Jaffe AE, Hyde T, Kleinman J, Weinberger DR, Chenoweth JG, McKay RD, Leek JT, Colantuoni C.

BMC Bioinformatics. 2016 Aug 10;17:302. doi: 10.1186/s12859-016-1152-0. No abstract available.


A "Hit and Run" Approach to Inducible Direct Reprogramming of Astrocytes to Neural Stem Cells.

Poulou M, Mandalos NP, Karnavas T, Saridaki M, McKay RD, Remboutsika E.

Front Physiol. 2016 Apr 12;7:127. doi: 10.3389/fphys.2016.00127. eCollection 2016.


Strong Components of Epigenetic Memory in Cultured Human Fibroblasts Related to Site of Origin and Donor Age.

Ivanov NA, Tao R, Chenoweth JG, Brandtjen A, Mighdoll MI, Genova JD, McKay RD, Jia Y, Weinberger DR, Kleinman JE, Hyde TM, Jaffe AE.

PLoS Genet. 2016 Feb 25;12(2):e1005819. doi: 10.1371/journal.pgen.1005819. eCollection 2016 Feb.


Endocrine Pancreas Development and Regeneration: Noncanonical Ideas From Neural Stem Cell Biology.

Masjkur J, Poser SW, Nikolakopoulou P, Chrousos G, McKay RD, Bornstein SR, Jones PM, Androutsellis-Theotokis A.

Diabetes. 2016 Feb;65(2):314-30. doi: 10.2337/db15-1099.


STAT3-Ser/Hes3 Signaling: A New Molecular Component of the Neuroendocrine System?

Nikolakopoulou P, Poser SW, Masjkur J, Fernandez Rubin de Celis M, Toutouna L, Andoniadou CL, McKay RD, Chrousos G, Ehrhart-Bornstein M, Bornstein SR, Androutsellis-Theotokis A.

Horm Metab Res. 2016 Feb;48(2):77-82. doi: 10.1055/s-0041-111699. Epub 2016 Jan 19. Review.


Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders.

Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R.

Stem Cell Reports. 2015 Dec 8;5(6):933-945. doi: 10.1016/j.stemcr.2015.10.011. Epub 2015 Nov 21.


Practical impacts of genomic data "cleaning" on biological discovery using surrogate variable analysis.

Jaffe AE, Hyde T, Kleinman J, Weinbergern DR, Chenoweth JG, McKay RD, Leek JT, Colantuoni C.

BMC Bioinformatics. 2015 Nov 6;16:372. doi: 10.1186/s12859-015-0808-5. Erratum in: BMC Bioinformatics. 2016;17:302.


Concise Review: Reprogramming, Behind the Scenes: Noncanonical Neural Stem Cell Signaling Pathways Reveal New, Unseen Regulators of Tissue Plasticity With Therapeutic Implications.

Poser SW, Chenoweth JG, Colantuoni C, Masjkur J, Chrousos G, Bornstein SR, McKay RD, Androutsellis-Theotokis A.

Stem Cells Transl Med. 2015 Nov;4(11):1251-7. doi: 10.5966/sctm.2015-0105. Epub 2015 Sep 14. Review.


Epigenomic comparison reveals activation of "seed" enhancers during transition from naive to primed pluripotency.

Factor DC, Corradin O, Zentner GE, Saiakhova A, Song L, Chenoweth JG, McKay RD, Crawford GE, Scacheri PC, Tesar PJ.

Cell Stem Cell. 2014 Jun 5;14(6):854-63. doi: 10.1016/j.stem.2014.05.005.


Directed differentiation of human induced pluripotent stem cells toward bone and cartilage: in vitro versus in vivo assays.

Phillips MD, Kuznetsov SA, Cherman N, Park K, Chen KG, McClendon BN, Hamilton RS, McKay RD, Chenoweth JG, Mallon BS, Robey PG.

Stem Cells Transl Med. 2014 Jul;3(7):867-78. doi: 10.5966/sctm.2013-0154. Epub 2014 May 22.


Developmental insights from early mammalian embryos and core signaling pathways that influence human pluripotent cell growth and differentiation.

Chen KG, Mallon BS, Johnson KR, Hamilton RS, McKay RD, Robey PG.

Stem Cell Res. 2014 May;12(3):610-21. doi: 10.1016/j.scr.2014.02.002. Epub 2014 Feb 19. Review.


Speeding to pluripotency.

Chenoweth JG, McKay RD.

Cell. 2014 Feb 13;156(4):631-2. doi: 10.1016/j.cell.2014.01.046.


Human pluripotent stem cell culture: considerations for maintenance, expansion, and therapeutics.

Chen KG, Mallon BS, McKay RD, Robey PG.

Cell Stem Cell. 2014 Jan 2;14(1):13-26. doi: 10.1016/j.stem.2013.12.005. Review.


Neuronal activity-dependent STAT3 localization to nucleus is dependent on Tyr-705 and Ser-727 phosphorylation in rat hippocampal neurons.

Murase S, McKay RD.

Eur J Neurosci. 2014 Feb;39(4):557-65. doi: 10.1111/ejn.12412. Epub 2013 Nov 6.


FGF2 and insulin signaling converge to regulate cyclin D expression in multipotent neural stem cells.

Adepoju A, Micali N, Ogawa K, Hoeppner DJ, McKay RD.

Stem Cells. 2014 Mar;32(3):770-8. doi: 10.1002/stem.1575.


Atrophy of pyramidal neurons and increased stress-induced glutamate levels in CA3 following chronic suppression of adult neurogenesis.

Schloesser RJ, Jimenez DV, Hardy NF, Paredes D, Catlow BJ, Manji HK, McKay RD, Martinowich K.

Brain Struct Funct. 2014 May;219(3):1139-48. doi: 10.1007/s00429-013-0532-8. Epub 2013 Mar 13.


Hes3 regulates cell number in cultures from glioblastoma multiforme with stem cell characteristics.

Park DM, Jung J, Masjkur J, Makrogkikas S, Ebermann D, Saha S, Rogliano R, Paolillo N, Pacioni S, McKay RD, Poser S, Androutsellis-Theotokis A.

Sci Rep. 2013;3:1095. doi: 10.1038/srep01095. Epub 2013 Feb 5.


Fast, potent pharmacological expansion of endogenous hes3+/sox2+ cells in the adult mouse and rat hippocampus.

Pacioni S, Rueger MA, Nisticò G, Bornstein SR, Park DM, McKay RD, Androutsellis-Theotokis A.

PLoS One. 2012;7(12):e51630. doi: 10.1371/journal.pone.0051630. Epub 2012 Dec 10.


StemCellDB: the human pluripotent stem cell database at the National Institutes of Health.

Mallon BS, Chenoweth JG, Johnson KR, Hamilton RS, Tesar PJ, Yavatkar AS, Tyson LJ, Park K, Chen KG, Fann YC, McKay RD.

Stem Cell Res. 2013 Jan;10(1):57-66. doi: 10.1016/j.scr.2012.09.002. Epub 2012 Sep 26.


Loss of signal transducer and activator of transcription 3 (STAT3) signaling during elevated activity causes vulnerability in hippocampal neurons.

Murase S, Kim E, Lin L, Hoffman DA, McKay RD.

J Neurosci. 2012 Oct 31;32(44):15511-20. doi: 10.1523/JNEUROSCI.2940-12.2012.


Expression profiles of the nuclear receptors and their transcriptional coregulators during differentiation of neural stem cells.

Androutsellis-Theotokis A, Chrousos GP, McKay RD, DeCherney AH, Kino T.

Horm Metab Res. 2013 Feb;45(2):159-68. doi: 10.1055/s-0032-1321789. Epub 2012 Sep 18.


Non-colony type monolayer culture of human embryonic stem cells.

Chen KG, Mallon BS, Hamilton RS, Kozhich OA, Park K, Hoeppner DJ, Robey PG, McKay RD.

Stem Cell Res. 2012 Nov;9(3):237-48. doi: 10.1016/j.scr.2012.06.003. Epub 2012 Jun 28.


Sox2 acts through Sox21 to regulate transcription in pluripotent and differentiated cells.

Kuzmichev AN, Kim SK, D'Alessio AC, Chenoweth JG, Wittko IM, Campanati L, McKay RD.

Curr Biol. 2012 Sep 25;22(18):1705-10. doi: 10.1016/j.cub.2012.07.013. Epub 2012 Aug 16.


Regulation and expression of the ATP-binding cassette transporter ABCG2 in human embryonic stem cells.

Padmanabhan R, Chen KG, Gillet JP, Handley M, Mallon BS, Hamilton RS, Park K, Varma S, Mehaffey MG, Robey PG, McKay RD, Gottesman MM.

Stem Cells. 2012 Oct;30(10):2175-87. doi: 10.1002/stem.1195.


Matrix metalloproteinase-9 regulates survival of neurons in newborn hippocampus.

Murase S, McKay RD.

J Biol Chem. 2012 Apr 6;287(15):12184-94. doi: 10.1074/jbc.M111.297671. Epub 2012 Feb 20.


Direct and indirect contribution of human embryonic stem cell-derived hepatocyte-like cells to liver repair in mice.

Woo DH, Kim SK, Lim HJ, Heo J, Park HS, Kang GY, Kim SE, You HJ, Hoeppner DJ, Kim Y, Kwon H, Choi TH, Lee JH, Hong SH, Song KW, Ahn EK, Chenoweth JG, Tesar PJ, McKay RD, Kim JH.

Gastroenterology. 2012 Mar;142(3):602-11. doi: 10.1053/j.gastro.2011.11.030. Epub 2011 Dec 2.


Tuning DNA stability to achieve turnover in template for an enzymatic ligation reaction.

Kausar A, McKay RD, Lam J, Bhogal RS, Tang AY, Gibbs-Davis JM.

Angew Chem Int Ed Engl. 2011 Sep 12;50(38):8922-6. doi: 10.1002/anie.201102579. Epub 2011 Aug 17. No abstract available.


Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisions.

Lathia JD, Hitomi M, Gallagher J, Gadani SP, Adkins J, Vasanji A, Liu L, Eyler CE, Heddleston JM, Wu Q, Minhas S, Soeda A, Hoeppner DJ, Ravin R, McKay RD, McLendon RE, Corbeil D, Chenn A, Hjelmeland AB, Park DM, Rich JN.

Cell Death Dis. 2011 Sep 1;2:e200. doi: 10.1038/cddis.2011.80.


p53 controls neuronal death in the CA3 region of the newborn mouse hippocampus.

Murase S, Poser SW, Joseph J, McKay RD.

Eur J Neurosci. 2011 Aug;34(3):374-81. doi: 10.1111/j.1460-9568.2011.07758.x. Epub 2011 Jun 30.


In the newborn hippocampus, neurotrophin-dependent survival requires spontaneous activity and integrin signaling.

Murase S, Owens DF, McKay RD.

J Neurosci. 2011 May 25;31(21):7791-800. doi: 10.1523/JNEUROSCI.0202-11.2011.


Isolation of epiblast stem cells from preimplantation mouse embryos.

Najm FJ, Chenoweth JG, Anderson PD, Nadeau JH, Redline RW, McKay RD, Tesar PJ.

Cell Stem Cell. 2011 Mar 4;8(3):318-25. doi: 10.1016/j.stem.2011.01.016.


Cholera toxin regulates a signaling pathway critical for the expansion of neural stem cell cultures from the fetal and adult rodent brains.

Androutsellis-Theotokis A, Walbridge S, Park DM, Lonser RR, McKay RD.

PLoS One. 2010 May 26;5(5):e10841. doi: 10.1371/journal.pone.0010841.


Epiblast stem cells contribute new insight into pluripotency and gastrulation.

Chenoweth JG, McKay RD, Tesar PJ.

Dev Growth Differ. 2010 Apr;52(3):293-301. doi: 10.1111/j.1440-169X.2010.01171.x. Epub 2010 Mar 7. Review.


Human ES cell lines--introduction.

Andrews PW, Benvenisty N, Knowles BB, McKay RD, Oh SK, Pera MF, Rossant J, Stacey GN.

In Vitro Cell Dev Biol Anim. 2010 Apr;46(3-4):167-8. doi: 10.1007/s11626-010-9306-2. Epub 2010 Mar 7. No abstract available.


Angiogenic factors stimulate growth of adult neural stem cells.

Androutsellis-Theotokis A, Rueger MA, Park DM, Boyd JD, Padmanabhan R, Campanati L, Stewart CV, LeFranc Y, Plenz D, Walbridge S, Lonser RR, McKay RD.

PLoS One. 2010 Feb 26;5(2):e9414. doi: 10.1371/journal.pone.0009414.


Comparison of defined culture systems for feeder cell free propagation of human embryonic stem cells.

International Stem Cell Initiative Consortium, Akopian V, Andrews PW, Beil S, Benvenisty N, Brehm J, Christie M, Ford A, Fox V, Gokhale PJ, Healy L, Holm F, Hovatta O, Knowles BB, Ludwig TE, McKay RD, Miyazaki T, Nakatsuji N, Oh SK, Pera MF, Rossant J, Stacey GN, Suemori H.

In Vitro Cell Dev Biol Anim. 2010 Apr;46(3-4):247-58. doi: 10.1007/s11626-010-9297-z. Epub 2010 Feb 26.


Stem cells in 2009.

McKay RD, van der Kooy D, Zwaka TP, Lin H.

Cell Stem Cell. 2009 Nov 6;5(5):483-9. doi: 10.1016/j.stem.2009.10.012.


Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha.

Soeda A, Park M, Lee D, Mintz A, Androutsellis-Theotokis A, McKay RD, Engh J, Iwama T, Kunisada T, Kassam AB, Pollack IF, Park DM.

Oncogene. 2009 Nov 12;28(45):3949-59. doi: 10.1038/onc.2009.252. Epub 2009 Aug 31.


Targeting neural precursors in the adult brain rescues injured dopamine neurons.

Androutsellis-Theotokis A, Rueger MA, Park DM, Mkhikian H, Korb E, Poser SW, Walbridge S, Munasinghe J, Koretsky AP, Lonser RR, McKay RD.

Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13570-5. doi: 10.1073/pnas.0905125106. Epub 2009 Jul 23.


Stem cells by the sea.

McKay RD.

Cell Stem Cell. 2009 Jun 5;4(6):511-2. doi: 10.1016/j.stem.2009.05.009.


Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis.

Joksimovic M, Yun BA, Kittappa R, Anderegg AM, Chang WW, Taketo MM, McKay RD, Awatramani RB.

Nat Neurosci. 2009 Feb;12(2):125-31. doi: 10.1038/nn.2243. Epub 2009 Jan 4.


Potency and fate specification in CNS stem cell populations in vitro.

Ravin R, Hoeppner DJ, Munno DM, Carmel L, Sullivan J, Levitt DL, Miller JL, Athaide C, Panchision DM, McKay RD.

Cell Stem Cell. 2008 Dec 4;3(6):670-80. doi: 10.1016/j.stem.2008.09.012.


Signaling pathways controlling neural stem cells slow progressive brain disease.

Androutsellis-Theotokis A, Rueger MA, Mkhikian H, Korb E, McKay RD.

Cold Spring Harb Symp Quant Biol. 2008;73:403-10. doi: 10.1101/sqb.2008.73.018. Epub 2008 Nov 6. Review.


The growth factor environment defines distinct pluripotent ground states in novel blastocyst-derived stem cells.

Chou YF, Chen HH, Eijpe M, Yabuuchi A, Chenoweth JG, Tesar P, Lu J, McKay RD, Geijsen N.

Cell. 2008 Oct 31;135(3):449-61. doi: 10.1016/j.cell.2008.08.035.


The mammary microenvironment alters the differentiation repertoire of neural stem cells.

Booth BW, Mack DL, Androutsellis-Theotokis A, McKay RD, Boulanger CA, Smith GH.

Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14891-6. doi: 10.1073/pnas.0803214105. Epub 2008 Sep 22.

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