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Worm expulsion is independent of alterations in composition of the colonic bacteria that occur during experimental Hymenolepis diminuta-infection in mice.

Shute A, Wang A, Jayme TS, Strous M, McCoy KD, Buret AG, McKay DM.

Gut Microbes. 2020 Jan 13:1-14. doi: 10.1080/19490976.2019.1688065. [Epub ahead of print]


A Dual Role for Macrophages in Modulating Lung Tissue Damage/Repair during L2 Toxocara canis Infection.

Faz-López B, Mayoral-Reyes H, Hernández-Pando R, Martínez-Labat P, McKay DM, Medina-Andrade I, Olguín JE, Terrazas LI.

Pathogens. 2019 Dec 2;8(4). pii: E280. doi: 10.3390/pathogens8040280.


Enhanced E. coli LF82 translocation through follicle-associated epithelium in Crohn's disease is dependent on long polar fimbriae and CEACAM6-expression, and increases paracellular permeability.

Keita ÅV, Alkaissi LY, Holm EB, Heil SDS, Chassaing B, Darfeuille-Michaud A, McKay DM, Söderholm JD.

J Crohns Colitis. 2019 Aug 9. pii: jjz144. doi: 10.1093/ecco-jcc/jjz144. [Epub ahead of print]


Rethinking Graduate Education in Parasitology: A Case Study.

McKay DM, Summers M, Buret AG, Emmett T, Gilleard JS.

Trends Parasitol. 2019 Sep;35(9):665-668. doi: 10.1016/ Epub 2019 May 29. No abstract available.


Macrophages treated with antigen from the tapeworm Hymenolepis diminuta condition CD25+ T cells to suppress colitis.

Reyes JL, Lopes F, Leung G, Jayme TS, Matisz CE, Shute A, Burkhard R, Carneiro M, Workentine ML, Wang A, Petri B, Beck PL, Geuking MB, McKay DM.

FASEB J. 2019 Apr;33(4):5676-5689. doi: 10.1096/fj.201802160R. Epub 2019 Jan 22.


Itch induced by peripheral mu opioid receptors is dependent on TRPV1-expressing neurons and alleviated by channel activation.

Melo H, Basso L, Iftinca M, MacNaughton WK, Hollenberg MD, McKay DM, Altier C.

Sci Rep. 2018 Oct 19;8(1):15551. doi: 10.1038/s41598-018-33620-7.


Mast cell deficiency in mice results in biomass overgrowth and delayed expulsion of the rat tapeworm Hymenolepis diminuta.

González MI, Lopes F, McKay DM, Reyes JL.

Biosci Rep. 2018 Nov 30;38(6). pii: BSR20180687. doi: 10.1042/BSR20180687. Print 2018 Dec 21.


A Trypsin-Sensitive Proteoglycan from the Tapeworm Hymenolepis diminuta Inhibits Murine Neutrophil Chemotaxis in vitro by Suppressing p38 MAP Kinase Activation.

Graves N, Venu VP, Yipp BG, Petri B, Hirota S, Gilleard J, McKay DM, Lopes F.

J Innate Immun. 2019;11(2):136-149. doi: 10.1159/000492303. Epub 2018 Sep 11.


Modulation of the immune response by helminths: a role for serotonin?

Wang SJ, Sharkey KA, McKay DM.

Biosci Rep. 2018 Sep 20;38(5). pii: BSR20180027. doi: 10.1042/BSR20180027. Print 2018 Oct 31. Review.


Helminth Antigen-Conditioned Dendritic Cells Generate Anti-Inflammatory Cd4 T Cells Independent of Antigen Presentation via Major Histocompatibility Complex Class II.

Matisz CE, Geuking MB, Lopes F, Petri B, Wang A, Sharkey KA, McKay DM.

Am J Pathol. 2018 Nov;188(11):2589-2604. doi: 10.1016/j.ajpath.2018.07.008. Epub 2018 Aug 17.


Neuroimmunophysiology of the gut: advances and emerging concepts focusing on the epithelium.

Sharkey KA, Beck PL, McKay DM.

Nat Rev Gastroenterol Hepatol. 2018 Dec;15(12):765-784. doi: 10.1038/s41575-018-0051-4. Review.


Reduced intestinal epithelial mitochondrial function enhances in vitro interleukin-8 production in response to commensal Escherichia coli.

Saxena A, Lopes F, McKay DM.

Inflamm Res. 2018 Oct;67(10):829-837. doi: 10.1007/s00011-018-1172-5. Epub 2018 Jul 20.


Infliximab restores colonic barrier to adherent-invasive E. coli in Crohn's disease via effects on epithelial lipid rafts.

Yakymenko O, Schoultz I, Gullberg E, Ström M, Almer S, Wallon C, Wang A, Keita ÅV, Campbell BJ, McKay DM, Söderholm JD.

Scand J Gastroenterol. 2018 Jun;53(6):677-684. doi: 10.1080/00365521.2018.1458146. Epub 2018 Apr 24.


Young mice expel the tapeworm Hymenolepis diminuta and are protected from colitis by triggering a memory response with worm antigen.

Arai T, Lopes F, Shute A, Wang A, McKay DM.

Am J Physiol Gastrointest Liver Physiol. 2018 Apr 1;314(4):G461-G470. doi: 10.1152/ajpgi.00295.2017. Epub 2018 Jan 4.


ER-stress mobilization of death-associated protein kinase-1-dependent xenophagy counteracts mitochondria stress-induced epithelial barrier dysfunction.

Lopes F, Keita ÅV, Saxena A, Reyes JL, Mancini NL, Al Rajabi A, Wang A, Baggio CH, Dicay M, van Dalen R, Ahn Y, Carneiro MBH, Peters NC, Rho JM, MacNaughton WK, Girardin SE, Jijon H, Philpott DJ, Söderholm JD, McKay DM.

J Biol Chem. 2018 Mar 2;293(9):3073-3087. doi: 10.1074/jbc.RA117.000809. Epub 2018 Jan 9.


A Gut Microbial Mimic that Hijacks Diabetogenic Autoreactivity to Suppress Colitis.

Hebbandi Nanjundappa R, Ronchi F, Wang J, Clemente-Casares X, Yamanouchi J, Sokke Umeshappa C, Yang Y, Blanco J, Bassolas-Molina H, Salas A, Khan H, Slattery RM, Wyss M, Mooser C, Macpherson AJ, Sycuro LK, Serra P, McKay DM, McCoy KD, Santamaria P.

Cell. 2017 Oct 19;171(3):655-667.e17. doi: 10.1016/j.cell.2017.09.022.


Triggering immunological memory against the tapeworm Hymenolepis diminuta to protect against colitis.

Wang A, Arai T, Campbell A, Reyes JL, Lopes F, McKay DM.

Parasite Immunol. 2017 Nov;39(11). doi: 10.1111/pim.12490. Epub 2017 Oct 4.


A simple, cost-effective method for generating murine colonic 3D enteroids and 2D monolayers for studies of primary epithelial cell function.

Fernando EH, Dicay M, Stahl M, Gordon MH, Vegso A, Baggio C, Alston L, Lopes F, Baker K, Hirota S, McKay DM, Vallance B, MacNaughton WK.

Am J Physiol Gastrointest Liver Physiol. 2017 Nov 1;313(5):G467-G475. doi: 10.1152/ajpgi.00152.2017. Epub 2017 Jul 27.


Helminths and intestinal barrier function.

McKay DM, Shute A, Lopes F.

Tissue Barriers. 2017 Jan 2;5(1):e1283385. doi: 10.1080/21688370.2017.1283385. Review.


Absence of the NOD2 protein renders epithelia more susceptible to barrier dysfunction due to mitochondrial dysfunction.

Saxena A, Lopes F, Poon KKH, McKay DM.

Am J Physiol Gastrointest Liver Physiol. 2017 Jul 1;313(1):G26-G38. doi: 10.1152/ajpgi.00070.2017. Epub 2017 Apr 27.


Species dependent impact of helminth-derived antigens on human macrophages infected with Mycobacterium tuberculosis: Direct effect on the innate anti-mycobacterial response.

Aira N, Andersson AM, Singh SK, McKay DM, Blomgran R.

PLoS Negl Trop Dis. 2017 Feb 13;11(2):e0005390. doi: 10.1371/journal.pntd.0005390. eCollection 2017 Feb.


Suppression of colitis by adoptive transfer of helminth antigen-treated dendritic cells requires interleukin-4 receptor-α signaling.

Matisz CE, Faz-López B, Thomson E, Al Rajabi A, Lopes F, Terrazas LI, Wang A, Sharkey KA, McKay DM.

Sci Rep. 2017 Jan 17;7:40631. doi: 10.1038/srep40631.


Treatment with Cestode Parasite Antigens Results in Recruitment of CCR2+ Myeloid Cells, the Adoptive Transfer of Which Ameliorates Colitis.

Reyes JL, Lopes F, Leung G, Mancini NL, Matisz CE, Wang A, Thomson EA, Graves N, Gilleard J, McKay DM.

Infect Immun. 2016 Nov 18;84(12):3471-3483. Print 2016 Dec.


Helminth Regulation of Immunity: A Three-pronged Approach to Treat Colitis.

Lopes F, Matisz C, Reyes JL, Jijon H, Al-Darmaki A, Kaplan GG, McKay DM.

Inflamm Bowel Dis. 2016 Oct;22(10):2499-512. doi: 10.1097/MIB.0000000000000889. Review.


IL-22 Restrains Tapeworm-Mediated Protection against Experimental Colitis via Regulation of IL-25 Expression.

Reyes JL, Fernando MR, Lopes F, Leung G, Mancini NL, Matisz CE, Wang A, McKay DM.

PLoS Pathog. 2016 Apr 7;12(4):e1005481. doi: 10.1371/journal.ppat.1005481. eCollection 2016 Apr.


Butyrate enhances antibacterial effects while suppressing other features of alternative activation in IL-4-induced macrophages.

Fernando MR, Saxena A, Reyes JL, McKay DM.

Am J Physiol Gastrointest Liver Physiol. 2016 May 15;310(10):G822-31. doi: 10.1152/ajpgi.00440.2015. Epub 2016 Mar 24.


Cryopreserved Interleukin-4-Treated Macrophages Attenuate Murine Colitis in an Integrin β7 - Dependent Manner.

Leung G, Petri B, Reyes JL, Wang A, Iannuzzi J, McKay DM.

Mol Med. 2016 May;21(1):924-936. doi: 10.2119/molmed.2015.00193. Epub 2015 Dec 9.


Adoptive transfer of helminth antigen-pulsed dendritic cells protects against the development of experimental colitis in mice.

Matisz CE, Leung G, Reyes JL, Wang A, Sharkey KA, McKay DM.

Eur J Immunol. 2015 Nov;45(11):3126-39. doi: 10.1002/eji.201545579. Epub 2015 Sep 25.


Involvement of Mast Cells in α7 Nicotinic Receptor Agonist Exacerbation of Freund's Complete Adjuvant-Induced Monoarthritis in Mice.

Lopes F, Graepel R, Reyes JL, Wang A, Petri B, McDougall JJ, Sharkey KA, McKay DM.

Arthritis Rheumatol. 2016 Feb;68(2):542-52. doi: 10.1002/art.39411.


Enteric epithelial cells support growth of Hymenolepis diminuta in vitro and trigger TH2-promoting events in a species-specific manner.

Lopes F, Reyes JL, Wang A, Leung G, McKay DM.

Int J Parasitol. 2015 Sep;45(11):691-6. doi: 10.1016/j.ijpara.2015.05.004. Epub 2015 Jul 4.


The Src kinase Fyn is protective in acute chemical-induced colitis and promotes recovery from disease.

Lopes F, Wang A, Smyth D, Reyes JL, Doering A, Schenck LP, Beck P, Waterhouse C, McKay DM.

J Leukoc Biol. 2015 Jun;97(6):1089-99. doi: 10.1189/jlb.3A0814-405RR. Epub 2015 Apr 15.


Splenic B cells from Hymenolepis diminuta-infected mice ameliorate colitis independent of T cells and via cooperation with macrophages.

Reyes JL, Wang A, Fernando MR, Graepel R, Leung G, van Rooijen N, Sigvardsson M, McKay DM.

J Immunol. 2015 Jan 1;194(1):364-78. doi: 10.4049/jimmunol.1400738. Epub 2014 Dec 1.


Not all parasites are protective.

McKay DM.

Parasite Immunol. 2015 Jun;37(6):324-32. doi: 10.1111/pim.12160.


Targeting mitochondria-derived reactive oxygen species to reduce epithelial barrier dysfunction and colitis.

Wang A, Keita ÅV, Phan V, McKay CM, Schoultz I, Lee J, Murphy MP, Fernando M, Ronaghan N, Balce D, Yates R, Dicay M, Beck PL, MacNaughton WK, Söderholm JD, McKay DM.

Am J Pathol. 2014 Sep;184(9):2516-27. doi: 10.1016/j.ajpath.2014.05.019. Epub 2014 Jul 14.


The pro-inflammatory cytokine, interleukin-6, enhances the polarization of alternatively activated macrophages.

Fernando MR, Reyes JL, Iannuzzi J, Leung G, McKay DM.

PLoS One. 2014 Apr 15;9(4):e94188. doi: 10.1371/journal.pone.0094188. eCollection 2014.


P-selectin-mediated monocyte-cerebral endothelium adhesive interactions link peripheral organ inflammation to sickness behaviors.

D'Mello C, Riazi K, Le T, Stevens KM, Wang A, McKay DM, Pittman QJ, Swain MG.

J Neurosci. 2013 Sep 11;33(37):14878-88. doi: 10.1523/JNEUROSCI.1329-13.2013.


Cannabinoid 1 receptors are critical for the innate immune response to TLR4 stimulation.

Duncan M, Galic MA, Wang A, Chambers AP, McCafferty DM, McKay DM, Sharkey KA, Pittman QJ.

Am J Physiol Regul Integr Comp Physiol. 2013 Aug 1;305(3):R224-31. doi: 10.1152/ajpregu.00104.2013. Epub 2013 Jun 5.


Vasoactive intestinal polypeptide regulates barrier function via mast cells in human intestinal follicle-associated epithelium and during stress in rats.

Keita AV, Carlsson AH, Cigéhn M, Ericson AC, McKay DM, Söderholm JD.

Neurogastroenterol Motil. 2013 Jun;25(6):e406-17. doi: 10.1111/nmo.12127. Epub 2013 Apr 18.


Murine autoimmune arthritis is exaggerated by infection with the rat tapeworm, Hymenolepis diminuta.

Graepel R, Leung G, Wang A, Villemaire M, Jirik FR, Sharkey KA, McDougall JJ, McKay DM.

Int J Parasitol. 2013 Jun;43(7):593-601. doi: 10.1016/j.ijpara.2013.02.006. Epub 2013 Apr 11.


Bone marrow-derived alternatively activated macrophages reduce colitis without promoting fibrosis: participation of IL-10.

Leung G, Wang A, Fernando M, Phan VC, McKay DM.

Am J Physiol Gastrointest Liver Physiol. 2013 May 1;304(9):G781-92. doi: 10.1152/ajpgi.00055.2013. Epub 2013 Mar 14.


Loss of phosphoinositide 3-kinase P110γ is protective in the acute phase but detrimental in the resolution phase of hapten-induced colitis.

Prescott D, Atkinson B, Döring A, Brown S, Petri B, McKay DM, Waterhouse CC.

Inflamm Bowel Dis. 2013 Mar;19(3):489-500. doi: 10.1097/MIB.0b013e31827feb84.


Cestode regulation of inflammation and inflammatory diseases.

Hernandez JL, Leung G, McKay DM.

Int J Parasitol. 2013 Mar;43(3-4):233-43. doi: 10.1016/j.ijpara.2012.09.005. Epub 2012 Oct 8. Review.


Reduced surface expression of epithelial E-cadherin evoked by interferon-gamma is Fyn kinase-dependent.

Smyth D, Leung G, Fernando M, McKay DM.

PLoS One. 2012;7(6):e38441. doi: 10.1371/journal.pone.0038441. Epub 2012 Jun 8.


Indomethacin-induced translocation of bacteria across enteric epithelia is reactive oxygen species-dependent and reduced by vitamin C.

Schoultz I, McKay CM, Graepel R, Phan VC, Wang A, Söderholm J, McKay DM.

Am J Physiol Gastrointest Liver Physiol. 2012 Sep 1;303(5):G536-45. doi: 10.1152/ajpgi.00125.2012. Epub 2012 Jun 14.


Interferon-gamma signals via an ERK1/2-ARF6 pathway to promote bacterial internalization by gut epithelia.

Smyth D, McKay CM, Gulbransen BD, Phan VC, Wang A, McKay DM.

Cell Microbiol. 2012 Aug;14(8):1257-70. doi: 10.1111/j.1462-5822.2012.01796.x. Epub 2012 Apr 22.


Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis.

Gulbransen BD, Bashashati M, Hirota SA, Gui X, Roberts JA, MacDonald JA, Muruve DA, McKay DM, Beck PL, Mawe GM, Thompson RJ, Sharkey KA.

Nat Med. 2012 Mar 18;18(4):600-4. doi: 10.1038/nm.2679.


Is metabolic stress a common denominator in inflammatory bowel disease?

Schoultz I, Söderholm JD, McKay DM.

Inflamm Bowel Dis. 2011 Sep;17(9):2008-18. doi: 10.1002/ibd.21556. Epub 2010 Dec 3. Review.


Aspirin-triggered lipoxin enhances macrophage phagocytosis of bacteria while inhibiting inflammatory cytokine production.

Prescott D, McKay DM.

Am J Physiol Gastrointest Liver Physiol. 2011 Sep;301(3):G487-97. doi: 10.1152/ajpgi.00042.2011. Epub 2011 Jun 9.


Helminth parasites and the modulation of joint inflammation.

Matisz CE, McDougall JJ, Sharkey KA, McKay DM.

J Parasitol Res. 2011;2011:942616. doi: 10.1155/2011/942616. Epub 2011 Apr 18.

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