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The scfCDE Operon Encodes a Predicted ABC Importer Required for Fitness and Virulence during Group A Streptococcus Invasive Infection.

Braza RE, Le Breton Y, McIver KS.

Infect Immun. 2019 Nov 18;87(12). pii: e00613-19. doi: 10.1128/IAI.00613-19. Print 2019 Dec.


Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides.

Edgar RJ, van Hensbergen VP, Ruda A, Turner AG, Deng P, Le Breton Y, El-Sayed NM, Belew AT, McIver KS, McEwan AG, Morris AJ, Lambeau G, Walker MJ, Rush JS, Korotkov KV, Widmalm G, van Sorge NM, Korotkova N.

Nat Chem Biol. 2019 May;15(5):463-471. doi: 10.1038/s41589-019-0251-4. Epub 2019 Apr 1.


Streptococcal Lancefield polysaccharides are critical cell wall determinants for human Group IIA secreted phospholipase A2 to exert its bactericidal effects.

van Hensbergen VP, Movert E, de Maat V, Lüchtenborg C, Le Breton Y, Lambeau G, Payré C, Henningham A, Nizet V, van Strijp JAG, Brügger B, Carlsson F, McIver KS, van Sorge NM.

PLoS Pathog. 2018 Oct 15;14(10):e1007348. doi: 10.1371/journal.ppat.1007348. eCollection 2018 Oct.


Route of Glucose Uptake in the Group a Streptococcus Impacts SLS-Mediated Hemolysis and Survival in Human Blood.

Sundar GS, Islam E, Braza RD, Silver AB, Le Breton Y, McIver KS.

Front Cell Infect Microbiol. 2018 Mar 14;8:71. doi: 10.3389/fcimb.2018.00071. eCollection 2018.


Glucose Levels Alter the Mga Virulence Regulon in the Group A Streptococcus.

Valdes KM, Sundar GS, Belew AT, Islam E, El-Sayed NM, Le Breton Y, McIver KS.

Sci Rep. 2018 Mar 21;8(1):4971. doi: 10.1038/s41598-018-23366-7.


Endopeptidase PepO Regulates the SpeB Cysteine Protease and Is Essential for the Virulence of Invasive M1T1 Streptococcus pyogenes.

Brouwer S, Cork AJ, Ong CY, Barnett TC, West NP, McIver KS, Walker MJ.

J Bacteriol. 2018 Mar 26;200(8). pii: e00654-17. doi: 10.1128/JB.00654-17. Print 2018 Apr 15.


Genome-wide discovery of novel M1T1 group A streptococcal determinants important for fitness and virulence during soft-tissue infection.

Le Breton Y, Belew AT, Freiberg JA, Sundar GS, Islam E, Lieberman J, Shirtliff ME, Tettelin H, El-Sayed NM, McIver KS.

PLoS Pathog. 2017 Aug 23;13(8):e1006584. doi: 10.1371/journal.ppat.1006584. eCollection 2017 Aug.


Using a Concept Inventory to Reveal Student Thinking Associated with Common Misconceptions about Antibiotic Resistance.

Stevens AM, Smith AC, Marbach-Ad G, Balcom SA, Buchner J, Daniel SL, DeStefano JJ, El-Sayed NM, Frauwirth K, Lee VT, McIver KS, Melville SB, Mosser DM, Popham DL, Scharf BE, Schubot FD, Seyler RW Jr, Shields PA, Song W, Stein DC, Stewart RC, Thompson KV, Yang Z, Yarwood SA.

J Microbiol Biol Educ. 2017 Apr 21;18(1). pii: 18.1.10. doi: 10.1128/jmbe.v18i1.1281. eCollection 2017 Apr.


The Transcriptional Regulator CpsY Is Important for Innate Immune Evasion in Streptococcus pyogenes.

Vega LA, Valdes KM, Sundar GS, Belew AT, Islam E, Berge J, Curry P, Chen S, El-Sayed NM, Le Breton Y, McIver KS.

Infect Immun. 2017 Feb 23;85(3). pii: e00925-16. doi: 10.1128/IAI.00925-16. Print 2017 Mar.


Global Analysis and Comparison of the Transcriptomes and Proteomes of Group A Streptococcus Biofilms.

Freiberg JA, Le Breton Y, Tran BQ, Scott AJ, Harro JM, Ernst RK, Goo YA, Mongodin EF, Goodlett DR, McIver KS, Shirtliff ME.

mSystems. 2016 Dec 6;1(6). pii: e00149-16. eCollection 2016 Nov-Dec.


A PTS EII mutant library in Group A Streptococcus identifies a promiscuous man-family PTS transporter influencing SLS-mediated hemolysis.

Sundar GS, Islam E, Gera K, Le Breton Y, McIver KS.

Mol Microbiol. 2017 Feb;103(3):518-533. doi: 10.1111/mmi.13573. Epub 2016 Nov 29.


Virulence-Related Transcriptional Regulators of Streptococcus pyogenes.

Vega LA, Malke H, McIver KS.

In: Ferretti JJ, Stevens DL, Fischetti VA, editors. Streptococcus pyogenes : Basic Biology to Clinical Manifestations [Internet]. Oklahoma City (OK): University of Oklahoma Health Sciences Center; 2016-.
2016 Feb 10 [updated 2016 Mar 25].


The fruRBA Operon Is Necessary for Group A Streptococcal Growth in Fructose and for Resistance to Neutrophil Killing during Growth in Whole Human Blood.

Valdes KM, Sundar GS, Vega LA, Belew AT, Islam E, Binet R, El-Sayed NM, Le Breton Y, McIver KS.

Infect Immun. 2016 Mar 24;84(4):1016-1031. doi: 10.1128/IAI.01296-15. Print 2016 Apr.


GacA is essential for Group A Streptococcus and defines a new class of monomeric dTDP-4-dehydrorhamnose reductases (RmlD).

van der Beek SL, Le Breton Y, Ferenbach AT, Chapman RN, van Aalten DM, Navratilova I, Boons GJ, McIver KS, van Sorge NM, Dorfmueller HC.

Mol Microbiol. 2015 Dec;98(5):946-62. doi: 10.1111/mmi.13169. Epub 2015 Oct 1.


Essential Genes in the Core Genome of the Human Pathogen Streptococcus pyogenes.

Le Breton Y, Belew AT, Valdes KM, Islam E, Curry P, Tettelin H, Shirtliff ME, El-Sayed NM, McIver KS.

Sci Rep. 2015 May 21;5:9838. doi: 10.1038/srep09838.


The crimson conundrum: heme toxicity and tolerance in GAS.

Sachla AJ, Le Breton Y, Akhter F, McIver KS, Eichenbaum Z.

Front Cell Infect Microbiol. 2014 Nov 5;4:159. doi: 10.3389/fcimb.2014.00159. eCollection 2014.


In vivo expression of Streptococcus pyogenes immunogenic proteins during tibial foreign body infection.

Freiberg JA, McIver KS, Shirtliff ME.

Infect Immun. 2014 Sep;82(9):3891-9. doi: 10.1128/IAI.01831-14. Epub 2014 Jul 7.


Genetic manipulation of Streptococcus pyogenes (the Group A Streptococcus, GAS).

Le Breton Y, McIver KS.

Curr Protoc Microbiol. 2013 Oct 2;30:9D.3.1-9D.3.29. doi: 10.1002/9780471729259.mc09d03s30.


Laboratory growth and maintenance of Streptococcus pyogenes (the Group A Streptococcus, GAS).

Gera K, McIver KS.

Curr Protoc Microbiol. 2013 Oct 2;30:9D.2.1-9D.2.13. doi: 10.1002/9780471729259.mc09d02s30.


An extracellular bacterial pathogen modulates host metabolism to regulate its own sensing and proliferation.

Baruch M, Belotserkovsky I, Hertzog BB, Ravins M, Dov E, McIver KS, Le Breton YS, Zhou Y, Cheng CY, Hanski E.

Cell. 2014 Jan 16;156(1-2):97-108. doi: 10.1016/j.cell.2013.12.007. Erratum in: Cell. 2014 Jan 30;156(3):617. Chen, Catherine Youting [corrected to Cheng, Catherine Youting].


The phosphoenolpyruvate phosphotransferase system in group A Streptococcus acts to reduce streptolysin S activity and lesion severity during soft tissue infection.

Gera K, Le T, Jamin R, Eichenbaum Z, McIver KS.

Infect Immun. 2014 Mar;82(3):1192-204. doi: 10.1128/IAI.01271-13. Epub 2013 Dec 30.


PTS phosphorylation of Mga modulates regulon expression and virulence in the group A streptococcus.

Hondorp ER, Hou SC, Hause LL, Gera K, Lee CE, McIver KS.

Mol Microbiol. 2013 Jun;88(6):1176-93. doi: 10.1111/mmi.12250. Epub 2013 May 20. Erratum in: Mol Microbiol. 2014 Aug;93(4):834.


Genome-wide identification of genes required for fitness of group A Streptococcus in human blood.

Le Breton Y, Mistry P, Valdes KM, Quigley J, Kumar N, Tettelin H, McIver KS.

Infect Immun. 2013 Mar;81(3):862-75. doi: 10.1128/IAI.00837-12. Epub 2013 Jan 7.


Nucleotides critical for the interaction of the Streptococcus pyogenes Mga virulence regulator with Mga-regulated promoter sequences.

Hause LL, McIver KS.

J Bacteriol. 2012 Sep;194(18):4904-19. doi: 10.1128/JB.00809-12. Epub 2012 Jul 6.


Investigating how streptococcus responds to their environment: bringing together current research, a case study and laboratory investigation.

Quimby BB, McIver KS, Marbach-Ad G, Smith AC.

J Microbiol Biol Educ. 2011 Dec 1;12(2):176-84. doi: 10.1128/jmbe.v12i2.321. Print 2011.


A model for using a concept inventory as a tool for students' assessment and faculty professional development.

Marbach-Ad G, McAdams KC, Benson S, Briken V, Cathcart L, Chase M, El-Sayed NM, Frauwirth K, Fredericksen B, Joseph SW, Lee V, McIver KS, Mosser D, Quimby BB, Shields P, Song W, Stein DC, Stewart R, Thompson KV, Smith AC.

CBE Life Sci Educ. 2010 Winter;9(4):408-16. doi: 10.1187/cbe.10-05-0069.


MtsR is a dual regulator that controls virulence genes and metabolic functions in addition to metal homeostasis in the group A streptococcus.

Toukoki C, Gold KM, McIver KS, Eichenbaum Z.

Mol Microbiol. 2010 May;76(4):971-89. doi: 10.1111/j.1365-2958.2010.07157.x. Epub 2010 Apr 14.


Stand-alone response regulators controlling global virulence networks in streptococcus pyogenes.

McIver KS.

Contrib Microbiol. 2009;16:103-119. doi: 10.1159/000219375. Epub 2009 Jun 2. Review.


Assessing student understanding of host pathogen interactions using a concept inventory.

Marbach-Ad G, Briken V, El-Sayed NM, Frauwirth K, Fredericksen B, Hutcheson S, Gao LY, Joseph S, Lee VT, McIver KS, Mosser D, Quimby BB, Shields P, Song W, Stein DC, Yuan RT, Smith AC.

J Microbiol Biol Educ. 2009 Dec 17;10(1):43-50. Print 2009.


Mode of expression and functional characterization of FCT-3 pilus region-encoded proteins in Streptococcus pyogenes serotype M49.

Nakata M, Köller T, Moritz K, Ribardo D, Jonas L, McIver KS, Sumitomo T, Terao Y, Kawabata S, Podbielski A, Kreikemeyer B.

Infect Immun. 2009 Jan;77(1):32-44. doi: 10.1128/IAI.00772-08. Epub 2008 Oct 13.


Shr is a broad-spectrum surface receptor that contributes to adherence and virulence in group A streptococcus.

Fisher M, Huang YS, Li X, McIver KS, Toukoki C, Eichenbaum Z.

Infect Immun. 2008 Nov;76(11):5006-15. doi: 10.1128/IAI.00300-08. Epub 2008 Aug 18.


TrxR, a new CovR-repressed response regulator that activates the Mga virulence regulon in group A Streptococcus.

Leday TV, Gold KM, Kinkel TL, Roberts SA, Scott JR, McIver KS.

Infect Immun. 2008 Oct;76(10):4659-68. doi: 10.1128/IAI.00597-08. Epub 2008 Aug 4.


Skim milk enhances the preservation of thawed -80 degrees C bacterial stocks.

Cody WL, Wilson JW, Hendrixson DR, McIver KS, Hagman KE, Ott CM, Nickerson CA, Schurr MJ.

J Microbiol Methods. 2008 Sep;75(1):135-8. doi: 10.1016/j.mimet.2008.05.006. Epub 2008 May 14.


CcpA-mediated repression of streptolysin S expression and virulence in the group A streptococcus.

Kinkel TL, McIver KS.

Infect Immun. 2008 Aug;76(8):3451-63. doi: 10.1128/IAI.00343-08. Epub 2008 May 19.


The Mga virulence regulon: infection where the grass is greener.

Hondorp ER, McIver KS.

Mol Microbiol. 2007 Dec;66(5):1056-65. Review.


The catabolite control protein CcpA binds to Pmga and influences expression of the virulence regulator Mga in the Group A streptococcus.

Almengor AC, Kinkel TL, Day SJ, McIver KS.

J Bacteriol. 2007 Dec;189(23):8405-16. Epub 2007 Sep 28.


Identification of pyruvate kinase as an antigen associated with Tourette syndrome.

Kansy JW, Katsovich L, McIver KS, Pick J, Zabriskie JB, Lombroso PJ, Leckman JF, Bibb JA.

J Neuroimmunol. 2006 Dec;181(1-2):165-76. Epub 2006 Oct 2.


Virulence factor regulation and regulatory networks in Streptococcus pyogenes and their impact on pathogen-host interactions.

Kreikemeyer B, McIver KS, Podbielski A.

Trends Microbiol. 2003 May;11(5):224-32. Review.


Restoration of Mga function to a Streptococcus pyogenes strain (M Type 50) that is virulent in mice.

Limbago B, McIver KS, Penumalli V, Weinrick B, Scott JR.

Infect Immun. 2001 Feb;69(2):1215-20.


Attenuated expression of the mga virulence regulon in an M serotype 50 mouse-virulent group A streptococcal strain.

Yung DL, McIver KS, Scott JR, Hollingshead SK.

Infect Immun. 1999 Dec;67(12):6691-4.

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