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Items: 1 to 50 of 241

1.

ADAMDEC1 Maintains a Growth Factor Signaling Loop in Cancer Stem Cells.

Jimenez-Pascual A, Hale JS, Kordowski A, Pugh J, Silver DJ, Bayik D, Roversi G, Alban TJ, Rao S, Chen R, McIntyre TM, Colombo G, Taraboletti G, Holmberg KO, Forsberg-Nilsson K, Lathia JD, Siebzehnrubl FA.

Cancer Discov. 2019 Aug 21. doi: 10.1158/2159-8290.CD-18-1308. [Epub ahead of print]

PMID:
31434712
2.

Acute phase protein, α - 1- acid glycoprotein (AGP-1), has differential effects on TLR-2 and TLR-4 mediated responses.

Sumanth MS, Abhilasha KV, Jacob SP, Chaithra VH, Basrur V, Willard B, McIntyre TM, Prabhu KS, Marathe GK.

Immunobiology. 2019 Sep;224(5):672-680. doi: 10.1016/j.imbio.2019.06.003. Epub 2019 Jun 20.

PMID:
31239174
3.

CD36 Enhances Vascular Smooth Muscle Cell Proliferation and Development of Neointimal Hyperplasia.

Yue H, Febbraio M, Klenotic PA, Kennedy DJ, Wu Y, Chen S, Gohara AF, Li O, Belcher A, Kuang B, McIntyre TM, Silverstein RL, Li W.

Arterioscler Thromb Vasc Biol. 2019 Feb;39(2):263-275. doi: 10.1161/ATVBAHA.118.312186.

PMID:
30567481
4.
5.

Modulation of inflammatory platelet-activating factor (PAF) receptor by the acyl analogue of PAF.

Chaithra VH, Jacob SP, Lakshmikanth CL, Sumanth MS, Abhilasha KV, Chen CH, Thyagarajan A, Sahu RP, Travers JB, McIntyre TM, Kemparaju K, Marathe GK.

J Lipid Res. 2018 Nov;59(11):2063-2074. doi: 10.1194/jlr.M085704. Epub 2018 Aug 23.

PMID:
30139761
6.

D-2-Hydroxyglutarate Is an Intercellular Mediator in IDH-Mutant Gliomas Inhibiting Complement and T Cells.

Zhang L, Sorensen MD, Kristensen BW, Reifenberger G, McIntyre TM, Lin F.

Clin Cancer Res. 2018 Nov 1;24(21):5381-5391. doi: 10.1158/1078-0432.CCR-17-3855. Epub 2018 Jul 13.

PMID:
30006485
7.
8.

The soluble protease ADAMDEC1 released from activated platelets hydrolyzes platelet membrane pro-epidermal growth factor (EGF) to active high-molecular-weight EGF.

Chen R, Jin G, McIntyre TM.

J Biol Chem. 2017 Jun 16;292(24):10112-10122. doi: 10.1074/jbc.M116.771642. Epub 2017 Apr 28.

9.

Escherichia coli Braun Lipoprotein (BLP) exhibits endotoxemia - like pathology in Swiss albino mice.

Lakshmikanth CL, Jacob SP, Kudva AK, Latchoumycandane C, Yashaswini PS, Sumanth MS, Goncalves-de-Albuquerque CF, Silva AR, Singh SA, Castro-Faria-Neto HC, Prabhu SK, McIntyre TM, Marathe GK.

Sci Rep. 2016 Oct 4;6:34666. doi: 10.1038/srep34666.

10.

The Role of Platelet Activation and Inflammation in Early Brain Injury Following Subarachnoid Hemorrhage.

Frontera JA, Provencio JJ, Sehba FA, McIntyre TM, Nowacki AS, Gordon E, Weimer JM, Aledort L.

Neurocrit Care. 2017 Feb;26(1):48-57. doi: 10.1007/s12028-016-0292-4.

11.

PAF is a potent pyrogen and cryogen in rodents, but it does not mediate thermoregulatory responses to bacterial endotoxin.

Marathe GK, McIntyre TM.

Temperature (Austin). 2015 Dec 3;2(4):449-50. doi: 10.1080/23328940.2015.1096439. eCollection 2015 Oct-Dec.

12.

Lipopolysaccharide Cross-Tolerance Delays Platelet-Activating Factor-Induced Sudden Death in Swiss Albino Mice: Involvement of Cyclooxygenase in Cross-Tolerance.

Jacob SP, Lakshmikanth CL, Chaithra VH, Kumari TR, Chen CH, McIntyre TM, Marathe GK.

PLoS One. 2016 Apr 11;11(4):e0153282. doi: 10.1371/journal.pone.0153282. eCollection 2016.

13.

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk.

Zhu W, Gregory JC, Org E, Buffa JA, Gupta N, Wang Z, Li L, Fu X, Wu Y, Mehrabian M, Sartor RB, McIntyre TM, Silverstein RL, Tang WHW, DiDonato JA, Brown JM, Lusis AJ, Hazen SL.

Cell. 2016 Mar 24;165(1):111-124. doi: 10.1016/j.cell.2016.02.011. Epub 2016 Mar 10.

14.

Enhanced Sphingomyelinase Activity Contributes to the Apoptotic Capacity of Electronegative Low-Density Lipoprotein.

Ke LY, Chan HC, Chen CC, Lu J, Marathe GK, Chu CS, Chan HC, Wang CY, Tung YC, McIntyre TM, Yen JH, Chen CH.

J Med Chem. 2016 Feb 11;59(3):1032-40. doi: 10.1021/acs.jmedchem.5b01534. Epub 2016 Feb 2.

PMID:
26766134
15.

Inflammatory PAF Receptor Signaling Initiates Hedgehog Signaling and Kidney Fibrogenesis During Ethanol Consumption.

Latchoumycandane C, Hanouneh M, Nagy LE, McIntyre TM.

PLoS One. 2015 Dec 31;10(12):e0145691. doi: 10.1371/journal.pone.0145691. eCollection 2015.

16.

Longitudinal study of the feasibility of using ecological momentary assessment to study teacher stress: Objective and self-reported measures.

McIntyre TM, McIntyre SE, Barr CD, Woodward PS, Francis DJ, Durand AC, Mehta P, Kamarck TW.

J Occup Health Psychol. 2016 Oct;21(4):403-414. doi: 10.1037/a0039966. Epub 2015 Dec 14.

PMID:
26652265
17.

Deubiquitinases Modulate Platelet Proteome Ubiquitination, Aggregation, and Thrombosis.

Gupta N, Li W, McIntyre TM.

Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2657-66. doi: 10.1161/ATVBAHA.115.306054. Epub 2015 Oct 15.

18.

Platelet-activating factor receptor affects food intake and body weight.

Li W, McIntyre TM.

Genes Dis. 2015 Sep;2(3):255-260. doi: 10.1016/j.gendis.2015.06.002. Epub 2015 Jun 24.

19.

Myeloperoxidase formation of PAF receptor ligands induces PAF receptor-dependent kidney injury during ethanol consumption.

Latchoumycandane C, Nagy LE, McIntyre TM.

Free Radic Biol Med. 2015 Sep;86:179-90. doi: 10.1016/j.freeradbiomed.2015.05.020. Epub 2015 May 21.

20.

Thymidine phosphorylase participates in platelet signaling and promotes thrombosis.

Li W, Gigante A, Perez-Perez MJ, Yue H, Hirano M, McIntyre TM, Silverstein RL.

Circ Res. 2014 Dec 5;115(12):997-1006. doi: 10.1161/CIRCRESAHA.115.304591. Epub 2014 Oct 6.

21.

Exosome poly-ubiquitin inhibits platelet activation, downregulates CD36 and inhibits pro-atherothombotic cellular functions.

Srikanthan S, Li W, Silverstein RL, McIntyre TM.

J Thromb Haemost. 2014 Nov;12(11):1906-17. doi: 10.1111/jth.12712. Epub 2014 Oct 13.

22.

Apolipoprotein A1 regulates coenzyme Q10 absorption, mitochondrial function, and infarct size in a mouse model of myocardial infarction.

Dadabayev AR, Yin G, Latchoumycandane C, McIntyre TM, Lesnefsky EJ, Penn MS.

J Nutr. 2014 Jul;144(7):1030-6. doi: 10.3945/jn.113.184291. Epub 2014 Apr 23.

23.

OxNASH score correlates with histologic features and severity of nonalcoholic fatty liver disease.

Alkhouri N, Berk M, Yerian L, Lopez R, Chung YM, Zhang R, McIntyre TM, Feldstein AE, Hazen SL.

Dig Dis Sci. 2014 Jul;59(7):1617-24. doi: 10.1007/s10620-014-3031-8. Epub 2014 Jan 25.

24.

Chronic ethanol ingestion induces oxidative kidney injury through taurine-inhibitable inflammation.

Latchoumycandane C, Nagy LE, McIntyre TM.

Free Radic Biol Med. 2014 Apr;69:403-16. doi: 10.1016/j.freeradbiomed.2014.01.001. Epub 2014 Jan 8.

25.

Proteasome proteolysis supports stimulated platelet function and thrombosis.

Gupta N, Li W, Willard B, Silverstein RL, McIntyre TM.

Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):160-8. doi: 10.1161/ATVBAHA.113.302116. Epub 2013 Oct 31.

26.

Lipopolysaccharide stimulates platelets through an IL-1β autocrine loop.

Brown GT, Narayanan P, Li W, Silverstein RL, McIntyre TM.

J Immunol. 2013 Nov 15;191(10):5196-203. doi: 10.4049/jimmunol.1300354. Epub 2013 Sep 30.

27.

Aspirin hydrolysis in plasma is a variable function of butyrylcholinesterase and platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2).

Zhou G, Marathe GK, Hartiala J, Hazen SL, Allayee H, Tang WH, McIntyre TM.

J Biol Chem. 2013 Apr 26;288(17):11940-8. doi: 10.1074/jbc.M112.427674. Epub 2013 Mar 18.

28.

Translational control of JunB, an AP-1 transcription factor, in activated human endothelial cells.

Schmid DI, Schwertz H, Jiang H, Campbell RA, Weyrich AS, McIntyre TM, Zimmerman GA, Kraiss LW.

J Cell Biochem. 2013 Jul;114(7):1519-28. doi: 10.1002/jcb.24493.

29.

Circulating biologically active oxidized phospholipids show on-going and increased oxidative stress in older male mice.

Liu J, Li W, Chen R, McIntyre TM.

Redox Biol. 2013;1:110-4. doi: 10.1016/j.redox.2012.11.011. Epub 2013 Jan 30.

30.

Ferric chloride-induced murine carotid arterial injury: A model of redox pathology.

Li W, McIntyre TM, Silverstein RL.

Redox Biol. 2013 Jan 26;1:50-5. doi: 10.1016/j.redox.2012.11.001. eCollection 2013.

31.

A novel role of complement in retinal degeneration.

Yu M, Zou W, Peachey NS, McIntyre TM, Liu J.

Invest Ophthalmol Vis Sci. 2012 Nov 19;53(12):7684-92. doi: 10.1167/iovs.12-10069.

32.

Determination of phospholipase activity of PAF acetylhydrolase.

Stafforini DM, McIntyre TM.

Free Radic Biol Med. 2013 Jun;59:100-7. doi: 10.1016/j.freeradbiomed.2012.05.031. Epub 2012 May 29.

33.

Bioactive oxidatively truncated phospholipids in inflammation and apoptosis: formation, targets, and inactivation.

McIntyre TM.

Biochim Biophys Acta. 2012 Oct;1818(10):2456-64. doi: 10.1016/j.bbamem.2012.03.004. Epub 2012 Mar 16. Review.

34.

Oxidatively truncated phospholipids are required agents of tumor necrosis factor α (TNFα)-induced apoptosis.

Latchoumycandane C, Marathe GK, Zhang R, McIntyre TM.

J Biol Chem. 2012 May 18;287(21):17693-705. doi: 10.1074/jbc.M111.300012. Epub 2012 Mar 20.

35.

Intracellular erythrocyte platelet-activating factor acetylhydrolase I inactivates aspirin in blood.

Zhou G, Marathe GK, Willard B, McIntyre TM.

J Biol Chem. 2011 Oct 7;286(40):34820-9. doi: 10.1074/jbc.M111.267161. Epub 2011 Aug 15.

36.

Lipopolysaccharide signaling without a nucleus: kinase cascades stimulate platelet shedding of proinflammatory IL-1β-rich microparticles.

Brown GT, McIntyre TM.

J Immunol. 2011 May 1;186(9):5489-96. doi: 10.4049/jimmunol.1001623. Epub 2011 Mar 23.

37.

Human TMEM30a promotes uptake of antitumor and bioactive choline phospholipids into mammalian cells.

Chen R, Brady E, McIntyre TM.

J Immunol. 2011 Mar 1;186(5):3215-25. doi: 10.4049/jimmunol.1002710. Epub 2011 Feb 2.

38.

Circulating platelet-activating factor is primarily cleared by transport, not intravascular hydrolysis by lipoprotein-associated phospholipase A2/ PAF acetylhydrolase.

Liu J, Chen R, Marathe GK, Febbraio M, Zou W, McIntyre TM.

Circ Res. 2011 Feb 18;108(4):469-77. doi: 10.1161/CIRCRESAHA.110.228742. Epub 2010 Dec 23.

39.

Lipid oxidation and cardiovascular disease: introduction to a review series.

McIntyre TM, Hazen SL.

Circ Res. 2010 Nov 12;107(10):1167-9. doi: 10.1161/CIRCRESAHA.110.224618. No abstract available.

PMID:
21071714
40.

Mass spectrometric profiling of oxidized lipid products in human nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.

Feldstein AE, Lopez R, Tamimi TA, Yerian L, Chung YM, Berk M, Zhang R, McIntyre TM, Hazen SL.

J Lipid Res. 2010 Oct;51(10):3046-54. doi: 10.1194/jlr.M007096. Epub 2010 Jul 14.

41.

An antimicrobial peptide regulates tumor-associated macrophage trafficking via the chemokine receptor CCR2, a model for tumorigenesis.

Jin G, Kawsar HI, Hirsch SA, Zeng C, Jia X, Feng Z, Ghosh SK, Zheng QY, Zhou A, McIntyre TM, Weinberg A.

PLoS One. 2010 Jun 8;5(6):e10993. doi: 10.1371/journal.pone.0010993.

42.

Chronic alcohol exposure increases circulating bioactive oxidized phospholipids.

Yang L, Latchoumycandane C, McMullen MR, Pratt BT, Zhang R, Papouchado BG, Nagy LE, Feldstein AE, McIntyre TM.

J Biol Chem. 2010 Jul 16;285(29):22211-20. doi: 10.1074/jbc.M110.119982. Epub 2010 May 11.

43.

Suppression of mitochondrial function by oxidatively truncated phospholipids is reversible, aided by bid, and suppressed by Bcl-XL.

Chen R, Feldstein AE, McIntyre TM.

J Biol Chem. 2009 Sep 25;284(39):26297-308. doi: 10.1074/jbc.M109.018978. Epub 2009 Aug 4.

44.

PAF-acetylhydrolase expressed during megakaryocyte differentiation inactivates PAF-like lipids.

Foulks JM, Marathe GK, Michetti N, Stafforini DM, Zimmerman GA, McIntyre TM, Weyrich AS.

Blood. 2009 Jun 25;113(26):6699-706. doi: 10.1182/blood-2008-11-186312. Epub 2009 Apr 24.

45.

Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase.

Li ZZ, Berk M, McIntyre TM, Feldstein AE.

J Biol Chem. 2009 Feb 27;284(9):5637-44. doi: 10.1074/jbc.M807616200. Epub 2009 Jan 1.

46.

Platelet activation by low concentrations of intact oxidized LDL particles involves the PAF receptor.

Chen R, Chen X, Salomon RG, McIntyre TM.

Arterioscler Thromb Vasc Biol. 2009 Mar;29(3):363-71. doi: 10.1161/ATVBAHA.108.178731. Epub 2008 Dec 26.

47.

The emerging roles of PAF acetylhydrolase.

McIntyre TM, Prescott SM, Stafforini DM.

J Lipid Res. 2009 Apr;50 Suppl:S255-9. doi: 10.1194/jlr.R800024-JLR200. Epub 2008 Oct 6.

48.

Lipopolysaccharide is a direct agonist for platelet RNA splicing.

Shashkin PN, Brown GT, Ghosh A, Marathe GK, McIntyre TM.

J Immunol. 2008 Sep 1;181(5):3495-502.

49.

A yeast PAF acetylhydrolase ortholog suppresses oxidative death.

Foulks JM, Weyrich AS, Zimmerman GA, McIntyre TM.

Free Radic Biol Med. 2008 Aug 15;45(4):434-42. doi: 10.1016/j.freeradbiomed.2008.04.034. Epub 2008 May 3.

50.

The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity.

Li Z, Berk M, McIntyre TM, Gores GJ, Feldstein AE.

Hepatology. 2008 May;47(5):1495-503. doi: 10.1002/hep.22183.

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