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A Controlled Human Infection Model of Group A Streptococcus Pharyngitis: Which Strain and Why?

Osowicki J, Azzopardi KI, McIntyre L, Rivera-Hernandez T, Ong CY, Baker C, Gillen CM, Walker MJ, Smeesters PR, Davies MR, Steer AC.

mSphere. 2019 Feb 13;4(1). pii: e00647-18. doi: 10.1128/mSphere.00647-18.


Detection of epidemic scarlet fever group A Streptococcus in Australia.

Walker MJ, Brouwer S, Forde BM, Worthing KA, McIntyre L, Sundac L, Maloney S, Roberts LW, Barnett TC, Richter J, Cork AJ, Irwin AD, You Y, Zhang J, Dougan G, Yuen KY, Nizet V, Beatson SA, Grimwood K, Davies MR.

Clin Infect Dis. 2019 Feb 5. doi: 10.1093/cid/ciz099. [Epub ahead of print]


Effects of Mesenchymal Stem Cell Treatment on Systemic Cytokine Levels in a Phase 1 Dose Escalation Safety Trial of Septic Shock Patients.

Schlosser K, Wang JP, Dos Santos C, Walley KR, Marshall J, Fergusson DA, Winston BW, Granton J, Watpool I, Stewart DJ, McIntyre LA, Mei SHJ; Canadian Critical Care Trials Group and the Canadian Critical Care Translational Biology Group.

Crit Care Med. 2019 Feb 1. doi: 10.1097/CCM.0000000000003657. [Epub ahead of print]


Cost-Effectiveness Analysis of Needle Arthroscopy Versus Magnetic Resonance Imaging in the Diagnosis and Treatment of Meniscal Tears of the Knee.

Amin N, McIntyre L, Carter T, Xerogeanes J, Voigt J.

Arthroscopy. 2019 Feb;35(2):554-562.e13. doi: 10.1016/j.arthro.2018.09.030.


Household Food Insecurity Narrows the Sex Gap in Five Adverse Mental Health Outcomes among Canadian Adults.

Jessiman-Perreault G, McIntyre L.

Int J Environ Res Public Health. 2019 Jan 24;16(3). pii: E319. doi: 10.3390/ijerph16030319.


A Systematic Review of the Impact of Surgical Special Care Units on Patient Outcomes and Health Care Resource Utilization.

Mendis N, Hamilton GM, McIsaac DI, Fergusson DA, Wunsch H, Dubois D, Montroy J, Chassé M, Turgeon AF, McIntyre L, McDonald H, Yang H, Sampson SD, McCartney CJL, Shorr R, Denault A, Lalu MM; Canadian Perioperative Anesthesia Clinical Trials Group (PACT).

Anesth Analg. 2019 Jan 21. doi: 10.1213/ANE.0000000000003942. [Epub ahead of print]


Caloric intake and the fat-to-carbohydrate ratio in hypercapnic acute respiratory failure: Post-hoc analysis of the PermiT trial.

Al-Dorzi HM, Aldawood AS, Tamim H, Haddad SH, Jones G, McIntyre L, Solaiman O, Sakhija M, Sadat M, Afesh L, Kumar A, Bagshaw SM, Mehta S, M Arabi Y.

Clin Nutr ESPEN. 2019 Feb;29:175-182. doi: 10.1016/j.clnesp.2018.10.012. Epub 2018 Nov 13.


Do patient-reported outcome measures for SAH include patient, family, and caregiver priorities? A scoping review.

Saigle V, Asad S, Presseau J, Chassé M, McIntyre L, English SW.

Neurology. 2019 Feb 5;92(6):281-295. doi: 10.1212/WNL.0000000000006883. Epub 2019 Jan 9.


Kinetic Analysis of Hepatic Metabolism Using Hyperpolarized Dihydroxyacetone.

Kirpich A, Ragavan M, Bankson JA, McIntyre LM, Merritt ME.

J Chem Inf Model. 2019 Jan 28;59(1):605-614. doi: 10.1021/acs.jcim.8b00745. Epub 2019 Jan 15.


CD11a expression distinguishes infiltrating myeloid cells from plaque-associated microglia in Alzheimer's disease.

Shukla AK, McIntyre LL, Marsh SE, Schneider CA, Hoover EM, Walsh CM, Lodoen MB, Blurton-Jones M, Inlay MA.

Glia. 2018 Dec 26. doi: 10.1002/glia.23575. [Epub ahead of print]


Variability in adaptive behaviour in young children with autism spectrum disorder.

Golya N, McIntyre LL.

J Intellect Dev Disabil. 2018;43(1):102-111. doi: 10.3109/13668250.2017.1287886. Epub 2017 Feb 1.


Examining the utilisation and usefulness of social support for mothers with young children with autism spectrum disorder.

McIntyre LL, Brown M.

J Intellect Dev Disabil. 2018;43(1):93-101. doi: 10.3109/13668250.2016.1262534. Epub 2016 Nov 30.


Association of protein intake with the outcomes of critically ill patients: a post hoc analysis of the PermiT trial.

Arabi YM, Al-Dorzi HM, Mehta S, Tamim HM, Haddad SH, Jones G, McIntyre L, Solaiman O, Sakkijha MH, Sadat M, Afesh L, Kumar A, Bagshaw SM, Aldawood AS; PermiT Trial Group.

Am J Clin Nutr. 2018 Nov 1;108(5):988-996. doi: 10.1093/ajcn/nqy189.


Stakeholder views regarding ethical issues in the design and conduct of pragmatic trials: study protocol.

Nicholls SG, Carroll K, Brehaut J, Weijer C, Hey SP, Goldstein CE, Zwarenstein M, Graham ID, McKenzie JE, McIntyre L, Jairath V, Campbell MK, Grimshaw JM, Fergusson DA, Taljaard M.

BMC Med Ethics. 2018 Nov 20;19(1):90. doi: 10.1186/s12910-018-0332-z.


The application of 'valence' to the idea of household food insecurity in Canada.

McIntyre L, Patterson PB, Mah CL.

Soc Sci Med. 2019 Jan;220:176-183. doi: 10.1016/j.socscimed.2018.11.016. Epub 2018 Nov 10.


Competitive Luminex immunoassays for detection of antibodies to foot-and-mouth disease and vesicular stomatitis viruses in multiple susceptible hosts.

Nfon C, Lusansky D, Goolia M, Yang M, Hole K, McIntyre L.

Can J Vet Res. 2018 Oct;82(4):316-321.


Interleukin 30 to Interleukin 40.

Catalan-Dibene J, McIntyre LL, Zlotnik A.

J Interferon Cytokine Res. 2018 Oct;38(10):423-439. doi: 10.1089/jir.2018.0089.


Optimizing Clinical Use of Biologics in Orthopaedic Surgery: Consensus Recommendations From the 2018 AAOS/NIH U-13 Conference.

Chu CR, Rodeo S, Bhutani N, Goodrich LR, Huard J, Irrgang J, LaPrade RF, Lattermann C, Lu Y, Mandelbaum B, Mao J, McIntyre L, Mishra A, Muschler GF, Piuzzi NS, Potter H, Spindler K, Tokish JM, Tuan R, Zaslav K, Maloney W.

J Am Acad Orthop Surg. 2019 Jan 15;27(2):e50-e63. doi: 10.5435/JAAOS-D-18-00305.


Developing a framework for the ethical design and conduct of pragmatic trials in healthcare: a mixed methods research protocol.

Taljaard M, Weijer C, Grimshaw JM, Ali A, Brehaut JC, Campbell MK, Carroll K, Edwards S, Eldridge S, Forrest CB, Giraudeau B, Goldstein CE, Graham ID, Hemming K, Hey SP, Horn AR, Jairath V, Klassen TP, London AJ, Marlin S, Marshall JC, McIntyre L, McKenzie JE, Nicholls SG, Alison Paprica P, Zwarenstein M, Fergusson DA.

Trials. 2018 Sep 27;19(1):525. doi: 10.1186/s13063-018-2895-x.


Safety and Efficacy of Adult Stem Cell Therapy for Acute Myocardial Infarction and Ischemic Heart Failure (SafeCell Heart): A Systematic Review and Meta-Analysis.

Lalu MM, Mazzarello S, Zlepnig J, Dong YYR, Montroy J, McIntyre L, Devereaux PJ, Stewart DJ, David Mazer C, Barron CC, McIsaac DI, Fergusson DA.

Stem Cells Transl Med. 2018 Dec;7(12):857-866. doi: 10.1002/sctm.18-0120. Epub 2018 Sep 26.


The Ottawa SAH search algorithms: protocol for a multi- centre validation study of primary subarachnoid hemorrhage prediction models using health administrative data (the SAHepi prediction study protocol).

English SW, McIntyre L, Saigle V, Chassé M, Fergusson DA, Turgeon AF, Lauzier F, Griesdale D, Garland A, Zarychanski R, Algird A, van Walraven C.

BMC Med Res Methodol. 2018 Sep 15;18(1):94. doi: 10.1186/s12874-018-0553-3.


A Robust Methodology for Assessing Differential Homeolog Contributions to the Transcriptomes of Allopolyploids.

Boatwright JL, McIntyre LM, Morse AM, Chen S, Yoo MJ, Koh J, Soltis PS, Soltis DE, Barbazuk WB.

Genetics. 2018 Nov;210(3):883-894. doi: 10.1534/genetics.118.301564. Epub 2018 Sep 13.


FLUID trial: a protocol for a hospital-wide open-label cluster crossover pragmatic comparative effectiveness randomised pilot trial.

McIntyre L, Taljaard M, McArdle T, Fox-Robichaud A, English SW, Martin C, Marshall J, Menon K, Muscedere J, Cook DJ, Weijer C, Saginur R, Maybee A, Iyengar A, Forster A, Graham ID, Hawken S, McCartney C, Seely AJ, Stiell IG, Thavorn K, Fergusson DA.

BMJ Open. 2018 Aug 23;8(8):e022780. doi: 10.1136/bmjopen-2018-022780.


Comparison of crystalloid resuscitation fluids for treatment of acute brain injury: a clinical and pre-clinical systematic review and network meta-analysis protocol.

Thompson M, McIntyre L, Hutton B, Tran A, Wolfe D, Hutchison J, Fergusson D, Turgeon AF, English SW.

Syst Rev. 2018 Aug 17;7(1):125. doi: 10.1186/s13643-018-0790-x.


Characterisation of Staphylococcus felis isolated from cats using whole genome sequencing.

Worthing K, Pang S, Trott DJ, Abraham S, Coombs GW, Jordan D, McIntyre L, Davies MR, Norris J.

Vet Microbiol. 2018 Aug;222:98-104. doi: 10.1016/j.vetmic.2018.07.002. Epub 2018 Jul 6.


Promoting remyelination through cell transplantation therapies in a model of viral-induced neurodegenerative disease.

Mangale V, McIntyre LL, Walsh CM, Loring JF, Lane TE.

Dev Dyn. 2019 Jan;248(1):43-52. doi: 10.1002/dvdy.24658. Epub 2018 Sep 6. Review.


The effect of child hunger on educational attainment and early childbearing outcomes in a longitudinal population sample of Canadian youth.

McIntyre L, Kwok C, Patten SB.

Paediatr Child Health. 2018 Aug;23(5):e77-e84. doi: 10.1093/pch/pxx177. Epub 2017 Dec 22.


Recent Developments in Workers' Compensation and Employers' Liability Law.

Torrey DB, McIntyre LD, Black KD, Beck JD.

Tort Trial Insur Pract Law J. 2018;53(2):703-39.


Event Analysis: Using Transcript Events To Improve Estimates of Abundance in RNA-seq Data.

Newman JRB, Concannon P, Tardaguila M, Conesa A, McIntyre LM.

G3 (Bethesda). 2018 Aug 30;8(9):2923-2940. doi: 10.1534/g3.118.200373.


Anemia prevalence and incidence and red blood cell transfusion practices in aneurysmal subarachnoid hemorrhage: results of a multicenter cohort study.

English SW, Chassé M, Turgeon AF, Lauzier F, Griesdale D, Garland A, Fergusson D, Zarychanski R, van Walraven C, Montroy K, Ziegler J, Dupont-Chouinard R, Carignan R, Dhaliwal A, Mallick R, Sinclair J, Boutin A, Pagliarello G, Tinmouth A, McIntyre L; Canadian Critical Care Trials Group.

Crit Care. 2018 Jul 4;22(1):169. doi: 10.1186/s13054-018-2089-7.


Outbreak of Vibrio parahaemolyticus Associated with Consumption of Raw Oysters in Canada, 2015.

Taylor M, Cheng J, Sharma D, Bitzikos O, Gustafson R, Fyfe M, Greve R, Murti M, Stone J, Honish L, Mah V, Punja N, Hexemer A, McIntyre L, Henry B, Kendall P, Atkinson R, Buenaventura E, Martinez-Perez A, Galanis E, Team TOI.

Foodborne Pathog Dis. 2018 Sep;15(9):554-559. doi: 10.1089/fpd.2017.2415. Epub 2018 Jun 29.


Random serum free cortisol and total cortisol measurements in pediatric septic shock.

Menon K, McNally D, Acharya A, O'Hearn K, Choong K, Wong HR, McIntyre L, Lawson M; Canadian Critical Care Trials Group.

J Pediatr Endocrinol Metab. 2018 Jul 26;31(7):757-762. doi: 10.1515/jpem-2018-0027.


Analysis of Gene Expression Variance in Schizophrenia Using Structural Equation Modeling.

Igolkina AA, Armoskus C, Newman JRB, Evgrafov OV, McIntyre LM, Nuzhdin SV, Samsonova MG.

Front Mol Neurosci. 2018 Jun 11;11:192. doi: 10.3389/fnmol.2018.00192. eCollection 2018.


The More Dialogue, the Better.

McIntyre LM, Griffen AM, BrintzenhofeSzoc K.

J Hum Lact. 2018 Aug;34(3):584. doi: 10.1177/0890334418778509. Epub 2018 Jun 21. No abstract available.


Variable selection in omics data: A practical evaluation of small sample sizes.

Kirpich A, Ainsworth EA, Wedow JM, Newman JRB, Michailidis G, McIntyre LM.

PLoS One. 2018 Jun 21;13(6):e0197910. doi: 10.1371/journal.pone.0197910. eCollection 2018.


Overexpression of TaCML20, a calmodulin-like gene, enhances water soluble carbohydrate accumulation and yield in wheat.

Kalaipandian S, Xue GP, Rae AL, Glassop D, Bonnett GD, McIntyre LC.

Physiol Plant. 2018 Jun 14. doi: 10.1111/ppl.12786. [Epub ahead of print]


Breast Is Best . . . Except When It's Not.

McIntyre LM, Griffen AM, BrintzenhofeSzoc K.

J Hum Lact. 2018 Aug;34(3):575-580. doi: 10.1177/0890334418774011. Epub 2018 May 22. No abstract available.


Linking the Medical and Educational Home to Support Children With Autism Spectrum Disorder: Practice Recommendations.

Shahidullah JD, Azad G, Mezher KR, McClain MB, McIntyre LL.

Clin Pediatr (Phila). 2018 Nov;57(13):1496-1505. doi: 10.1177/0009922818774344. Epub 2018 May 3.


SECIMTools: a suite of metabolomics data analysis tools.

Kirpich AS, Ibarra M, Moskalenko O, Fear JM, Gerken J, Mi X, Ashrafi A, Morse AM, McIntyre LM.

BMC Bioinformatics. 2018 Apr 20;19(1):151. doi: 10.1186/s12859-018-2134-1.


Editorial Commentary: Are We Running Out of Treatments for Osteoarthritis of the Knee?

McIntyre LF.

Arthroscopy. 2018 Mar;34(3):660-662. doi: 10.1016/j.arthro.2017.10.014.


Arthroscopic Lysis of Adhesions for Treatment of Post-traumatic Arthrofibrosis of the Knee Joint.

Stiefel EC, McIntyre L.

Arthrosc Tech. 2017 Jul 3;6(4):e939-e944. doi: 10.1016/j.eats.2017.03.001. eCollection 2017 Aug.


Near-Real-Time Surveillance of Illnesses Related to Shellfish Consumption in British Columbia: Analysis of Poison Center Data.

Wan V, McIntyre L, Kent D, Leong D, Henderson SB.

JMIR Public Health Surveill. 2018 Feb 23;4(1):e17. doi: 10.2196/publichealth.8944.


Interventions to prevent hemodynamic instability during renal replacement therapy in critically ill patients: a systematic review.

Douvris A, Malhi G, Hiremath S, McIntyre L, Silver SA, Bagshaw SM, Wald R, Ronco C, Sikora L, Weber C, Clark EG.

Crit Care. 2018 Feb 22;22(1):41. doi: 10.1186/s13054-018-1965-5. Review.


Hemoglobin thresholds and red blood cell transfusion in adult patients with moderate or severe traumatic brain injuries: A retrospective cohort study.

Boutin A, Moore L, Green RS, Zarychanski R, Erdogan M, Lauzier F, English S, Fergusson DA, Butler M, McIntyre L, Chassé M, Lessard Bonaventure P, Léger C, Desjardins P, Griesdale D, Lacroix J, Turgeon AF.

J Crit Care. 2018 Jun;45:133-139. doi: 10.1016/j.jcrc.2018.01.023. Epub 2018 Jan 31.


7 versus 14 days of antibiotic treatment for critically ill patients with bloodstream infection: a pilot randomized clinical trial.

Daneman N, Rishu AH, Pinto R, Aslanian P, Bagshaw SM, Carignan A, Charbonney E, Coburn B, Cook DJ, Detsky ME, Dodek P, Hall R, Kumar A, Lamontagne F, Lauzier F, Marshall JC, Martin CM, McIntyre L, Muscedere J, Reynolds S, Sligl W, Stelfox HT, Wilcox ME, Fowler RA; Canadian Critical Care Trials Group.

Trials. 2018 Feb 17;19(1):111. doi: 10.1186/s13063-018-2474-1.


Is hemoglobin good for cerebral oxygenation and clinical outcome in acute brain injury?

English SW, McIntyre L.

Curr Opin Crit Care. 2018 Apr;24(2):91-96. doi: 10.1097/MCC.0000000000000485.


A social network analysis of Canadian food insecurity policy actors.

McIntyre L, Jessiman-Perreault G, Mah CL, Godley J.

Can J Diet Pract Res. 2018 Jun 1;79(2):60-66. doi: 10.3148/cjdpr-2017-034. Epub 2018 Jan 31.


The household food insecurity gradient and potential reductions in adverse population mental health outcomes in Canadian adults.

Jessiman-Perreault G, McIntyre L.

SSM Popul Health. 2017 May 31;3:464-472. doi: 10.1016/j.ssmph.2017.05.013. eCollection 2017 Dec.


Scarlet Fever Epidemic in China Caused by Streptococcus pyogenes Serotype M12: Epidemiologic and Molecular Analysis.

You Y, Davies MR, Protani M, McIntyre L, Walker MJ, Zhang J.

EBioMedicine. 2018 Feb;28:128-135. doi: 10.1016/j.ebiom.2018.01.010. Epub 2018 Jan 11.


Behavioral interventions for reducing head motion during MRI scans in children.

Greene DJ, Koller JM, Hampton JM, Wesevich V, Van AN, Nguyen AL, Hoyt CR, McIntyre L, Earl EA, Klein RL, Shimony JS, Petersen SE, Schlaggar BL, Fair DA, Dosenbach NUF.

Neuroimage. 2018 May 1;171:234-245. doi: 10.1016/j.neuroimage.2018.01.023. Epub 2018 Jan 12.

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