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Omalizumab for asthma and allergic bronchopulmonary aspergillosis in adults with cystic fibrosis.

Koutsokera A, Corriveau S, Sykes J, Coriati A, Cortes D, Vadas P, Chaparro C, McIntyre K, Tullis E, Stephenson AL.

J Cyst Fibros. 2019 Aug 9. pii: S1569-1993(19)30832-X. doi: 10.1016/j.jcf.2019.07.011. [Epub ahead of print]


Evidence of adaptation of maternofetal transport of glutamine relative to placental size in normal mice, and in those with fetal growth restriction.

McIntyre KR, Hayward CE, Sibley CP, Greenwood SL, Dilworth MR.

J Physiol. 2019 Aug 10. doi: 10.1113/JP278226. [Epub ahead of print]


Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain.

Burke JR, Cheng L, Gillooly KM, Strnad J, Zupa-Fernandez A, Catlett IM, Zhang Y, Heimrich EM, McIntyre KW, Cunningham MD, Carman JA, Zhou X, Banas D, Chaudhry C, Li S, D'Arienzo C, Chimalakonda A, Yang X, Xie JH, Pang J, Zhao Q, Rose SM, Huang J, Moslin RM, Wrobleski ST, Weinstein DS, Salter-Cid LM.

Sci Transl Med. 2019 Jul 24;11(502). pii: eaaw1736. doi: 10.1126/scitranslmed.aaw1736.


Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165.

Wrobleski ST, Moslin R, Lin S, Zhang Y, Spergel S, Kempson J, Tokarski JS, Strnad J, Zupa-Fernandez A, Cheng L, Shuster D, Gillooly K, Yang X, Heimrich E, McIntyre KW, Chaudhry C, Khan J, Ruzanov M, Tredup J, Mulligan D, Xie D, Sun H, Huang C, D'Arienzo C, Aranibar N, Chiney M, Chimalakonda A, Pitts WJ, Lombardo L, Carter PH, Burke JR, Weinstein DS.

J Med Chem. 2019 Jul 18. doi: 10.1021/acs.jmedchem.9b00444. [Epub ahead of print]


Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2).

Moslin R, Zhang Y, Wrobleski ST, Lin S, Mertzman M, Spergel S, Tokarski JS, Strnad J, Gillooly K, McIntyre KW, Zupa-Fernandez A, Cheng L, Sun H, Chaudhry C, Huang C, D'Arienzo C, Heimrich E, Yang X, Muckelbauer JK, Chang C, Tredup J, Mulligan D, Xie D, Aranibar N, Chiney M, Burke JR, Lombardo L, Carter PH, Weinstein DS.

J Med Chem. 2019 Jul 17. doi: 10.1021/acs.jmedchem.9b00443. [Epub ahead of print]


Forensic Competency Assessment with Digital Technologies.

Luxton DD, Lexcen FJ, McIntyre KA.

Curr Psychiatry Rep. 2019 Jun 20;21(7):60. doi: 10.1007/s11920-019-1037-9. Review.


Health-related quality of life in patients receiving first-line eribulin mesylate with or without trastuzumab for locally recurrent or metastatic breast cancer.

Schwartzberg L, McIntyre K, Wilks S, Puhalla S, O'Shaughnessy J, Berrak E, He Y, Vahdat L.

BMC Cancer. 2019 Jun 13;19(1):578. doi: 10.1186/s12885-019-5674-5.


SVEPM 2018 - Classic problems, future focus, and engagement of stakeholders in veterinary epidemiology and economics, Society of Veterinary Epidemiology and Preventive Medicine Conference, Tallinn, Estonia, 21st-23rd March 2018.

McIntyre KM, Calvo-Artavia FF, Dórea FC, Nielsen LR.

Prev Vet Med. 2019 Jun 1;167:46-47. doi: 10.1016/j.prevetmed.2019.03.012. Epub 2019 Mar 21. No abstract available.


Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK).

Watterson SH, Liu Q, Beaudoin Bertrand M, Batt DG, Li L, Pattoli MA, Skala S, Cheng L, Obermeier MT, Moore R, Yang Z, Vickery R, Elzinga PA, Discenza L, D'Arienzo C, Gillooly KM, Taylor TL, Pulicicchio C, Zhang Y, Heimrich E, McIntyre KW, Ruan Q, Westhouse RA, Catlett IM, Zheng N, Chaudhry C, Dai J, Galella MA, Tebben AJ, Pokross M, Li J, Zhao R, Smith D, Rampulla R, Allentoff A, Wallace MA, Mathur A, Salter-Cid L, Macor JE, Carter PH, Fura A, Burke JR, Tino JA.

J Med Chem. 2019 Apr 11;62(7):3228-3250. doi: 10.1021/acs.jmedchem.9b00167. Epub 2019 Mar 29.


Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors.

Liu C, Lin J, Moslin R, Tokarski JS, Muckelbauer J, Chang C, Tredup J, Xie D, Park H, Li P, Wu DR, Strnad J, Zupa-Fernandez A, Cheng L, Chaudhry C, Chen J, Chen C, Sun H, Elzinga P, D'arienzo C, Gillooly K, Taylor TL, McIntyre KW, Salter-Cid L, Lombardo LJ, Carter PH, Aranibar N, Burke JR, Weinstein DS.

ACS Med Chem Lett. 2019 Feb 21;10(3):383-388. doi: 10.1021/acsmedchemlett.9b00035. eCollection 2019 Mar 14.


Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis.

Spergel SH, Mertzman ME, Kempson J, Guo J, Stachura S, Haque L, Lippy JS, Zhang RF, Galella M, Pitt S, Shen G, Fura A, Gillooly K, McIntyre KW, Tang V, Tokarski J, Sack JS, Khan J, Carter PH, Barrish JC, Nadler SG, Salter-Cid LM, Schieven GL, Wrobleski ST, Pitts WJ.

ACS Med Chem Lett. 2019 Feb 13;10(3):306-311. doi: 10.1021/acsmedchemlett.8b00508. eCollection 2019 Mar 14.


Evaluation of Miracle Mouthwash plus Hydrocortisone Versus Prednisolone Mouth Rinses as Prophylaxis for Everolimus-Associated Stomatitis: A Randomized Phase II Study.

Jones VE, McIntyre KJ, Paul D, Wilks ST, Ondreyco SM, Sedlacek S, Melnyk A, Oommen SP, Wang Y, Peck SR, O'Shaughnessy JA.

Oncologist. 2019 Mar 4. pii: theoncologist.2018-0340. doi: 10.1634/theoncologist.2018-0340. [Epub ahead of print]


Identification and Preclinical Pharmacology of ((1 R,3 S)-1-Amino-3-(( S)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P1) Modulator Advanced into Clinical Trials.

Gilmore JL, Xiao HY, Dhar TGM, Yang MG, Xiao Z, Xie J, Lehman-McKeeman LD, Gong L, Sun H, Lecureux L, Chen C, Wu DR, Dabros M, Yang X, Taylor TL, Zhou XD, Heimrich EM, Thomas R, McIntyre KW, Borowski V, Warrack BM, Li Y, Shi H, Levesque PC, Yang Z, Marino AM, Cornelius G, D'Arienzo CJ, Mathur A, Rampulla R, Gupta A, Pragalathan B, Shen DR, Cvijic ME, Salter-Cid LM, Carter PH, Dyckman AJ.

J Med Chem. 2019 Mar 14;62(5):2265-2285. doi: 10.1021/acs.jmedchem.8b01695. Epub 2019 Mar 6.


Effect of aerobic exercise on cognition in younger adults: A randomized clinical trial.

Stern Y, MacKay-Brandt A, Lee S, McKinley P, McIntyre K, Razlighi Q, Agarunov E, Bartels M, Sloan RP.

Neurology. 2019 Feb 26;92(9):e905-e916. doi: 10.1212/WNL.0000000000007003. Epub 2019 Jan 30. Erratum in: Neurology. 2019 Jul 23;93(4):185.


Leptospirosis under the bibliometrics radar: evidence for a vicious circle of neglect.

Goarant C, Picardeau M, Morand S, McIntyre KM.

J Glob Health. 2019 Jun;9(1):010302. doi: 10.7189/jogh.09.010302. Review. No abstract available.


A High-Throughput Method for the Analysis of Erythrocyte Fatty Acids and the Omega-3 Index.

Alqarni A, Mcintyre KJ, Brown SHJ, Meyer BJ, Mitchell TW.

Lipids. 2018 Oct;53(10):1005-1015. doi: 10.1002/lipd.12108.


Anger-reduction treatment reduces negative affect reactivity to daily stressors.

McIntyre KM, Mogle JA, Scodes JM, Pavlicova M, Shapiro PA, Gorenstein EE, Tager FA, Monk C, Almeida DM, Sloan RP.

J Consult Clin Psychol. 2019 Feb;87(2):141-150. doi: 10.1037/ccp0000359. Epub 2018 Dec 3.


Mechanisms Underpinning Adaptations in Placental Calcium Transport in Normal Mice and Those With Fetal Growth Restriction.

Hayward CE, McIntyre KR, Sibley CP, Greenwood SL, Dilworth MR.

Front Endocrinol (Lausanne). 2018 Nov 20;9:671. doi: 10.3389/fendo.2018.00671. eCollection 2018.


Are the Hands of Veterinary Staff a Reservoir for Antimicrobial-Resistant Bacteria? A Randomized Study to Evaluate Two Hand Hygiene Rubs in a Veterinary Hospital.

Espadale E, Pinchbeck G, Williams NJ, Timofte D, McIntyre KM, Schmidt VM.

Microb Drug Resist. 2018 Nov 2. doi: 10.1089/mdr.2018.0183. [Epub ahead of print]


Routine antibiotic therapy in dogs increases the detection of antimicrobial-resistant faecal Escherichia coli.

Schmidt VM, Pinchbeck G, McIntyre KM, Nuttall T, McEwan N, Dawson S, Williams NJ.

J Antimicrob Chemother. 2018 Dec 1;73(12):3305-3316. doi: 10.1093/jac/dky352.


Using registry data to improve quality of care.

McIntyre K, Bertrand DP, Rault G.

J Cyst Fibros. 2018 Sep;17(5):566-572. doi: 10.1016/j.jcf.2018.06.006. Epub 2018 Jul 5. Review.


Impact of recent and future climate change on vector-borne diseases.

Caminade C, McIntyre KM, Jones AE.

Ann N Y Acad Sci. 2019 Jan;1436(1):157-173. doi: 10.1111/nyas.13950. Epub 2018 Aug 18. Review.


Foodborne and Food-Handler Norovirus Outbreaks: A Systematic Review.

Hardstaff JL, Clough HE, Lutje V, McIntyre KM, Harris JP, Garner P, O'Brien SJ.

Foodborne Pathog Dis. 2018 Oct;15(10):589-597. doi: 10.1089/fpd.2018.2452. Epub 2018 Aug 15.


Evaluation of How Integrative Oncology Services Are Valued between Hematology/Oncology Patients and Hematologists/Oncologists at a Tertiary Care Center.

Hansra DM, McIntyre K, Ramdial J, Sacks S, Patrick CS, Cutler J, McIntyre B, Feister K, Miller M, Taylor AK, Farooq F, de Mayolo JA, Ahn E.

Evid Based Complement Alternat Med. 2018 Apr 12;2018:8081018. doi: 10.1155/2018/8081018. eCollection 2018.


The Methylome of Vertebrate Sex Chromosomes.

Waters SA, Capraro A, McIntyre KL, Marshall Graves JA, Waters PD.

Genes (Basel). 2018 May 1;9(5). pii: E230. doi: 10.3390/genes9050230. Review.


Author Correction: Systematic Assessment of the Climate Sensitivity of Important Human and Domestic Animals Pathogens in Europe.

McIntyre KM, Setzkorn C, Hepworth PJ, Morand S, Morse AP, Baylis M.

Sci Rep. 2018 Apr 25;8(1):6773. doi: 10.1038/s41598-018-24606-6.


Impact of systemic antimicrobial therapy on mucosal staphylococci in a population of dogs in Northwest England.

Schmidt VM, Pinchbeck G, Nuttall T, Shaw S, McIntyre KM, McEwan N, Dawson S, Williams NJ.

Vet Dermatol. 2018 Jun;29(3):192-e70. doi: 10.1111/vde.12538. Epub 2018 Apr 17.


Five-year results of a phase II trial of preoperative 5-fluorouracil, epirubicin, cyclophosphamide followed by docetaxel with capecitabine (wTX) (with trastuzumab in HER2-positive patients) for patients with stage II or III breast cancer.

Holmes FA, Hellerstedt BA, Pippen JE Jr, Vukelja SJ, Collea RP, Kocs DM, Blum JL, McIntyre KJ, Barve MA, Brooks BD, Osborne CR, Wang Y, Asmar L, O'Shaughnessy J.

Cancer Med. 2018 Jun;7(6):2288-2298. doi: 10.1002/cam4.1472. Epub 2018 Mar 26.


Addition of the PARP inhibitor veliparib plus carboplatin or carboplatin alone to standard neoadjuvant chemotherapy in triple-negative breast cancer (BrighTNess): a randomised, phase 3 trial.

Loibl S, O'Shaughnessy J, Untch M, Sikov WM, Rugo HS, McKee MD, Huober J, Golshan M, von Minckwitz G, Maag D, Sullivan D, Wolmark N, McIntyre K, Ponce Lorenzo JJ, Metzger Filho O, Rastogi P, Symmans WF, Liu X, Geyer CE Jr.

Lancet Oncol. 2018 Apr;19(4):497-509. doi: 10.1016/S1470-2045(18)30111-6. Epub 2018 Feb 28.


Bad Is Stronger Than Good for Stigmatized, but Not Admired Outgroups: Meta-Analytical Tests of Intergroup Valence Asymmetry in Individual-to-Group Generalization Experiments.

Paolini S, McIntyre K.

Pers Soc Psychol Rev. 2019 Feb;23(1):3-47. doi: 10.1177/1088868317753504. Epub 2018 Feb 23. Review.


SVEPM 2017-Recent developments and contemporary foci in veterinary epidemiology and economics, Society of Veterinary Epidemiology and Preventive Medicine conference Inverness, Scotland 29-31 March 2017.

McIntyre KM, van den Borne BHP, Calvo-Artavia FF, van Schaik G.

Prev Vet Med. 2018 Feb 1;150:133-134. doi: 10.1016/j.prevetmed.2017.11.024. Epub 2017 Dec 2. No abstract available.


[10]-gingerol induces apoptosis and inhibits metastatic dissemination of triple negative breast cancer in vivo.

Martin ACBM, Fuzer AM, Becceneri AB, da Silva JA, Tomasin R, Denoyer D, Kim SH, McIntyre KA, Pearson HB, Yeo B, Nagpal A, Ling X, Selistre-de-Araújo HS, Vieira PC, Cominetti MR, Pouliot N.

Oncotarget. 2017 Aug 10;8(42):72260-72271. doi: 10.18632/oncotarget.20139. eCollection 2017 Sep 22.


Systematic Assessment of the Climate Sensitivity of Important Human and Domestic Animals Pathogens in Europe.

McIntyre KM, Setzkorn C, Hepworth PJ, Morand S, Morse AP, Baylis M.

Sci Rep. 2017 Aug 2;7(1):7134. doi: 10.1038/s41598-017-06948-9. Erratum in: Sci Rep. 2018 Apr 25;8(1):6773.


Bruton's tyrosine kinase inhibitor BMS-986142 in experimental models of rheumatoid arthritis enhances efficacy of agents representing clinical standard-of-care.

Gillooly KM, Pulicicchio C, Pattoli MA, Cheng L, Skala S, Heimrich EM, McIntyre KW, Taylor TL, Kukral DW, Dudhgaonkar S, Nagar J, Banas D, Watterson SH, Tino JA, Fura A, Burke JR.

PLoS One. 2017 Jul 24;12(7):e0181782. doi: 10.1371/journal.pone.0181782. eCollection 2017.


The Association of Cigarette Smoking With High-Frequency Heart Rate Variability: An Ecological Momentary Assessment Study.

Bodin F, McIntyre KM, Schwartz JE, McKinley PS, Cardetti C, Shapiro PA, Gorenstein E, Sloan RP.

Psychosom Med. 2017 Nov/Dec;79(9):1045-1050. doi: 10.1097/PSY.0000000000000507.


Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders.

Liu Q, Shi Q, Marcoux D, Batt DG, Cornelius L, Qin LY, Ruan Z, Neels J, Beaudoin-Bertrand M, Srivastava AS, Li L, Cherney RJ, Gong H, Watterson SH, Weigelt C, Gillooly KM, McIntyre KW, Xie JH, Obermeier MT, Fura A, Sleczka B, Stefanski K, Fancher RM, Padmanabhan S, Rp T, Kundu I, Rajareddy K, Smith R, Hennan JK, Xing D, Fan J, Levesque PC, Ruan Q, Pitt S, Zhang R, Pedicord D, Pan J, Yarde M, Lu H, Lippy J, Goldstine C, Skala S, Rampulla RA, Mathur A, Gupta A, Arunachalam PN, Sack JS, Muckelbauer JK, Cvijic ME, Salter-Cid LM, Bhide RS, Poss MA, Hynes J, Carter PH, Macor JE, Ruepp S, Schieven GL, Tino JA.

J Med Chem. 2017 Jun 22;60(12):5193-5208. doi: 10.1021/acs.jmedchem.7b00618. Epub 2017 Jun 5.


Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors.

Hynes J Jr, Wu H, Kempson J, Duan JJ, Lu Z, Jiang B, Stachura S, Tokarski JS, Sack JS, Khan JA, Lippy JS, Zhang RF, Pitt S, Shen G, Gillooly K, McIntyre K, Carter PH, Barrish JC, Nadler SG, Salter-Cid LM, Fura A, Schieven GL, Pitts WJ, Wrobleski ST.

Bioorg Med Chem Lett. 2017 Jul 15;27(14):3101-3106. doi: 10.1016/j.bmcl.2017.05.043. Epub 2017 May 15.


SVEPM 2016 - Current multidisciplinary advances in veterinary epidemiology and economics, Society of Veterinary Epidemiology and Preventive Medicine conference Elsinore, Denmark 16-18 March 2016.

van den Borne BH, Calvo-Artavia FF, Brodbelt D, McIntyre KM.

Prev Vet Med. 2017 Apr 1;139(Pt B):91-92. doi: 10.1016/j.prevetmed.2017.03.004. No abstract available.


Reply to Gautret et al.

Caminade C, McIntyre KM, Jones AE.

J Infect Dis. 2017 Feb 15;215(4):661-662. doi: 10.1093/infdis/jix022. No abstract available.


Incremental diagnostic quality gain of CTA over V/Q scan in the assessment of pulmonary embolism by means of a Wells score Bayesian model: results from the ACDC collaboration.

Cochon L, McIntyre K, Nicolás JM, Baez AA.

Emerg Radiol. 2017 Aug;24(4):355-359. doi: 10.1007/s10140-017-1486-6. Epub 2017 Feb 24.


A phase 2 safety study of accelerated elotuzumab infusion, over less than 1 h, in combination with lenalidomide and dexamethasone, in patients with multiple myeloma.

Berenson J, Manges R, Badarinath S, Cartmell A, McIntyre K, Lyons R, Harb W, Mohamed H, Nourbakhsh A, Rifkin R.

Am J Hematol. 2017 May;92(5):460-466. doi: 10.1002/ajh.24687. Epub 2017 Mar 22.


Comparative Efficacy and Safety of Adjuvant Letrozole Versus Anastrozole in Postmenopausal Patients With Hormone Receptor-Positive, Node-Positive Early Breast Cancer: Final Results of the Randomized Phase III Femara Versus Anastrozole Clinical Evaluation (FACE) Trial.

Smith I, Yardley D, Burris H, De Boer R, Amadori D, McIntyre K, Ejlertsen B, Gnant M, Jonat W, Pritchard KI, Dowsett M, Hart L, Poggio S, Comarella L, Salomon H, Wamil B, O'Shaughnessy J.

J Clin Oncol. 2017 Apr 1;35(10):1041-1048. doi: 10.1200/JCO.2016.69.2871. Epub 2017 Jan 23. Erratum in: J Clin Oncol. 2019 Feb 1;37(4):359.


The Rise of Post-Grant Proceedings.

Bianco KE, McIntyre K.

ACS Med Chem Lett. 2016 Dec 16;8(1):4-6. doi: 10.1021/acsmedchemlett.6b00460. eCollection 2017 Jan 12.


Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity.

Dudhgaonkar S, Ranade S, Nagar J, Subramani S, Prasad DS, Karunanithi P, Srivastava R, Venkatesh K, Selvam S, Krishnamurthy P, Mariappan TT, Saxena A, Fan L, Stetsko DK, Holloway DA, Li X, Zhu J, Yang WP, Ruepp S, Nair S, Santella J, Duncia J, Hynes J, McIntyre KW, Carman JA.

J Immunol. 2017 Feb 1;198(3):1308-1319. doi: 10.4049/jimmunol.1600583. Epub 2016 Dec 21.


Asymmetric Hydroboration Approach to the Scalable Synthesis of ((1R,3S)-1-Amino-3-((R)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986104) as a Potent S1P1 Receptor Modulator.

Yang MG, Xiao Z, Dhar TG, Xiao HY, Gilmore JL, Marcoux D, Xie JH, McIntyre KW, Taylor TL, Borowski V, Heimrich E, Li YW, Feng J, Fernandes A, Yang Z, Balimane P, Marino AM, Cornelius G, Warrack BM, Mathur A, Wu DR, Li P, Gupta A, Pragalathan B, Shen DR, Cvijic ME, Lehman-McKeeman LD, Salter-Cid L, Barrish JC, Carter PH, Dyckman AJ.

J Med Chem. 2016 Dec 22;59(24):11138-11147. doi: 10.1021/acs.jmedchem.6b01433. Epub 2016 Dec 7.


Identification of potent tricyclic prodrug S1P1 receptor modulators.

Marcoux D, Xiao HY, Murali Dhar TG, Xie J, Lehman-McKeeman LD, Wu DR, Dabros M, Yang X, Taylor TL, Zhou XD, Heimrich EM, Thomas R, McIntyre KW, Shi H, Levesque PC, Sun H, Yang Z, Marino AM, Cornelius G, D'Arienzo CJ, Gupta A, Pragalathan B, Rampulla R, Mathur A, Shen DR, Cvijic ME, Salter-Cid L, Lombardo LJ, Carter PH, Dyckman AJ.

Medchemcomm. 2016 Nov 25;8(4):725-729. doi: 10.1039/c6md00539j. eCollection 2017 Apr 1.


Identification of Tricyclic Agonists of Sphingosine-1-phosphate Receptor 1 (S1P1) Employing Ligand-Based Drug Design.

Xiao HY, Watterson SH, Langevine CM, Srivastava AS, Ko SS, Zhang Y, Cherney RJ, Guo WW, Gilmore JL, Sheppeck JE 2nd, Wu DR, Li P, Ramasamy D, Arunachalam P, Mathur A, Taylor TL, Shuster DJ, McIntyre KW, Shen DR, Yarde M, Cvijic ME, Marino AM, Balimane PV, Yang Z, Banas DM, Cornelius G, D'Arienzo CJ, Warrack BM, Lehman-McKeeman L, Salter-Cid LM, Xie J, Barrish JC, Carter PH, Dyckman AJ, Dhar TG.

J Med Chem. 2016 Nov 10;59(21):9837-9854. Epub 2016 Oct 20.


Evidence-based conservative rehabilitation for posterior glenohumeral instability: A systematic review.

McIntyre K, Bélanger A, Dhir J, Somerville L, Watson L, Willis M, Sadi J.

Phys Ther Sport. 2016 Nov;22:94-100. doi: 10.1016/j.ptsp.2016.06.002. Epub 2016 Jun 7. Review.


Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers.

Watterson SH, De Lucca GV, Shi Q, Langevine CM, Liu Q, Batt DG, Beaudoin Bertrand M, Gong H, Dai J, Yip S, Li P, Sun D, Wu DR, Wang C, Zhang Y, Traeger SC, Pattoli MA, Skala S, Cheng L, Obermeier MT, Vickery R, Discenza LN, D'Arienzo CJ, Zhang Y, Heimrich E, Gillooly KM, Taylor TL, Pulicicchio C, McIntyre KW, Galella MA, Tebben AJ, Muckelbauer JK, Chang C, Rampulla R, Mathur A, Salter-Cid L, Barrish JC, Carter PH, Fura A, Burke JR, Tino JA.

J Med Chem. 2016 Oct 13;59(19):9173-9200. Epub 2016 Sep 19.


Small Molecule Reversible Inhibitors of Bruton's Tyrosine Kinase (BTK): Structure-Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177).

De Lucca GV, Shi Q, Liu Q, Batt DG, Beaudoin Bertrand M, Rampulla R, Mathur A, Discenza L, D'Arienzo C, Dai J, Obermeier M, Vickery R, Zhang Y, Yang Z, Marathe P, Tebben AJ, Muckelbauer JK, Chang CJ, Zhang H, Gillooly K, Taylor T, Pattoli MA, Skala S, Kukral DW, McIntyre KW, Salter-Cid L, Fura A, Burke JR, Barrish JC, Carter PH, Tino JA.

J Med Chem. 2016 Sep 8;59(17):7915-35. doi: 10.1021/acs.jmedchem.6b00722. Epub 2016 Aug 26.


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