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Items: 1 to 50 of 280

1.

Clinical relevance of midline fluid percussion brain injury: Acute deficits, chronic morbidities and the utility of biomarkers.

Lifshitz J, Rowe RK, Griffiths DR, Evilsizor MN, Thomas TC, Adelson PD, McIntosh TK.

Brain Inj. 2016;30(11):1293-1301. doi: 10.1080/02699052.2016.1193628. Epub 2016 Aug 11. Review.

2.

Delayed neuromotor recovery and increased memory acquisition dysfunction following experimental brain trauma in mice lacking the DNA repair gene XPA.

Tomasevic G, Laurer HL, Mattiasson G, van Steeg H, Wieloch T, McIntosh TK.

J Neurosurg. 2012 Jun;116(6):1368-78. doi: 10.3171/2012.2.JNS11888. Epub 2012 Mar 30.

PMID:
22462511
3.

Deletion of the p53 tumor suppressor gene improves neuromotor function but does not attenuate regional neuronal cell loss following experimental brain trauma in mice.

Tomasevic G, Raghupathi R, Scherbel U, Wieloch T, McIntosh TK.

J Neurosci Res. 2010 Nov 15;88(15):3414-23. doi: 10.1002/jnr.22491.

PMID:
20890990
4.

Assessment of metabolic brain damage and recovery following mild traumatic brain injury: a multicentre, proton magnetic resonance spectroscopic study in concussed patients.

Vagnozzi R, Signoretti S, Cristofori L, Alessandrini F, Floris R, Isgrò E, Ria A, Marziali S, Zoccatelli G, Tavazzi B, Del Bolgia F, Sorge R, Broglio SP, McIntosh TK, Lazzarino G.

Brain. 2010 Nov;133(11):3232-42. doi: 10.1093/brain/awq200. Epub 2010 Aug 23. Erratum in: Brain. 2013 Nov;136(Pt 11):i1. Marziale, Simone [corrected to Marziali, Simone].

PMID:
20736189
5.

Genetic deletion and pharmacological inhibition of Nogo-66 receptor impairs cognitive outcome after traumatic brain injury in mice.

Hånell A, Clausen F, Björk M, Jansson K, Philipson O, Nilsson LN, Hillered L, Weinreb PH, Lee D, McIntosh TK, Gimbel DA, Strittmatter SM, Marklund N.

J Neurotrauma. 2010 Jul;27(7):1297-309. doi: 10.1089/neu.2009.1255.

6.

Functional outcome is impaired following traumatic brain injury in aging Nogo-A/B-deficient mice.

Marklund N, Morales D, Clausen F, Hånell A, Kiwanuka O, Pitkänen A, Gimbel DA, Philipson O, Lannfelt L, Hillered L, Strittmatter SM, McIntosh TK.

Neuroscience. 2009 Oct 6;163(2):540-51. doi: 10.1016/j.neuroscience.2009.06.042. Epub 2009 Jun 23.

7.

C1-inhibitor attenuates neurobehavioral deficits and reduces contusion volume after controlled cortical impact brain injury in mice.

Longhi L, Perego C, Ortolano F, Zanier ER, Bianchi P, Stocchetti N, McIntosh TK, De Simoni MG.

Crit Care Med. 2009 Feb;37(2):659-65. doi: 10.1097/CCM.0b013e318195998a.

PMID:
19114897
8.

Erythropoietin as a neuroprotective agent in traumatic brain injury Review.

Mammis A, McIntosh TK, Maniker AH.

Surg Neurol. 2009 May;71(5):527-31; discussion 531. doi: 10.1016/j.surneu.2008.02.040. Epub 2008 Sep 11. Review.

PMID:
18789503
9.

The use of Hypertonic Saline in the Treatment of Post-Traumatic Cerebral Edema: A Review.

Catrambone JE, He W, Prestigiacomo CJ, McIntosh TK, Carmel PW, Maniker A.

Eur J Trauma Emerg Surg. 2008 Aug;34(4):397-409. doi: 10.1007/s00068-007-7068-7. Epub 2007 Oct 11.

PMID:
26815818
10.

TrkB gene transfer does not alter hippocampal neuronal loss and cognitive deficits following traumatic brain injury in mice.

Conte V, Raghupathi R, Watson DJ, Fujimoto S, Royo NC, Marklund N, Stocchetti N, McIntosh TK.

Restor Neurol Neurosci. 2008;26(1):45-56.

11.
12.

The novel antiepileptic agent RWJ-333369-A, but not its analog RWJ-333369, reduces regional cerebral edema without affecting neurobehavioral outcome or cell death following experimental traumatic brain injury.

Keck CA, Thompson HJ, Pitkänen A, LeBold DG, Morales DM, Plevy JB, Puri R, Zhao B, Dichter M, McIntosh TK.

Restor Neurol Neurosci. 2007;25(2):77-90.

13.

Tissue sparing and functional recovery following experimental traumatic brain injury is provided by treatment with an anti-myelin-associated glycoprotein antibody.

Thompson HJ, Marklund N, LeBold DG, Morales DM, Keck CA, Vinson M, Royo NC, Grundy R, McIntosh TK.

Eur J Neurosci. 2006 Dec;24(11):3063-72.

14.

No evidence for the presence of apolipoprotein epsilon4, interleukin-lalpha allele 2 and interleukin-1beta allele 2 cause an increase in programmed cell death following traumatic brain injury in humans.

Johnson VE, Murray L, Raghupathi R, Stewart J, Nicoll JA, MacKinnon MA, McIntosh TK, Graham DI.

Clin Neuropathol. 2006 Nov-Dec;25(6):255-64.

PMID:
17140155
15.

Thalamic nuclei after human blunt head injury.

Maxwell WL, MacKinnon MA, Smith DH, McIntosh TK, Graham DI.

J Neuropathol Exp Neurol. 2006 May;65(5):478-88.

PMID:
16772871
16.

Evaluation of pharmacological treatment strategies in traumatic brain injury.

Marklund N, Bakshi A, Castelbuono DJ, Conte V, McIntosh TK.

Curr Pharm Des. 2006;12(13):1645-80. Review.

PMID:
16729876
17.

Cognitive evaluation of traumatically brain-injured rats using serial testing in the Morris water maze.

Thompson HJ, LeBold DG, Marklund N, Morales DM, Hagner AP, McIntosh TK.

Restor Neurol Neurosci. 2006;24(2):109-14.

18.

A model of posttraumatic epilepsy induced by lateral fluid-percussion brain injury in rats.

Kharatishvili I, Nissinen JP, McIntosh TK, Pitkänen A.

Neuroscience. 2006 Jun 30;140(2):685-97. Epub 2006 May 2.

PMID:
16650603
19.

Neural progenitor cells engineered to secrete GDNF show enhanced survival, neuronal differentiation and improve cognitive function following traumatic brain injury.

Bakshi A, Shimizu S, Keck CA, Cho S, LeBold DG, Morales D, Arenas E, Snyder EY, Watson DJ, McIntosh TK.

Eur J Neurosci. 2006 Apr;23(8):2119-34.

PMID:
16630059
20.

Hippocampal vulnerability following traumatic brain injury: a potential role for neurotrophin-4/5 in pyramidal cell neuroprotection.

Royo NC, Conte V, Saatman KE, Shimizu S, Belfield CM, Soltesz KM, Davis JE, Fujimoto ST, McIntosh TK.

Eur J Neurosci. 2006 Mar;23(5):1089-102.

PMID:
16553773
21.

Animal models of post-traumatic epilepsy.

Pitkänen A, McIntosh TK.

J Neurotrauma. 2006 Feb;23(2):241-61. Review.

PMID:
16503807
22.

Activation of Rho after traumatic brain injury and seizure in rats.

Dubreuil CI, Marklund N, Deschamps K, McIntosh TK, McKerracher L.

Exp Neurol. 2006 Apr;198(2):361-9. Epub 2006 Jan 31.

PMID:
16448651
23.
24.

Acute, transient hemorrhagic hypotension does not aggravate structural damage or neurologic motor deficits but delays the long-term cognitive recovery following mild to moderate traumatic brain injury.

Schütz C, Stover JF, Thompson HJ, Hoover RC, Morales DM, Schouten JW, McMillan A, Soltesz K, Motta M, Spangler Z, Neugebauer E, McIntosh TK.

Crit Care Med. 2006 Feb;34(2):492-501.

25.

Stem cell transplantation as a therapeutic strategy for traumatic brain injury.

Longhi L, Zanier ER, Royo N, Stocchetti N, McIntosh TK.

Transpl Immunol. 2005 Dec;15(2):143-8. Epub 2005 Oct 6. Review.

PMID:
16412958
26.

Delayed transplantation of human neurons following brain injury in rats: a long-term graft survival and behavior study.

Zhang C, Saatman KE, Royo NC, Soltesz KM, Millard M, Schouten JW, Motta M, Hoover RC, McMillan A, Watson DJ, Lee VM, Trojanowski JQ, McIntosh TK.

J Neurotrauma. 2005 Dec;22(12):1456-74.

PMID:
16379583
27.
28.

Caspase-mediated cell death predominates following engraftment of neural progenitor cells into traumatically injured rat brain.

Bakshi A, Keck CA, Koshkin VS, LeBold DG, Siman R, Snyder EY, McIntosh TK.

Brain Res. 2005 Dec 14;1065(1-2):8-19. Epub 2005 Nov 23.

PMID:
16309635
29.

Photon correlation spectroscopy of brain mitochondrial populations: application to traumatic brain injury.

Lifshitz J, Janmey PA, McIntosh TK.

Exp Neurol. 2006 Feb;197(2):318-29. Epub 2005 Nov 14.

PMID:
16289540
30.

Experimental models of traumatic brain injury: do we really need to build a better mousetrap?

Morales DM, Marklund N, Lebold D, Thompson HJ, Pitkanen A, Maxwell WL, Longhi L, Laurer H, Maegele M, Neugebauer E, Graham DI, Stocchetti N, McIntosh TK.

Neuroscience. 2005;136(4):971-89. Epub 2005 Oct 20. Review.

PMID:
16242846
31.

Newly born granule cells in the dentate gyrus rapidly extend axons into the hippocampal CA3 region following experimental brain injury.

Emery DL, Fulp CT, Saatman KE, Schütz C, Neugebauer E, McIntosh TK.

J Neurotrauma. 2005 Sep;22(9):978-88.

PMID:
16156713
32.

Mitochondrial damage and dysfunction in traumatic brain injury.

Lifshitz J, Sullivan PG, Hovda DA, Wieloch T, McIntosh TK.

Mitochondrion. 2004 Sep;4(5-6):705-13.

PMID:
16120426
33.
34.

Reversal of neuromotor and cognitive dysfunction in an enriched environment combined with multimodal early onset stimulation after traumatic brain injury in rats.

Maegele M, Lippert-Gruener M, Ester-Bode T, Sauerland S, Schäfer U, Molcanyi M, Lefering R, Bouillon B, Neiss WF, Angelov DN, Klug N, McIntosh TK, Neugebauer EA.

J Neurotrauma. 2005 Jul;22(7):772-82. Erratum in: J Neurotrauma. 2007 Dec;24(12):1889. Molcany, Marek [corrected to Molcanyi, Marek].

PMID:
16004580
35.

Delayed inhibition of Nogo-A does not alter injury-induced axonal sprouting but enhances recovery of cognitive function following experimental traumatic brain injury in rats.

Lenzlinger PM, Shimizu S, Marklund N, Thompson HJ, Schwab ME, Saatman KE, Hoover RC, Bareyre FM, Motta M, Luginbuhl A, Pape R, Clouse AK, Morganti-Kossmann C, McIntosh TK.

Neuroscience. 2005;134(3):1047-56.

PMID:
15979242
36.

Administration of monoclonal antibodies neutralizing the inflammatory mediators tumor necrosis factor alpha and interleukin -6 does not attenuate acute behavioral deficits following experimental traumatic brain injury in the rat.

Marklund N, Keck C, Hoover R, Soltesz K, Millard M, LeBold D, Spangler Z, Banning A, Benson J, McIntosh TK.

Restor Neurol Neurosci. 2005;23(1):31-42.

PMID:
15846030
37.

Characterization of a new rat model of experimental combined neurotrauma.

Maegele M, Riess P, Sauerland S, Bouillon B, Hess S, McIntosh TK, Mautes A, Brockmann M, Koebke J, Knifka J, Neugebauer EA.

Shock. 2005 May;23(5):476-81.

PMID:
15834316
38.

Ex vivo gene therapy using targeted engraftment of NGF-expressing human NT2N neurons attenuates cognitive deficits following traumatic brain injury in mice.

Longhi L, Watson DJ, Saatman KE, Thompson HJ, Zhang C, Fujimoto S, Royo N, Castelbuono D, Raghupathi R, Trojanowski JQ, Lee VM, Wolfe JH, Stocchetti N, McIntosh TK.

J Neurotrauma. 2004 Dec;21(12):1723-36.

PMID:
15684764
39.

A review and rationale for the use of cellular transplantation as a therapeutic strategy for traumatic brain injury.

Schouten JW, Fulp CT, Royo NC, Saatman KE, Watson DJ, Snyder EY, Trojanowski JQ, Prockop DJ, Maas AI, McIntosh TK.

J Neurotrauma. 2004 Nov;21(11):1501-38. Review.

PMID:
15684646
40.

Temporal window of vulnerability to repetitive experimental concussive brain injury.

Longhi L, Saatman KE, Fujimoto S, Raghupathi R, Meaney DF, Davis J, McMillan B S A, Conte V, Laurer HL, Stein S, Stocchetti N, McIntosh TK.

Neurosurgery. 2005 Feb;56(2):364-74; discussion 364-74.

PMID:
15670384
41.

Lateral fluid percussion brain injury: a 15-year review and evaluation.

Thompson HJ, Lifshitz J, Marklund N, Grady MS, Graham DI, Hovda DA, McIntosh TK.

J Neurotrauma. 2005 Jan;22(1):42-75. Review.

PMID:
15665602
42.

Development of posttraumatic hyperthermia after traumatic brain injury in rats is associated with increased periventricular inflammation.

Thompson HJ, Hoover RC, Tkacs NC, Saatman KE, McIntosh TK.

J Cereb Blood Flow Metab. 2005 Feb;25(2):163-76.

PMID:
15647747
43.

Differential responses in three thalamic nuclei in moderately disabled, severely disabled and vegetative patients after blunt head injury.

Maxwell WL, Pennington K, MacKinnon MA, Smith DH, McIntosh TK, Wilson JT, Graham DI.

Brain. 2004 Nov;127(Pt 11):2470-8. Epub 2004 Sep 29.

PMID:
15456707
44.

Motor and cognitive function evaluation following experimental traumatic brain injury.

Fujimoto ST, Longhi L, Saatman KE, Conte V, Stocchetti N, McIntosh TK.

Neurosci Biobehav Rev. 2004 Jul;28(4):365-78. Review. Erratum in: Neurosci Biobehav Rev. 2005 Jan;28(8):877. Conte, Valeria [added]; Stocchetti, Nino [added].

PMID:
15341032
45.

Inhibition of vascular endothelial growth factor receptor (VEGFR) signaling by BSF476921 attenuates regional cerebral edema following traumatic brain injury in rats.

Lenzlinger PM, Saatman KE, Hoover RC, Cheney JA, Bareyre FM, Raghupathi R, Arnold LD, McIntosh TK.

Restor Neurol Neurosci. 2004;22(2):73-9.

PMID:
15272142
46.

Vitamin E reduces amyloidosis and improves cognitive function in Tg2576 mice following repetitive concussive brain injury.

Conte V, Uryu K, Fujimoto S, Yao Y, Rokach J, Longhi L, Trojanowski JQ, Lee VM, McIntosh TK, Praticò D.

J Neurochem. 2004 Aug;90(3):758-64. Erratum in: J Neurochem. 2004 Sep;90(6):1541.

47.

Traumatic brain injury elevates glycogen and induces tolerance to ischemia in rat brain.

Otori T, Friedland JC, Sinson G, McIntosh TK, Raghupathi R, Welsh FA.

J Neurotrauma. 2004 Jun;21(6):707-18.

PMID:
15253799
48.

Proteins released from degenerating neurons are surrogate markers for acute brain damage.

Siman R, McIntosh TK, Soltesz KM, Chen Z, Neumar RW, Roberts VL.

Neurobiol Dis. 2004 Jul;16(2):311-20.

PMID:
15193288
49.

Methodological considerations regarding single-cell gene expression profiling for brain injury.

Davis JE, Eberwine JH, Hinkle DA, Marciano PG, Meaney DF, McIntosh TK.

Neurochem Res. 2004 Jun;29(6):1113-21. Review.

PMID:
15176468
50.

Differential effects of the anticonvulsant topiramate on neurobehavioral and histological outcomes following traumatic brain injury in rats.

Hoover RC, Motta M, Davis J, Saatman KE, Fujimoto ST, Thompson HJ, Stover JF, Dichter MA, Twyman R, White HS, McIntosh TK.

J Neurotrauma. 2004 May;21(5):501-12.

PMID:
15165359

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