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Items: 1 to 50 of 295

1.

α-Conotoxin VnIB from Conus ventricosus is a potent and selective antagonist of α6β4* nicotinic acetylcholine receptors.

van Hout M, Valdes A, Christensen SB, Tran PT, Watkins M, Gajewiak J, Jensen AA, Olivera BM, McIntosh JM.

Neuropharmacology. 2019 Oct;157:107691. doi: 10.1016/j.neuropharm.2019.107691. Epub 2019 Jun 28.

PMID:
31255696
2.

PeIA-5466: A Novel Peptide Antagonist Containing Non-natural Amino Acids That Selectively Targets α3β2 Nicotinic Acetylcholine Receptors.

Hone AJ, Fisher F, Christensen S, Gajewiak J, Larkin D, Whiteaker P, McIntosh JM.

J Med Chem. 2019 Jul 11;62(13):6262-6275. doi: 10.1021/acs.jmedchem.9b00566. Epub 2019 Jun 27.

PMID:
31194549
3.

SLPI Inhibits ATP-Mediated Maturation of IL-1β in Human Monocytic Leukocytes: A Novel Function of an Old Player.

Zakrzewicz A, Richter K, Zakrzewicz D, Siebers K, Damm J, Agné A, Hecker A, McIntosh JM, Chamulitrat W, Krasteva-Christ G, Manzini I, Tikkanen R, Padberg W, Janciauskiene S, Grau V.

Front Immunol. 2019 Apr 4;10:664. doi: 10.3389/fimmu.2019.00664. eCollection 2019.

4.

Alpha6-containing nicotinic acetylcholine receptor is a highly sensitive target of alcohol.

Gao F, Chen D, Ma X, Sudweeks S, Yorgason JT, Gao M, Turner D, Eaton JB, McIntosh JM, Lukas RJ, Whiteaker P, Chang Y, Steffensen SC, Wu J.

Neuropharmacology. 2019 May 1;149:45-54. doi: 10.1016/j.neuropharm.2019.01.021. Epub 2019 Jan 30.

PMID:
30710570
5.

Conopeptides [V11L;V16D]ArIB and RgIA4: Powerful Tools for the Identification of Novel Nicotinic Acetylcholine Receptors in Monocytes.

Grau V, Richter K, Hone AJ, McIntosh JM.

Front Pharmacol. 2019 Jan 7;9:1499. doi: 10.3389/fphar.2018.01499. eCollection 2018.

6.

Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain.

Arribas-Blázquez M, Olivos-Oré LA, Barahona MV, Sánchez de la Muela M, Solar V, Jiménez E, Gualix J, McIntosh JM, Ferrer-Montiel A, Miras-Portugal MT, Artalejo AR.

Int J Mol Sci. 2019 Jan 3;20(1). pii: E155. doi: 10.3390/ijms20010155.

7.

Potent Antiglioblastoma Agents by Hybridizing the Onium-Alkyloxy-Stilbene Based Structures of an α7-nAChR, α9-nAChR Antagonist and of a Pro-Oxidant Mitocan.

Bavo F, Pucci S, Fasoli F, Lammi C, Moretti M, Mucchietto V, Lattuada D, Viani P, De Palma C, Budriesi R, Corradini I, Dowell C, McIntosh JM, Clementi F, Bolchi C, Gotti C, Pallavicini M.

J Med Chem. 2018 Dec 13;61(23):10531-10544. doi: 10.1021/acs.jmedchem.8b01052. Epub 2018 Nov 26.

PMID:
30403486
8.

Neuronal nicotinic acetylcholine receptors mediate ∆9 -THC dependence: Mouse and human studies.

Donvito G, Muldoon PP, Jackson KJ, Ahmad U, Zaveri NT, McIntosh JM, Chen X, Lichtman AH, Damaj MI.

Addict Biol. 2018 Oct 31. doi: 10.1111/adb.12691. [Epub ahead of print]

PMID:
30378732
9.

Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors.

Hone AJ, Talley TT, Bobango J, Huidobro Melo C, Hararah F, Gajewiak J, Christensen S, Harvey PJ, Craik DJ, McIntosh JM.

J Biol Chem. 2018 Nov 16;293(46):17838-17852. doi: 10.1074/jbc.RA118.005649. Epub 2018 Sep 24.

10.

C-Reactive Protein Stimulates Nicotinic Acetylcholine Receptors to Control ATP-Mediated Monocytic Inflammasome Activation.

Richter K, Sagawe S, Hecker A, Küllmar M, Askevold I, Damm J, Heldmann S, Pöhlmann M, Ruhrmann S, Sander M, Schlüter KD, Wilker S, König IR, Kummer W, Padberg W, Hone AJ, McIntosh JM, Zakrzewicz AT, Koch C, Grau V.

Front Immunol. 2018 Jul 30;9:1604. doi: 10.3389/fimmu.2018.01604. eCollection 2018.

11.

Phosphocholine-Modified Lipooligosaccharides of Haemophilus influenzae Inhibit ATP-Induced IL-1β Release by Pulmonary Epithelial Cells.

Richter K, Koch C, Perniss A, Wolf PM, Schweda EKH, Wichmann S, Wilker S, Magel I, Sander M, McIntosh JM, Padberg W, Grau V.

Molecules. 2018 Aug 8;23(8). pii: E1979. doi: 10.3390/molecules23081979.

12.

Alpha-1 Antitrypsin Inhibits ATP-Mediated Release of Interleukin-1β via CD36 and Nicotinic Acetylcholine Receptors.

Siebers K, Fink B, Zakrzewicz A, Agné A, Richter K, Konzok S, Hecker A, Zukunft S, Küllmar M, Klein J, McIntosh JM, Timm T, Sewald K, Padberg W, Aggarwal N, Chamulitrat W, Santoso S, Xia W, Janciauskiene S, Grau V.

Front Immunol. 2018 Apr 25;9:877. doi: 10.3389/fimmu.2018.00877. eCollection 2018.

13.

Pharmacological and functional comparisons of α6/α3β2β3-nAChRs and α4β2-nAChRs heterologously expressed in the human epithelial SH-EP1 cell line.

Chen DJ, Gao FF, Ma XK, Shi GG, Huang YB, Su QX, Sudweeks S, Gao M, Dharshaun T, Eaton JB, Chang YC, Mcintosh JM, Lukas RJ, Whiteaker P, Steffensen SC, Wu J.

Acta Pharmacol Sin. 2018 Oct;39(10):1571-1581. doi: 10.1038/aps.2017.209. Epub 2018 May 24.

14.

Nicotinic Cholinergic Receptors in VTA Glutamate Neurons Modulate Excitatory Transmission.

Yan Y, Peng C, Arvin MC, Jin XT, Kim VJ, Ramsey MD, Wang Y, Banala S, Wokosin DL, McIntosh JM, Lavis LD, Drenan RM.

Cell Rep. 2018 May 22;23(8):2236-2244. doi: 10.1016/j.celrep.2018.04.062.

15.

Gene editing vectors for studying nicotinic acetylcholine receptors in cholinergic transmission.

Peng C, Yan Y, Kim VJ, Engle SE, Berry JN, McIntosh JM, Neve RL, Drenan RM.

Eur J Neurosci. 2019 Aug;50(3):2224-2238. doi: 10.1111/ejn.13957. Epub 2018 Jul 25.

PMID:
29779223
16.

β-Nicotinamide Adenine Dinucleotide (β-NAD) Inhibits ATP-Dependent IL-1β Release from Human Monocytic Cells.

Hiller SD, Heldmann S, Richter K, Jurastow I, Küllmar M, Hecker A, Wilker S, Fuchs-Moll G, Manzini I, Schmalzing G, Kummer W, Padberg W, McIntosh JM, Damm J, Zakrzewicz A, Grau V.

Int J Mol Sci. 2018 Apr 10;19(4). pii: E1126. doi: 10.3390/ijms19041126.

17.

Photoactivatable drugs for nicotinic optopharmacology.

Banala S, Arvin MC, Bannon NM, Jin XT, Macklin JJ, Wang Y, Peng C, Zhao G, Marshall JJ, Gee KR, Wokosin DL, Kim VJ, McIntosh JM, Contractor A, Lester HA, Kozorovitskiy Y, Drenan RM, Lavis LD.

Nat Methods. 2018 May;15(5):347-350. doi: 10.1038/nmeth.4637. Epub 2018 Mar 26.

18.

Muscle Nicotinic Acetylcholine Receptors May Mediate Trans-Synaptic Signaling at the Mouse Neuromuscular Junction.

Wang X, McIntosh JM, Rich MM.

J Neurosci. 2018 Feb 14;38(7):1725-1736. doi: 10.1523/JNEUROSCI.1789-17.2018. Epub 2018 Jan 11.

19.

Human nicotinic receptors in chromaffin cells: characterization and pharmacology.

Albillos A, McIntosh JM.

Pflugers Arch. 2018 Jan;470(1):21-27. doi: 10.1007/s00424-017-2073-0. Epub 2017 Oct 20. Review.

20.

Nicotinic acetylcholine receptors in neuropathic and inflammatory pain.

Hone AJ, McIntosh JM.

FEBS Lett. 2018 Apr;592(7):1045-1062. doi: 10.1002/1873-3468.12884. Epub 2017 Oct 27. Review.

21.

RgIA4 Potently Blocks Mouse α9α10 nAChRs and Provides Long Lasting Protection against Oxaliplatin-Induced Cold Allodynia.

Christensen SB, Hone AJ, Roux I, Kniazeff J, Pin JP, Upert G, Servent D, Glowatzki E, McIntosh JM.

Front Cell Neurosci. 2017 Jul 21;11:219. doi: 10.3389/fncel.2017.00219. eCollection 2017.

22.

Altered nicotine reward-associated behavior following α4 nAChR subunit deletion in ventral midbrain.

Peng C, Engle SE, Yan Y, Weera MM, Berry JN, Arvin MC, Zhao G, McIntosh JM, Chester JA, Drenan RM.

PLoS One. 2017 Jul 31;12(7):e0182142. doi: 10.1371/journal.pone.0182142. eCollection 2017.

23.

Chemokines (CCL3, CCL4, and CCL5) Inhibit ATP-Induced Release of IL-1β by Monocytic Cells.

Amati AL, Zakrzewicz A, Siebers R, Wilker S, Heldmann S, Zakrzewicz D, Hecker A, McIntosh JM, Padberg W, Grau V.

Mediators Inflamm. 2017;2017:1434872. doi: 10.1155/2017/1434872. Epub 2017 Jul 5.

24.

Canonical and Novel Non-Canonical Cholinergic Agonists Inhibit ATP-Induced Release of Monocytic Interleukin-1β via Different Combinations of Nicotinic Acetylcholine Receptor Subunits α7, α9 and α10.

Zakrzewicz A, Richter K, Agné A, Wilker S, Siebers K, Fink B, Krasteva-Christ G, Althaus M, Padberg W, Hone AJ, McIntosh JM, Grau V.

Front Cell Neurosci. 2017 Jul 5;11:189. doi: 10.3389/fncel.2017.00189. eCollection 2017.

25.

α6β2 subunit containing nicotinic acetylcholine receptors exert opposing actions on rapid dopamine signaling in the nucleus accumbens of rats with high-versus low-response to novelty.

Siciliano CA, McIntosh JM, Jones SR, Ferris MJ.

Neuropharmacology. 2017 Nov;126:281-291. doi: 10.1016/j.neuropharm.2017.06.028. Epub 2017 Jun 27.

26.

α9-containing nicotinic acetylcholine receptors and the modulation of pain.

Hone AJ, Servent D, McIntosh JM.

Br J Pharmacol. 2018 Jun;175(11):1915-1927. doi: 10.1111/bph.13931. Epub 2017 Jul 30. Review.

27.

Differential Control of Dopaminergic Excitability and Locomotion by Cholinergic Inputs in Mouse Substantia Nigra.

Estakhr J, Abazari D, Frisby K, McIntosh JM, Nashmi R.

Curr Biol. 2017 Jul 10;27(13):1900-1914.e4. doi: 10.1016/j.cub.2017.05.084. Epub 2017 Jun 22.

28.

α-Conotoxin [S9A]TxID Potently Discriminates between α3β4 and α6/α3β4 Nicotinic Acetylcholine Receptors.

Wu Y, Zhangsun D, Zhu X, Kaas Q, Zhangsun M, Harvey PJ, Craik DJ, McIntosh JM, Luo S.

J Med Chem. 2017 Jul 13;60(13):5826-5833. doi: 10.1021/acs.jmedchem.7b00546. Epub 2017 Jun 21.

29.

αO-Conotoxin GeXIVA disulfide bond isomers exhibit differential sensitivity for various nicotinic acetylcholine receptors but retain potency and selectivity for the human α9α10 subtype.

Zhangsun D, Zhu X, Kaas Q, Wu Y, Craik DJ, McIntosh JM, Luo S.

Neuropharmacology. 2017 Dec;127:243-252. doi: 10.1016/j.neuropharm.2017.04.015. Epub 2017 Apr 14.

30.

Surfactant inhibits ATP-induced release of interleukin-1β via nicotinic acetylcholine receptors.

Backhaus S, Zakrzewicz A, Richter K, Damm J, Wilker S, Fuchs-Moll G, Küllmar M, Hecker A, Manzini I, Ruppert C, McIntosh JM, Padberg W, Grau V.

J Lipid Res. 2017 Jun;58(6):1055-1066. doi: 10.1194/jlr.M071506. Epub 2017 Apr 12.

31.

Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain.

Romero HK, Christensen SB, Di Cesare Mannelli L, Gajewiak J, Ramachandra R, Elmslie KS, Vetter DE, Ghelardini C, Iadonato SP, Mercado JL, Olivera BM, McIntosh JM.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1825-E1832. doi: 10.1073/pnas.1621433114. Epub 2017 Feb 21.

32.

Nicotine regulates activity of lateral habenula neurons via presynaptic and postsynaptic mechanisms.

Zuo W, Xiao C, Gao M, Hopf FW, Krnjević K, McIntosh JM, Fu R, Wu J, Bekker A, Ye JH.

Sci Rep. 2016 Sep 6;6:32937. doi: 10.1038/srep32937.

33.

Phosphocholine - an agonist of metabotropic but not of ionotropic functions of α9-containing nicotinic acetylcholine receptors.

Richter K, Mathes V, Fronius M, Althaus M, Hecker A, Krasteva-Christ G, Padberg W, Hone AJ, McIntosh JM, Zakrzewicz A, Grau V.

Sci Rep. 2016 Jun 28;6:28660. doi: 10.1038/srep28660.

34.

The α9α10 nicotinic receptor antagonist α-conotoxin RgIA prevents neuropathic pain induced by oxaliplatin treatment.

Pacini A, Micheli L, Maresca M, Branca JJ, McIntosh JM, Ghelardini C, Di Cesare Mannelli L.

Exp Neurol. 2016 Aug;282:37-48. doi: 10.1016/j.expneurol.2016.04.022. Epub 2016 Apr 28.

PMID:
27132993
35.

Assessment of the expression and role of the α1-nAChR subunit in efferent cholinergic function during the development of the mammalian cochlea.

Roux I, Wu JS, McIntosh JM, Glowatzki E.

J Neurophysiol. 2016 Aug 1;116(2):479-92. doi: 10.1152/jn.01038.2015. Epub 2016 Apr 20.

36.

Habenula cholinergic neurons regulate anxiety during nicotine withdrawal via nicotinic acetylcholine receptors.

Pang X, Liu L, Ngolab J, Zhao-Shea R, McIntosh JM, Gardner PD, Tapper AR.

Neuropharmacology. 2016 Aug;107:294-304. doi: 10.1016/j.neuropharm.2016.03.039. Epub 2016 Mar 26.

37.

Prior nicotine self-administration attenuates subsequent dopaminergic deficits of methamphetamine in rats: role of nicotinic acetylcholine receptors.

Baladi MG, Nielsen SM, McIntosh JM, Hanson GR, Fleckenstein AE.

Behav Pharmacol. 2016 Aug;27(5):422-30. doi: 10.1097/FBP.0000000000000215.

38.

α7 nicotinic receptor agonists reduce levodopa-induced dyskinesias with severe nigrostriatal damage.

Zhang D, McGregor M, Bordia T, Perez XA, McIntosh JM, Decker MW, Quik M.

Mov Disord. 2015 Dec;30(14):1901-1911. doi: 10.1002/mds.26453. Epub 2015 Nov 17.

39.

Nicotine Dependence Reveals Distinct Responses from Neurons and Their Resident Nicotinic Receptors in Medial Habenula.

Shih PY, McIntosh JM, Drenan RM.

Mol Pharmacol. 2015 Dec;88(6):1035-44. doi: 10.1124/mol.115.101444. Epub 2015 Oct 1.

40.

Chronic Nicotine Exposure Attenuates Methamphetamine-Induced Dopaminergic Deficits.

Vieira-Brock PL, McFadden LM, Nielsen SM, Ellis JD, Walters ET, Stout KA, McIntosh JM, Wilkins DG, Hanson GR, Fleckenstein AE.

J Pharmacol Exp Ther. 2015 Dec;355(3):463-72. doi: 10.1124/jpet.114.221945. Epub 2015 Sep 21.

41.

α-Conotoxins Identify the α3β4* Subtype as the Predominant Nicotinic Acetylcholine Receptor Expressed in Human Adrenal Chromaffin Cells.

Hone AJ, McIntosh JM, Azam L, Lindstrom J, Lucero L, Whiteaker P, Passas J, Blázquez J, Albillos A.

Mol Pharmacol. 2015 Nov;88(5):881-93. doi: 10.1124/mol.115.100982. Epub 2015 Sep 1. Erratum in: Mol Pharmacol. 2016 Feb;89(2):322.

42.

r-bPiDI, an α6β2* Nicotinic Receptor Antagonist, Decreases Nicotine-Evoked Dopamine Release and Nicotine Reinforcement.

Beckmann JS, Meyer AC, Pivavarchyk M, Horton DB, Zheng G, Smith AM, Wooters TE, McIntosh JM, Crooks PA, Bardo MT, Dwoskin LP.

Neurochem Res. 2015 Oct;40(10):2121-30. doi: 10.1007/s11064-015-1680-4. Epub 2015 Jul 31.

43.

α6-Containing nicotinic acetylcholine receptors in midbrain dopamine neurons are poised to govern dopamine-mediated behaviors and synaptic plasticity.

Berry JN, Engle SE, McIntosh JM, Drenan RM.

Neuroscience. 2015 Sep 24;304:161-75. doi: 10.1016/j.neuroscience.2015.07.052. Epub 2015 Jul 23.

44.

Chronic treatment with varenicline changes expression of four nAChR binding sites in mice.

Marks MJ, O'Neill HC, Wynalda-Camozzi KM, Ortiz NC, Simmons EE, Short CA, Butt CM, McIntosh JM, Grady SR.

Neuropharmacology. 2015 Dec;99:142-55. doi: 10.1016/j.neuropharm.2015.07.019. Epub 2015 Jul 17.

45.

Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist.

Luo S, Zhangsun D, Harvey PJ, Kaas Q, Wu Y, Zhu X, Hu Y, Li X, Tsetlin VI, Christensen S, Romero HK, McIntyre M, Dowell C, Baxter JC, Elmslie KS, Craik DJ, McIntosh JM.

Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4026-35. doi: 10.1073/pnas.1503617112. Epub 2015 Jul 13.

46.

Limited efficacy of α-conopeptides, Vc1.1 and RgIA, to inhibit sensory neuron CaV current.

Wright AB, Norimatsu Y, McIntosh JM, Elmslie KS.

eNeuro. 2015 Jan-Feb;2(1). doi: 10.1523/ENEURO.0057-14.2015.

47.

αS-conotoxin GVIIIB potently and selectively blocks α9α10 nicotinic acetylcholine receptors.

Christensen SB, Bandyopadhyay PK, Olivera BM, McIntosh JM.

Biochem Pharmacol. 2015 Aug 15;96(4):349-56. doi: 10.1016/j.bcp.2015.06.007. Epub 2015 Jun 11.

48.

Evidence for a role for α6(∗) nAChRs in l-dopa-induced dyskinesias using Parkinsonian α6(∗) nAChR gain-of-function mice.

Bordia T, McGregor M, McIntosh JM, Drenan RM, Quik M.

Neuroscience. 2015 Jun 4;295:187-97. doi: 10.1016/j.neuroscience.2015.03.040. Epub 2015 Mar 24.

49.

Molecular interaction of α-conotoxin RgIA with the rat α9α10 nicotinic acetylcholine receptor.

Azam L, Papakyriakou A, Zouridakis M, Giastas P, Tzartos SJ, McIntosh JM.

Mol Pharmacol. 2015 May;87(5):855-64. doi: 10.1124/mol.114.096511. Epub 2015 Mar 4. Erratum in: Mol Pharmacol. 2016 Oct;90(4):415-7.

50.

Pharmacologically distinct nicotinic acetylcholine receptors drive efferent-mediated excitation in calyx-bearing vestibular afferents.

Holt JC, Kewin K, Jordan PM, Cameron P, Klapczynski M, McIntosh JM, Crooks PA, Dwoskin LP, Lysakowski A.

J Neurosci. 2015 Feb 25;35(8):3625-43. doi: 10.1523/JNEUROSCI.3388-14.2015.

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