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Items: 1 to 50 of 161

1.

Toxicity related to standard TB therapy for pulmonary tuberculosis and treatment outcomes in the REMoxTB study according to HIV status.

Tweed CD, Crook AM, Dawson R, Diacon AH, McHugh TD, Mendel CM, Meredith SK, Mohapi L, Murphy ME, Nunn AJ, Phillips PPJ, Singh KP, Spigelman M, Gillespie SH.

BMC Pulm Med. 2019 Aug 14;19(1):152. doi: 10.1186/s12890-019-0907-6.

2.

Fluoroquinolones and isoniazid-resistant tuberculosis: implications for the 2018 WHO guidance.

Stagg HR, Bothamley GH, Davidson JA, Kunst H, Lalor MK, Lipman MC, Loutet MG, Lozewicz S, Mohiyuddin T, Abbara A, Alexander E, Booth H, Creer DD, Harris RJ, Kon OM, Loebinger MR, McHugh TD, Milburn HJ, Palchaudhuri P, Phillips PPJ, Schmok E, Taylor L, Abubakar I; London INH-R TB study group.

Eur Respir J. 2019 Oct 10;54(4). pii: 1900982. doi: 10.1183/13993003.00982-2019. Print 2019 Oct.

3.

A Systematic Review and Meta-analysis of the Diagnostic Accuracy of Nucleic Acid Amplification Tests for Tuberculous Meningitis.

Pormohammad A, Nasiri MJ, McHugh TD, Riahi SM, Bahr NC.

J Clin Microbiol. 2019 May 24;57(6). pii: e01113-18. doi: 10.1128/JCM.01113-18. Print 2019 Jun. Review.

PMID:
30944198
4.

New drugs to treat difficult tuberculous and nontuberculous mycobacterial pulmonary disease.

Lee SFK, Laughon BE, McHugh TD, Lipman M.

Curr Opin Pulm Med. 2019 May;25(3):271-280. doi: 10.1097/MCP.0000000000000570.

PMID:
30865034
5.

Revolutionary new treatment regimens for multidrug-resistant tuberculosis.

McHugh TD, Honeyborne I, Lipman M, Zumla A.

Lancet Infect Dis. 2019 Mar;19(3):233-234. doi: 10.1016/S1473-3099(19)30060-X. No abstract available.

PMID:
30833051
6.

World Tuberculosis Day March 24th 2019 Theme: "It's TIME" - International Journal of Infectious Diseases Tuberculosis Theme Series.

Petersen E, Rao M, Ippolito G, Gualano G, Chakaya J, Ntoumi F, Moore D, Allen R, Gaskell K, Öhd JN, Hergens MP, Krishnamoorthy S, Ugarte-Gil C, Kirwan DE, Honeyborne I, McHugh TD, Köser CU, Kranzer K, Tiberi S, Migliori GB, Mao Q, Yang Y, Oliveira SP, Cardoso RF, Detjen A, Marais B, de Gijsel D, von Reyn CF, Goscé L, Abubakar I, Maeurer M, Zumla A.

Int J Infect Dis. 2019 Mar;80S:S1-S5. doi: 10.1016/j.ijid.2019.02.024. Epub 2019 Feb 23. No abstract available.

7.

Smartphone-enabled video-observed versus directly observed treatment for tuberculosis: a multicentre, analyst-blinded, randomised, controlled superiority trial.

Story A, Aldridge RW, Smith CM, Garber E, Hall J, Ferenando G, Possas L, Hemming S, Wurie F, Luchenski S, Abubakar I, McHugh TD, White PJ, Watson JM, Lipman M, Garfein R, Hayward AC.

Lancet. 2019 Mar 23;393(10177):1216-1224. doi: 10.1016/S0140-6736(18)32993-3. Epub 2019 Feb 21.

8.

The changing treatment landscape for MDR/XDR-TB - Can current clinical trials revolutionise and inform a brave new world?

Honeyborne I, Lipman M, Zumla A, McHugh TD.

Int J Infect Dis. 2019 Mar;80S:S23-S28. doi: 10.1016/j.ijid.2019.02.006. Epub 2019 Feb 15. No abstract available.

9.

Airway microbiome in adult survivors of extremely preterm birth: the EPICure study.

Rofael SAD, McHugh TD, Troughton R, Beckmann J, Spratt D, Marlow N, Hurst JR.

Eur Respir J. 2019 Jan 10;53(1). pii: 1801225. doi: 10.1183/13993003.01225-2018. Print 2019 Jan.

PMID:
30464016
10.

Monkeypox - Enhancing public health preparedness for an emerging lethal human zoonotic epidemic threat in the wake of the smallpox post-eradication era.

Petersen E, Abubakar I, Ihekweazu C, Heymann D, Ntoumi F, Blumberg L, Asogun D, Mukonka V, Lule SA, Bates M, Honeyborne I, Mfinanga S, Mwaba P, Dar O, Vairo F, Mukhtar M, Kock R, McHugh TD, Ippolito G, Zumla A.

Int J Infect Dis. 2019 Jan;78:78-84. doi: 10.1016/j.ijid.2018.11.008. Epub 2018 Nov 16. Review.

11.

Detection of carbapenemases, AmpC and ESBL genes in Acinetobacter isolates from ICUs by DNA microarray.

Uddin F, McHugh TD, Roulston K, Platt G, Khan TA, Sohail M.

J Microbiol Methods. 2018 Dec;155:19-23. doi: 10.1016/j.mimet.2018.11.004. Epub 2018 Nov 10.

PMID:
30423363
12.

Gender differences in tuberculosis treatment outcomes: a post hoc analysis of the REMoxTB study.

Murphy ME, Wills GH, Murthy S, Louw C, Bateson ALC, Hunt RD, McHugh TD, Nunn AJ, Meredith SK, Mendel CM, Spigelman M, Crook AM, Gillespie SH; REMoxTB consortium.

BMC Med. 2018 Oct 17;16(1):189. doi: 10.1186/s12916-018-1169-5.

13.

Toxicity associated with tuberculosis chemotherapy in the REMoxTB study.

Tweed CD, Crook AM, Amukoye EI, Dawson R, Diacon AH, Hanekom M, McHugh TD, Mendel CM, Meredith SK, Murphy ME, Murthy SE, Nunn AJ, Phillips PPJ, Singh KP, Spigelman M, Wills GH, Gillespie SH.

BMC Infect Dis. 2018 Jul 11;18(1):317. doi: 10.1186/s12879-018-3230-6.

14.

Hepatitis C among vulnerable populations: A seroprevalence study of homeless, people who inject drugs and prisoners in London.

Aisyah DN, Shallcross L, Hayward A, Aldridge RW, Hemming S, Yates S, Ferenando G, Possas L, Garber E, Watson JM, Geretti AM, McHugh TD, Lipman M, Story A.

J Viral Hepat. 2018 Nov;25(11):1260-1269. doi: 10.1111/jvh.12936. Epub 2018 Jun 20.

PMID:
29851232
15.

Direct Whole-Genome Sequencing of Sputum Accurately Identifies Drug-Resistant Mycobacterium tuberculosis Faster than MGIT Culture Sequencing.

Doyle RM, Burgess C, Williams R, Gorton R, Booth H, Brown J, Bryant JM, Chan J, Creer D, Holdstock J, Kunst H, Lozewicz S, Platt G, Romero EY, Speight G, Tiberi S, Abubakar I, Lipman M, McHugh TD, Breuer J.

J Clin Microbiol. 2018 Jul 26;56(8). pii: e00666-18. doi: 10.1128/JCM.00666-18. Print 2018 Aug.

16.

Pretreatment chest x-ray severity and its relation to bacterial burden in smear positive pulmonary tuberculosis.

Murthy SE, Chatterjee F, Crook A, Dawson R, Mendel C, Murphy ME, Murray SR, Nunn AJ, Phillips PPJ, Singh KP, McHugh TD, Gillespie SH; REMoxTB Consortium.

BMC Med. 2018 May 21;16(1):73. doi: 10.1186/s12916-018-1053-3.

17.

Full blood count values as a predictor of poor outcome of pneumonia among HIV-infected patients.

Camon S, Quiros C, Saubi N, Moreno A, Marcos MA, Eto Y, Rofael S, Monclus E, Brown J, McHugh TD, Mallolas J, Perello R.

BMC Infect Dis. 2018 Apr 19;18(1):189. doi: 10.1186/s12879-018-3090-0.

18.

Cell-wall synthesis and ribosome maturation are co-regulated by an RNA switch in Mycobacterium tuberculosis.

Schwenk S, Moores A, Nobeli I, McHugh TD, Arnvig KB.

Nucleic Acids Res. 2018 Jun 20;46(11):5837-5849. doi: 10.1093/nar/gky226.

19.

Liver toxicity associated with tuberculosis chemotherapy in the REMoxTB study.

Tweed CD, Wills GH, Crook AM, Dawson R, Diacon AH, Louw CE, McHugh TD, Mendel C, Meredith S, Mohapi L, Murphy ME, Murray S, Murthy S, Nunn AJ, Phillips PPJ, Singh K, Spigelman M, Gillespie SH.

BMC Med. 2018 Mar 28;16(1):46. doi: 10.1186/s12916-018-1033-7.

20.

Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies.

Tiberi S, du Plessis N, Walzl G, Vjecha MJ, Rao M, Ntoumi F, Mfinanga S, Kapata N, Mwaba P, McHugh TD, Ippolito G, Migliori GB, Maeurer MJ, Zumla A.

Lancet Infect Dis. 2018 Jul;18(7):e183-e198. doi: 10.1016/S1473-3099(18)30110-5. Epub 2018 Mar 23. Review. Erratum in: Lancet Infect Dis. 2018 Apr 27;:.

PMID:
29580819
21.

Tuberculosis: advances and challenges in development of new diagnostics and biomarkers.

Walzl G, McNerney R, du Plessis N, Bates M, McHugh TD, Chegou NN, Zumla A.

Lancet Infect Dis. 2018 Jul;18(7):e199-e210. doi: 10.1016/S1473-3099(18)30111-7. Epub 2018 Mar 23. Review.

PMID:
29580818
22.

High prevalence of latent tuberculosis and bloodborne virus infection in a homeless population.

Aldridge RW, Hayward AC, Hemming S, Yates SK, Ferenando G, Possas L, Garber E, Watson JM, Geretti AM, McHugh TD, Lipman M, Story A.

Thorax. 2018 Jun;73(6):557-564. doi: 10.1136/thoraxjnl-2016-209579. Epub 2018 Jan 29.

23.

Analogues of Disulfides from Allium stipitatum Demonstrate Potent Anti-tubercular Activities through Drug Efflux Pump and Biofilm Inhibition.

Danquah CA, Kakagianni E, Khondkar P, Maitra A, Rahman M, Evangelopoulos D, McHugh TD, Stapleton P, Malkinson J, Bhakta S, Gibbons S.

Sci Rep. 2018 Jan 18;8(1):1150. doi: 10.1038/s41598-017-18948-w.

24.

A comparison of liquid and solid culture for determining relapse and durable cure in phase III TB trials for new regimens.

Phillips PPJ, Mendel CM, Nunn AJ, McHugh TD, Crook AM, Hunt R, Bateson A, Gillespie SH.

BMC Med. 2017 Nov 24;15(1):207. doi: 10.1186/s12916-017-0955-9.

25.

Chloroform extract of turmeric inhibits biofilm formation, EPS production and motility in antibiotic resistant bacteria.

Hayat S, Sabri AN, McHugh TD.

J Gen Appl Microbiol. 2018 Jan 15;63(6):325-338. doi: 10.2323/jgam.2017.01.004. Epub 2017 Nov 15.

26.

Mycobacterium tuberculosis and whole-genome sequencing: how close are we to unleashing its full potential?

Satta G, Lipman M, Smith GP, Arnold C, Kon OM, McHugh TD.

Clin Microbiol Infect. 2018 Jun;24(6):604-609. doi: 10.1016/j.cmi.2017.10.030. Epub 2017 Nov 3. Review.

27.

Spot sputum samples are at least as good as early morning samples for identifying Mycobacterium tuberculosis.

Murphy ME, Phillips PPJ, Mendel CM, Bongard E, Bateson ALC, Hunt R, Murthy S, Singh KP, Brown M, Crook AM, Nunn AJ, Meredith SK, Lipman M, McHugh TD, Gillespie SH; REMoxTB Consortium.

BMC Med. 2017 Oct 27;15(1):192. doi: 10.1186/s12916-017-0947-9.

28.

Sequence analysis of the rifampicin resistance determining region (RRDR) of rpoB gene in multidrug resistance confirmed and newly diagnosed tuberculosis patients of Punjab, Pakistan.

Hameed S, Moganeradj K, Mahmood N, McHugh TD, Chaudhry MN, Arnold C.

PLoS One. 2017 Aug 17;12(8):e0183363. doi: 10.1371/journal.pone.0183363. eCollection 2017.

29.

Rapid identification of a Mycobacterium tuberculosis full genetic drug resistance profile through whole genome sequencing directly from sputum.

Nimmo C, Doyle R, Burgess C, Williams R, Gorton R, McHugh TD, Brown M, Morris-Jones S, Booth H, Breuer J.

Int J Infect Dis. 2017 Sep;62:44-46. doi: 10.1016/j.ijid.2017.07.007. Epub 2017 Jul 14.

30.

Assessment of treatment response by colony forming units, time to culture positivity and the molecular bacterial load assay compared in a mouse tuberculosis model.

de Knegt GJ, Dickinson L, Pertinez H, Evangelopoulos D, McHugh TD, Bakker-Woudenberg IAJM, Davies GR, de Steenwinkel JEM.

Tuberculosis (Edinb). 2017 Jul;105:113-118. doi: 10.1016/j.tube.2017.05.002. Epub 2017 May 8.

31.

Carriage of extended-spectrum beta-lactamase-producing Enterobacteriaceae in HIV-infected children in Zimbabwe.

Wilmore SMS, Kranzer K, Williams A, Makamure B, Nhidza AF, Mayini J, Bandason T, Metcalfe J, Nicol MP, Balakrishnan I, Ellington MJ, Woodford N, Hopkins S, McHugh TD, Ferrand RA.

J Med Microbiol. 2017 May;66(5):609-615. doi: 10.1099/jmm.0.000474. Epub 2017 May 18.

32.

Blood and sputum eosinophils in COPD; relationship with bacterial load.

Kolsum U, Donaldson GC, Singh R, Barker BL, Gupta V, George L, Webb AJ, Thurston S, Brookes AJ, McHugh TD, Wedzicha JA, Brightling CE, Singh D.

Respir Res. 2017 May 8;18(1):88. doi: 10.1186/s12931-017-0570-5.

33.

Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach.

Ryan A, Polycarpou E, Lack NA, Evangelopoulos D, Sieg C, Halman A, Bhakta S, Eleftheriadou O, McHugh TD, Keany S, Lowe ED, Ballet R, Abuhammad A, Jacobs WR Jr, Ciulli A, Sim E.

Br J Pharmacol. 2017 Jul;174(14):2209-2224. doi: 10.1111/bph.13810. Epub 2017 May 9.

34.

Use of whole-genome sequencing to distinguish relapse from reinfection in a completed tuberculosis clinical trial.

Witney AA, Bateson AL, Jindani A, Phillips PP, Coleman D, Stoker NG, Butcher PD, McHugh TD; RIFAQUIN Study Team.

BMC Med. 2017 Mar 29;15(1):71. doi: 10.1186/s12916-017-0834-4.

35.

Pediatric tuberculosis-human immunodeficiency virus co-infection in the United Kingdom highlights the need for better therapy monitoring tools: a case report.

Evangelopoulos D, Whittaker E, Honeyborne I, McHugh TD, Klein N, Shingadia D.

J Med Case Rep. 2017 Feb 26;11(1):52. doi: 10.1186/s13256-017-1222-6.

36.

Isoniazid-resistant tuberculosis: a cause for concern?

Stagg HR, Lipman MC, McHugh TD, Jenkins HE.

Int J Tuberc Lung Dis. 2017 Feb 1;21(2):129-139. doi: 10.5588/ijtld.16.0716. Review.

37.

Occupational Tuberculosis despite Minimal Nosocomial Contact in a Health Care Worker Undergoing Treatment with a Tumor Necrosis Factor Inhibitor.

Murphy ME, Wilmore S, Satta G, Witney A, Atzeni A, Sturgeon K, Cropley I, McHugh TD, Hopkins S, Lipman M.

Ann Am Thorac Soc. 2016 Dec;13(12):2275-2277. No abstract available.

PMID:
27925777
38.

Mycobacterium tuberculosis and whole genome sequencing: a practical guide and online tools available for the clinical microbiologist.

Satta G, Atzeni A, McHugh TD.

Clin Microbiol Infect. 2017 Feb;23(2):69-72. doi: 10.1016/j.cmi.2016.09.005. Epub 2016 Sep 15. Review.

39.

Genetic variation in Mycobacterium tuberculosis isolates from a London outbreak associated with isoniazid resistance.

Satta G, Witney AA, Shorten RJ, Karlikowska M, Lipman M, McHugh TD.

BMC Med. 2016 Aug 16;14(1):117. doi: 10.1186/s12916-016-0659-6.

40.

The use of digital PCR to improve the application of quantitative molecular diagnostic methods for tuberculosis.

Devonshire AS, O'Sullivan DM, Honeyborne I, Jones G, Karczmarczyk M, Pavšič J, Gutteridge A, Milavec M, Mendoza P, Schimmel H, Van Heuverswyn F, Gorton R, Cirillo DM, Borroni E, Harris K, Barnard M, Heydenrych A, Ndusilo N, Wallis CL, Pillay K, Barry T, Reddington K, Richter E, Mozioğlu E, Akyürek S, Yalçınkaya B, Akgoz M, Žel J, Foy CA, McHugh TD, Huggett JF.

BMC Infect Dis. 2016 Aug 3;16:366. doi: 10.1186/s12879-016-1696-7.

41.

Optimising molecular diagnostic capacity for effective control of tuberculosis in high-burden settings.

Sabiiti W, Mtafya B, Kuchaka D, Azam K, Viegas S, Mdolo A, Farmer EC, Khonga M, Evangelopoulos D, Honeyborne I, Rachow A, Heinrich N, Ntinginya NE, Bhatt N, Davies GR, Jani IV, McHugh TD, Kibiki G, Hoelscher M, Gillespie SH; PANBIOME (Pan-African Biomarker Expansion Programme) consortium.

Int J Tuberc Lung Dis. 2016 Aug;20(8):1004-9. doi: 10.5588/ijtld.15.0951.

PMID:
27393531
42.

DNA sequence-selective C8-linked pyrrolobenzodiazepine-heterocyclic polyamide conjugates show anti-tubercular-specific activities.

Brucoli F, Guzman JD, Basher MA, Evangelopoulos D, McMahon E, Munshi T, McHugh TD, Fox KR, Bhakta S.

J Antibiot (Tokyo). 2016 Dec;69(12):843-849. doi: 10.1038/ja.2016.43. Epub 2016 May 11.

PMID:
27168314
43.

Repurposing drugs for treatment of tuberculosis: a role for non-steroidal anti-inflammatory drugs.

Maitra A, Bates S, Shaik M, Evangelopoulos D, Abubakar I, McHugh TD, Lipman M, Bhakta S.

Br Med Bull. 2016 Jun;118(1):138-48. doi: 10.1093/bmb/ldw019. Epub 2016 May 5. Review.

44.

Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy.

Honeyborne I, McHugh TD, Kuittinen I, Cichonska A, Evangelopoulos D, Ronacher K, van Helden PD, Gillespie SH, Fernandez-Reyes D, Walzl G, Rousu J, Butcher PD, Waddell SJ.

BMC Med. 2016 Apr 7;14:68. doi: 10.1186/s12916-016-0609-3.

45.

World TB Day 2016: an interview with leading experts in tuberculosis research.

Phillips PP, Fletcher HA, Abubakar I, Lipman MC, McHugh TD.

BMC Med. 2016 Mar 23;14:55. doi: 10.1186/s12916-016-0591-9.

46.

Uniting to end the TB epidemic: advances in disease control from prevention to better diagnosis and treatment.

Abubakar I, Lipman M, McHugh TD, Fletcher H.

BMC Med. 2016 Mar 23;14:47. doi: 10.1186/s12916-016-0599-1.

47.

Design and Synthesis of 1-((1,5-Bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methylpiperazine (BM212) and N-Adamantan-2-yl-N'-((E)-3,7-dimethylocta-2,6-dienyl)ethane-1,2-diamine (SQ109) Pyrrole Hybrid Derivatives: Discovery of Potent Antitubercular Agents Effective against Multidrug-Resistant Mycobacteria.

Bhakta S, Scalacci N, Maitra A, Brown AK, Dasugari S, Evangelopoulos D, McHugh TD, Mortazavi PN, Twist A, Petricci E, Manetti F, Castagnolo D.

J Med Chem. 2016 Mar 24;59(6):2780-93. doi: 10.1021/acs.jmedchem.6b00031. Epub 2016 Mar 8.

PMID:
26907951
48.

A Rapid and Sensitive Diagnostic Screening Assay for Detection of Mycobacteria Including Mycobacterium tuberculosis Directly from Sputum without Extraction.

Cross LJ, Anscombe C, McHugh TD, Abubakar I, Shorten RJ, Thorne N, Arnold C.

Int J Bacteriol. 2015;2015:593745. doi: 10.1155/2015/593745. Epub 2015 Jan 6.

49.

The transmission of Mycobacterium tuberculosis in high burden settings.

Yates TA, Khan PY, Knight GM, Taylor JG, McHugh TD, Lipman M, White RG, Cohen T, Cobelens FG, Wood R, Moore DA, Abubakar I.

Lancet Infect Dis. 2016 Feb;16(2):227-38. doi: 10.1016/S1473-3099(15)00499-5. Epub 2016 Jan 26. Review. Erratum in: Lancet Infect Dis. 2016 Mar;16(3):279.

PMID:
26867464
50.

Effectiveness of peer educators on the uptake of mobile X-ray tuberculosis screening at homeless hostels: a cluster randomised controlled trial.

Aldridge RW, Hayward AC, Hemming S, Possas L, Ferenando G, Garber E, Lipman M, McHugh TD, Story A.

BMJ Open. 2015 Sep 21;5(9):e008050. doi: 10.1136/bmjopen-2015-008050.

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