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Items: 1 to 50 of 64

1.

Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors.

Thomas AM, Brolih S, McGouran JF, El-Sagheer AH, Ptchelkine D, Jones M, McDonald NQ, McHugh PJ, Brown T.

Chem Commun (Camb). 2019 Sep 26;55(78):11671-11674. doi: 10.1039/c9cc05476f.

PMID:
31497827
2.

Squaramide-Based 5'-Phosphate Replacements Bind to the DNA Repair Exonuclease SNM1A.

Dürr EM, Doherty W, Lee SY, El-Sagheer AH, Shivalingam A, McHugh PJ, Brown T, McGouran JF.

ChemistrySelect. 2018 Dec 6;3(45):12824-12829. doi: 10.1002/slct.201803375. Epub 2018 Dec 4.

3.

A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A.

Doherty W, Dürr EM, Baddock HT, Lee SY, McHugh PJ, Brown T, Senge MO, Scanlan EM, McGouran JF.

Org Biomol Chem. 2019 Sep 21;17(35):8094-8105. doi: 10.1039/c9ob01133a. Epub 2019 Aug 5.

PMID:
31380542
4.

The Effects of Ultrasound on the Electro-Oxidation of Sulfate Solutions at Low pH.

Wallace AG, McHugh PJ, Symes MD.

Chemphyschem. 2019 Nov 19;20(22):3134-3140. doi: 10.1002/cphc.201900346. Epub 2019 Jun 26.

5.

Microhomologies are prevalent at Cas9-induced larger deletions.

Owens DDG, Caulder A, Frontera V, Harman JR, Allan AJ, Bucakci A, Greder L, Codner GF, Hublitz P, McHugh PJ, Teboul L, de Bruijn MFTR.

Nucleic Acids Res. 2019 Aug 22;47(14):7402-7417. doi: 10.1093/nar/gkz459.

6.

Antiviral activity of bone morphogenetic proteins and activins.

Eddowes LA, Al-Hourani K, Ramamurthy N, Frankish J, Baddock HT, Sandor C, Ryan JD, Fusco DN, Arezes J, Giannoulatou E, Boninsegna S, Chevaliez S, Owens BMJ, Sun CC, Fabris P, Giordani MT, Martines D, Vukicevic S, Crowe J, Lin HY, Rehwinkel J, McHugh PJ, Binder M, Babitt JL, Chung RT, Lawless MW, Armitage AE, Webber C, Klenerman P, Drakesmith H.

Nat Microbiol. 2019 Feb;4(2):339-351. doi: 10.1038/s41564-018-0301-9. Epub 2018 Dec 3.

7.

Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading.

Amunugama R, Willcox S, Wu RA, Abdullah UB, El-Sagheer AH, Brown T, McHugh PJ, Griffith JD, Walter JC.

Cell Rep. 2018 Jun 19;23(12):3419-3428. doi: 10.1016/j.celrep.2018.05.061.

8.

Translational study identifies XPF and MUS81 as predictive biomarkers for oxaliplatin-based peri-operative chemotherapy in patients with esophageal adenocarcinoma.

MacGregor TP, Carter R, Gillies RS, Findlay JM, Kartsonaki C, Castro-Giner F, Sahgal N, Wang LM, Chetty R, Maynard ND, Cazier JB, Buffa F, McHugh PJ, Tomlinson I, Middleton MR, Sharma RA.

Sci Rep. 2018 May 8;8(1):7265. doi: 10.1038/s41598-018-24232-2.

9.

PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation.

Ronson GE, Piberger AL, Higgs MR, Olsen AL, Stewart GS, McHugh PJ, Petermann E, Lakin ND.

Nat Commun. 2018 Feb 21;9(1):746. doi: 10.1038/s41467-018-03159-2.

10.

In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors.

Cain R, Brem J, Zollman D, McDonough MA, Johnson RM, Spencer J, Makena A, Abboud MI, Cahill S, Lee SY, McHugh PJ, Schofield CJ, Fishwick CWG.

J Med Chem. 2018 Feb 8;61(3):1255-1260. doi: 10.1021/acs.jmedchem.7b01728. Epub 2018 Jan 10.

11.

Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.

Ward TA, McHugh PJ, Durant ST.

PLoS One. 2017 Jun 19;12(6):e0179278. doi: 10.1371/journal.pone.0179278. eCollection 2017.

12.

RPA activates the XPF-ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks.

Abdullah UB, McGouran JF, Brolih S, Ptchelkine D, El-Sagheer AH, Brown T, McHugh PJ.

EMBO J. 2017 Jul 14;36(14):2047-2060. doi: 10.15252/embj.201796664. Epub 2017 Jun 12.

13.

A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1.

Erdal E, Haider S, Rehwinkel J, Harris AL, McHugh PJ.

Genes Dev. 2017 Feb 15;31(4):353-369. doi: 10.1101/gad.289769.116. Epub 2017 Mar 9.

14.

Mgm101: A double-duty Rad52-like protein.

Rendeková J, Ward TA, Šimoničová L, Thomas PH, Nosek J, Tomáška Ľ, McHugh PJ, Chovanec M.

Cell Cycle. 2016 Dec;15(23):3169-3176. Epub 2016 Sep 16.

15.

Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo.

Lee SY, Brem J, Pettinati I, Claridge TD, Gileadi O, Schofield CJ, McHugh PJ.

Chem Commun (Camb). 2016 May 10;52(40):6727-30. doi: 10.1039/c6cc00529b.

16.

EXD2 promotes homologous recombination by facilitating DNA end resection.

Broderick R, Nieminuszczy J, Baddock HT, Deshpande R, Gileadi O, Paull TT, McHugh PJ, Niedzwiedz W.

Nat Cell Biol. 2016 Mar;18(3):271-280. doi: 10.1038/ncb3303. Epub 2016 Jan 25.

17.

The Chemical Biology of Human Metallo-β-Lactamase Fold Proteins.

Pettinati I, Brem J, Lee SY, McHugh PJ, Schofield CJ.

Trends Biochem Sci. 2016 Apr;41(4):338-355. doi: 10.1016/j.tibs.2015.12.007. Epub 2016 Jan 21. Review.

18.

The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities.

Allerston CK, Lee SY, Newman JA, Schofield CJ, McHugh PJ, Gileadi O.

Nucleic Acids Res. 2015 Dec 15;43(22):11047-60. doi: 10.1093/nar/gkv1256. Epub 2015 Nov 17.

19.

Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers.

Brem J, van Berkel SS, Zollman D, Lee SY, Gileadi O, McHugh PJ, Walsh TR, McDonough MA, Schofield CJ.

Antimicrob Agents Chemother. 2015 Oct 19;60(1):142-50. doi: 10.1128/AAC.01335-15. Print 2016 Jan.

20.

CSB interacts with SNM1A and promotes DNA interstrand crosslink processing.

Iyama T, Lee SY, Berquist BR, Gileadi O, Bohr VA, Seidman MM, McHugh PJ, Wilson DM 3rd.

Nucleic Acids Res. 2015 Jan;43(1):247-58. doi: 10.1093/nar/gku1279. Epub 2014 Dec 10.

21.

A UV-induced genetic network links the RSC complex to nucleotide excision repair and shows dose-dependent rewiring.

Srivas R, Costelloe T, Carvunis AR, Sarkar S, Malta E, Sun SM, Pool M, Licon K, van Welsem T, van Leeuwen F, McHugh PJ, van Attikum H, Ideker T.

Cell Rep. 2013 Dec 26;5(6):1714-24. doi: 10.1016/j.celrep.2013.11.035. Epub 2013 Dec 19.

22.

XPF protein levels determine sensitivity of malignant melanoma cells to oxaliplatin chemotherapy: suitability as a biomarker for patient selection.

Hatch SB, Swift LP, Caporali S, Carter R, Hill EJ, MacGregor TP, D'Atri S, Middleton MR, McHugh PJ, Sharma RA.

Int J Cancer. 2014 Mar 15;134(6):1495-503. doi: 10.1002/ijc.28454. Epub 2013 Nov 14.

23.

A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.

Nguyen GH, Dexheimer TS, Rosenthal AS, Chu WK, Singh DK, Mosedale G, Bachrati CZ, Schultz L, Sakurai M, Savitsky P, Abu M, McHugh PJ, Bohr VA, Harris CC, Jadhav A, Gileadi O, Maloney DJ, Simeonov A, Hickson ID.

Chem Biol. 2013 Jan 24;20(1):55-62. doi: 10.1016/j.chembiol.2012.10.016.

24.

Quantitative analysis of survivin protein expression and its therapeutic depletion by an antisense oligonucleotide in human lung tumors.

Olsen AL, Davies JM, Medley L, Breen D, Talbot DC, McHugh PJ.

Mol Ther Nucleic Acids. 2012 Jun 19;1:e30. doi: 10.1038/mtna.2012.19.

25.

Components of a Fanconi-like pathway control Pso2-independent DNA interstrand crosslink repair in yeast.

Ward TA, Dudášová Z, Sarkar S, Bhide MR, Vlasáková D, Chovanec M, McHugh PJ.

PLoS Genet. 2012;8(8):e1002884. doi: 10.1371/journal.pgen.1002884. Epub 2012 Aug 9.

26.

A prototypical Fanconi anemia pathway in lower eukaryotes?

McHugh PJ, Ward TA, Chovanec M.

Cell Cycle. 2012 Oct 15;11(20):3739-44. doi: 10.4161/cc.21727. Epub 2012 Aug 16.

27.

Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases.

Sengerová B, Allerston CK, Abu M, Lee SY, Hartley J, Kiakos K, Schofield CJ, Hartley JA, Gileadi O, McHugh PJ.

J Biol Chem. 2012 Jul 27;287(31):26254-67. doi: 10.1074/jbc.M112.367243. Epub 2012 Jun 11.

28.

Orchestrating the nucleases involved in DNA interstrand cross-link (ICL) repair.

Sengerová B, Wang AT, McHugh PJ.

Cell Cycle. 2011 Dec 1;10(23):3999-4008. doi: 10.4161/cc.10.23.18385. Epub 2011 Dec 1. Review.

29.

Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair.

Wang AT, Sengerová B, Cattell E, Inagawa T, Hartley JM, Kiakos K, Burgess-Brown NA, Swift LP, Enzlin JH, Schofield CJ, Gileadi O, Hartley JA, McHugh PJ.

Genes Dev. 2011 Sep 1;25(17):1859-70. doi: 10.1101/gad.15699211.

30.

Human HEL308 localizes to damaged replication forks and unwinds lagging strand structures.

Tafel AA, Wu L, McHugh PJ.

J Biol Chem. 2011 May 6;286(18):15832-40. doi: 10.1074/jbc.M111.228189. Epub 2011 Mar 11.

31.

Pathways for Holliday junction processing during homologous recombination in Saccharomyces cerevisiae.

Ashton TM, Mankouri HW, Heidenblut A, McHugh PJ, Hickson ID.

Mol Cell Biol. 2011 May;31(9):1921-33. doi: 10.1128/MCB.01130-10. Epub 2011 Feb 22.

32.

The Ino80 chromatin-remodeling complex restores chromatin structure during UV DNA damage repair.

Sarkar S, Kiely R, McHugh PJ.

J Cell Biol. 2010 Dec 13;191(6):1061-8. doi: 10.1083/jcb.201006178. Epub 2010 Dec 6.

33.

Tumor survivin is downregulated by the antisense oligonucleotide LY2181308: a proof-of-concept, first-in-human dose study.

Talbot DC, Ranson M, Davies J, Lahn M, Callies S, André V, Kadam S, Burgess M, Slapak C, Olsen AL, McHugh PJ, de Bono JS, Matthews J, Saleem A, Price P.

Clin Cancer Res. 2010 Dec 15;16(24):6150-8. doi: 10.1158/1078-0432.CCR-10-1932. Epub 2010 Nov 1. Erratum in: Clin Cancer Res. 2011 Apr 15;17(8):2602.

34.

The SNM1/Pso2 family of ICL repair nucleases: from yeast to man.

Cattell E, Sengerová B, McHugh PJ.

Environ Mol Mutagen. 2010 Jul;51(6):635-45. doi: 10.1002/em.20556.

PMID:
20175117
35.

XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.

Bhagwat N, Olsen AL, Wang AT, Hanada K, Stuckert P, Kanaar R, D'Andrea A, Niedernhofer LJ, McHugh PJ.

Mol Cell Biol. 2009 Dec;29(24):6427-37. doi: 10.1128/MCB.00086-09. Epub 2009 Oct 5.

36.

Apollo: a healer of the genome?

Wang AT, McHugh PJ.

Cell Cycle. 2009 Jul 1;8(13):1980-1. Epub 2009 Jul 1. No abstract available.

PMID:
19550156
37.

Human SNM1A suppresses the DNA repair defects of yeast pso2 mutants.

Hazrati A, Ramis-Castelltort M, Sarkar S, Barber LJ, Schofield CJ, Hartley JA, McHugh PJ.

DNA Repair (Amst). 2008 Feb 1;7(2):230-8. Epub 2007 Nov 19.

PMID:
18006388
39.

DNA interstrand cross-link repair in Saccharomyces cerevisiae.

Lehoczký P, McHugh PJ, Chovanec M.

FEMS Microbiol Rev. 2007 Mar;31(2):109-33. Epub 2006 Nov 9. Review.

40.

DNA interstrand cross-link repair in the cell cycle: a critical role for polymerase zeta in G1 phase.

McHugh PJ, Sarkar S.

Cell Cycle. 2006 May;5(10):1044-7. Epub 2006 May 15. Review.

PMID:
16687932
41.

DNA interstrand crosslink repair during G1 involves nucleotide excision repair and DNA polymerase zeta.

Sarkar S, Davies AA, Ulrich HD, McHugh PJ.

EMBO J. 2006 Mar 22;25(6):1285-94. Epub 2006 Feb 16.

42.

A FancD2-monoubiquitin fusion reveals hidden functions of Fanconi anemia core complex in DNA repair.

Matsushita N, Kitao H, Ishiai M, Nagashima N, Hirano S, Okawa K, Ohta T, Yu DS, McHugh PJ, Hickson ID, Venkitaraman AR, Kurumizaka H, Takata M.

Mol Cell. 2005 Sep 16;19(6):841-7.

43.
45.

SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity.

Hartley JA, Spanswick VJ, Brooks N, Clingen PH, McHugh PJ, Hochhauser D, Pedley RB, Kelland LR, Alley MC, Schultz R, Hollingshead MG, Schweikart KM, Tomaszewski JE, Sausville EA, Gregson SJ, Howard PW, Thurston DE.

Cancer Res. 2004 Sep 15;64(18):6693-9.

46.

Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis.

Merryweather-Clarke AT, Cadet E, Bomford A, Capron D, Viprakasit V, Miller A, McHugh PJ, Chapman RW, Pointon JJ, Wimhurst VL, Livesey KJ, Tanphaichitr V, Rochette J, Robson KJ.

Hum Mol Genet. 2003 Sep 1;12(17):2241-7. Epub 2003 Jul 15.

PMID:
12915468
47.

Schizosaccharomyces pombe checkpoint response to DNA interstrand cross-links.

Lambert S, Mason SJ, Barber LJ, Hartley JA, Pearce JA, Carr AM, McHugh PJ.

Mol Cell Biol. 2003 Jul;23(13):4728-37.

48.

Saccharomyces cerevisiae RAD5 influences the excision repair of DNA minor groove adducts.

Kiakos K, Howard TT, Lee M, Hartley JA, McHugh PJ.

J Biol Chem. 2002 Nov 15;277(46):44576-81. Epub 2002 Sep 10.

49.

Defects in interstrand cross-link uncoupling do not account for the extreme sensitivity of ERCC1 and XPF cells to cisplatin.

De Silva IU, McHugh PJ, Clingen PH, Hartley JA.

Nucleic Acids Res. 2002 Sep 1;30(17):3848-56.

50.

Repair of DNA interstrand crosslinks: molecular mechanisms and clinical relevance.

McHugh PJ, Spanswick VJ, Hartley JA.

Lancet Oncol. 2001 Aug;2(8):483-90. Review.

PMID:
11905724

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