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The reliability of immunoassays to detect autoantibodies in patients with myositis is dependent on autoantibody specificity.

Tansley SL, Li D, Betteridge ZE, McHugh NJ.

Rheumatology (Oxford). 2020 Feb 6. pii: keaa021. doi: 10.1093/rheumatology/keaa021. [Epub ahead of print]


Autoantibodies in connective tissue disease.

Mulhearn B, Tansley SL, McHugh NJ.

Best Pract Res Clin Rheumatol. 2019 Dec 14:101462. doi: 10.1016/j.berh.2019.101462. [Epub ahead of print] Review.


The myositis clinical phenotype associated with anti-Zo autoantibodies: a case series of nine UK patients.

Tansley SL, Betteridge Z, Lu H, Davies E, Rothwell S, New PP, Chinoy H, Gordon P, Gunawardena H, Lloyd M, Stratton R, Cooper R, McHugh NJ.

Rheumatology (Oxford). 2019 Oct 26. pii: kez504. doi: 10.1093/rheumatology/kez504. [Epub ahead of print]


Comment on: The temporal relationship between cancer and adult onset anti-transcriptional intermediary factor 1 antibody-positive dermatomyositis: Reply.

Oldroyd A, Sergeant JC, New RP, McHugh NJ, Betteridge Z, Lamb JA, Ollier WE, Cooper RG, Chinoy H.

Rheumatology (Oxford). 2019 Nov 1;58(11):2073-2074. doi: 10.1093/rheumatology/kez329. No abstract available.


Focused HLA analysis in Caucasians with myositis identifies significant associations with autoantibody subgroups.

Rothwell S, Chinoy H, Lamb JA, Miller FW, Rider LG, Wedderburn LR, McHugh NJ, Mammen AL, Betteridge ZE, Tansley SL, Bowes J, Vencovský J, Deakin CT, Dankó K, Vidya L, Selva-O'Callaghan A, Pachman LM, Reed AM, Molberg Ø, Benveniste O, Mathiesen PR, Radstake TRDJ, Doria A, de Bleecker J, Lee AT, Hanna MG, Machado PM, Ollier WE, Gregersen PK, Padyukov L, O'Hanlon TP, Cooper RG, Lundberg IE; Myositis Genetics Consortium (MYOGEN).

Ann Rheum Dis. 2019 Jul;78(7):996-1002. doi: 10.1136/annrheumdis-2019-215046. Epub 2019 May 28.


Psoriatic Nail Dystrophy Is Associated with Erosive Disease in the Distal Interphalangeal Joints in Psoriatic Arthritis: A Retrospective Cohort Study.

Antony AS, Allard A, Rambojun A, Lovell CR, Shaddick G, Robinson G, Jadon DR, Holland R, Cavill C, Korendowych E, McHugh NJ, Tillett W.

J Rheumatol. 2019 Sep;46(9):1097-1102. doi: 10.3899/jrheum.180796. Epub 2019 Mar 1.


Patient-reported outcome instruments for assessing Raynaud's phenomenon in systemic sclerosis: A SCTC Vascular Working Group Report.

Pauling JD, Frech TM, Hughes M, Gordon JK, Domsic RT, Anderson ME, Ingegnoli F, McHugh NJ, Johnson SR, Hudson M, Boin F, Ong VH, Matucci-Cerinic M, Altorok N, Scolnik M, Nikpour M, Shah A, Pope JE, Khanna D, Herrick AL.

J Scleroderma Relat Disord. 2018 Oct;3(3):249-252. doi: 10.1177/2397198318774307. Epub 2018 May 24.


The temporal relationship between cancer and adult onset anti-transcriptional intermediary factor 1 antibody-positive dermatomyositis.

Oldroyd A, Sergeant JC, New P, McHugh NJ, Betteridge Z, Lamb JA, Ollier WE, Cooper RG, Chinoy H; UKMyoNet.

Rheumatology (Oxford). 2019 Apr 1;58(4):650-655. doi: 10.1093/rheumatology/key357.


The performance of the European League Against Rheumatism/American College of Rheumatology idiopathic inflammatory myopathies classification criteria in an expert-defined 10 year incident cohort.

Parker MJS, Oldroyd A, Roberts ME, Lilleker JB, Betteridge ZE, McHugh NJ, Herrick AL, Cooper RG, Chinoy H.

Rheumatology (Oxford). 2019 Mar 1;58(3):468-475. doi: 10.1093/rheumatology/key343.


Histological heterogeneity in a large clinical cohort of juvenile idiopathic inflammatory myopathy: analysis by myositis autoantibody and pathological features.

Yasin SA, Schutz PW, Deakin CT, Sag E, Varsani H, Simou S, Marshall LR, Tansley SL, McHugh NJ, Holton JL, Wedderburn LR, Jacques TS; UK Juvenile Dermatomyositis Research Group (UK and Ireland).

Neuropathol Appl Neurobiol. 2019 Aug;45(5):495-512. doi: 10.1111/nan.12528. Epub 2019 Mar 11.


Investigation of myositis and scleroderma specific autoantibodies in patients with lung cancer.

Betteridge ZE, Priest L, Cooper RG, McHugh NJ, Blackhall F, Lamb JA.

Arthritis Res Ther. 2018 Aug 9;20(1):176. doi: 10.1186/s13075-018-1678-9.


Expression of myxovirus-resistance protein A: a possible marker of muscle disease activity and autoantibody specificities in juvenile dermatomyositis.

Soponkanaporn S, Deakin CT, Schutz PW, Marshall LR, Yasin SA, Johnson CM, Sag E, Tansley SL, McHugh NJ, Wedderburn LR, Jacques TS.

Neuropathol Appl Neurobiol. 2019 Jun;45(4):410-420. doi: 10.1111/nan.12498. Epub 2018 Jun 4.


Autoantibodies in myositis.

McHugh NJ, Tansley SL.

Nat Rev Rheumatol. 2018 Apr 20;14(5):290-302. doi: 10.1038/nrrheum.2018.56. Review.


Multinational Qualitative Research Study Exploring the Patient Experience of Raynaud's Phenomenon in Systemic Sclerosis.

Pauling JD, Domsic RT, Saketkoo LA, Almeida C, Withey J, Jay H, Frech TM, Ingegnoli F, Dures E, Robson J, McHugh NJ, Herrick AL, Matucci-Cerinic M, Khanna D, Hewlett S.

Arthritis Care Res (Hoboken). 2018 Sep;70(9):1373-1384. doi: 10.1002/acr.23475. Epub 2018 Aug 16.


A Multicenter Study of the Validity and Reliability of Responses to Hand Cold Challenge as Measured by Laser Speckle Contrast Imaging and Thermography: Outcome Measures for Systemic Sclerosis-Related Raynaud's Phenomenon.

Wilkinson JD, Leggett SA, Marjanovic EJ, Moore TL, Allen J, Anderson ME, Britton J, Buch MH, Del Galdo F, Denton CP, Dinsdale G, Griffiths B, Hall F, Howell K, MacDonald A, McHugh NJ, Manning JB, Pauling JD, Roberts C, Shipley JA, Herrick AL, Murray AK.

Arthritis Rheumatol. 2018 Jun;70(6):903-911. doi: 10.1002/art.40457. Epub 2018 Apr 23.


Presence of anti-eukaryotic initiation factor-2B, anti-RuvBL1/2 and anti-synthetase antibodies in patients with anti-nuclear antibody negative systemic sclerosis.

Pauling JD, Salazar G, Lu H, Betteridge ZE, Assassi S, Mayes MD, McHugh NJ.

Rheumatology (Oxford). 2018 Apr 1;57(4):712-717. doi: 10.1093/rheumatology/kex458.


Short-term efficacy and safety of rituximab therapy in refractory systemic lupus erythematosus: results from the British Isles Lupus Assessment Group Biologics Register.

McCarthy EM, Sutton E, Nesbit S, White J, Parker B, Jayne D, Griffiths B, Isenberg DA, Rahman A, Gordon C, D'Cruz DP, Rhodes B, Lanyon P, Vital EM, Yee CS, Edwards CJ, Teh LS, Akil M, McHugh NJ, Zoma A, Bruce IN; British Isles Lupus Assessment Group Biologics Register.

Rheumatology (Oxford). 2018 Mar 1;57(3):470-479. doi: 10.1093/rheumatology/kex395.


Validation of the Psoriatic Arthritis Impact of Disease (PsAID) Questionnaire and its potential as a single-item outcome measure in clinical practice.

Holland R, Tillett W, Korendowych E, Cavill C, Waldron N, Brooke M, McHugh NJ.

Ann Rheum Dis. 2018 Mar;77(3):343-347. doi: 10.1136/annrheumdis-2017-211996. Epub 2017 Nov 16.


Serum bone-turnover biomarkers are associated with the occurrence of peripheral and axial arthritis in psoriatic disease: a prospective cross-sectional comparative study.

Jadon DR, Sengupta R, Nightingale A, Lu H, Dunphy J, Green A, Elder JT, Nair RP, Korendowych E, Lindsay MA, McHugh NJ.

Arthritis Res Ther. 2017 Sep 21;19(1):210. doi: 10.1186/s13075-017-1417-7.


Transcriptional profiling identifies differential expression of long non-coding RNAs in Jo-1 associated and inclusion body myositis.

Hamann PD, Roux BT, Heward JA, Love S, McHugh NJ, Jones SW, Lindsay MA.

Sci Rep. 2017 Aug 14;7(1):8024. doi: 10.1038/s41598-017-08603-9.


Autoantibodies in juvenile-onset myositis: Their diagnostic value and associated clinical phenotype in a large UK cohort.

Tansley SL, Simou S, Shaddick G, Betteridge ZE, Almeida B, Gunawardena H, Thomson W, Beresford MW, Midgley A, Muntoni F, Wedderburn LR, McHugh NJ.

J Autoimmun. 2017 Nov;84:55-64. doi: 10.1016/j.jaut.2017.06.007. Epub 2017 Jun 26.


The potential overlapping populations for treatment with belimumab and rituximab using current NHS England and National Institute for Health and Care Excellence Guidelines in England and Wales.

McCarthy EM, Sutton E, Nesbit S, Parker B, Jayne D, Griffiths B, Isenberg DA, Rahman A, Gordon C, D'Cruz DP, Rhodes B, Lanyon P, Vital EM, Yee CS, Edwards CJ, Teh LS, Akil M, McHugh NJ, Zoma A, Bruce IN; British Isles Lupus Assessment Group Biologics Register.

Rheumatology (Oxford). 2017 Jun 1;56(6):1049. doi: 10.1093/rheumatology/kex218. No abstract available.


The potential overlapping populations for treatment with belimumab and rituximab using current NHS England and National Institute for Health and Care Excellence Guidelines in England and Wales.

McCarthy EM, Sutton E, Nesbit S, Parker B, Jayne D, Griffiths B, Isenberg DA, Rahman A, Gordon C, D'Cruz DP, Rhodes B, Lanyon P, Vital EM, Yee CS, Edwards CJ, Teh LS, Akil M, McHugh NJ, Zoma A, Bruce IN; British Isles Lupus Assessment Group Biologics Register.

Rheumatology (Oxford). 2017 Jun 1;56(6):1041-1043. doi: 10.1093/rheumatology/kex044. No abstract available. Erratum in: Rheumatology (Oxford). 2017 Jun 1;56(6):1049.


Presentation of SLE in UK primary care using the Clinical Practice Research Datalink.

Nightingale AL, Davidson JE, Molta CT, Kan HJ, McHugh NJ.

Lupus Sci Med. 2017 Feb 10;4(1):e000172. doi: 10.1136/lupus-2016-000172. eCollection 2017.


Anti-HMGCR Autoantibodies in Juvenile Idiopathic Inflammatory Myopathies Identify a Rare but Clinically Important Subset of Patients.

Tansley SL, Betteridge ZE, Simou S, Jacques TS, Pilkington C, Wood M, Warrier K, Wedderburn LR, McHugh NJ; Juvenile Dermatomyositis Research Group.

J Rheumatol. 2017 Apr;44(4):488-492. doi: 10.3899/jrheum.160871. Epub 2017 Feb 15. Erratum in: J Rheumatol. 2017 Sep;44(9):1417.


Cytosolic 5'-nucleotidase 1A autoantibody profile and clinical characteristics in inclusion body myositis.

Lilleker JB, Rietveld A, Pye SR, Mariampillai K, Benveniste O, Peeters MT, Miller JA, Hanna MG, Machado PM, Parton MJ, Gheorghe KR, Badrising UA, Lundberg IE, Sacconi S, Herbert MK, McHugh NJ, Lecky BR, Brierley C, Hilton-Jones D, Lamb JA, Roberts ME, Cooper RG, Saris CG, Pruijn GJ, Chinoy H, van Engelen BG; all UKMYONET contributors.

Ann Rheum Dis. 2017 May;76(5):862-868. doi: 10.1136/annrheumdis-2016-210282. Epub 2017 Jan 25.


Microparticle subpopulations are potential markers of disease progression and vascular dysfunction across a spectrum of connective tissue disease.

McCarthy EM, Moreno-Martinez D, Wilkinson FL, McHugh NJ, Bruce IN, Pauling JD, Alexander MY, Parker B.

BBA Clin. 2016 Nov 10;7:16-22. doi: 10.1016/j.bbacli.2016.11.003. eCollection 2017 Jun.


Subjective and Objective Measures of Dryness Symptoms in Primary Sjögren's Syndrome: Capturing the Discrepancy.

Bezzina OM, Gallagher P, Mitchell S, Bowman SJ, Griffiths B, Hindmarsh V, Hargreaves B, Price EJ, Pease CT, Emery P, Lanyon P, Bombardieri M, Sutcliffe N, Pitzalis C, Hunter J, Gupta M, McLaren J, Cooper AM, Regan M, Giles IP, Isenberg DA, Saravanan V, Coady D, Dasgupta B, McHugh NJ, Young-Min SA, Moots RJ, Gendi N, Akil M, MacKay K, Ng WF, Robinson LJ; UK Primary Sjögren's Syndrome Registry.

Arthritis Care Res (Hoboken). 2017 Nov;69(11):1714-1723. doi: 10.1002/acr.23165. Epub 2017 Oct 9.


Axial Disease in Psoriatic Arthritis study: defining the clinical and radiographic phenotype of psoriatic spondyloarthritis.

Jadon DR, Sengupta R, Nightingale A, Lindsay M, Korendowych E, Robinson G, Jobling A, Shaddick G, Bi J, Winchester R, Giles JT, McHugh NJ.

Ann Rheum Dis. 2017 Apr;76(4):701-707. doi: 10.1136/annrheumdis-2016-209853. Epub 2016 Dec 2.


Brief Report: Anti-Eukaryotic Initiation Factor 2B Autoantibodies Are Associated With Interstitial Lung Disease in Patients With Systemic Sclerosis.

Betteridge ZE, Woodhead F, Lu H, Shaddick G, Bunn CC, Denton CP, Abraham DJ, du Bois RM, Lewis M, Wells AU, McHugh NJ.

Arthritis Rheumatol. 2016 Nov;68(11):2778-2783. doi: 10.1002/art.39755.


Muscle Biopsy Findings in Combination With Myositis-Specific Autoantibodies Aid Prediction of Outcomes in Juvenile Dermatomyositis.

Deakin CT, Yasin SA, Simou S, Arnold KA, Tansley SL, Betteridge ZE, McHugh NJ, Varsani H, Holton JL, Jacques TS, Pilkington CA, Nistala K, Wedderburn LR; UK Juvenile Dermatomyositis Research Group.

Arthritis Rheumatol. 2016 Nov;68(11):2806-2816. doi: 10.1002/art.39753. Epub 2016 Oct 9.


Systematic protein-protein interaction and pathway analyses in the idiopathic inflammatory myopathies.

Parkes JE, Rothwell S, Day PJ, McHugh NJ, Betteridge ZE, Cooper RG, Ollier WE, Chinoy H, Lamb JA; Myositis Genetics Consortium (MYOGEN).

Arthritis Res Ther. 2016 Jul 7;18(1):156. doi: 10.1186/s13075-016-1061-7.


Symptoms of Raynaud's phenomenon (RP) in fibromyalgia syndrome are similar to those reported in primary RP despite differences in objective assessment of digital microvascular function and morphology.

Scolnik M, Vasta B, Hart DJ, Shipley JA, McHugh NJ, Pauling JD.

Rheumatol Int. 2016 Oct;36(10):1371-7. doi: 10.1007/s00296-016-3483-6. Epub 2016 May 2.


Report of the GRAPPA-OMERACT Psoriatic Arthritis Working Group from the GRAPPA 2015 Annual Meeting.

Orbai AM, Mease PJ, de Wit M, Kalyoncu U, Campbell W, Tillett W, Eder L, Elmamoun M, FitzGerald O, Gladman DD, Goel N, Gossec L, Lindsay CA, Steinkoenig I, Helliwell PS, McHugh NJ, Strand V, Ogdie A.

J Rheumatol. 2016 May;43(5):965-9. doi: 10.3899/jrheum.160116.


Association of Toll-like receptor 4 (TLR4) with chronic plaque type psoriasis and psoriatic arthritis.

Smith RL, Hébert HL, Massey J, Bowes J, Marzo-Ortega H, Ho P, McHugh NJ, Worthington J, Barton A, Griffiths CE, Warren RB.

Arch Dermatol Res. 2016 Apr;308(3):201-5. doi: 10.1007/s00403-016-1620-4. Epub 2016 Feb 1.


Serological subsets of juvenile idiopathic inflammatory myopathies--an update.

Tansley SL, McHugh NJ.

Expert Rev Clin Immunol. 2016;12(4):427-37. doi: 10.1586/1744666X.2016.1131126. Epub 2016 Jan 13. Review.


Verna Wright Lecture: Psoriatic Arthritis: The Need for Early Intervention.

McHugh NJ.

J Rheumatol Suppl. 2015 Nov;93:10-3. doi: 10.3899/jrheum.150625.


Early Psoriatic Arthritis.

McHugh NJ.

Rheum Dis Clin North Am. 2015 Nov;41(4):615-22. doi: 10.1016/j.rdc.2015.07.005. Epub 2015 Aug 24. Review.


The evidence for immunotherapy in dermatomyositis and polymyositis: a systematic review.

Vermaak E, Tansley SL, McHugh NJ.

Clin Rheumatol. 2015 Dec;34(12):2089-95. doi: 10.1007/s10067-015-3059-y. Epub 2015 Aug 25. Review.


Estimating the diagnostic accuracy of rheumatoid factor in UK primary care: a study using the Clinical Practice Research Datalink.

Miller A, Nightingale AL, Sammon CJ, Mahtani KR, Holt TA, McHugh NJ, Luqmani RA.

Rheumatology (Oxford). 2015 Oct;54(10):1882-9. doi: 10.1093/rheumatology/kev131. Epub 2015 Jun 8.


Use of Laser Speckle Contrast Imaging to Assess Digital Microvascular Function in Primary Raynaud Phenomenon and Systemic Sclerosis: A Comparison Using the Raynaud Condition Score Diary.

Pauling JD, Shipley JA, Hart DJ, McGrogan A, McHugh NJ.

J Rheumatol. 2015 Jul;42(7):1163-8. doi: 10.3899/jrheum.141437. Epub 2015 Jun 1.


Psoriatic Arthritis Mutilans: Characteristics and Natural Radiographic History.

Jadon DR, Shaddick G, Tillett W, Korendowych E, Robinson G, Waldron N, Cavill C, McHugh NJ.

J Rheumatol. 2015 Jul;42(7):1169-76. doi: 10.3899/jrheum.150083. Epub 2015 May 15.


Enhanced Patient Involvement and the Need to Revise the Core Set - Report from the Psoriatic Arthritis Working Group at OMERACT 2014.

Tillett W, Eder L, Goel N, De Wit M, Gladman DD, FitzGerald O, Campbell W, Helliwell PS, Gossec L, Orbai AM, Ogdie A, Strand V, McHugh NJ, Mease PJ.

J Rheumatol. 2015 Nov;42(11):2198-203. doi: 10.3899/jrheum.141156. Epub 2015 May 1. Review.


Missing laboratory test data in electronic general practice records: analysis of rheumatoid factor recording in the clinical practice research datalink.

Sammon CJ, Miller A, Mahtani KR, Holt TA, McHugh NJ, Luqmani RA, Nightingale AL.

Pharmacoepidemiol Drug Saf. 2015 May;24(5):504-9. doi: 10.1002/pds.3750. Epub 2015 Mar 10.


Myositis specific and associated autoantibodies in the diagnosis and management of juvenile and adult idiopathic inflammatory myopathies.

Tansley SL, McHugh NJ.

Curr Rheumatol Rep. 2014 Dec;16(12):464. doi: 10.1007/s11926-014-0464-1. Review.


Serum soluble bone turnover biomarkers in psoriatic arthritis and psoriatic spondyloarthropathy.

Jadon DR, Nightingale AL, McHugh NJ, Lindsay MA, Korendowych E, Sengupta R.

J Rheumatol. 2015 Jan;42(1):21-30. doi: 10.3899/jrheum.140223. Epub 2014 Nov 1. Review.


Identification of loci associated with late-onset psoriasis using dense genotyping of immune-related regions.

Hébert HL, Bowes J, Smith RL, Flynn E, Parslew R, Alsharqi A, McHugh NJ, Barker JN, Griffiths CE, Barton A, Warren RB.

Br J Dermatol. 2015 Apr;172(4):933-9. doi: 10.1111/bjd.13340. Epub 2015 Feb 5.


Anti-MDA5 autoantibodies in juvenile dermatomyositis identify a distinct clinical phenotype: a prospective cohort study.

Tansley SL, Betteridge ZE, Gunawardena H, Jacques TS, Owens CM, Pilkington C, Arnold K, Yasin S, Moraitis E, Wedderburn LR, McHugh NJ; UK Juvenile Dermatomyositis Research Group.

Arthritis Res Ther. 2014 Jul 2;16(4):R138. doi: 10.1186/ar4600.


Calcinosis in juvenile dermatomyositis is influenced by both anti-NXP2 autoantibody status and age at disease onset.

Tansley SL, Betteridge ZE, Shaddick G, Gunawardena H, Arnold K, Wedderburn LR, McHugh NJ; Juvenile Dermatomyositis Research Group.

Rheumatology (Oxford). 2014 Dec;53(12):2204-8. doi: 10.1093/rheumatology/keu259. Epub 2014 Jul 1.


Patient participation in psoriasis and psoriatic arthritis outcome research: a report from the GRAPPA 2013 Annual Meeting.

de Wit M, Campbell W, FitzGerald O, Gladman DD, Helliwell PS, James J, Lindsay C, MacDonald R, McHugh NJ, Mease PJ, Orbai AM, Palominos P, Parkinson A, Tillett W, Goel N.

J Rheumatol. 2014 Jun;41(6):1206-11. doi: 10.3899/jrheum.140171.


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