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Items: 1 to 50 of 833

1.

Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC).

Ward RA, Anderton MJ, Bethel P, Breed J, Cook C, Davies EJ, Dobson A, Dong Z, Fairley G, Farrington P, Feron L, Flemington V, Gibbons FD, Graham MA, Greenwood R, Hanson L, Hopcroft P, Howells R, Hudson J, James M, Jones CD, Jones CR, Li Y, Lamont S, Lewis R, Lindsay N, McCabe J, McGuire T, Rawlins P, Roberts K, Sandin L, Simpson I, Swallow S, Tang J, Tomkinson G, Tonge M, Wang Z, Zhai B.

J Med Chem. 2019 Nov 25. doi: 10.1021/acs.jmedchem.9b01295. [Epub ahead of print]

PMID:
31710489
2.

Inhibition of immune checkpoints prevents injury-induced heterotopic ossification.

Kan C, Yang J, Na D, Xu Y, Yang B, Zhao H, Lu H, Li Y, Zhang K, McGuire TL, Kessler JA, Kan L.

Bone Res. 2019 Nov 1;7:33. doi: 10.1038/s41413-019-0074-7. eCollection 2019.

3.

Role of protein arginine methyltransferase 5 in group 3 (MYC-driven) Medulloblastoma.

Chaturvedi NK, Mahapatra S, Kesherwani V, Kling MJ, Shukla M, Ray S, Kanchan R, Perumal N, McGuire TR, Sharp JG, Joshi SS, Coulter DW.

BMC Cancer. 2019 Nov 6;19(1):1056. doi: 10.1186/s12885-019-6291-z.

4.

Antifungal agents for invasive candidiasis in non-neutropenic critically ill adults: What do the guidelines recommend?

Wang Y, McGuire TM, Hollingworth SA, Dong Y, Van Driel ML.

Int J Infect Dis. 2019 Dec;89:137-145. doi: 10.1016/j.ijid.2019.10.016. Epub 2019 Oct 19.

5.

Spinal Cord Injury Results in Chronic Mechanical Stiffening.

Cooper JG, Sicard D, Sharma S, Van Gulden S, McGuire TL, Cajiao MP, Tschumperlin DJ, Kessler JA.

J Neurotrauma. 2019 Oct 18. doi: 10.1089/neu.2019.6540. [Epub ahead of print]

PMID:
31516087
6.

Effects of novel pyrrolomycin MP1 in MYCN amplified chemoresistant neuroblastoma cell lines alone and combined with temsirolimus.

McGuire TR, Coulter DW, Bai D, Sughroue JA, Li J, Yang Z, Qiao Z, Liu Y, Murry DJ, Chhonker YS, McIntyre EM, Alexander G, Sharp JG, Li R.

BMC Cancer. 2019 Aug 27;19(1):837. doi: 10.1186/s12885-019-6033-2.

7.

Divergent Catalytic Strategies for the Cis/Trans Stereoselective Ring-Opening Polymerization of a Dual Cyclic Carbonate/Olefin Monomer.

McGuire TM, Pérale C, Castaing R, Kociok-Köhn G, Buchard A.

J Am Chem Soc. 2019 Aug 28;141(34):13301-13305. doi: 10.1021/jacs.9b06259. Epub 2019 Aug 20.

PMID:
31429566
8.

Association between High Proportions of Seriously Mentally Ill Nursing Home Residents and the Quality of Resident Care.

McGarry BE, Joyce NR, McGuire TG, Mitchell SL, Bartels SJ, Grabowski DC.

J Am Geriatr Soc. 2019 Nov;67(11):2346-2352. doi: 10.1111/jgs.16080. Epub 2019 Jul 29.

PMID:
31355443
9.

Limitations of P-Values and R-squared for Stepwise Regression Building: A Fairness Demonstration in Health Policy Risk Adjustment.

Rose S, McGuire TG.

Am Stat. 2019;73(Suppl 1):152-156. doi: 10.1080/00031305.2018.1518269. Epub 2019 Mar 20.

PMID:
31263291
10.

Data transformations to improve the performance of health plan payment methods.

Bergquist SL, Layton TJ, McGuire TG, Rose S.

J Health Econ. 2019 Jul;66:195-207. doi: 10.1016/j.jhealeco.2019.05.005. Epub 2019 May 24.

PMID:
31255968
11.

Pubertal Maturation and Trajectories of Depression During Early Adolescence.

McGuire TC, McCormick KC, Koch MK, Mendle J.

Front Psychol. 2019 Jun 12;10:1362. doi: 10.3389/fpsyg.2019.01362. eCollection 2019.

12.

Implementing a sustainable medication reconciliation process in Australian hospitals: The World Health Organization High 5s project.

Stark HE, Graudins LV, McGuire TM, Lee CYY, Duguid MJ.

Res Social Adm Pharm. 2019 May 23. pii: S1551-7411(18)30962-8. doi: 10.1016/j.sapharm.2019.05.011. [Epub ahead of print]

PMID:
31176651
13.

Network meta-analysis and pharmacoeconomic evaluation of antibiotics for the treatment of patients infected with complicated skin and soft structure infection and hospital-acquired or ventilator-associated penumonia.

Zhang Y, Wang Y, Van Driel ML, McGuire TM, Zhang T, Dong Y, Liu Y, Liu L, Hao R, Cao L, Xing J, Dong Y.

Antimicrob Resist Infect Control. 2019 May 6;8:72. doi: 10.1186/s13756-019-0518-2. eCollection 2019.

14.

The Comparative Advantage of Medicare Advantage.

Newhouse JP, Landrum MB, Price M, McWilliams JM, Hsu J, McGuire TG.

Am J Health Econ. 2019 Spring;5(2):281-301. Epub 2019 Apr 23.

PMID:
31032383
15.

Longitudinal impact of the Women's Health Initiative study on hormone therapy use in Australia.

Natari RB, McGuire TM, Baker PJ, Clavarino AM, Dingle KD, Hollingworth SA.

Climacteric. 2019 Oct;22(5):489-497. doi: 10.1080/13697137.2019.1593357. Epub 2019 Apr 23.

PMID:
31010331
16.

Market Concentration and Potential Competition in Medicare Advantage.

Frank RG, McGuire TG.

Issue Brief (Commonw Fund). 2019 Feb 1;2019:1-8.

PMID:
30883075
17.

Does size matter? Addressing pack size and antibiotic duration.

McGuire TM.

Aust Prescr. 2019 Feb;42(1):2-3. doi: 10.18773/austprescr.2019.005. Epub 2019 Feb 1. No abstract available.

18.

College Football Players Less Likely to Report Concussions and Other Injuries with Increased Injury Accumulation.

Baugh CM, Meehan WP 3rd, Kroshus E, McGuire TG, Hatfield LA.

J Neurotrauma. 2019 Jul 1;36(13):2065-2072. doi: 10.1089/neu.2018.6161. Epub 2019 Mar 28.

PMID:
30688141
19.

BMP-dependent, injury-induced stem cell niche as a mechanism of heterotopic ossification.

Kan C, Ding N, Yang J, Tan Z, McGuire TL, Lu H, Zhang K, Berger DMP, Kessler JA, Kan L.

Stem Cell Res Ther. 2019 Jan 11;10(1):14. doi: 10.1186/s13287-018-1107-7.

20.

13 Reasons Why: Viewing Patterns and Perceived Impact Among Youths at Risk of Suicide.

Hong V, Ewell Foster CJ, Magness CS, McGuire TC, Smith PK, King CA.

Psychiatr Serv. 2019 Feb 1;70(2):107-114. doi: 10.1176/appi.ps.201800384. Epub 2018 Nov 20.

PMID:
30453859
21.

Immune regulation and anti-cancer activity by lipid inflammatory mediators.

Khadge S, Sharp JG, McGuire TR, Thiele GM, Black P, DiRusso C, Cook L, Klassen LW, Talmadge JE.

Int Immunopharmacol. 2018 Dec;65:580-592. doi: 10.1016/j.intimp.2018.10.026. Epub 2018 Nov 14. Review.

22.

Heliox for croup in children.

Moraa I, Sturman N, McGuire TM, van Driel ML.

Cochrane Database Syst Rev. 2018 Oct 29;10:CD006822. doi: 10.1002/14651858.CD006822.pub5.

23.

Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent.

Foote KM, Nissink JWM, McGuire T, Turner P, Guichard S, Yates JWT, Lau A, Blades K, Heathcote D, Odedra R, Wilkinson G, Wilson Z, Wood CM, Jewsbury PJ.

J Med Chem. 2018 Nov 21;61(22):9889-9907. doi: 10.1021/acs.jmedchem.8b01187. Epub 2018 Nov 10.

PMID:
30346772
24.

Long-chain omega-3 polyunsaturated fatty acids decrease mammary tumor growth, multiorgan metastasis and enhance survival.

Khadge S, Thiele GM, Sharp JG, McGuire TR, Klassen LW, Black PN, DiRusso CC, Cook L, Talmadge JE.

Clin Exp Metastasis. 2018 Dec;35(8):797-818. doi: 10.1007/s10585-018-9941-7. Epub 2018 Oct 16.

PMID:
30327985
25.

Sample Selection for Medicare Risk Adjustment Due to Systematically Missing Data.

Bergquist SL, McGuire TG, Layton TJ, Rose S.

Health Serv Res. 2018 Dec;53(6):4204-4223. doi: 10.1111/1475-6773.13046. Epub 2018 Sep 11.

26.

Homeopathic medicinal products for preventing and treating acute respiratory tract infections in children.

Hawke K, van Driel ML, Buffington BJ, McGuire TM, King D.

Cochrane Database Syst Rev. 2018 Sep 9;9:CD005974. doi: 10.1002/14651858.CD005974.pub5. Review.

27.

Impact of miRNA-mRNA Profiling and Their Correlation on Medulloblastoma Tumorigenesis.

Kumar V, Kumar V, Chaudhary AK, Coulter DW, McGuire T, Mahato RI.

Mol Ther Nucleic Acids. 2018 Sep 7;12:490-503. doi: 10.1016/j.omtn.2018.06.004. Epub 2018 Jun 19.

28.

Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors.

Barlaam B, Cadogan E, Campbell A, Colclough N, Dishington A, Durant S, Goldberg K, Hassall LA, Hughes GD, MacFaul PA, McGuire TM, Pass M, Patel A, Pearson S, Petersen J, Pike KG, Robb G, Stratton N, Xin G, Zhai B.

ACS Med Chem Lett. 2018 Jul 13;9(8):809-814. doi: 10.1021/acsmedchemlett.8b00200. eCollection 2018 Aug 9.

29.

Dual Roles for Potassium Hydride in Haloarene Reduction: CSNAr and Single Electron Transfer Reduction via Organic Electron Donors Formed in Benzene.

Barham JP, Dalton SE, Allison M, Nocera G, Young A, John MP, McGuire T, Campos S, Tuttle T, Murphy JA.

J Am Chem Soc. 2018 Sep 12;140(36):11510-11518. doi: 10.1021/jacs.8b07632. Epub 2018 Aug 30.

30.

Deriving risk adjustment payment weights to maximize efficiency of health insurance markets.

Layton TJ, McGuire TG, van Kleef RC.

J Health Econ. 2018 Sep;61:93-110. doi: 10.1016/j.jhealeco.2018.07.001. Epub 2018 Jul 23.

31.

Breastfeeding questions to medicines call centres from the Australian public and health professionals.

Stephens A, Brodribb W, McGuire T, Deckx L.

Aust J Prim Health. 2018 Nov;24(5):409-416. doi: 10.1071/PY18010.

PMID:
30086825
32.

Chemogenomics Systems Pharmacology Mapping of Potential Drug Targets for Treatment of Traumatic Brain Injury.

Wang L, Ma S, Hu Z, McGuire TF, Xie XQ.

J Neurotrauma. 2019 Feb 15;36(4):565-575. doi: 10.1089/neu.2018.5757. Epub 2018 Sep 6.

PMID:
30014763
33.

Electron Transfer Reactions: KO tBu (but not NaO tBu) Photoreduces Benzophenone under Activation by Visible Light.

Nocera G, Young A, Palumbo F, Emery KJ, Coulthard G, McGuire T, Tuttle T, Murphy JA.

J Am Chem Soc. 2018 Aug 1;140(30):9751-9757. doi: 10.1021/jacs.8b06089. Epub 2018 Jul 24.

PMID:
29996048
34.

Correction to Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase.

Degorce SL, Barlaam B, Cadogan E, Dishington A, Ducray R, Glossop SC, Hassall LA, Lach F, Lau A, McGuire TM, Nowak T, Ouvry G, Pike KG, Thomason AG.

J Med Chem. 2018 Jul 26;61(14):6398. doi: 10.1021/acs.jmedchem.8b00936. Epub 2018 Jul 3. No abstract available.

PMID:
29969258
35.

Does consumer medicines interest reflect medicines use? An observational study comparing medicines call center queries with medicines use.

Pache DM, Hollingworth SA, van Driel ML, McGuire TM.

Res Social Adm Pharm. 2019 Apr;15(4):440-447. doi: 10.1016/j.sapharm.2018.06.012. Epub 2018 Jun 18.

PMID:
29935855
36.

Antibacterial, antifungal, anticancer activities and structural bioinformatics analysis of six naturally occurring temporins.

Mishra B, Wang X, Lushnikova T, Zhang Y, Golla RM, Narayana JL, Wang C, McGuire TR, Wang G.

Peptides. 2018 Aug;106:9-20. doi: 10.1016/j.peptides.2018.05.011. Epub 2018 May 26.

37.

The Impact of Dementia Special Care Units on Quality of Care: An Instrumental Variables Analysis.

Joyce NR, McGuire TG, Bartels SJ, Mitchell SL, Grabowski DC.

Health Serv Res. 2018 Oct;53(5):3657-3679. doi: 10.1111/1475-6773.12867. Epub 2018 May 7.

38.

Fibronectin EDA forms the chronic fibrotic scar after contusive spinal cord injury.

Cooper JG, Jeong SJ, McGuire TL, Sharma S, Wang W, Bhattacharyya S, Varga J, Kessler JA.

Neurobiol Dis. 2018 Aug;116:60-68. doi: 10.1016/j.nbd.2018.04.014. Epub 2018 Apr 27.

39.

The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imidazo[4,5- c]quinolin-2-one).

Pike KG, Barlaam B, Cadogan E, Campbell A, Chen Y, Colclough N, Davies NL, de-Almeida C, Degorce SL, Didelot M, Dishington A, Ducray R, Durant ST, Hassall LA, Holmes J, Hughes GD, MacFaul PA, Mulholland KR, McGuire TM, Ouvry G, Pass M, Robb G, Stratton N, Wang Z, Wilson J, Zhai B, Zhao K, Al-Huniti N.

J Med Chem. 2018 May 10;61(9):3823-3841. doi: 10.1021/acs.jmedchem.7b01896. Epub 2018 May 2.

PMID:
29683659
40.

Improved therapy for medulloblastoma: targeting hedgehog and PI3K-mTOR signaling pathways in combination with chemotherapy.

Chaturvedi NK, Kling MJ, Coulter DW, McGuire TR, Ray S, Kesherwani V, Joshi SS, Sharp JG.

Oncotarget. 2018 Mar 30;9(24):16619-16633. doi: 10.18632/oncotarget.24618. eCollection 2018 Mar 30.

41.

Learnings and challenges to deploy an interprofessional and independent medical education programme to a new audience.

Van Driel ML, McGuire TM, Stark R, Lazure P, Garcia T, Sullivan L.

J Eur CME. 2017 Nov 12;6(1):1400857. doi: 10.1080/21614083.2017.1400857. eCollection 2017.

42.

Homeopathic medicinal products for preventing and treating acute respiratory tract infections in children.

Hawke K, van Driel ML, Buffington BJ, McGuire TM, King D.

Cochrane Database Syst Rev. 2018 Apr 9;4:CD005974. doi: 10.1002/14651858.CD005974.pub4. Review. Update in: Cochrane Database Syst Rev. 2018 Sep 09;9:CD005974.

43.

Complexation of Chol-DsiRNA in place of Chol-siRNA greatly increases the duration of mRNA suppression by polyplexes of PLL(30)-PEG(5K) in primary murine syngeneic breast tumors after i.v. administration.

Ambardekar VV, Wakaskar RR, Ye Z, Curran SM, McGuire TR, Coulter DW, Singh RK, Vetro JA.

Int J Pharm. 2018 May 30;543(1-2):130-138. doi: 10.1016/j.ijpharm.2018.03.045. Epub 2018 Mar 27.

44.

Long-Chain Omega-3 Polyunsaturated Fatty Acids Modulate Mammary Gland Composition and Inflammation.

Khadge S, Thiele GM, Sharp JG, McGuire TR, Klassen LW, Black PN, DiRusso CC, Talmadge JE.

J Mammary Gland Biol Neoplasia. 2018 Jun;23(1-2):43-58. doi: 10.1007/s10911-018-9391-5. Epub 2018 Mar 25.

PMID:
29574638
45.

Changing environment of hyperglycemia in pregnancy: Gestational diabetes and diabetes mellitus in pregnancy.

Gray SG, Sweeting AN, Mcguire TM, Cohen N, Ross GP, Little PJ.

J Diabetes. 2018 Aug;10(8):633-640. doi: 10.1111/1753-0407.12660. Epub 2018 Apr 26. Review.

PMID:
29573162
46.

Drugs affecting milk supply during lactation.

McGuire TM.

Aust Prescr. 2018 Feb;41(1):7-9. doi: 10.18773/austprescr.2018.002. Epub 2018 Feb 1. Review. No abstract available.

47.

Matching and Imputation Methods for Risk Adjustment in the Health Insurance Marketplaces.

Rose S, Shi J, McGuire TG, Normand ST.

Stat Biosci. 2017 Dec;9(2):525-542. doi: 10.1007/s12561-015-9135-7. Epub 2015 Aug 5.

48.

BMP-Responsive Protease HtrA1 Is Differentially Expressed in Astrocytes and Regulates Astrocytic Development and Injury Response.

Chen J, Van Gulden S, McGuire TL, Fleming AC, Oka C, Kessler JA, Peng CY.

J Neurosci. 2018 Apr 11;38(15):3840-3857. doi: 10.1523/JNEUROSCI.2031-17.2018. Epub 2018 Feb 26.

49.

Implications of family risk pooling for individual health insurance markets.

Sinaiko AD, Layton TJ, Rose S, McGuire TG.

Health Serv Outcomes Res Methodol. 2017 Dec;17(3-4):219-236. doi: 10.1007/s10742-017-0170-3. Epub 2017 May 26.

50.

Creating a stem cell niche in the inner ear using self-assembling peptide amphiphiles.

Matsuoka AJ, Sayed ZA, Stephanopoulos N, Berns EJ, Wadhwani AR, Morrissey ZD, Chadly DM, Kobayashi S, Edelbrock AN, Mashimo T, Miller CA, McGuire TL, Stupp SI, Kessler JA.

PLoS One. 2017 Dec 28;12(12):e0190150. doi: 10.1371/journal.pone.0190150. eCollection 2017.

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