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Impaired insulin signaling in the B10.D2-Hc0 H2d H2-T18c/oSnJ mouse model of complement factor 5 deficiency.

Peterson KR, Gutierrez DA, Kikuchi T, Anderson-Baucum EK, Winn NC, Shuey MM, Bolus WR, McGuinness OP, Hasty AH.

Am J Physiol Endocrinol Metab. 2019 Aug 1;317(2):E200-E211. doi: 10.1152/ajpendo.00042.2019. Epub 2019 May 14.


Rapid changes in the microvascular circulation of skeletal muscle impair insulin delivery during sepsis.

Mignemi NA, McClatchey PM, Kilchrist KV, Williams IM, Millis BA, Syring KE, Duvall CL, Wasserman DH, McGuinness OP.

Am J Physiol Endocrinol Metab. 2019 Jun 1;316(6):E1012-E1023. doi: 10.1152/ajpendo.00501.2018. Epub 2019 Mar 12.


Systemic bile acids induce insulin resistance in a TGR5-independent manner.

Syring KE, Cyphert TJ, Beck TC, Flynn CR, Mignemi NA, McGuinness OP.

Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E782-E793. doi: 10.1152/ajpendo.00362.2018. Epub 2019 Feb 19.


Repeated clodronate-liposome treatment results in neutrophilia and is not effective in limiting obesity-linked metabolic impairments.

Bader JE, Enos RT, Velázquez KT, Carson MS, Sougiannis AT, McGuinness OP, Robinson CM, Murphy EA.

Am J Physiol Endocrinol Metab. 2019 Mar 1;316(3):E358-E372. doi: 10.1152/ajpendo.00438.2018. Epub 2018 Dec 21.


Automated quantification of microvascular perfusion.

McClatchey PM, Mignemi NA, Xu Z, Williams IM, Reusch JEB, McGuinness OP, Wasserman DH.

Microcirculation. 2018 Aug;25(6):e12482. doi: 10.1111/micc.12482. Epub 2018 Jul 15.


Hepatic Gi signaling regulates whole-body glucose homeostasis.

Rossi M, Zhu L, McMillin SM, Pydi SP, Jain S, Wang L, Cui Y, Lee RJ, Cohen AH, Kaneto H, Birnbaum MJ, Ma Y, Rotman Y, Liu J, Cyphert TJ, Finkel T, McGuinness OP, Wess J.

J Clin Invest. 2018 Feb 1;128(2):746-759. doi: 10.1172/JCI94505. Epub 2018 Jan 16.


Effects of G6pc2 deletion on body weight and cholesterol in mice.

Boortz KA, Syring KE, Pound LD, Mo H, Bastarache L, Oeser JK, McGuinness OP, Denny JC, O'Brien RM.

J Mol Endocrinol. 2017 Apr;58(3):127-139. doi: 10.1530/JME-16-0202. Epub 2017 Jan 25.


G6PC2 Modulates the Effects of Dexamethasone on Fasting Blood Glucose and Glucose Tolerance.

Boortz KA, Syring KE, Lee RA, Dai C, Oeser JK, McGuinness OP, Wang JC, O'Brien RM.

Endocrinology. 2016 Nov;157(11):4133-4145. Epub 2016 Sep 21.


Combined Deletion of Slc30a7 and Slc30a8 Unmasks a Critical Role for ZnT8 in Glucose-Stimulated Insulin Secretion.

Syring KE, Boortz KA, Oeser JK, Ustione A, Platt KA, Shadoan MK, McGuinness OP, Piston DW, Powell DR, O'Brien RM.

Endocrinology. 2016 Dec;157(12):4534-4541. Epub 2016 Oct 18.


G6PC2 Modulates Fasting Blood Glucose In Male Mice in Response to Stress.

Boortz KA, Syring KE, Dai C, Pound LD, Oeser JK, Jacobson DA, Wang JC, McGuinness OP, Powers AC, O'Brien RM.

Endocrinology. 2016 Aug;157(8):3002-8. doi: 10.1210/en.2016-1245. Epub 2016 Jun 14.


The microRNA-29 Family Dictates the Balance Between Homeostatic and Pathological Glucose Handling in Diabetes and Obesity.

Dooley J, Garcia-Perez JE, Sreenivasan J, Schlenner SM, Vangoitsenhoven R, Papadopoulou AS, Tian L, Schonefeldt S, Serneels L, Deroose C, Staats KA, Van der Schueren B, De Strooper B, McGuinness OP, Mathieu C, Liston A.

Diabetes. 2016 Jan;65(1):53-61. doi: 10.2337/db15-0770.


Enhanced Glucose Transport, but not Phosphorylation Capacity, Ameliorates Lipopolysaccharide-Induced Impairments in Insulin-Stimulated Muscle Glucose Uptake.

Otero YF, Mulligan KX, Barnes TM, Ford EA, Malabanan CM, Zong H, Pessin JE, Wasserman DH, McGuinness OP.

Shock. 2016 Jun;45(6):677-85. doi: 10.1097/SHK.0000000000000550.


The PGE2 EP3 Receptor Regulates Diet-Induced Adiposity in Male Mice.

Ceddia RP, Lee D, Maulis MF, Carboneau BA, Threadgill DW, Poffenberger G, Milne G, Boyd KL, Powers AC, McGuinness OP, Gannon M, Breyer RM.

Endocrinology. 2016 Jan;157(1):220-32. doi: 10.1210/en.2015-1693. Epub 2015 Oct 20.


NF-κB-dependent airway inflammation triggers systemic insulin resistance.

Cyphert TJ, Morris RT, House LM, Barnes TM, Otero YF, Barham WJ, Hunt RP, Zaynagetdinov R, Yull FE, Blackwell TS, McGuinness OP.

Am J Physiol Regul Integr Comp Physiol. 2015 Nov 1;309(9):R1144-52. doi: 10.1152/ajpregu.00442.2014. Epub 2015 Sep 16.


Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex.

Kolumam G, Chen MZ, Tong R, Zavala-Solorio J, Kates L, van Bruggen N, Ross J, Wyatt SK, Gandham VD, Carano RA, Dunshee DR, Wu AL, Haley B, Anderson K, Warming S, Rairdan XY, Lewin-Koh N, Zhang Y, Gutierrez J, Baruch A, Gelzleichter TR, Stevens D, Rajan S, Bainbridge TW, Vernes JM, Meng YG, Ziai J, Soriano RH, Brauer MJ, Chen Y, Stawicki S, Kim HS, Comps-Agrar L, Luis E, Spiess C, Wu Y, Ernst JA, McGuinness OP, Peterson AS, Sonoda J.

EBioMedicine. 2015 May 30;2(7):730-43. doi: 10.1016/j.ebiom.2015.05.028. eCollection 2015 Jul.


Tissue inflammation and nitric oxide-mediated alterations in cardiovascular function are major determinants of endotoxin-induced insulin resistance.

House LM 2nd, Morris RT, Barnes TM, Lantier L, Cyphert TJ, McGuinness OP, Otero YF.

Cardiovasc Diabetol. 2015 May 20;14:56. doi: 10.1186/s12933-015-0223-2.


Differential impact of selective GH deficiency and endogenous GH excess on insulin-mediated actions in muscle and liver of male mice.

Cordoba-Chacon J, Gahete MD, McGuinness OP, Kineman RD.

Am J Physiol Endocrinol Metab. 2014 Nov 15;307(10):E928-34. doi: 10.1152/ajpendo.00420.2014. Epub 2014 Sep 30.


Interleukin-6 amplifies glucagon secretion: coordinated control via the brain and pancreas.

Barnes TM, Otero YF, Elliott AD, Locke AD, Malabanan CM, Coldren AG, Brissova M, Piston DW, McGuinness OP.

Am J Physiol Endocrinol Metab. 2014 Nov 15;307(10):E896-905. doi: 10.1152/ajpendo.00343.2014. Epub 2014 Sep 9.


Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity.

Chen Z, Guo L, Zhang Y, Walzem RL, Pendergast JS, Printz RL, Morris LC, Matafonova E, Stien X, Kang L, Coulon D, McGuinness OP, Niswender KD, Davies SS.

J Clin Invest. 2014 Aug;124(8):3391-406. doi: 10.1172/JCI72517. Epub 2014 Jun 24.


Pathway-selective insulin resistance and metabolic disease: the importance of nutrient flux.

Otero YF, Stafford JM, McGuinness OP.

J Biol Chem. 2014 Jul 25;289(30):20462-9. Review.


Liver but not adipose tissue is responsive to the pattern of enteral feeding.

Otero YF, Lundblad TM, Ford EA, House LM, McGuinness OP.

Physiol Rep. 2014 Feb 25;2(2):e00250. doi: 10.1002/phy2.250. eCollection 2014 Feb 1.


Liver, but not muscle, has an entrainable metabolic memory.

Chen SS, Otero YF, Mulligan KX, Lundblad TM, Williams PE, McGuinness OP.

PLoS One. 2014 Jan 23;9(1):e86164. doi: 10.1371/journal.pone.0086164. eCollection 2014.


Cholesteryl ester transfer protein protects against insulin resistance in obese female mice.

Cappel DA, Palmisano BT, Emfinger CH, Martinez MN, McGuinness OP, Stafford JM.

Mol Metab. 2013 Sep 2;2(4):457-67. doi: 10.1016/j.molmet.2013.08.007. eCollection 2013.


A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition.

Wei K, Piecewicz SM, McGinnis LM, Taniguchi CM, Wiegand SJ, Anderson K, Chan CW, Mulligan KX, Kuo D, Yuan J, Vallon M, Morton L, Lefai E, Simon MC, Maher JJ, Mithieux G, Rajas F, Annes J, McGuinness OP, Thurston G, Giaccia AJ, Kuo CJ.

Nat Med. 2013 Oct;19(10):1331-1337. doi: 10.1038/nm.3295. Epub 2013 Sep 15.


Vascular endothelial growth factor-a and islet vascularization are necessary in developing, but not adult, pancreatic islets.

Reinert RB, Brissova M, Shostak A, Pan FC, Poffenberger G, Cai Q, Hundemer GL, Kantz J, Thompson CS, Dai C, McGuinness OP, Powers AC.

Diabetes. 2013 Dec;62(12):4154-64. doi: 10.2337/db13-0071. Epub 2013 Jul 24.


A novel experimental strategy to assess the metabolic effects of selective activation of a G(q)-coupled receptor in hepatocytes in vivo.

Li JH, Jain S, McMillin SM, Cui Y, Gautam D, Sakamoto W, Lu H, Jou W, McGuinness OP, Gavrilova O, Wess J.

Endocrinology. 2013 Oct;154(10):3539-51. doi: 10.1210/en.2012-2127. Epub 2013 Jul 16.


Circadian disruption leads to insulin resistance and obesity.

Shi SQ, Ansari TS, McGuinness OP, Wasserman DH, Johnson CH.

Curr Biol. 2013 Mar 4;23(5):372-81. doi: 10.1016/j.cub.2013.01.048. Epub 2013 Feb 21.


Amino acids as metabolic substrates during cardiac ischemia.

Drake KJ, Sidorov VY, McGuinness OP, Wasserman DH, Wikswo JP.

Exp Biol Med (Maywood). 2012 Dec;237(12):1369-78. doi: 10.1258/ebm.2012.012025. Review.


Regulation of endogenous glucose production in glucose transporter 4 over-expressing mice.

Berglund ED, Li CY, Ayala JE, McGuinness OP, Wasserman DH.

PLoS One. 2012;7(12):e52355. doi: 10.1371/journal.pone.0052355. Epub 2012 Dec 17.


G6PC2: a negative regulator of basal glucose-stimulated insulin secretion.

Pound LD, Oeser JK, O'Brien TP, Wang Y, Faulman CJ, Dadi PK, Jacobson DA, Hutton JC, McGuinness OP, Shiota M, O'Brien RM.

Diabetes. 2013 May;62(5):1547-56. doi: 10.2337/db12-1067. Epub 2012 Dec 28.


Inflammation during obesity is not all bad: evidence from animal and human studies.

Ye J, McGuinness OP.

Am J Physiol Endocrinol Metab. 2013 Mar 1;304(5):E466-77. doi: 10.1152/ajpendo.00266.2012. Epub 2012 Dec 26. Review.


Estrogen treatment after ovariectomy protects against fatty liver and may improve pathway-selective insulin resistance.

Zhu L, Brown WC, Cai Q, Krust A, Chambon P, McGuinness OP, Stafford JM.

Diabetes. 2013 Feb;62(2):424-34. doi: 10.2337/db11-1718. Epub 2012 Sep 10.


Neuron-specific deletion of peroxisome proliferator-activated receptor delta (PPARδ) in mice leads to increased susceptibility to diet-induced obesity.

Kocalis HE, Turney MK, Printz RL, Laryea GN, Muglia LJ, Davies SS, Stanwood GD, McGuinness OP, Niswender KD.

PLoS One. 2012;7(8):e42981. doi: 10.1371/journal.pone.0042981. Epub 2012 Aug 20.


The physiological effects of deleting the mouse SLC30A8 gene encoding zinc transporter-8 are influenced by gender and genetic background.

Pound LD, Sarkar SA, Ustione A, Dadi PK, Shadoan MK, Lee CE, Walters JA, Shiota M, McGuinness OP, Jacobson DA, Piston DW, Hutton JC, Powell DR, O'Brien RM.

PLoS One. 2012;7(7):e40972. doi: 10.1371/journal.pone.0040972. Epub 2012 Jul 19.


Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation.

Haldar SM, Jeyaraj D, Anand P, Zhu H, Lu Y, Prosdocimo DA, Eapen B, Kawanami D, Okutsu M, Brotto L, Fujioka H, Kerner J, Rosca MG, McGuinness OP, Snow RJ, Russell AP, Gerber AN, Bai X, Yan Z, Nosek TM, Brotto M, Hoppel CL, Jain MK.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6739-44. doi: 10.1073/pnas.1121060109. Epub 2012 Apr 9.


Adropin deficiency is associated with increased adiposity and insulin resistance.

Ganesh Kumar K, Zhang J, Gao S, Rossi J, McGuinness OP, Halem HH, Culler MD, Mynatt RL, Butler AA.

Obesity (Silver Spring). 2012 Jul;20(7):1394-402. doi: 10.1038/oby.2012.31. Epub 2012 Feb 9.


Disassociation of muscle insulin signaling and insulin-stimulated glucose uptake during endotoxemia.

Mulligan KX, Morris RT, Otero YF, Wasserman DH, McGuinness OP.

PLoS One. 2012;7(1):e30160. doi: 10.1371/journal.pone.0030160. Epub 2012 Jan 20.


Hyperinsulinemic-euglycemic clamps in conscious, unrestrained mice.

Ayala JE, Bracy DP, Malabanan C, James FD, Ansari T, Fueger PT, McGuinness OP, Wasserman DH.

J Vis Exp. 2011 Nov 16;(57). pii: 3188. doi: 10.3791/3188.


Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues.

Lin L, Saha PK, Ma X, Henshaw IO, Shao L, Chang BH, Buras ED, Tong Q, Chan L, McGuinness OP, Sun Y.

Aging Cell. 2011 Dec;10(6):996-1010. doi: 10.1111/j.1474-9726.2011.00740.x. Epub 2011 Oct 12.


Assessment of different bariatric surgeries in the treatment of obesity and insulin resistance in mice.

Yin DP, Gao Q, Ma LL, Yan W, Williams PE, McGuinness OP, Wasserman DH, Abumrad NN.

Ann Surg. 2011 Jul;254(1):73-82. doi: 10.1097/SLA.0b013e3182197035.


Continuous low-dose fructose infusion does not reverse glucagon-mediated decrease in hepatic glucose utilization.

Johnson PM, Chen SS, Santomango TS, Williams PE, Lacy DB, McGuinness OP.

Metabolism. 2011 Jun;60(6):867-73. doi: 10.1016/j.metabol.2010.08.006. Epub 2010 Oct 12.


Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice.

Ayala JE, Samuel VT, Morton GJ, Obici S, Croniger CM, Shulman GI, Wasserman DH, McGuinness OP; NIH Mouse Metabolic Phenotyping Center Consortium.

Dis Model Mech. 2010 Sep-Oct;3(9-10):525-34. doi: 10.1242/dmm.006239. Epub 2010 Aug 16.


Advantages of dynamic "closed loop" stable isotope flux phenotyping over static "open loop" clamps in detecting silent genetic and dietary phenotypes.

Vaitheesvaran B, Chueh FY, Xu J, Trujillo C, Saad MF, Lee WN, McGuinness OP, Kurland IJ.

Metabolomics. 2010 Jun;6(2):180-190. Epub 2009 Nov 12.


Impaired glucose tolerance and predisposition to the fasted state in liver glycogen synthase knock-out mice.

Irimia JM, Meyer CM, Peper CL, Zhai L, Bock CB, Previs SF, McGuinness OP, DePaoli-Roach A, Roach PJ.

J Biol Chem. 2010 Apr 23;285(17):12851-61. doi: 10.1074/jbc.M110.106534. Epub 2010 Feb 23.


Circadian clock gene Bmal1 is not essential; functional replacement with its paralog, Bmal2.

Shi S, Hida A, McGuinness OP, Wasserman DH, Yamazaki S, Johnson CH.

Curr Biol. 2010 Feb 23;20(4):316-21. doi: 10.1016/j.cub.2009.12.034. Epub 2010 Feb 11.


Metabolic response to endotoxin in vivo in the conscious mouse: role of interleukin-6.

Tweedell A, Mulligan KX, Martel JE, Chueh FY, Santomango T, McGuinness OP.

Metabolism. 2011 Jan;60(1):92-8. doi: 10.1016/j.metabol.2009.12.022. Epub 2010 Jan 27.


Lost in translation.

Wasserman DH, Ayala JE, McGuinness OP.

Diabetes. 2009 Sep;58(9):1947-50. doi: 10.2337/db09-0537. No abstract available.


NIH experiment in centralized mouse phenotyping: the Vanderbilt experience and recommendations for evaluating glucose homeostasis in the mouse.

McGuinness OP, Ayala JE, Laughlin MR, Wasserman DH.

Am J Physiol Endocrinol Metab. 2009 Oct;297(4):E849-55. doi: 10.1152/ajpendo.90996.2008. Epub 2009 Jul 28. Review.


Skeletal muscle AMP-activated protein kinase is essential for the metabolic response to exercise in vivo.

Lee-Young RS, Griffee SR, Lynes SE, Bracy DP, Ayala JE, McGuinness OP, Wasserman DH.

J Biol Chem. 2009 Sep 4;284(36):23925-34. doi: 10.1074/jbc.M109.021048. Epub 2009 Jun 12.


Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion.

Pound LD, Sarkar SA, Benninger RK, Wang Y, Suwanichkul A, Shadoan MK, Printz RL, Oeser JK, Lee CE, Piston DW, McGuinness OP, Hutton JC, Powell DR, O'Brien RM.

Biochem J. 2009 Jul 15;421(3):371-6. doi: 10.1042/BJ20090530.

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