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Items: 1 to 50 of 283

1.

Interventions for preventing falls in people with multiple sclerosis.

Hayes S, Galvin R, Kennedy C, Finlayson M, McGuigan C, Walsh CD, Coote S.

Cochrane Database Syst Rev. 2019 Nov 28;11:CD012475. doi: 10.1002/14651858.CD012475.pub2. Review.

PMID:
31778221
2.

The accuracy of standard multiple sclerosis MRI brain sequences for the diagnosis of optic neuropathy.

Healy GM, Redmond CE, Gaughan M, Fleming H, Carroll AG, Purcell YM, McGuigan C, McNeill G, Killeen RP.

Mult Scler Relat Disord. 2019 Nov 12;38:101521. doi: 10.1016/j.msard.2019.101521. [Epub ahead of print]

PMID:
31756609
3.

Polyfluoroaromatic stavudine (d4T) ProTides exhibit enhanced anti-HIV activity.

Kandil S, Pannecouque C, Chapman FM, Westwell AD, McGuigan C.

Bioorg Med Chem Lett. 2019 Dec 15;29(24):126721. doi: 10.1016/j.bmcl.2019.126721. Epub 2019 Oct 23.

PMID:
31679972
4.

Redefining the Multiple Sclerosis Severity Score (MSSS): The effect of sex and onset phenotype.

Zhou Y, Claflin SB, Stankovich J, van der Mei I, Simpson S Jr, Roxburgh RH, Kalincik T, Blizzard L, Lugaresi A, Alroughani R, Sajedi SA, Butzkueven H, Pucci E, Spitaleri D, Granella F, Cristiano E, Yamout B, Hughes S, Gouider R, Sánchez Menoyo JL, Olascoaga J, McGuigan C, Shaw C, Kermode AG, Kasa K, Al-Harbi T, Altintas A, Laureys G, Fragoso Y, Hardy TA, Csepany T, Sirbu CA, Decoo D, Sas A, Alvarez-Cermeño JC, Kotkata K, Millán-Pascual J, Taylor BV.

Mult Scler. 2019 Oct 31:1352458519881994. doi: 10.1177/1352458519881994. [Epub ahead of print]

PMID:
31668127
5.

Moderate-to-vigorous exercise is beneficial and can improve symptoms of fatigue and depression in young people with paediatric-onset multiple sclerosis and other demyelinating conditions.

McGuigan K, McGuigan CJ.

Evid Based Nurs. 2019 Aug 28. pii: ebnurs-2019-103117. doi: 10.1136/ebnurs-2019-103117. [Epub ahead of print] No abstract available.

PMID:
31462426
6.

Rash developing after cessation of Daclizumab for relapsing remitting MS; a case series.

Lockhart A, Kirby B, McGuigan C.

Mult Scler Relat Disord. 2019 Oct;35:239-240. doi: 10.1016/j.msard.2019.08.008. Epub 2019 Aug 5.

PMID:
31421627
7.

A new series of bicalutamide, enzalutamide and enobosarm derivatives carrying pentafluorosulfanyl (SF5) and pentafluoroethyl (C2F5) substituents: Improved antiproliferative agents against prostate cancer.

Pertusati F, Ferla S, Bassetto M, Brancale A, Khandil S, Westwell AD, McGuigan C.

Eur J Med Chem. 2019 Oct 15;180:1-14. doi: 10.1016/j.ejmech.2019.07.001. Epub 2019 Jul 3.

PMID:
31288149
8.

Chronic skin disorders negatively impact women's quality of life and sexual function.

McGuigan K, McGuigan CJ.

Evid Based Nurs. 2019 Oct;22(4):114. doi: 10.1136/ebnurs-2018-103040. Epub 2019 Jun 22. No abstract available.

PMID:
31229959
9.

Association of Initial Disease-Modifying Therapy With Later Conversion to Secondary Progressive Multiple Sclerosis.

Brown JWL, Coles A, Horakova D, Havrdova E, Izquierdo G, Prat A, Girard M, Duquette P, Trojano M, Lugaresi A, Bergamaschi R, Grammond P, Alroughani R, Hupperts R, McCombe P, Van Pesch V, Sola P, Ferraro D, Grand'Maison F, Terzi M, Lechner-Scott J, Flechter S, Slee M, Shaygannejad V, Pucci E, Granella F, Jokubaitis V, Willis M, Rice C, Scolding N, Wilkins A, Pearson OR, Ziemssen T, Hutchinson M, Harding K, Jones J, McGuigan C, Butzkueven H, Kalincik T, Robertson N; MSBase Study Group.

JAMA. 2019 Jan 15;321(2):175-187. doi: 10.1001/jama.2018.20588.

10.

Monocytes exposed to plasma from patients with Alzheimer's disease undergo metabolic reprogramming.

Wolfe H, Mela V, Minogue AM, Miller AM, McGuigan C, Williams L, Lohan D, Lawlor BA, Lynch MA.

Neurosci Res. 2019 Nov;148:54-60. doi: 10.1016/j.neures.2019.01.001. Epub 2019 Jan 12.

PMID:
30641113
11.

Symmetrical Diamidates as a Class of Phosphate Prodrugs to Deliver the 5'-Monophosphate Forms of Anticancer Nucleoside Analogues.

Slusarczyk M, Ferrari V, Serpi M, Gönczy B, Balzarini J, McGuigan C.

ChemMedChem. 2018 Nov 6;13(21):2305-2316. doi: 10.1002/cmdc.201800504.

PMID:
30199147
12.

IRAK1 Limits TLR3/4- and IFNAR-Driven IL-27 Production through a STAT1-Dependent Mechanism.

Bruni D, Dignam A, Dunne S, Wall-Coughlan D, McCrudden A, O'Connell K, Lyons C, McGuigan C, Tubridy N, Butler MP.

J Immunol. 2018 Oct 1;201(7):2070-2081. doi: 10.4049/jimmunol.1701373. Epub 2018 Aug 24.

13.

Discriminative ability and clinical utility of the Timed Up and Go (TUG) in identifying falls risk in people with multiple sclerosis: a prospective cohort study.

Quinn G, Comber L, McGuigan C, Galvin R, Coote S.

Clin Rehabil. 2019 Feb;33(2):317-326. doi: 10.1177/0269215518793481. Epub 2018 Aug 14.

PMID:
30103642
14.

2017 McDonald diagnostic criteria: A review of the evidence.

McNicholas N, Hutchinson M, McGuigan C, Chataway J.

Mult Scler Relat Disord. 2018 Aug;24:48-54. doi: 10.1016/j.msard.2018.05.011. Epub 2018 Jun 21. Review.

PMID:
29936325
15.

Platelet Releasate Proteome Profiling Reveals a Core Set of Proteins with Low Variance between Healthy Adults.

Parsons MEM, Szklanna PB, Guerrero JA, Wynne K, Dervin F, O'Connell K, Allen S, Egan K, Bennett C, McGuigan C, Gheveart C, Ní Áinle F, Maguire PB.

Proteomics. 2018 Aug;18(15):e1800219. doi: 10.1002/pmic.201800219. Epub 2018 Jul 15.

PMID:
29932309
16.

FDG-PET diagnoses of sporadic Creutzfeldt-Jakob disease: radiology-pathology correlation.

Duignan J, Healy GM, Hughes NM, Redmond CE, McGuigan C, Beausang A, Killeen RP.

QJM. 2018 Sep 1;111(9):679. doi: 10.1093/qjmed/hcy090. No abstract available.

PMID:
29788451
17.

RPtag as an Orally Bioavailable, Hyperstable Epitope Tag and Generalizable Protein Binding Scaffold.

DeRosa JR, Moyer BS, Lumen E, Wolfe AJ, Sleeper MB, Bianchi AH, Crawford A, McGuigan C, Wortel D, Fisher C, Moody KJ, Blanden AR.

Biochemistry. 2018 May 29;57(21):3036-3049. doi: 10.1021/acs.biochem.8b00170. Epub 2018 May 15.

PMID:
29722979
18.

New versus old: Implications of evolving diagnostic criteria for relapsing-remitting multiple sclerosis.

McNicholas N, Lockhart A, Yap SM, O'Connell K, Tubridy N, Hutchinson M, McGuigan C.

Mult Scler. 2019 May;25(6):867-870. doi: 10.1177/1352458518770088. Epub 2018 Apr 12.

PMID:
29648501
19.

FDG-PET diagnoses of sporadic Creutzfeldt-Jakob disease: radiology-pathology correlation.

Duignan J, Healy GM, Hughes NM, Redmond CE, McGuigan C, Beausang A, Killeen RP.

QJM. 2018 Sep 1;111(9):669-670. doi: 10.1093/qjmed/hcy071. No abstract available. Erratum in: QJM. 2018 Sep 1;111(9):679.

PMID:
29617881
20.

Societal costs of multiple sclerosis in Ireland.

Carney P, O'Boyle D, Larkin A, McGuigan C, O'Rourke K.

J Med Econ. 2018 May;21(5):425-437. doi: 10.1080/13696998.2018.1427100. Epub 2018 Feb 7.

PMID:
29320900
21.

Thrombin generation correlates with disease duration in multiple sclerosis (MS): Novel insights into the MS-associated prothrombotic state.

Parsons ME, O'Connell K, Allen S, Egan K, Szklanna PB, McGuigan C, Ní Áinle F, Maguire PB.

Mult Scler J Exp Transl Clin. 2017 Dec 26;3(4):2055217317747624. doi: 10.1177/2055217317747624. eCollection 2017 Oct-Dec.

22.

Synthesis and biological evaluation of 6-substituted-5-fluorouridine ProTides.

Slusarczyk M, Ferla S, Brancale A, McGuigan C.

Bioorg Med Chem. 2018 Feb 1;26(3):551-565. doi: 10.1016/j.bmc.2017.11.037. Epub 2017 Dec 2.

PMID:
29277307
23.

Correction to: MRI and multiple sclerosis-the evolving role of MRI in the diagnosis and management of MS: a clinician's perspective.

Kearney H, Cahalane AM, Killeen RP, McGuigan C.

Ir J Med Sci. 2018 May;187(2):499. doi: 10.1007/s11845-017-1719-4.

PMID:
29181830
24.

MRI and multiple sclerosis--the evolving role of MRI in the diagnosis and management of MS: the radiologist's perspective.

Cahalane AM, Kearney H, Purcell YM, McGuigan C, Killeen RP.

Ir J Med Sci. 2018 Aug;187(3):781-787. doi: 10.1007/s11845-017-1714-9. Epub 2017 Nov 25. Review.

PMID:
29177917
25.

A Protocol for Improved Precision and Increased Confidence in Nanoparticle Tracking Analysis Concentration Measurements between 50 and 120 nm in Biological Fluids.

Parsons MEM, McParland D, Szklanna PB, Guang MHZ, O'Connell K, O'Connor HD, McGuigan C, Ní Áinle F, McCann A, Maguire PB.

Front Cardiovasc Med. 2017 Nov 3;4:68. doi: 10.3389/fcvm.2017.00068. eCollection 2017.

26.

Effects of Intravenous Cold Saline on Hyperthermic Athletes Representative of Large Football Players and Small Endurance Runners.

Morrison KE, Desai N, McGuigan C, Lennon M, Godek SF.

Clin J Sport Med. 2018 Nov;28(6):493-499. doi: 10.1097/JSM.0000000000000505.

PMID:
29112514
27.

MRI and multiple sclerosis-the evolving role of MRI in the diagnosis and management of MS: a clinician's perspective.

Kearney H, Cahalane AM, Killeen RP, McGuigan C.

Ir J Med Sci. 2018 May;187(2):493-498. doi: 10.1007/s11845-017-1691-z. Epub 2017 Oct 10. Review. Erratum in: Ir J Med Sci. 2017 Nov 28;:.

PMID:
29019147
28.

Effects of vitamin D3 in clinically isolated syndrome and healthy control participants: A double-blind randomised controlled trial.

O'Connell K, Sulaimani J, Basdeo SA, Kinsella K, Jordan S, Kenny O, Kelly SB, Murphy D, Heffernan E, Killeen RP, Mulready K, MacMahon M, Brady JJ, McKenna C, Muldowney C, Cassidy L, Walsh C, O'Rourke K, Tubridy N, McGuigan C, Fletcher JM, Hutchinson M.

Mult Scler J Exp Transl Clin. 2017 Sep 21;3(3):2055217317727296. doi: 10.1177/2055217317727296. eCollection 2017 Jul-Sep.

29.

Medication usage and falls in people with multiple sclerosis.

Comber L, Quinn G, McGuigan C, Galvin R, Coote S.

Mult Scler. 2018 Jun;24(7):995-998. doi: 10.1177/1352458517731912. Epub 2017 Sep 18.

PMID:
28920765
30.

Virtual Screening of Acyclovir Derivatives as Potential Antiviral Agents: Design, Synthesis, and Biological Evaluation of New Acyclic Nucleoside ProTides.

Derudas M, Vanpouille C, Carta D, Zicari S, Andrei G, Snoeck R, Brancale A, Margolis L, Balzarini J, McGuigan C.

J Med Chem. 2017 Sep 28;60(18):7876-7896. doi: 10.1021/acs.jmedchem.7b01009. Epub 2017 Sep 19.

31.

Immediate thrombocytopenia at time of alemtuzumab infusion for multiple sclerosis - Not always self-limiting, fully reversible or predictable.

Yap SM, McNicholas N, Hutchinson M, McGuigan C.

Mult Scler. 2018 Apr;24(4):552-553. doi: 10.1177/1352458517719151. Epub 2017 Jun 29. No abstract available.

PMID:
28661220
32.

Clinical Consensus Guidelines on the Application of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease Diagnosis: Recommendations of the Irish Network for Biomarkers in Neurodegeneration.

Miller AM, Begley E, Coen R, Doyle M, Dunne J, Hutchinson S, Kennelly SP, Kenny RA, Killeen RP, Lynch A, O'Dwyer S, O'Neill C, O'Sullvan SS, Rowan MJ, Sheehy N, McGuigan C, Lawlor BA.

Ir Med J. 2016 Dec 12;109(10):483.

PMID:
28644588
33.

Synthetic Approaches for the Preparation of Phosphoramidate Prodrugs of 2'-Deoxypseudoisocytidine.

Serpi M, De Biasi R, Pertusati F, Slusarczyk M, McGuigan C.

ChemistryOpen. 2017 May 5;6(3):424-436. doi: 10.1002/open.201700019. eCollection 2017 Jun.

34.

Rational design and synthesis of novel phenylsulfonyl-benzamides as anti-prostate cancer agents.

Bassetto M, Ferla S, Giancotti G, Pertusati F, Westwell AD, Brancale A, McGuigan C.

Medchemcomm. 2017 May 26;8(7):1414-1420. doi: 10.1039/c7md00164a. eCollection 2017 Jul 1.

35.

Incidence of multiple sclerosis in the Republic of Ireland: A prospective population-based study.

O'Connell K, Tubridy N, Hutchinson M, McGuigan C.

Mult Scler Relat Disord. 2017 Apr;13:75-80. doi: 10.1016/j.msard.2017.02.010. Epub 2017 Feb 14.

PMID:
28427707
36.

Semi-quantitative analysis of cerebral FDG-PET reveals striatal hypermetabolism and normal cortical metabolism in a case of VGKCC limbic encephalitis.

Moloney P, Boylan R, Elamin M, O'Riordan S, Killeen R, McGuigan C.

Neuroradiol J. 2017 Apr;30(2):160-163. doi: 10.1177/1971400916689578. Epub 2017 Jan 1.

37.

Cognitive dysfunction in early multiple sclerosis: a review.

McNicholas N, O'Connell K, Yap SM, Killeen RP, Hutchinson M, McGuigan C.

QJM. 2018 Jun 1;111(6):359-364. doi: 10.1093/qjmed/hcx070. Review.

PMID:
28371862
38.

FDG PET diagnosis of primary intracranial lymphoma: radiology-pathology correlation.

Kenny C, Healy GM, Redmond CE, Farrell M, Connaghan G, McGuigan C, Killeen RP.

QJM. 2017 May 1;110(5):317-318. doi: 10.1093/qjmed/hcx054. No abstract available.

PMID:
28340028
39.

High-frequency MRI monitoring should be performed in natalizumab-treated MS patients with higher risk of PML - YES.

Yap SM, McGuigan C.

Mult Scler. 2017 May;23(6):765-767. doi: 10.1177/1352458517697909. Epub 2017 Mar 1. No abstract available.

PMID:
28287039
40.

Kinase-independent phosphoramidate S1P1 receptor agonist benzyl ether derivatives.

James E, Pertusati F, Brancale A, McGuigan C.

Bioorg Med Chem Lett. 2017 Mar 15;27(6):1371-1378. doi: 10.1016/j.bmcl.2017.02.011. Epub 2017 Feb 9.

PMID:
28236593
41.

Treatment effectiveness of alemtuzumab compared with natalizumab, fingolimod, and interferon beta in relapsing-remitting multiple sclerosis: a cohort study.

Kalincik T, Brown JWL, Robertson N, Willis M, Scolding N, Rice CM, Wilkins A, Pearson O, Ziemssen T, Hutchinson M, McGuigan C, Jokubaitis V, Spelman T, Horakova D, Havrdova E, Trojano M, Izquierdo G, Lugaresi A, Prat A, Girard M, Duquette P, Grammond P, Alroughani R, Pucci E, Sola P, Hupperts R, Lechner-Scott J, Terzi M, Van Pesch V, Rozsa C, Grand'Maison F, Boz C, Granella F, Slee M, Spitaleri D, Olascoaga J, Bergamaschi R, Verheul F, Vucic S, McCombe P, Hodgkinson S, Sanchez-Menoyo JL, Ampapa R, Simo M, Csepany T, Ramo C, Cristiano E, Barnett M, Butzkueven H, Coles A; MSBase Study Group.

Lancet Neurol. 2017 Apr;16(4):271-281. doi: 10.1016/S1474-4422(17)30007-8. Epub 2017 Feb 11.

PMID:
28209331
42.

Cervical spine arteriovenous fistula associated with hereditary haemorrhagic telangiectasia.

McGurgan IJ, Lonergan R, Killeen R, McGuigan C.

BMJ Case Rep. 2017 Feb 7;2017. pii: bcr2016218172. doi: 10.1136/bcr-2016-218172.

43.

Neurosarcoidosis: clinical presentations and changing treatment patterns in an Irish Caucasian population.

O'Connell K, Williams L, Jones J, McCabe DJH, Murphy D, Killeen R, Tubridy N, O'Riordan S, McGuigan C.

Ir J Med Sci. 2017 Aug;186(3):759-766. doi: 10.1007/s11845-016-1539-y. Epub 2017 Jan 18.

PMID:
28101825
44.

Acid-suppression medications and bacterial gastroenteritis: a population-based cohort study.

Wei L, Ratnayake L, Phillips G, McGuigan CC, Morant SV, Flynn RW, Mackenzie IS, MacDonald TM.

Br J Clin Pharmacol. 2017 Jun;83(6):1298-1308. doi: 10.1111/bcp.13205. Epub 2017 Jan 23.

45.

Natalizumab-associated progressive multifocal leukoencephalopathy: successful treatment without plasma exchange and its associated risks.

Maloney E, Molloy A, Al Hussona M, O'Donnell L, Killeen R, McGuigan C.

J Neurol. 2017 Feb;264(2):401-403. doi: 10.1007/s00415-016-8372-0. Epub 2016 Dec 30. No abstract available.

PMID:
28039520
46.

Alemtuzumab Use in Clinical Practice: Recommendations from European Multiple Sclerosis Experts.

Berger T, Elovaara I, Fredrikson S, McGuigan C, Moiola L, Myhr KM, Oreja-Guevara C, Stoliarov I, Zettl UK.

CNS Drugs. 2017 Jan;31(1):33-50. doi: 10.1007/s40263-016-0394-8. Review.

47.

ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites.

Kandil S, Balzarini J, Rat S, Brancale A, Westwell AD, McGuigan C.

Bioorg Med Chem Lett. 2016 Dec 1;26(23):5618-5623. doi: 10.1016/j.bmcl.2016.10.077. Epub 2016 Oct 27.

48.

Myasthenia gravis: a population-based epidemiological study.

Rutledge S, Kenny O, O'Riordan S, McGuigan C, Tubridy N.

Ir Med J. 2016 Feb 19;109(2):355.

PMID:
27685688
49.

Anti-flavivirus Activity of Different Tritylated Pyrimidine and Purine Nucleoside Analogues.

McGuigan C, Serpi M, Slusarczyk M, Ferrari V, Pertusati F, Meneghesso S, Derudas M, Farleigh L, Zanetta P, Bugert J.

ChemistryOpen. 2016 Jan 21;5(3):227-35. doi: 10.1002/open.201500216. eCollection 2016 Jun.

50.

Increased expression of Tbet in CD4(+) T cells from clinically isolated syndrome patients at high risk of conversion to clinically definite MS.

Basdeo SA, Kelly S, O'Connell K, Tubridy N, McGuigan C, Fletcher JM.

Springerplus. 2016 Jun 18;5(1):779. doi: 10.1186/s40064-016-2510-0. eCollection 2016.

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