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Items: 19


Osteopontin is An Important Regulative Component of the Fetal Bone Marrow Hematopoietic Stem Cell Niche.

Cao H, Cao B, Heazlewood CK, Domingues M, Sun X, Debele E, McGregor NE, Sims NA, Heazlewood SY, Nilsson SK.

Cells. 2019 Aug 27;8(9). pii: E985. doi: 10.3390/cells8090985.


Dynll1 is essential for development and promotes endochondral bone formation by regulating intraflagellar Dynein function in primary cilia.

King A, Hoch NC, McGregor NE, Sims NA, Smyth IM, Heierhorst J.

Hum Mol Genet. 2019 Apr 22. pii: ddz083. doi: 10.1093/hmg/ddz083. [Epub ahead of print]


IL-6 exhibits both cis- and trans-signaling in osteocytes and osteoblasts, but only trans-signaling promotes bone formation and osteoclastogenesis.

McGregor NE, Murat M, Elango J, Poulton IJ, Walker EC, Crimeen-Irwin B, Ho PWM, Gooi JH, Martin TJ, Sims NA.

J Biol Chem. 2019 May 10;294(19):7850-7863. doi: 10.1074/jbc.RA119.008074. Epub 2019 Mar 28.


Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease.

Tsantikos E, Lau M, Castelino CM, Maxwell MJ, Passey SL, Hansen MJ, McGregor NE, Sims NA, Steinfort DP, Irving LB, Anderson GP, Hibbs ML.

J Clin Invest. 2018 Jun 1;128(6):2406-2418. doi: 10.1172/JCI98224. Epub 2018 Apr 30.


IL-6 trans-signalling mediates trabecular, but not cortical, bone loss after ovariectomy.

Lazzaro L, Tonkin BA, Poulton IJ, McGregor NE, Ferlin W, Sims NA.

Bone. 2018 Jul;112:120-127. doi: 10.1016/j.bone.2018.04.015. Epub 2018 Apr 19.


Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6.

Cho DC, Brennan HJ, Johnson RW, Poulton IJ, Gooi JH, Tonkin BA, McGregor NE, Walker EC, Handelsman DJ, Martin TJ, Sims NA.

Nat Commun. 2017 Oct 9;8(1):806. doi: 10.1038/s41467-017-00920-x.


Correction: Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification.

Tonna S, Poulton IJ, Taykar F, Ho PW, Tonkin B, Crimeen-Irwin B, Tatarczuch L, McGregor NE, Mackie EJ, Martin TJ, Sims NA.

Development. 2017 Feb 1;144(3):530. doi: 10.1242/dev.148460. No abstract available.


Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification.

Tonna S, Poulton IJ, Taykar F, Ho PW, Tonkin B, Crimeen-Irwin B, Tatarczuch L, McGregor NE, Mackie EJ, Martin TJ, Sims NA.

Development. 2016 Feb 15;143(4):648-57. doi: 10.1242/dev.125625. Epub 2016 Jan 11. Erratum in: Development. 2017 Feb 1;144(3):530.


Glycoprotein130 (Gp130)/interleukin-6 (IL-6) signalling in osteoclasts promotes bone formation in periosteal and trabecular bone.

Johnson RW, McGregor NE, Brennan HJ, Crimeen-Irwin B, Poulton IJ, Martin TJ, Sims NA.

Bone. 2015 Dec;81:343-351. doi: 10.1016/j.bone.2015.08.005. Epub 2015 Aug 7.


gp130 in late osteoblasts and osteocytes is required for PTH-induced osteoblast differentiation.

Standal T, Johnson RW, McGregor NE, Poulton IJ, Ho PW, Martin TJ, Sims NA.

J Endocrinol. 2014 Nov;223(2):181-90. doi: 10.1530/JOE-14-0424. Epub 2014 Sep 16.


EphrinB2 signaling in osteoblasts promotes bone mineralization by preventing apoptosis.

Tonna S, Takyar FM, Vrahnas C, Crimeen-Irwin B, Ho PW, Poulton IJ, Brennan HJ, McGregor NE, Allan EH, Nguyen H, Forwood MR, Tatarczuch L, Mackie EJ, Martin TJ, Sims NA.

FASEB J. 2014 Oct;28(10):4482-96. doi: 10.1096/fj.14-254300. Epub 2014 Jun 30. Erratum in: FASEB J. 2017 Mar;31(3):1249.


The primary function of gp130 signaling in osteoblasts is to maintain bone formation and strength, rather than promote osteoclast formation.

Johnson RW, Brennan HJ, Vrahnas C, Poulton IJ, McGregor NE, Standal T, Walker EC, Koh TT, Nguyen H, Walsh NC, Forwood MR, Martin TJ, Sims NA.

J Bone Miner Res. 2014 Jun;29(6):1492-505. doi: 10.1002/jbmr.2159.


Sustained RANKL response to parathyroid hormone in oncostatin M receptor-deficient osteoblasts converts anabolic treatment to a catabolic effect in vivo.

Walker EC, Poulton IJ, McGregor NE, Ho PW, Allan EH, Quach JM, Martin TJ, Sims NA.

J Bone Miner Res. 2012 Apr;27(4):902-12. doi: 10.1002/jbmr.1506.


Contrasting roles of leukemia inhibitory factor in murine bone development and remodeling involve region-specific changes in vascularization.

Poulton IJ, McGregor NE, Pompolo S, Walker EC, Sims NA.

J Bone Miner Res. 2012 Mar;27(3):586-95. doi: 10.1002/jbmr.1485.


Ciliary neurotrophic factor inhibits bone formation and plays a sex-specific role in bone growth and remodeling.

McGregor NE, Poulton IJ, Walker EC, Pompolo S, Quinn JM, Martin TJ, Sims NA.

Calcif Tissue Int. 2010 Mar;86(3):261-70. doi: 10.1007/s00223-010-9337-4. Epub 2010 Feb 16. Erratum in: Calcif Tissue Int. 2013 May;92(5):493.


Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice.

Walker EC, McGregor NE, Poulton IJ, Solano M, Pompolo S, Fernandes TJ, Constable MJ, Nicholson GC, Zhang JG, Nicola NA, Gillespie MT, Martin TJ, Sims NA.

J Clin Invest. 2010 Feb;120(2):582-92. doi: 10.1172/JCI40568. Epub 2010 Jan 4.


Germline deletion of AMP-activated protein kinase beta subunits reduces bone mass without altering osteoclast differentiation or function.

Quinn JM, Tam S, Sims NA, Saleh H, McGregor NE, Poulton IJ, Scott JW, Gillespie MT, Kemp BE, van Denderen BJ.

FASEB J. 2010 Jan;24(1):275-85. doi: 10.1096/fj.09-137158. Epub 2009 Sep 1.


Osteoclast inhibitory lectin, an immune cell product that is required for normal bone physiology in vivo.

Kartsogiannis V, Sims NA, Quinn JM, Ly C, Cipetic M, Poulton IJ, Walker EC, Saleh H, McGregor NE, Wallace ME, Smyth MJ, Martin TJ, Zhou H, Ng KW, Gillespie MT.

J Biol Chem. 2008 Nov 7;283(45):30850-60. doi: 10.1074/jbc.M801761200. Epub 2008 Sep 8.


Cardiotrophin-1 is an osteoclast-derived stimulus of bone formation required for normal bone remodeling.

Walker EC, McGregor NE, Poulton IJ, Pompolo S, Allan EH, Quinn JM, Gillespie MT, Martin TJ, Sims NA.

J Bone Miner Res. 2008 Dec;23(12):2025-32. doi: 10.1359/jbmr.080706.

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