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Thirty sweet years of GLUT4.

Klip A, McGraw TE, James DE.

J Biol Chem. 2019 Jul 26;294(30):11369-11381. doi: 10.1074/jbc.REV119.008351. Epub 2019 Jun 7. Review.


Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects.

Syed I, Lee J, Peroni OD, Yore MM, Moraes-Vieira PM, Santoro A, Wellenstein K, Smith U, McGraw TE, Saghatelian A, Kahn BB.

Cell Metab. 2018 Oct 2;28(4):543-546. doi: 10.1016/j.cmet.2018.09.007. Epub 2018 Sep 20.


SNAP23 regulates BAX-dependent adipocyte programmed cell death independently of canonical macroautophagy.

Feng D, Amgalan D, Singh R, Wei J, Wen J, Wei TP, McGraw TE, Kitsis RN, Pessin JE.

J Clin Invest. 2018 Aug 31;128(9):3941-3956. doi: 10.1172/JCI99217. Epub 2018 Aug 13.


Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport.

Vijayakumar A, Aryal P, Wen J, Syed I, Vazirani RP, Moraes-Vieira PM, Camporez JP, Gallop MR, Perry RJ, Peroni OD, Shulman GI, Saghatelian A, McGraw TE, Kahn BB.

Cell Rep. 2017 Oct 24;21(4):1021-1035. doi: 10.1016/j.celrep.2017.09.091.


Biochemical and cellular properties of insulin receptor signalling.

Haeusler RA, McGraw TE, Accili D.

Nat Rev Mol Cell Biol. 2018 Jan;19(1):31-44. doi: 10.1038/nrm.2017.89. Epub 2017 Oct 4. Review.


Secretion of Adipsin as an Assay to Measure Flux from the Endoplasmic Reticulum (ER).

Brumfield A, Chaudhary N, McGraw TE.

Bio Protoc. 2017 Apr 5;7(7). pii: e2204. doi: 10.21769/BioProtoc.2204.


Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin.

Waldhart AN, Dykstra H, Peck AS, Boguslawski EA, Madaj ZB, Wen J, Veldkamp K, Hollowell M, Zheng B, Cantley LC, McGraw TE, Wu N.

Cell Rep. 2017 Jun 6;19(10):2005-2013. doi: 10.1016/j.celrep.2017.05.041.


Distinct Akt phosphorylation states are required for insulin regulated Glut4 and Glut1-mediated glucose uptake.

Beg M, Abdullah N, Thowfeik FS, Altorki NK, McGraw TE.

Elife. 2017 Jun 7;6. pii: e26896. doi: 10.7554/eLife.26896.


Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise.

Mera P, Laue K, Ferron M, Confavreux C, Wei J, Galán-Díez M, Lacampagne A, Mitchell SJ, Mattison JA, Chen Y, Bacchetta J, Szulc P, Kitsis RN, de Cabo R, Friedman RA, Torsitano C, McGraw TE, Puchowicz M, Kurland I, Karsenty G.

Cell Metab. 2017 Jan 10;25(1):218. doi: 10.1016/j.cmet.2016.12.003. No abstract available.


Adenovirus Protein E4-ORF1 Activation of PI3 Kinase Reveals Differential Regulation of Downstream Effector Pathways in Adipocytes.

Chaudhary N, Gonzalez E, Chang SH, Geng F, Rafii S, Altorki NK, McGraw TE.

Cell Rep. 2016 Dec 20;17(12):3305-3318. doi: 10.1016/j.celrep.2016.11.082.


Downregulation of a GPCR by β-Arrestin2-Mediated Switch from an Endosomal to a TGN Recycling Pathway.

Abdullah N, Beg M, Soares D, Dittman JS, McGraw TE.

Cell Rep. 2016 Dec 13;17(11):2966-2978. doi: 10.1016/j.celrep.2016.11.050.


Dendritic cells maintain dermal adipose-derived stromal cells in skin fibrosis.

Chia JJ, Zhu T, Chyou S, Dasoveanu DC, Carballo C, Tian S, Magro CM, Rodeo S, Spiera RF, Ruddle NH, McGraw TE, Browning JL, Lafyatis R, Gordon JK, Lu TT.

J Clin Invest. 2016 Nov 1;126(11):4331-4345. doi: 10.1172/JCI85740. Epub 2016 Oct 10.


SEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes.

Bruno J, Brumfield A, Chaudhary N, Iaea D, McGraw TE.

J Cell Biol. 2016 Jul 4;214(1):61-76. doi: 10.1083/jcb.201509052. Epub 2016 Jun 27.


Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise.

Mera P, Laue K, Ferron M, Confavreux C, Wei J, Galán-Díez M, Lacampagne A, Mitchell SJ, Mattison JA, Chen Y, Bacchetta J, Szulc P, Kitsis RN, de Cabo R, Friedman RA, Torsitano C, McGraw TE, Puchowicz M, Kurland I, Karsenty G.

Cell Metab. 2016 Jun 14;23(6):1078-1092. doi: 10.1016/j.cmet.2016.05.004. Erratum in: Cell Metab. 2017 Jan 10;25(1):218.


Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance.

Vazirani RP, Verma A, Sadacca LA, Buckman MS, Picatoste B, Beg M, Torsitano C, Bruno JH, Patel RT, Simonyte K, Camporez JP, Moreira G, Falcone DJ, Accili D, Elemento O, Shulman GI, Kahn BB, McGraw TE.

Diabetes. 2016 Jun;65(6):1577-89. doi: 10.2337/db15-1128. Epub 2016 Mar 25.


Altered Plasma Profile of Antioxidant Proteins as an Early Correlate of Pancreatic β Cell Dysfunction.

Kuo T, Kim-Muller JY, McGraw TE, Accili D.

J Biol Chem. 2016 Apr 29;291(18):9648-56. doi: 10.1074/jbc.M115.702183. Epub 2016 Feb 25.


The Microenvironment of Lung Cancer and Therapeutic Implications.

Mittal V, El Rayes T, Narula N, McGraw TE, Altorki NK, Barcellos-Hoff MH.

Adv Exp Med Biol. 2016;890:75-110. doi: 10.1007/978-3-319-24932-2_5. Review.


Development of a new model system to dissect isoform specific Akt signalling in adipocytes.

Kajno E, McGraw TE, Gonzalez E.

Biochem J. 2015 Jun 15;468(3):425-34. doi: 10.1042/BJ20150191. Epub 2015 Apr 9.


Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects.

Yore MM, Syed I, Moraes-Vieira PM, Zhang T, Herman MA, Homan EA, Patel RT, Lee J, Chen S, Peroni OD, Dhaneshwar AS, Hammarstedt A, Smith U, McGraw TE, Saghatelian A, Kahn BB.

Cell. 2014 Oct 9;159(2):318-32. doi: 10.1016/j.cell.2014.09.035.


Anorexia and impaired glucose metabolism in mice with hypothalamic ablation of Glut4 neurons.

Ren H, Lu TY, McGraw TE, Accili D.

Diabetes. 2015 Feb;64(2):405-17. doi: 10.2337/db14-0752. Epub 2014 Sep 3.


A naturally occurring GIP receptor variant undergoes enhanced agonist-induced desensitization, which impairs GIP control of adipose insulin sensitivity.

Mohammad S, Patel RT, Bruno J, Panhwar MS, Wen J, McGraw TE.

Mol Cell Biol. 2014 Oct 1;34(19):3618-29. doi: 10.1128/MCB.00256-14. Epub 2014 Jul 21.


Reciprocal regulation of endocytosis and metabolism.

Antonescu CN, McGraw TE, Klip A.

Cold Spring Harb Perspect Biol. 2014 Jul 1;6(7):a016964. doi: 10.1101/cshperspect.a016964. Review.


Specialized sorting of GLUT4 and its recruitment to the cell surface are independently regulated by distinct Rabs.

Sadacca LA, Bruno J, Wen J, Xiong W, McGraw TE.

Mol Biol Cell. 2013 Aug;24(16):2544-57. doi: 10.1091/mbc.E13-02-0103. Epub 2013 Jun 26.


Metabolic alterations in lung cancer-associated fibroblasts correlated with increased glycolytic metabolism of the tumor.

Chaudhri VK, Salzler GG, Dick SA, Buckman MS, Sordella R, Karoly ED, Mohney R, Stiles BM, Elemento O, Altorki NK, McGraw TE.

Mol Cancer Res. 2013 Jun;11(6):579-92. doi: 10.1158/1541-7786.MCR-12-0437-T. Epub 2013 Mar 8.


AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1.

Wu N, Zheng B, Shaywitz A, Dagon Y, Tower C, Bellinger G, Shen CH, Wen J, Asara J, McGraw TE, Kahn BB, Cantley LC.

Mol Cell. 2013 Mar 28;49(6):1167-75. doi: 10.1016/j.molcel.2013.01.035. Epub 2013 Feb 28.


TNF-α up-regulates protein level and cell surface expression of the leptin receptor by stimulating its export via a PKC-dependent mechanism.

Gan L, Guo K, Cremona ML, McGraw TE, Leibel RL, Zhang Y.

Endocrinology. 2012 Dec;153(12):5821-33. doi: 10.1210/en.2012-1510. Epub 2012 Oct 15.


Ratio of positron emission tomography uptake to tumor size in surgically resected non-small cell lung cancer.

Stiles BM, Nasar A, Mirza F, Paul S, Lee PC, Port JL, McGraw TE, Altorki NK.

Ann Thorac Surg. 2013 Feb;95(2):397-403; discussion 404. doi: 10.1016/j.athoracsur.2012.07.038. Epub 2012 Sep 20.


Gastric inhibitory peptide controls adipose insulin sensitivity via activation of cAMP-response element-binding protein and p110β isoform of phosphatidylinositol 3-kinase.

Mohammad S, Ramos LS, Buck J, Levin LR, Rubino F, McGraw TE.

J Biol Chem. 2011 Dec 16;286(50):43062-70. doi: 10.1074/jbc.M111.289009. Epub 2011 Oct 25.


Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor.

Gonzalez E, Flier E, Molle D, Accili D, McGraw TE.

Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10162-7. doi: 10.1073/pnas.1019268108. Epub 2011 Jun 6.


Rosiglitazone, PPARγ, and type 2 diabetes.

Kahn BB, McGraw TE.

N Engl J Med. 2010 Dec 30;363(27):2667-9. doi: 10.1056/NEJMcibr1012075. No abstract available.


Insulin-regulated aminopeptidase is a key regulator of GLUT4 trafficking by controlling the sorting of GLUT4 from endosomes to specialized insulin-regulated vesicles.

Jordens I, Molle D, Xiong W, Keller SR, McGraw TE.

Mol Biol Cell. 2010 Jun 15;21(12):2034-44. doi: 10.1091/mbc.E10-02-0158. Epub 2010 Apr 21.


GLUT4 is sorted to vesicles whose accumulation beneath and insertion into the plasma membrane are differentially regulated by insulin and selectively affected by insulin resistance.

Xiong W, Jordens I, Gonzalez E, McGraw TE.

Mol Biol Cell. 2010 Apr 15;21(8):1375-86. doi: 10.1091/mbc.E09-08-0751. Epub 2010 Feb 24.


Stem cells: Metabolism regulates differentiation.

McGraw TE, Mittal V.

Nat Chem Biol. 2010 Mar;6(3):176-177. No abstract available.


Metabolic surgery: the role of the gastrointestinal tract in diabetes mellitus.

Rubino F, R'bibo SL, del Genio F, Mazumdar M, McGraw TE.

Nat Rev Endocrinol. 2010 Feb;6(2):102-9. doi: 10.1038/nrendo.2009.268. Review.


The Akt kinases: isoform specificity in metabolism and cancer.

Gonzalez E, McGraw TE.

Cell Cycle. 2009 Aug 15;8(16):2502-8. Epub 2009 Aug 23. Review.


Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling.

Gonzalez E, McGraw TE.

Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7004-9. doi: 10.1073/pnas.0901933106. Epub 2009 Apr 16.


The CB1 endocannabinoid system modulates adipocyte insulin sensitivity.

Motaghedi R, McGraw TE.

Obesity (Silver Spring). 2008 Aug;16(8):1727-34. doi: 10.1038/oby.2008.309. Epub 2008 Jun 12.


Molecular mechanisms controlling GLUT4 intracellular retention.

Blot V, McGraw TE.

Mol Biol Cell. 2008 Aug;19(8):3477-87. doi: 10.1091/mbc.E08-03-0236. Epub 2008 Jun 11.


Insulin regulates leptin secretion from 3T3-L1 adipocytes by a PI 3 kinase independent mechanism.

Zeigerer A, Rodeheffer MS, McGraw TE, Friedman JM.

Exp Cell Res. 2008 Jul 1;314(11-12):2249-56. doi: 10.1016/j.yexcr.2008.04.003. Epub 2008 Apr 12.


Endocytosis: biochemical analyses.

McGraw TE, Subtil A.

Curr Protoc Cell Biol. 2001 May;Chapter 15:Unit 15.3. doi: 10.1002/0471143030.cb1503s03.


Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane.

Sano H, Eguez L, Teruel MN, Fukuda M, Chuang TD, Chavez JA, Lienhard GE, McGraw TE.

Cell Metab. 2007 Apr;5(4):293-303.


Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein.

Eguez L, Lee A, Chavez JA, Miinea CP, Kane S, Lienhard GE, McGraw TE.

Cell Metab. 2005 Oct;2(4):263-72.


The transcription factor CCAAT/enhancer-binding protein alpha is required for the intracellular retention of GLUT4.

Wertheim N, Cai Z, McGraw TE.

J Biol Chem. 2004 Oct 1;279(40):41468-76. Epub 2004 Jul 23.


Insulin stimulation of GLUT4 exocytosis, but not its inhibition of endocytosis, is dependent on RabGAP AS160.

Zeigerer A, McBrayer MK, McGraw TE.

Mol Biol Cell. 2004 Oct;15(10):4406-15. Epub 2004 Jul 14.


Chemical genetic screening identifies sulfonamides that raise organellar pH and interfere with membrane traffic.

Nieland TJ, Feng Y, Brown JX, Chuang TD, Buckett PD, Wang J, Xie XS, McGraw TE, Kirchhausen T, Wessling-Resnick M.

Traffic. 2004 Jul;5(7):478-92.


Endocytic recycling.

Maxfield FR, McGraw TE.

Nat Rev Mol Cell Biol. 2004 Feb;5(2):121-32. Review.


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