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Items: 25


The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones.

Sowers CR, Wang R, Bourne RA, McGrath BC, Hu J, Bevilacqua SC, Paton JC, Paton AW, Collardeau-Frachon S, Nicolino M, Cavener DR.

J Biol Chem. 2018 Apr 6;293(14):5134-5149. doi: 10.1074/jbc.M117.813790. Epub 2018 Feb 14.


PERK regulates Gq protein-coupled intracellular Ca2+ dynamics in primary cortical neurons.

Zhu S, McGrath BC, Bai Y, Tang X, Cavener DR.

Mol Brain. 2016 Oct 1;9(1):87.


PERK Regulates Working Memory and Protein Synthesis-Dependent Memory Flexibility.

Zhu S, Henninger K, McGrath BC, Cavener DR.

PLoS One. 2016 Sep 14;11(9):e0162766. doi: 10.1371/journal.pone.0162766. eCollection 2016.


Giraffe genome sequence reveals clues to its unique morphology and physiology.

Agaba M, Ishengoma E, Miller WC, McGrath BC, Hudson CN, Bedoya Reina OC, Ratan A, Burhans R, Chikhi R, Medvedev P, Praul CA, Wu-Cavener L, Wood B, Robertson H, Penfold L, Cavener DR.

Nat Commun. 2016 May 17;7:11519. doi: 10.1038/ncomms11519.


Perk gene dosage regulates glucose homeostasis by modulating pancreatic β-cell functions.

Wang R, Munoz EE, Zhu S, McGrath BC, Cavener DR.

PLoS One. 2014 Jun 10;9(6):e99684. doi: 10.1371/journal.pone.0099684. eCollection 2014.


GCN2 in the brain programs PPARγ2 and triglyceride storage in the liver during perinatal development in response to maternal dietary fat.

Xu X, Hu J, McGrath BC, Cavener DR.

PLoS One. 2013 Oct 10;8(10):e75917. doi: 10.1371/journal.pone.0075917. eCollection 2013.


Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK (EIF2AK3) in concert with calcineurin.

Wang R, McGrath BC, Kopp RF, Roe MW, Tang X, Chen G, Cavener DR.

J Biol Chem. 2013 Nov 22;288(47):33824-36. doi: 10.1074/jbc.M113.503664. Epub 2013 Oct 10.


GCN2 regulates the CCAAT enhancer binding protein beta and hepatic gluconeogenesis.

Xu X, Hu J, McGrath BC, Cavener DR.

Am J Physiol Endocrinol Metab. 2013 Oct 15;305(8):E1007-17. doi: 10.1152/ajpendo.00063.2013. Epub 2013 Jul 30.


Hyperthermia induces the ER stress pathway.

Xu X, Gupta S, Hu W, McGrath BC, Cavener DR.

PLoS One. 2011;6(8):e23740. doi: 10.1371/journal.pone.0023740. Epub 2011 Aug 18.


PERK in beta cell biology and insulin biogenesis.

Cavener DR, Gupta S, McGrath BC.

Trends Endocrinol Metab. 2010 Dec;21(12):714-21. doi: 10.1016/j.tem.2010.08.005. Epub 2010 Sep 17. Review.


Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation.

Feng D, Wei J, Gupta S, McGrath BC, Cavener DR.

BMC Cell Biol. 2009 Sep 4;10:61. doi: 10.1186/1471-2121-10-61.


PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice.

Iida K, Li Y, McGrath BC, Frank A, Cavener DR.

BMC Cell Biol. 2007 Aug 29;8:38.


Tryptophan catabolism generates autoimmune-preventive regulatory T cells.

Fallarino F, Grohmann U, You S, McGrath BC, Cavener DR, Vacca C, Orabona C, Bianchi R, Belladonna ML, Volpi C, Fioretti MC, Puccetti P.

Transpl Immunol. 2006 Dec;17(1):58-60. Epub 2006 Oct 10.


The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells.

Fallarino F, Grohmann U, You S, McGrath BC, Cavener DR, Vacca C, Orabona C, Bianchi R, Belladonna ML, Volpi C, Santamaria P, Fioretti MC, Puccetti P.

J Immunol. 2006 Jun 1;176(11):6752-61.


PERK is responsible for the increased phosphorylation of eIF2alpha and the severe inhibition of protein synthesis after transient global brain ischemia.

Owen CR, Kumar R, Zhang P, McGrath BC, Cavener DR, Krause GS.

J Neurochem. 2005 Sep;94(5):1235-42. Epub 2005 Jul 5.


Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex.

Hao S, Sharp JW, Ross-Inta CM, McDaniel BJ, Anthony TG, Wek RC, Cavener DR, McGrath BC, Rudell JB, Koehnle TJ, Gietzen DW.

Science. 2005 Mar 18;307(5716):1776-8.


Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.

Anthony TG, McDaniel BJ, Byerley RL, McGrath BC, Cavener DR, McNurlan MA, Wek RC.

J Biol Chem. 2004 Aug 27;279(35):36553-61. Epub 2004 Jun 22.


Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response.

Jiang HY, Wek SA, McGrath BC, Lu D, Hai T, Harding HP, Wang X, Ron D, Cavener DR, Wek RC.

Mol Cell Biol. 2004 Feb;24(3):1365-77.


Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses.

Jiang HY, Wek SA, McGrath BC, Scheuner D, Kaufman RJ, Cavener DR, Wek RC.

Mol Cell Biol. 2003 Aug;23(16):5651-63.


The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.

Zhang P, McGrath BC, Reinert J, Olsen DS, Lei L, Gill S, Wek SA, Vattem KM, Wek RC, Kimball SR, Jefferson LS, Cavener DR.

Mol Cell Biol. 2002 Oct;22(19):6681-8.


Identification of an immunologically important hypervariable domain of major outer surface protein A of Borrelia burgdorferi.

McGrath BC, Dunn JJ, Gorgone G, Guttman D, Dykhuizen D, Luft BJ.

Infect Immun. 1995 Apr;63(4):1356-61. Erratum in: Infect Immun 1995 Jun;63(6):2390.


Energy dependence of O-antigen synthesis in Salmonella typhimurium.

Marino PA, McGrath BC, Osborn MJ.

J Bacteriol. 1991 May;173(10):3128-33.


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