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Items: 28


Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer.

McGrail DJ, Garnett J, Yin J, Dai H, Shih DJH, Lam TNA, Li Y, Sun C, Li Y, Schmandt R, Wu JY, Hu L, Liang Y, Peng G, Jonasch E, Menter D, Yates MS, Kopetz S, Lu KH, Broaddus R, Mills GB, Sahni N, Lin SY.

Cancer Cell. 2020 Mar 16;37(3):371-386.e12. doi: 10.1016/j.ccell.2020.01.011. Epub 2020 Feb 27.


Nucleostemin Modulates Outcomes of Hepatocellular Carcinoma via a Tumor Adaptive Mechanism to Genomic Stress.

Wang J, McGrail DJ, Bhupal PK, Zhang W, Lin KY, Ku YH, Lin T, Wu H, Tsai KC, Li K, Peng CY, Finegold MJ, Lin SY, Tsai RYL.

Mol Cancer Res. 2020 Feb 12. doi: 10.1158/1541-7786.MCR-19-0777. [Epub ahead of print]


Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy.

Fang Y, McGrail DJ, Sun C, Labrie M, Chen X, Zhang D, Ju Z, Vellano CP, Lu Y, Li Y, Jeong KJ, Ding Z, Liang J, Wang SW, Dai H, Lee S, Sahni N, Mercado-Uribe I, Kim TB, Chen K, Lin SY, Peng G, Westin SN, Liu J, O'Connor MJ, Yap TA, Mills GB.

Cancer Cell. 2019 Jun 10;35(6):851-867.e7. doi: 10.1016/j.ccell.2019.05.001.


Nucleostemin reveals a dichotomous nature of genome maintenance in mammary tumor progression.

Lin T, Lin TC, McGrail DJ, Bhupal PK, Ku YH, Zhang W, Meng L, Lin SY, Peng G, Tsai RYL.

Oncogene. 2019 May;38(20):3919-3931. doi: 10.1038/s41388-019-0710-0. Epub 2019 Jan 28.


MERIT: Systematic Analysis and Characterization of Mutational Effect on RNA Interactome Topology.

Li Y, McGrail DJ, Xu J, Li J, Liu NN, Sun M, Lin R, Pancsa R, Zhang J, Lee JS, Wang H, Mills GB, Li X, Yi S, Sahni N.

Hepatology. 2019 Aug;70(2):532-546. doi: 10.1002/hep.30242. Epub 2019 Jan 19.


PARP inhibitors synergize with gemcitabine by potentiating DNA damage in non-small-cell lung cancer.

Jiang Y, Dai H, Li Y, Yin J, Guo S, Lin SY, McGrail DJ.

Int J Cancer. 2019 Mar 1;144(5):1092-1103. doi: 10.1002/ijc.31770. Epub 2018 Sep 24.


Gene Regulatory Network Perturbation by Genetic and Epigenetic Variation.

Li Y, McGrail DJ, Xu J, Mills GB, Sahni N, Yi S.

Trends Biochem Sci. 2018 Aug;43(8):576-592. doi: 10.1016/j.tibs.2018.05.002. Epub 2018 Jun 22. Review.


CHD4 mutations promote endometrial cancer stemness by activating TGF-beta signaling.

Li Y, Liu Q, McGrail DJ, Dai H, Li K, Lin SY.

Am J Cancer Res. 2018 May 1;8(5):903-914. eCollection 2018.


Defective Replication Stress Response Is Inherently Linked to the Cancer Stem Cell Phenotype.

McGrail DJ, Lin CC, Dai H, Mo W, Li Y, Stephan C, Davies P, Lu Z, Mills GB, Lee JS, Lin SY.

Cell Rep. 2018 May 15;23(7):2095-2106. doi: 10.1016/j.celrep.2018.04.068.


Pathway perturbations in signaling networks: Linking genotype to phenotype.

Li Y, McGrail DJ, Latysheva N, Yi S, Babu MM, Sahni N.

Semin Cell Dev Biol. 2018 May 10. pii: S1084-9521(17)30528-1. doi: 10.1016/j.semcdb.2018.05.001. [Epub ahead of print] Review.


Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers.

McGrail DJ, Federico L, Li Y, Dai H, Lu Y, Mills GB, Yi S, Lin SY, Sahni N.

Nat Commun. 2018 Apr 3;9(1):1317. doi: 10.1038/s41467-018-03730-x.


Revealing the Determinants of Widespread Alternative Splicing Perturbation in Cancer.

Li Y, Sahni N, Pancsa R, McGrail DJ, Xu J, Hua X, Coulombe-Huntington J, Ryan M, Tychhon B, Sudhakar D, Hu L, Tyers M, Jiang X, Lin SY, Babu MM, Yi S.

Cell Rep. 2017 Oct 17;21(3):798-812. doi: 10.1016/j.celrep.2017.09.071.


Improved prediction of PARP inhibitor response and identification of synergizing agents through use of a novel gene expression signature generation algorithm.

McGrail DJ, Lin CC, Garnett J, Liu Q, Mo W, Dai H, Lu Y, Yu Q, Ju Z, Yin J, Vellano CP, Hennessy B, Mills GB, Lin SY.

NPJ Syst Biol Appl. 2017 Mar 6;3:8. doi: 10.1038/s41540-017-0011-6. eCollection 2017.


A murine preclinical syngeneic transplantation model for breast cancer precision medicine.

Federico L, Chong Z, Zhang D, McGrail DJ, Zhao W, Jeong KJ, Vellano CP, Ju Z, Gagea M, Liu S, Mitra S, Dennison JB, Lorenzi PL, Cardnell R, Diao L, Wang J, Lu Y, Byers LA, Perou CM, Lin SY, Mills GB.

Sci Adv. 2017 Apr 19;3(4):e1600957. doi: 10.1126/sciadv.1600957. eCollection 2017 Apr.


TGF-β1 Pretreatment Improves the Function of Mesenchymal Stem Cells in the Wound Bed.

Ghosh D, McGrail DJ, Dawson MR.

Front Cell Dev Biol. 2017 Apr 4;5:28. doi: 10.3389/fcell.2017.00028. eCollection 2017.


Mesenchymal Stem Cells Induce Directional Migration of Invasive Breast Cancer Cells through TGF-β.

McAndrews KM, McGrail DJ, Ravikumar N, Dawson MR.

Sci Rep. 2015 Nov 20;5:16941. doi: 10.1038/srep16941.


Osmotic Regulation Is Required for Cancer Cell Survival under Solid Stress.

McGrail DJ, McAndrews KM, Brandenburg CP, Ravikumar N, Kieu QM, Dawson MR.

Biophys J. 2015 Oct 6;109(7):1334-7. doi: 10.1016/j.bpj.2015.07.046.


Enhanced Adhesion of Stromal Cells to Invasive Cancer Cells Regulated by Cadherin 11.

McAndrews KM, Yi J, McGrail DJ, Dawson MR.

ACS Chem Biol. 2015 Aug 21;10(8):1932-8. doi: 10.1021/acschembio.5b00353. Epub 2015 Jun 17.


Alterations in ovarian cancer cell adhesion drive taxol resistance by increasing microtubule dynamics in a FAK-dependent manner.

McGrail DJ, Khambhati NN, Qi MX, Patel KS, Ravikumar N, Brandenburg CP, Dawson MR.

Sci Rep. 2015 Apr 17;5:9529. doi: 10.1038/srep09529.


Actomyosin tension as a determinant of metastatic cancer mechanical tropism.

McGrail DJ, Kieu QM, Iandoli JA, Dawson MR.

Phys Biol. 2015 Feb 23;12(2):026001. doi: 10.1088/1478-3975/12/2/026001.


SNAIL-induced epithelial-to-mesenchymal transition produces concerted biophysical changes from altered cytoskeletal gene expression.

McGrail DJ, Mezencev R, Kieu QM, McDonald JF, Dawson MR.

FASEB J. 2015 Apr;29(4):1280-9. doi: 10.1096/fj.14-257345. Epub 2014 Dec 9.


Spatially coordinated changes in intracellular rheology and extracellular force exertion during mesenchymal stem cell differentiation.

McAndrews KM, McGrail DJ, Quach ND, Dawson MR.

Phys Biol. 2014 Aug 26;11(5):056004. doi: 10.1088/1478-3975/11/5/056004.


Poldip2 controls vascular smooth muscle cell migration by regulating focal adhesion turnover and force polarization.

Datla SR, McGrail DJ, Vukelic S, Huff LP, Lyle AN, Pounkova L, Lee M, Seidel-Rogol B, Khalil MK, Hilenski LL, Terada LS, Dawson MR, Lassègue B, Griendling KK.

Am J Physiol Heart Circ Physiol. 2014 Oct 1;307(7):H945-57. doi: 10.1152/ajpheart.00918.2013. Epub 2014 Jul 25.


Architectural and mechanical cues direct mesenchymal stem cell interactions with crosslinked gelatin scaffolds.

McAndrews KM, Kim MJ, Lam TY, McGrail DJ, Dawson MR.

Tissue Eng Part A. 2014 Dec;20(23-24):3252-60. doi: 10.1089/ten.TEA.2013.0753.


The malignancy of metastatic ovarian cancer cells is increased on soft matrices through a mechanosensitive Rho-ROCK pathway.

McGrail DJ, Kieu QM, Dawson MR.

J Cell Sci. 2014 Jun 15;127(Pt 12):2621-6. doi: 10.1242/jcs.144378. Epub 2014 Apr 16.


Integral role of platelet-derived growth factor in mediating transforming growth factor-β1-dependent mesenchymal stem cell stiffening.

Ghosh D, Lili L, McGrail DJ, Matyunina LV, McDonald JF, Dawson MR.

Stem Cells Dev. 2014 Feb 1;23(3):245-61. doi: 10.1089/scd.2013.0240. Epub 2013 Nov 8.


Biomechanical analysis predicts decreased human mesenchymal stem cell function before molecular differences.

McGrail DJ, McAndrews KM, Dawson MR.

Exp Cell Res. 2013 Mar 10;319(5):684-96. doi: 10.1016/j.yexcr.2012.11.017. Epub 2012 Dec 7.


Differential mechanical response of mesenchymal stem cells and fibroblasts to tumor-secreted soluble factors.

McGrail DJ, Ghosh D, Quach ND, Dawson MR.

PLoS One. 2012;7(3):e33248. doi: 10.1371/journal.pone.0033248. Epub 2012 Mar 16.

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