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Items: 1 to 50 of 343

1.

A Comprehensive Analysis of Key Immune Checkpoint Receptors on Tumor-Infiltrating T Cells From Multiple Types of Cancer.

Li X, Wang R, Fan P, Yao X, Qin L, Peng Y, Ma M, Asley N, Chang X, Feng Y, Hu Y, Zhang Y, Li C, Fanning G, Jones S, Verrill C, Maldonado-Perez D, Sopp P, Waugh C, Taylor S, Mcgowan S, Cerundolo V, Conlon C, McMichael A, Lu S, Wang X, Li N, Dong T.

Front Oncol. 2019 Oct 25;9:1066. doi: 10.3389/fonc.2019.01066. eCollection 2019.

PMID:
31709176
2.

Implementing the SRRR Taskforce Recommendations to Transform Stroke Recovery Research.

Holmes K, Corbett D, McGowan S.

Neurorehabil Neural Repair. 2019 Nov 1:1545968319888638. doi: 10.1177/1545968319888638. [Epub ahead of print] No abstract available.

PMID:
31674266
3.

Implementing the SRRR taskforce recommendations to transform stroke recovery research.

Holmes K, Corbett D, McGowan S.

Int J Stroke. 2019 Oct;14(8):763-765. doi: 10.1177/1747493019884272. No abstract available.

PMID:
31658891
4.

Development of a dyadic sleep intervention for Alzheimer's disease patients and their caregivers.

Song Y, McCurry SM, Lee D, Josephson KR, McGowan SK, Fung CH, Irwin MR, Teng E, Alessi CA, Martin JL.

Disabil Rehabil. 2019 Oct 26:1-11. doi: 10.1080/09638288.2019.1680748. [Epub ahead of print]

PMID:
31656109
5.

Strategies for Increasing Protein Stability.

Chandler PG, Broendum SS, Riley BT, Spence MA, Jackson CJ, McGowan S, Buckle AM.

Methods Mol Biol. 2020;2073:163-181. doi: 10.1007/978-1-4939-9869-2_10.

PMID:
31612442
6.

Design and testing of microbubble-based MRI contrast agents for gastric pressure measurement.

Abdurakman E, Bencsik M, Cave GWV, Hoad CL, McGowan S, Fairhurst DJ, Major G, Gowland PA, Bowtell R.

Magn Reson Med. 2019 Sep 16. doi: 10.1002/mrm.27992. [Epub ahead of print]

PMID:
31524306
7.

Cephamycins inhibit pathogen sporulation and effectively treat recurrent Clostridioides difficile infection.

Srikhanta YN, Hutton ML, Awad MM, Drinkwater N, Singleton J, Day SL, Cunningham BA, McGowan S, Lyras D.

Nat Microbiol. 2019 Aug 12. doi: 10.1038/s41564-019-0519-1. [Epub ahead of print]

PMID:
31406331
8.

Crystal structure of the inhibitor-free form of the serine protease kallikrein-4.

Riley BT, Hoke DE, McGowan S, Buckle AM.

Acta Crystallogr F Struct Biol Commun. 2019 Aug 1;75(Pt 8):543-546. doi: 10.1107/S2053230X19009610. Epub 2019 Jul 16.

PMID:
31397325
9.

Majeed syndrome: description of a novel mutation and therapeutic response to bisphosphonates and IL-1 blockade with anakinra.

Roy NBA, Zaal AI, Hall G, Wilkinson N, Proven M, McGowan S, Hipkiss R, Buckle V, Kavirayani A, Babbs C.

Rheumatology (Oxford). 2019 Aug 4. pii: kez317. doi: 10.1093/rheumatology/kez317. [Epub ahead of print] No abstract available.

PMID:
31377798
10.

Admixture between ancient lineages, selection, and the formation of sympatric stickleback species-pairs.

Dean LL, Magalhaes IS, Foote A, D'Agostino D, McGowan S, MacColl ADC.

Mol Biol Evol. 2019 Jul 12. pii: msz161. doi: 10.1093/molbev/msz161. [Epub ahead of print]

11.

Novel Human Aminopeptidase N Inhibitors: Discovery and Optimization of Subsite Binding Interactions.

Lee J, Vinh NB, Drinkwater N, Yang W, Kannan Sivaraman K, Schembri LS, Gazdik M, Grin PM, Butler GS, Overall CM, Charman SA, McGowan S, Scammells PJ.

J Med Chem. 2019 Aug 8;62(15):7185-7209. doi: 10.1021/acs.jmedchem.9b00757. Epub 2019 Jul 18.

PMID:
31251594
12.

Are CT Scans Overutilized in the Workup of Vertebral Compression Fractures?

McGowan SM, Ramski DE, Homcha B, Sokunbi G.

Clin Spine Surg. 2019 May;32(4):166-169. doi: 10.1097/BSD.0000000000000816.

PMID:
30920414
13.

Reactive centre loop dynamics and serpin specificity.

Marijanovic EM, Fodor J, Riley BT, Porebski BT, Costa MGS, Kass I, Hoke DE, McGowan S, Buckle AM.

Sci Rep. 2019 Mar 7;9(1):3870. doi: 10.1038/s41598-019-40432-w.

14.

The lipofibroblast: more than a lipid-storage depot.

McGowan SE.

Am J Physiol Lung Cell Mol Physiol. 2019 May 1;316(5):L869-L871. doi: 10.1152/ajplung.00109.2019. Epub 2019 Mar 6. No abstract available.

PMID:
30840482
15.

Correction: Diatom evidence of 20th century ecosystem change in Lake Baikal, Siberia.

Roberts SL, Swann GEA, McGowan S, Panizzo VN, Vologina EG, Sturm M, Mackay AW.

PLoS One. 2019 Feb 28;14(2):e0213413. doi: 10.1371/journal.pone.0213413. eCollection 2019.

16.

Unravelling Intratumoral Heterogeneity through High-Sensitivity Single-Cell Mutational Analysis and Parallel RNA Sequencing.

Rodriguez-Meira A, Buck G, Clark SA, Povinelli BJ, Alcolea V, Louka E, McGowan S, Hamblin A, Sousos N, Barkas N, Giustacchini A, Psaila B, Jacobsen SEW, Thongjuea S, Mead AJ.

Mol Cell. 2019 Mar 21;73(6):1292-1305.e8. doi: 10.1016/j.molcel.2019.01.009. Epub 2019 Feb 12.

17.

M17 aminopeptidases diversify function by moderating their macromolecular assemblies and active site environment.

Drinkwater N, Malcolm TR, McGowan S.

Biochimie. 2019 Nov;166:38-51. doi: 10.1016/j.biochi.2019.01.007. Epub 2019 Jan 14. Review.

PMID:
30654132
18.

Identification of the Binding Site of Apical Membrane Antigen 1 (AMA1) Inhibitors Using a Paramagnetic Probe.

Akter M, Drinkwater N, Devine SM, Drew SC, Krishnarjuna B, Debono CO, Wang G, Scanlon MJ, Scammells PJ, McGowan S, MacRaild CA, Norton RS.

ChemMedChem. 2019 Mar 5;14(5):603-612. doi: 10.1002/cmdc.201800802. Epub 2019 Feb 13.

PMID:
30653832
19.

Diatom evidence of 20th century ecosystem change in Lake Baikal, Siberia.

Roberts SL, Swann GEA, McGowan S, Panizzo VN, Vologina EG, Sturm M, Mackay AW.

PLoS One. 2018 Dec 19;13(12):e0208765. doi: 10.1371/journal.pone.0208765. eCollection 2018. Erratum in: PLoS One. 2019 Feb 28;14(2):e0213413.

20.

Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases.

Vinh NB, Drinkwater N, Malcolm TR, Kassiou M, Lucantoni L, Grin PM, Butler GS, Duffy S, Overall CM, Avery VM, Scammells PJ, McGowan S.

J Med Chem. 2019 Jan 24;62(2):622-640. doi: 10.1021/acs.jmedchem.8b01310. Epub 2019 Jan 4.

PMID:
30537832
21.

Molecular and in vitro characterisation of hepatitis E virus from UK pigs.

Grierson SS, McGowan S, Cook C, Steinbach F, Choudhury B.

Virology. 2019 Jan 15;527:116-121. doi: 10.1016/j.virol.2018.10.018. Epub 2018 Nov 26.

PMID:
30496912
22.

Virus-free and oncogene-free induced pluripotent stem cell reprogramming in cord blood and peripheral blood in patients with lung disease.

Kamath A, Ternes S, McGowan S, Moy AB.

Regen Med. 2018 Dec;13(8):889-915. doi: 10.2217/rme-2018-0041. Epub 2018 Nov 29.

23.

Mapping the Pathway and Dynamics of Bestatin Inhibition of the Plasmodium falciparum M1 Aminopeptidase PfA-M1.

Yang W, Riley BT, Lei X, Porebski BT, Kass I, Buckle AM, McGowan S.

ChemMedChem. 2018 Dec 6;13(23):2504-2513. doi: 10.1002/cmdc.201800563. Epub 2018 Nov 9.

PMID:
30318749
24.

Fisetin is a senotherapeutic that extends health and lifespan.

Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, Burd CE, Arriaga EA, Ladiges WL, Tchkonia T, Kirkland JL, Robbins PD, Niedernhofer LJ.

EBioMedicine. 2018 Oct;36:18-28. doi: 10.1016/j.ebiom.2018.09.015. Epub 2018 Sep 29.

25.

Germinal Center B Cells Replace Their Antigen Receptors in Dark Zones and Fail Light Zone Entry when Immunoglobulin Gene Mutations are Damaging.

Stewart I, Radtke D, Phillips B, McGowan SJ, Bannard O.

Immunity. 2018 Sep 18;49(3):477-489.e7. doi: 10.1016/j.immuni.2018.08.025.

26.

Catalytic diversity and cell wall binding repeats in the phage-encoded endolysins.

Broendum SS, Buckle AM, McGowan S.

Mol Microbiol. 2018 Dec;110(6):879-896. doi: 10.1111/mmi.14134. Epub 2018 Nov 13. Review.

PMID:
30230642
27.

Pharyngeal electrical stimulation for early decannulation in tracheotomised patients with neurogenic dysphagia after stroke (PHAST-TRAC): a prospective, single-blinded, randomised trial.

Dziewas R, Stellato R, van der Tweel I, Walther E, Werner CJ, Braun T, Citerio G, Jandl M, Friedrichs M, Nötzel K, Vosko MR, Mistry S, Hamdy S, McGowan S, Warnecke T, Zwittag P, Bath PM; PHAST-TRAC investigators.

Lancet Neurol. 2018 Oct;17(10):849-859. doi: 10.1016/S1474-4422(18)30255-2. Epub 2018 Aug 28.

PMID:
30170898
28.

Disruption of TWIST1 translation by 5' UTR variants in Saethre-Chotzen syndrome.

Zhou Y, Koelling N, Fenwick AL, McGowan SJ, Calpena E, Wall SA, Smithson SF, Wilkie AOM, Twigg SRF.

Hum Mutat. 2018 Oct;39(10):1360-1365. doi: 10.1002/humu.23598. Epub 2018 Aug 7.

29.

Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation.

Zhao J, Zhang L, Mu X, Doebelin C, Nguyen W, Wallace C, Reay DP, McGowan SJ, Corbo L, Clemens PR, Wilson GM, Watkins SC, Solt LA, Cameron MD, Huard J, Niedernhofer LJ, Kamenecka TM, Robbins PD.

PLoS Biol. 2018 Jun 11;16(6):e2004663. doi: 10.1371/journal.pbio.2004663. eCollection 2018 Jun.

30.

Sequencing of human genomes extracted from single cancer cells isolated in a valveless microfluidic device.

Marie R, Pødenphant M, Koprowska K, Bærlocher L, Vulders RCM, Wilding J, Ashley N, McGowan SJ, van Strijp D, van Hemert F, Olesen T, Agersnap N, Bilenberg B, Sabatel C, Schira J, Kristensen A, Bodmer W, van der Zaag PJ, Mir KU.

Lab Chip. 2018 Jun 26;18(13):1891-1902. doi: 10.1039/c8lc00169c.

PMID:
29873383
31.

De Novo and Inherited Loss-of-Function Variants in TLK2: Clinical and Genotype-Phenotype Evaluation of a Distinct Neurodevelopmental Disorder.

Reijnders MRF, Miller KA, Alvi M, Goos JAC, Lees MM, de Burca A, Henderson A, Kraus A, Mikat B, de Vries BBA, Isidor B, Kerr B, Marcelis C, Schluth-Bolard C, Deshpande C, Ruivenkamp CAL, Wieczorek D; Deciphering Developmental Disorders Study, Baralle D, Blair EM, Engels H, Lüdecke HJ, Eason J, Santen GWE, Clayton-Smith J, Chandler K, Tatton-Brown K, Payne K, Helbig K, Radtke K, Nugent KM, Cremer K, Strom TM, Bird LM, Sinnema M, Bitner-Glindzicz M, van Dooren MF, Alders M, Koopmans M, Brick L, Kozenko M, Harline ML, Klaassens M, Steinraths M, Cooper NS, Edery P, Yap P, Terhal PA, van der Spek PJ, Lakeman P, Taylor RL, Littlejohn RO, Pfundt R, Mercimek-Andrews S, Stegmann APA, Kant SG, McLean S, Joss S, Swagemakers SMA, Douzgou S, Wall SA, Küry S, Calpena E, Koelling N, McGowan SJ, Twigg SRF, Mathijssen IMJ, Nellaker C, Brunner HG, Wilkie AOM.

Am J Hum Genet. 2018 Jun 7;102(6):1195-1203. doi: 10.1016/j.ajhg.2018.04.014. Epub 2018 May 31.

32.

ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation.

Czerwińska J, Nowak M, Wojtczak P, Dziuban-Lech D, Cieśla JM, Kołata D, Gajewska B, Barańczyk-Kuźma A, Robinson AR, Shane HL, Gregg SQ, Rigatti LH, Yousefzadeh MJ, Gurkar AU, McGowan SJ, Kosicki K, Bednarek M, Zarakowska E, Gackowski D, Oliński R, Speina E, Niedernhofer LJ, Tudek B.

Free Radic Biol Med. 2018 Aug 20;124:79-96. doi: 10.1016/j.freeradbiomed.2018.05.088. Epub 2018 Jun 1.

33.

Diversity and signature of small RNA in different bodily fluids using next generation sequencing.

El-Mogy M, Lam B, Haj-Ahmad TA, McGowan S, Yu D, Nosal L, Rghei N, Roberts P, Haj-Ahmad Y.

BMC Genomics. 2018 May 29;19(1):408. doi: 10.1186/s12864-018-4785-8.

34.

Regional versus local drivers of water quality in the Windermere catchment, Lake District, United Kingdom: The dominant influence of wastewater pollution over the past 200 years.

Moorhouse HL, McGowan S, Taranu ZE, Gregory-Eaves I, Leavitt PR, Jones MD, Barker P, Brayshaw SA.

Glob Chang Biol. 2018 Sep;24(9):4009-4022. doi: 10.1111/gcb.14299. Epub 2018 Jun 7.

PMID:
29749028
35.

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging.

Robinson AR, Yousefzadeh MJ, Rozgaja TA, Wang J, Li X, Tilstra JS, Feldman CH, Gregg SQ, Johnson CH, Skoda EM, Frantz MC, Bell-Temin H, Pope-Varsalona H, Gurkar AU, Nasto LA, Robinson RAS, Fuhrmann-Stroissnigg H, Czerwinska J, McGowan SJ, Cantu-Medellin N, Harris JB, Maniar S, Ross MA, Trussoni CE, LaRusso NF, Cifuentes-Pagano E, Pagano PJ, Tudek B, Vo NV, Rigatti LH, Opresko PL, Stolz DB, Watkins SC, Burd CE, Croix CMS, Siuzdak G, Yates NA, Robbins PD, Wang Y, Wipf P, Kelley EE, Niedernhofer LJ.

Redox Biol. 2018 Jul;17:259-273. doi: 10.1016/j.redox.2018.04.007. Epub 2018 Apr 13.

36.

Incursion of Schmallenberg virus into Great Britain in 2011 and emergence of variant sequences in 2016.

McGowan SL, La Rocca SA, Grierson SS, Dastjerdi A, Choudhury B, Steinbach F.

Vet J. 2018 Apr;234:77-84. doi: 10.1016/j.tvjl.2018.02.001. Epub 2018 Feb 8.

PMID:
29680399
37.

Interlaboratory Comparison of Six Real-Time PCR Assays for Detection of Bovine Leukemia Virus Proviral DNA.

Jaworski JP, Pluta A, Rola-Łuszczak M, McGowan SL, Finnegan C, Heenemann K, Carignano HA, Alvarez I, Murakami K, Willems L, Vahlenkamp TW, Trono KG, Choudhury B, Kuźmak J.

J Clin Microbiol. 2018 Jun 25;56(7). pii: e00304-18. doi: 10.1128/JCM.00304-18. Print 2018 Jul.

38.

Clostridium sordellii outer spore proteins maintain spore structural integrity and promote bacterial clearance from the gastrointestinal tract.

Rabi R, Larcombe S, Mathias R, McGowan S, Awad M, Lyras D.

PLoS Pathog. 2018 Apr 18;14(4):e1007004. doi: 10.1371/journal.ppat.1007004. eCollection 2018 Apr.

39.

Neuropilin-1 and platelet-derived growth factor receptors cooperatively regulate intermediate filaments and mesenchymal cell migration during alveolar septation.

McGowan SE, McCoy DM.

Am J Physiol Lung Cell Mol Physiol. 2018 Jul 1;315(1):L102-L115. doi: 10.1152/ajplung.00511.2017. Epub 2018 Mar 15.

40.

Historical atmospheric pollution trends in Southeast Asia inferred from lake sediment records.

Engels S, Fong LSRZ, Chen Q, Leng MJ, McGowan S, Idris M, Rose NL, Ruslan MS, Taylor D, Yang H.

Environ Pollut. 2018 Apr;235:907-917. doi: 10.1016/j.envpol.2018.01.007. Epub 2018 Feb 21.

PMID:
29353806
41.

Functional attributes of epilithic diatoms for palaeoenvironmental interpretations in South-West Greenland lakes.

McGowan S, Gunn HV, Whiteford EJ, John Anderson N, Jones VJ, Law AC.

J Paleolimnol. 2018;60(2):273-298. doi: 10.1007/s10933-017-9968-9. Epub 2017 Jun 9.

42.

Long-term outcome of thyrotoxicosis in childhood and adolescence in the west of Scotland: the case for long-term antithyroid treatment and the importance of initial counselling.

Kourime M, McGowan S, Al Towati M, Ahmed SF, Stewart G, Williamson S, Hunter I, Donaldson MDC.

Arch Dis Child. 2018 Jul;103(7):637-642. doi: 10.1136/archdischild-2017-313454. Epub 2017 Dec 21.

43.

Characterisation of a major phytoplankton bloom in the River Thames (UK) using flow cytometry and high performance liquid chromatography.

Moorhouse HL, Read DS, McGowan S, Wagner M, Roberts C, Armstrong LK, Nicholls DJE, Wickham HD, Hutchins MG, Bowes MJ.

Sci Total Environ. 2018 May 15;624:366-376. doi: 10.1016/j.scitotenv.2017.12.128. Epub 2017 Dec 16.

PMID:
29258037
44.

Effects of dam construction and increasing pollutants on the ecohydrological evolution of a shallow freshwater lake in the Yangtze floodplain.

Zeng L, McGowan S, Cao Y, Chen X.

Sci Total Environ. 2018 Apr 15;621:219-227. doi: 10.1016/j.scitotenv.2017.11.181. Epub 2017 Nov 24.

PMID:
29179078
45.

Sasquatch: predicting the impact of regulatory SNPs on transcription factor binding from cell- and tissue-specific DNase footprints.

Schwessinger R, Suciu MC, McGowan SJ, Telenius J, Taylor S, Higgs DR, Hughes JR.

Genome Res. 2017 Oct;27(10):1730-1742. doi: 10.1101/gr.220202.117. Epub 2017 Sep 13.

46.

Hydrogen peroxide production is affected by oxygen levels in mammalian cell culture.

Maddalena LA, Selim SM, Fonseca J, Messner H, McGowan S, Stuart JA.

Biochem Biophys Res Commun. 2017 Nov 4;493(1):246-251. doi: 10.1016/j.bbrc.2017.09.037. Epub 2017 Sep 9.

PMID:
28899780
47.

Efficient method to create integration-free, virus-free, Myc and Lin28-free human induced pluripotent stem cells from adherent cells.

Kamath A, Ternes S, McGowan S, English A, Mallampalli R, Moy AB.

Future Sci OA. 2017 May 12;3(3):FSO211. doi: 10.4155/fsoa-2017-0028. eCollection 2017 Aug.

48.

Identification of HSP90 inhibitors as a novel class of senolytics.

Fuhrmann-Stroissnigg H, Ling YY, Zhao J, McGowan SJ, Zhu Y, Brooks RW, Grassi D, Gregg SQ, Stripay JL, Dorronsoro A, Corbo L, Tang P, Bukata C, Ring N, Giacca M, Li X, Tchkonia T, Kirkland JL, Niedernhofer LJ, Robbins PD.

Nat Commun. 2017 Sep 4;8(1):422. doi: 10.1038/s41467-017-00314-z.

49.

Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype.

Ngo K, Patil P, McGowan SJ, Niedernhofer LJ, Robbins PD, Kang J, Sowa G, Vo N.

Mech Ageing Dev. 2017 Sep;166:16-23. doi: 10.1016/j.mad.2017.08.007. Epub 2017 Aug 19.

50.

Generation of AMBER force field parameters for zinc centres of M1 and M17 family aminopeptidases.

Yang W, Riley BT, Lei X, Porebski BT, Kass I, Buckle AM, McGowan S.

J Biomol Struct Dyn. 2018 Aug;36(10):2595-2604. doi: 10.1080/07391102.2017.1364669. Epub 2017 Aug 28.

PMID:
28782419

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