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Items: 19

1.

Towards a TREK-1/2 (TWIK-Related K+ Channel 1 and 2) dual activator tool compound: Multi-dimensional optimization of BL-1249.

Iwaki Y, Yashiro K, Kokubo M, Mori T, Wieting JM, McGowan KM, Bridges TM, Engers DW, Denton JS, Kurata H, Lindsley CW.

Bioorg Med Chem Lett. 2019 Jul 1;29(13):1601-1604. doi: 10.1016/j.bmcl.2019.04.048. Epub 2019 Apr 29.

PMID:
31072652
2.

Synthesis and Biological Evaluation of Fluorescent Bryostatin Analogues.

Cummins TJ, Kedei N, Czikora A, Lewin NE, Kirk S, Petersen ME, McGowan KM, Chen JQ, Luo X, Johnson RC, Ravichandran S, Blumberg PM, Keck GE.

Chembiochem. 2018 Apr 16;19(8):877-889. doi: 10.1002/cbic.201700655. Epub 2018 Mar 25.

PMID:
29424951
3.

VU6010608, a Novel mGlu7 NAM from a Series of N-(2-(1H-1,2,4-Triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamides.

Reed CW, McGowan KM, Spearing PK, Stansley BJ, Roenfanz HF, Engers DW, Rodriguez AL, Engelberg EM, Luscombe VB, Loch MT, Remke DH, Rook JM, Blobaum AL, Conn PJ, Niswender CM, Lindsley CW.

ACS Med Chem Lett. 2017 Nov 8;8(12):1326-1330. doi: 10.1021/acsmedchemlett.7b00429. eCollection 2017 Dec 14.

4.

Selective inhibition of M5 muscarinic acetylcholine receptors attenuates cocaine self-administration in rats.

Gunter BW, Gould RW, Bubser M, McGowan KM, Lindsley CW, Jones CK.

Addict Biol. 2018 Sep;23(5):1106-1116. doi: 10.1111/adb.12567. Epub 2017 Oct 18.

5.

Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies.

McGowan KM, Nance KD, Cho HP, Bridges TM, Conn PJ, Jones CK, Lindsley CW.

Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359. doi: 10.1016/j.bmcl.2017.02.020. Epub 2017 Feb 13.

6.

Brief report: Feasibility of a mindfulness and self-compassion based mobile intervention for adolescents.

Donovan E, Rodgers RF, Cousineau TM, McGowan KM, Luk S, Yates K, Franko DL.

J Adolesc. 2016 Dec;53:217-221. doi: 10.1016/j.adolescence.2016.09.009. Epub 2016 Nov 1.

PMID:
27814499
7.

Ligand-based virtual screen for the discovery of novel M5 inhibitor chemotypes.

Geanes AR, Cho HP, Nance KD, McGowan KM, Conn PJ, Jones CK, Meiler J, Lindsley CW.

Bioorg Med Chem Lett. 2016 Sep 15;26(18):4487-4491. doi: 10.1016/j.bmcl.2016.07.071. Epub 2016 Jul 30.

8.

Synthesis and Biological Evaluation of Several Bryostatin Analogues Bearing a Diacylglycerol Lactone C-Ring.

Baumann DO, McGowan KM, Kedei N, Peach ML, Blumberg PM, Keck GE.

J Org Chem. 2016 Sep 2;81(17):7862-83. doi: 10.1021/acs.joc.6b01516. Epub 2016 Aug 23.

PMID:
27494208
9.

Biological activity of the bryostatin analog Merle 23 on mouse epidermal cells and mouse skin.

Kelsey JS, Cataisson C, Chen J, Herrmann MA, Petersen ME, Baumann DO, McGowan KM, Yuspa SH, Keck GE, Blumberg PM.

Mol Carcinog. 2016 Dec;55(12):2183-2195. doi: 10.1002/mc.22460. Epub 2016 Feb 9.

PMID:
26859836
10.

Keratin 16 expression defines a subset of epithelial cells during skin morphogenesis and the hair cycle.

Bernot KM, Coulombe PA, McGowan KM.

J Invest Dermatol. 2002 Nov;119(5):1137-49.

11.

Keratin 17 null mice exhibit age- and strain-dependent alopecia.

McGowan KM, Tong X, Colucci-Guyon E, Langa F, Babinet C, Coulombe PA.

Genes Dev. 2002 Jun 1;16(11):1412-22.

13.
14.

Ectopic expression of Hel-N1, an RNA-binding protein, increases glucose transporter (GLUT1) expression in 3T3-L1 adipocytes.

Jain RG, Andrews LG, McGowan KM, Pekala PH, Keene JD.

Mol Cell Biol. 1997 Feb;17(2):954-62.

15.
16.

Glucose transporter gene expression: regulation of transcription and mRNA stability.

McGowan KM, Long SD, Pekala PH.

Pharmacol Ther. 1995 Jun;66(3):465-505. Review.

PMID:
7494856
17.

Hel-N1, an RNA-binding protein, is a ligand for an A + U rich region of the GLUT1 3' UTR.

Jain RG, Andrews LG, McGowan KM, Gao F, Keene JD, Pekala PP.

Nucleic Acids Symp Ser. 1995;(33):209-11.

PMID:
8643372
18.
19.

Altered radioprotective properties of interleukin I alpha (IL-1) in non-hematologic tumor-bearing animals.

Kovacs CJ, Gooya JM, Harrell JP, McGowan KM, Evans MJ.

Int J Radiat Oncol Biol Phys. 1991 Feb;20(2):307-10.

PMID:
1991693

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