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Dynamic Three-Dimensional Geometry of the Tricuspid Valve Annulus in Hypoplastic Left Heart Syndrome with a Fontan Circulation.

Nguyen AV, Lasso A, Nam HH, Faerber J, Aly AH, Pouch AM, Scanlan AB, McGowan FX, Mercer-Rosa L, Cohen MS, Simpson J, Fichtinger G, Jolley MA.

J Am Soc Echocardiogr. 2019 May;32(5):655-666.e13. doi: 10.1016/j.echo.2019.01.002. Epub 2019 Feb 28.


Toward predictive modeling of catheter-based pulmonary valve replacement into native right ventricular outflow tracts.

Jolley MA, Lasso A, Nam HH, Dinh PV, Scanlan AB, Nguyen AV, Ilina A, Morray B, Glatz AC, McGowan FX, Whitehead K, Dori Y, Gorman JH 3rd, Gorman RC, Fichtinger G, Gillespie MJ.

Catheter Cardiovasc Interv. 2019 Feb 15;93(3):E143-E152. doi: 10.1002/ccd.27962. Epub 2018 Nov 15.


Early Right Ventricular Systolic Dysfunction and Pulmonary Hypertension Are Associated With Worse Outcomes in Pediatric Acute Respiratory Distress Syndrome.

Himebauch AS, Yehya N, Wang Y, Conlon T, Kilbaugh TJ, McGowan FX, Mercer-Rosa L.

Crit Care Med. 2018 Nov;46(11):e1055-e1062. doi: 10.1097/CCM.0000000000003358.


Interaction with Volume-Rendered Three-Dimensional Echocardiographic Images in Virtual Reality.

Lasso A, Nam HH, Dinh PV, Pinter C, Fillion-Robin JC, Pieper S, Jhaveri S, Vimort JB, Martin K, Asselin M, McGowan FX, Kikinis R, Fichtinger G, Jolley MA.

J Am Soc Echocardiogr. 2018 Oct;31(10):1158-1160. doi: 10.1016/j.echo.2018.06.011. Epub 2018 Aug 6. No abstract available.


Comparison of 3D Echocardiogram-Derived 3D Printed Valve Models to Molded Models for Simulated Repair of Pediatric Atrioventricular Valves.

Scanlan AB, Nguyen AV, Ilina A, Lasso A, Cripe L, Jegatheeswaran A, Silvestro E, McGowan FX, Mascio CE, Fuller S, Spray TL, Cohen MS, Fichtinger G, Jolley MA.

Pediatr Cardiol. 2018 Mar;39(3):538-547. doi: 10.1007/s00246-017-1785-4. Epub 2017 Nov 27.


An International, Multicenter, Observational Study of Cerebral Oxygenation during Infant and Neonatal Anesthesia.

Olbrecht VA, Skowno J, Marchesini V, Ding L, Jiang Y, Ward CG, Yu G, Liu H, Schurink B, Vutskits L, de Graaff JC, McGowan FX Jr, von Ungern-Sternberg BS, Kurth CD, Davidson A.

Anesthesiology. 2018 Jan;128(1):85-96. doi: 10.1097/ALN.0000000000001920.


Responsive monitoring of mitochondrial redox states in heart muscle predicts impending cardiac arrest.

Perry DA, Salvin JW, Romfh P, Chen P, Krishnamurthy K, Thomson LM, Polizzotti BD, McGowan FX, Vakhshoori D, Kheir JN.

Sci Transl Med. 2017 Sep 20;9(408). pii: eaan0117. doi: 10.1126/scitranslmed.aan0117.


Cerebral Oxygen Saturation in Children With Congenital Heart Disease and Chronic Hypoxemia.

Kussman BD, Laussen PC, Benni PB, McGowan FX Jr, McElhinney DB.

Anesth Analg. 2017 Jul;125(1):234-240. doi: 10.1213/ANE.0000000000002073.


Image Segmentation and Modeling of the Pediatric Tricuspid Valve in Hypoplastic Left Heart Syndrome.

Pouch AM, Aly AH, Lasso A, Nguyen AV, Scanlan AB, McGowan FX, Fichtinger G, Gorman RC, Gorman JH 3rd, Yushkevich PA, Jolley MA.

Funct Imaging Model Heart. 2017;10263:95-105. Epub 2017 May 23.


Biomarkers, Genetics, and Epigenetic Studies to Explore the Neurocognitive Effects of Anesthesia in Children.

Levy RJ, Herbstman JB, Bosnjak ZJ, Loepke AW, McGowan FX.

J Neurosurg Anesthesiol. 2016 Oct;28(4):384-388. doi: 10.1097/ANA.0000000000000351.


Association Between a Single General Anesthesia Exposure Before Age 36 Months and Neurocognitive Outcomes in Later Childhood.

Sun LS, Li G, Miller TL, Salorio C, Byrne MW, Bellinger DC, Ing C, Park R, Radcliffe J, Hays SR, DiMaggio CJ, Cooper TJ, Rauh V, Maxwell LG, Youn A, McGowan FX.

JAMA. 2016 Jun 7;315(21):2312-20. doi: 10.1001/jama.2016.6967.


Effects of commonly used inotropes on myocardial function and oxygen consumption under constant ventricular loading conditions.

DeWitt ES, Black KJ, Thiagarajan RR, DiNardo JA, Colan SD, McGowan FX, Kheir JN.

J Appl Physiol (1985). 2016 Jul 1;121(1):7-14. doi: 10.1152/japplphysiol.00058.2016. Epub 2016 May 5.


PACES/HRS expert consensus statement on the use of catheter ablation in children and patients with congenital heart disease: Developed in partnership with the Pediatric and Congenital Electrophysiology Society (PACES) and the Heart Rhythm Society (HRS). Endorsed by the governing bodies of PACES, HRS, the American Academy of Pediatrics (AAP), the American Heart Association (AHA), and the Association for European Pediatric and Congenital Cardiology (AEPC).

Philip Saul J, Kanter RJ; WRITING COMMITTEE, Abrams D, Asirvatham S, Bar-Cohen Y, Blaufox AD, Cannon B, Clark J, Dick M, Freter A, Kertesz NJ, Kirsh JA, Kugler J, LaPage M, McGowan FX, Miyake CY, Nathan A, Papagiannis J, Paul T, Pflaumer A, Skanes AC, Stevenson WG, Von Bergen N, Zimmerman F.

Heart Rhythm. 2016 Jun;13(6):e251-89. doi: 10.1016/j.hrthm.2016.02.009. Epub 2016 Feb 17. Review. No abstract available.


Airway management complications in children with difficult tracheal intubation from the Pediatric Difficult Intubation (PeDI) registry: a prospective cohort analysis.

Fiadjoe JE, Nishisaki A, Jagannathan N, Hunyady AI, Greenberg RS, Reynolds PI, Matuszczak ME, Rehman MA, Polaner DM, Szmuk P, Nadkarni VM, McGowan FX Jr, Litman RS, Kovatsis PG.

Lancet Respir Med. 2016 Jan;4(1):37-48. doi: 10.1016/S2213-2600(15)00508-1. Epub 2015 Dec 17.


Neurotoxicity, general anesthesia in young children, and a survey of current pediatric anesthesia practice at US teaching institutions.

Ward CG, Hines SJ, Maxwell LG, McGowan FX, Sun LS.

Paediatr Anaesth. 2016 Jan;26(1):60-5. doi: 10.1111/pan.12814. Epub 2015 Nov 12.


Pharmacokinetics of tranexamic acid in neonates, infants, and children undergoing cardiac surgery with cardiopulmonary bypass.

Wesley MC, Pereira LM, Scharp LA, Emani SM, McGowan FX Jr, DiNardo JA.

Anesthesiology. 2015 Apr;122(4):746-58. doi: 10.1097/ALN.0000000000000570.


A word of caution: dexmedetomidine and pulmonary hypertension.

Nathan AT, Nicolson SC, McGowan FX.

Anesth Analg. 2014 Jul;119(1):216-7. doi: 10.1213/ANE.0000000000000236. No abstract available.


Impact of empiric nesiritide or milrinone infusion on early postoperative recovery after Fontan surgery: a randomized, double-blind, placebo-controlled trial.

Costello JM, Dunbar-Masterson C, Allan CK, Gauvreau K, Newburger JW, McGowan FX Jr, Wessel DL, Mayer JE Jr, Salvin JW, Dionne RE, Laussen PC.

Circ Heart Fail. 2014 Jul;7(4):596-604. doi: 10.1161/CIRCHEARTFAILURE.113.001312. Epub 2014 Jun 6.


Manufacture of concentrated, lipid-based oxygen microbubble emulsions by high shear homogenization and serial concentration.

Thomson LM, Polizzotti BD, McGowan FX, Kheir JN.

J Vis Exp. 2014 May 26;(87). doi: 10.3791/51467.


The advanced pediatric anesthesiology fellowship: moving beyond a clinical apprenticeship.

McGowan FX Jr, Davis PJ.

Anesth Analg. 2014 Apr;118(4):701-3. doi: 10.1213/ANE.0000000000000167. No abstract available.


Rosiglitazone causes cardiotoxicity via peroxisome proliferator-activated receptor ╬│-independent mitochondrial oxidative stress in mouse hearts.

He H, Tao H, Xiong H, Duan SZ, McGowan FX Jr, Mortensen RM, Balschi JA.

Toxicol Sci. 2014 Apr;138(2):468-81. doi: 10.1093/toxsci/kfu015. Epub 2014 Jan 21.


Optimization and characterization of stable lipid-based, oxygen-filled microbubbles by mixture design.

Polizzotti BD, Thomson LM, O'Connell DW, McGowan FX, Kheir JN.

J Biomed Mater Res B Appl Biomater. 2014 Aug;102(6):1148-56. doi: 10.1002/jbm.b.33096. Epub 2014 Jan 15.


Cardiac-specific VLCAD deficiency induces dilated cardiomyopathy and cold intolerance.

Xiong D, He H, James J, Tokunaga C, Powers C, Huang Y, Osinska H, Towbin JA, Purevjav E, Balschi JA, Javadov S, McGowan FX Jr, Strauss AW, Khuchua Z.

Am J Physiol Heart Circ Physiol. 2014 Feb;306(3):H326-38. doi: 10.1152/ajpheart.00931.2012. Epub 2013 Nov 27.


Biological characterization of F-18-labeled rhodamine B, a potential positron emission tomography perfusion tracer.

Bartholom├Ą MD, He H, Pacak CA, Dunning P, Fahey FH, McGowan FX, Cowan DB, Treves ST, Packard AB.

Nucl Med Biol. 2013 Nov;40(8):1043-8. doi: 10.1016/j.nucmedbio.2013.07.006. Epub 2013 Sep 4.


Preoperative steroid treatment does not improve markers of inflammation after cardiac surgery in neonates: results from a randomized trial.

Graham EM, Atz AM, McHugh KE, Butts RJ, Baker NL, Stroud RE, Reeves ST, Bradley SM, McGowan FX Jr, Spinale FG.

J Thorac Cardiovasc Surg. 2014 Mar;147(3):902-8. doi: 10.1016/j.jtcvs.2013.06.010. Epub 2013 Jul 16.


Bulk manufacture of concentrated oxygen gas-filled microparticles for intravenous oxygen delivery.

Kheir JN, Polizzotti BD, Thomson LM, O'Connell DW, Black KJ, Lee RW, Wilking JN, Graham AC, Bell DC, McGowan FX.

Adv Healthc Mater. 2013 Aug;2(8):1131-41. doi: 10.1002/adhm.201200350. Epub 2013 Mar 8.


Pressure-overload hypertrophy of the developing heart reveals activation of divergent gene and protein pathways in the left and right ventricular myocardium.

Friehs I, Cowan DB, Choi YH, Black KM, Barnett R, Bhasin MK, Daly C, Dillon SJ, Libermann TA, McGowan FX, del Nido PJ, Levitsky S, McCully JD.

Am J Physiol Heart Circ Physiol. 2013 Mar 1;304(5):H697-708. doi: 10.1152/ajpheart.00802.2012. Epub 2012 Dec 21.


Vitamin D status in neonates undergoing cardiac operations: relationship to cardiopulmonary bypass and association with outcomes.

Graham EM, Taylor SN, Zyblewski SC, Wolf B, Bradley SM, Hollis BW, McGowan FX Jr, Atz AM.

J Pediatr. 2013 Apr;162(4):823-6. doi: 10.1016/j.jpeds.2012.10.013. Epub 2012 Nov 10.


Feasibility and pilot study of the Pediatric Anesthesia NeuroDevelopment Assessment (PANDA) project.

Sun LS, Li G, DiMaggio CJ, Byrne MW, Ing C, Miller TL, Bellinger DC, Han S, McGowan FX.

J Neurosurg Anesthesiol. 2012 Oct;24(4):382-8. doi: 10.1097/ANA.0b013e31826a0371.


Endogenous angiogenesis inhibitors prevent adaptive capillary growth in left ventricular pressure overload hypertrophy.

Nikolova A, Ablasser K, Wyler von Ballmoos MC, Poutias D, Kaza E, McGowan FX, Moses MA, Del Nido PJ, Friehs I.

Ann Thorac Surg. 2012 Nov;94(5):1509-17. doi: 10.1016/j.athoracsur.2012.05.052. Epub 2012 Jul 12.


Oxygen gas-filled microparticles provide intravenous oxygen delivery.

Kheir JN, Scharp LA, Borden MA, Swanson EJ, Loxley A, Reese JH, Black KJ, Velazquez LA, Thomson LM, Walsh BK, Mullen KE, Graham DA, Lawlor MW, Brugnara C, Bell DC, McGowan FX Jr.

Sci Transl Med. 2012 Jun 27;4(140):140ra88. doi: 10.1126/scitranslmed.3003679.


Resting energy expenditure after Fontan surgery in children with single-ventricle heart defects.

Mehta NM, Costello JM, Bechard LJ, Johnson VM, Zurakowski D, McGowan FX, Laussen PC, Duggan CP.

JPEN J Parenter Enteral Nutr. 2012 Nov;36(6):685-92. doi: 10.1177/0148607112445581. Epub 2012 Apr 26.


Obstruction-induced pulmonary vascular remodeling.

Chow MJ, Zou Y, He H, McGowan FX, Zurakowski D, Zhang Y.

J Biomech Eng. 2011 Nov;133(11):111009. doi: 10.1115/1.4005301.


Differential effects of aprotinin and tranexamic acid on outcomes and cytokine profiles in neonates undergoing cardiac surgery.

Graham EM, Atz AM, Gillis J, Desantis SM, Haney AL, Deardorff RL, Uber WE, Reeves ST, McGowan FX Jr, Bradley SM, Spinale FG.

J Thorac Cardiovasc Surg. 2012 May;143(5):1069-76. doi: 10.1016/j.jtcvs.2011.08.051. Epub 2011 Nov 9.


Adult mouse epicardium modulates myocardial injury by secreting paracrine factors.

Zhou B, Honor LB, He H, Ma Q, Oh JH, Butterfield C, Lin RZ, Melero-Martin JM, Dolmatova E, Duffy HS, Gise Av, Zhou P, Hu YW, Wang G, Zhang B, Wang L, Hall JL, Moses MA, McGowan FX, Pu WT.

J Clin Invest. 2011 May;121(5):1894-904. doi: 10.1172/JCI45529. Epub 2011 Apr 18.


Efficacy of tranexamic acid in pediatric craniosynostosis surgery: a double-blind, placebo-controlled trial.

Goobie SM, Meier PM, Pereira LM, McGowan FX, Prescilla RP, Scharp LA, Rogers GF, Proctor MR, Meara JG, Soriano SG, Zurakowski D, Sethna NF.

Anesthesiology. 2011 Apr;114(4):862-71. doi: 10.1097/ALN.0b013e318210fd8f.


Blood transfusion after pediatric cardiac surgery is associated with prolonged hospital stay.

Salvin JW, Scheurer MA, Laussen PC, Wypij D, Polito A, Bacha EA, Pigula FA, McGowan FX, Costello JM, Thiagarajan RR.

Ann Thorac Surg. 2011 Jan;91(1):204-10. doi: 10.1016/j.athoracsur.2010.07.037.


The relationship between inflammatory activation and clinical outcome after infant cardiopulmonary bypass.

Allan CK, Newburger JW, McGrath E, Elder J, Psoinos C, Laussen PC, del Nido PJ, Wypij D, McGowan FX Jr.

Anesth Analg. 2010 Nov;111(5):1244-51. doi: 10.1213/ANE.0b013e3181f333aa. Epub 2010 Sep 9.


Detection of carbon monoxide during routine anesthetics in infants and children.

Levy RJ, Nasr VG, Rivera O, Roberts R, Slack M, Kanter JP, Ratnayaka K, Kaplan RF, McGowan FX Jr.

Anesth Analg. 2010 Mar 1;110(3):747-53. doi: 10.1213/ANE.0b013e3181cc4b9f.


Electron transport chain dysfunction in neonatal pressure-overload hypertrophy precedes cardiomyocyte apoptosis independent of oxidative stress.

Griffiths ER, Friehs I, Scherr E, Poutias D, McGowan FX, Del Nido PJ.

J Thorac Cardiovasc Surg. 2010 Jun;139(6):1609-17. doi: 10.1016/j.jtcvs.2009.08.060. Epub 2009 Dec 28.


Atrial remodeling after the Fontan operation.

Wolf CM, Seslar SP, den Boer K, Juraszek AL, McGowan FX, Cowan DB, Del Nido P, Triedman JK, Berul CI, Walsh EP.

Am J Cardiol. 2009 Dec 15;104(12):1737-42. doi: 10.1016/j.amjcard.2009.07.061.


Development of left ventricular diastolic dysfunction with preservation of ejection fraction during progression of infant right ventricular hypertrophy.

Kitahori K, He H, Kawata M, Cowan DB, Friehs I, Del Nido PJ, McGowan FX Jr.

Circ Heart Fail. 2009 Nov;2(6):599-607. doi: 10.1161/CIRCHEARTFAILURE.109.862664. Epub 2009 Sep 24.


CXCR4 enhances engraftment of muscle progenitor cells.

Perez AL, Bachrach E, Illigens BM, Jun SJ, Bagden E, Steffen L, Flint A, McGowan FX, Del Nido P, Montecino-Rodriguez E, Tidball JG, Kunkel LM.

Muscle Nerve. 2009 Oct;40(4):562-72. doi: 10.1002/mus.21317.


Divergent cardiopulmonary actions of heme oxygenase enzymatic products in chronic hypoxia.

Vitali SH, Mitsialis SA, Liang OD, Liu X, Fernandez-Gonzalez A, Christou H, Wu X, McGowan FX, Kourembanas S.

PLoS One. 2009 Jun 19;4(6):e5978. doi: 10.1371/journal.pone.0005978.


Myocyte apoptosis occurs early during the development of pressure-overload hypertrophy in infant myocardium.

Choi YH, Cowan DB, Moran AM, Colan SD, Stamm C, Takeuchi K, Friehs I, del Nido PJ, McGowan FX Jr.

J Thorac Cardiovasc Surg. 2009 Jun;137(6):1356-62, 1362.e1-3. doi: 10.1016/j.jtcvs.2008.12.020. Epub 2009 Mar 17.


Transcriptomic and proteomic analysis of global ischemia and cardioprotection in the rabbit heart.

McCully JD, Bhasin MK, Daly C, Guerrero MC, Dillon S, Liberman TA, Cowan DB, Mably JD, McGowan FX, Levitsky S.

Physiol Genomics. 2009 Jul 9;38(2):125-37. doi: 10.1152/physiolgenomics.00033.2009. Epub 2009 May 19.


Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart.

Zhou B, Ma Q, Kong SW, Hu Y, Campbell PH, McGowan FX, Ackerman KG, Wu B, Zhou B, Tevosian SG, Pu WT.

J Clin Invest. 2009 Jun;119(6):1462-76. doi: 10.1172/JCI38723.


The effect of milrinone on platelet activation as determined by TEG platelet mapping.

Wesley MC, McGowan FX, Castro RA, Dissanayake S, Zurakowski D, Dinardo JA.

Anesth Analg. 2009 May;108(5):1425-9. doi: 10.1213/ane.0b013e3181981fbe.


Oral tolerization with cardiac myosin peptide (614-629) ameliorates experimental autoimmune myocarditis: role of STAT 6 genes in BALB/CJ mice.

Gonnella PA, Del Nido PJ, McGowan FX.

J Clin Immunol. 2009 Jul;29(4):434-43. doi: 10.1007/s10875-009-9290-z. Epub 2009 Apr 8.


Prospective longitudinal study of coagulation profiles in children with hypoplastic left heart syndrome from stage I through Fontan completion.

Odegard KC, Zurakowski D, DiNardo JA, Castro RA, McGowan FX Jr, Neufeld EJ, Laussen PC.

J Thorac Cardiovasc Surg. 2009 Apr;137(4):934-41. doi: 10.1016/j.jtcvs.2008.09.031. Epub 2009 Feb 23.

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