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The phosphoinositide-3 kinase (PI3K)-δ,γ inhibitor, duvelisib shows preclinical synergy with multiple targeted therapies in hematologic malignancies.

Faia K, White K, Murphy E, Proctor J, Pink M, Kosmider N, McGovern K, Kutok J.

PLoS One. 2018 Aug 1;13(8):e0200725. doi: 10.1371/journal.pone.0200725. eCollection 2018.


Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme.

Triplett TA, Garrison KC, Marshall N, Donkor M, Blazeck J, Lamb C, Qerqez A, Dekker JD, Tanno Y, Lu WC, Karamitros CS, Ford K, Tan B, Zhang XM, McGovern K, Coma S, Kumada Y, Yamany MS, Sentandreu E, Fromm G, Tiziani S, Schreiber TH, Manfredi M, Ehrlich LIR, Stone E, Georgiou G.

Nat Biotechnol. 2018 Sep;36(8):758-764. doi: 10.1038/nbt.4180. Epub 2018 Jul 16.


Bilateral Angle Closure Following the Infusion of a Monoclonal Antibody to Treat Relapsing Multiple Myeloma.

Lee AC, Greaves G, Lee R, Zdravkova M, Ahmad S, McGovern K, Ghiuzeli C, Hymowitz M.

J Glaucoma. 2018 Sep;27(9):e145-e147. doi: 10.1097/IJG.0000000000000995.


The impact of dietary regimen compliance on outcomes for HNSCC patients treated with radiation therapy.

Kabarriti R, Bontempo A, Romano M, McGovern KP, Asaro A, Viswanathan S, Kalnicki S, Garg MK.

Support Care Cancer. 2018 Sep;26(9):3307-3313. doi: 10.1007/s00520-018-4198-x. Epub 2018 Apr 18.


Porous orbital implant after enucleation in retinoblastoma patients: indications and complications.

Lang P, Kim JW, McGovern K, Reid MW, Subramanian K, Murphree AL, Berry JL.

Orbit. 2018 Feb 20:1-6. doi: 10.1080/01676830.2018.1440605. [Epub ahead of print]


Neighborhood Factors and Urinary Metabolites of Nicotine, Phthalates, and Dichlorobenzene.

Galvez MP, McGovern K, Teitelbaum SL, Windham G, Wolff MS.

Pediatrics. 2018 Jan;141(Suppl 1):S87-S95. doi: 10.1542/peds.2017-1026L.


Potential of Aqueous Humor as a Surrogate Tumor Biopsy for Retinoblastoma.

Berry JL, Xu L, Murphree AL, Krishnan S, Stachelek K, Zolfaghari E, McGovern K, Lee TC, Carlsson A, Kuhn P, Kim JW, Cobrinik D, Hicks J.

JAMA Ophthalmol. 2017 Nov 1;135(11):1221-1230. doi: 10.1001/jamaophthalmol.2017.4097.


Dissecting Amyloid Beta Deposition Using Distinct Strains of the Neurotropic Parasite Toxoplasma gondii as a Novel Tool.

Cabral CM, McGovern KE, MacDonald WR, Franco J, Koshy AA.

ASN Neuro. 2017 Jul-Aug;9(4):1759091417724915. doi: 10.1177/1759091417724915.


The Selective Phosphoinoside-3-Kinase p110δ Inhibitor IPI-3063 Potently Suppresses B Cell Survival, Proliferation, and Differentiation.

Chiu H, Mallya S, Nguyen P, Mai A, Jackson LV, Winkler DG, DiNitto JP, Brophy EE, McGovern K, Kutok JL, Fruman DA.

Front Immunol. 2017 Jun 30;8:747. doi: 10.3389/fimmu.2017.00747. eCollection 2017.


Gratitude, psychological well-being, and perceptions of posttraumatic growth in adults who lost a parent in childhood.

Greene N, McGovern K.

Death Stud. 2017 Aug;41(7):436-446. doi: 10.1080/07481187.2017.1296505. Epub 2017 Feb 17.


Risk of metastasis and orbital recurrence in advanced retinoblastoma eyes treated with systemic chemoreduction versus primary enucleation.

Berry JL, Kogachi K, Aziz HA, McGovern K, Zolfaghari E, Murphree AL, Jubran R, Kim JW.

Pediatr Blood Cancer. 2017 Apr;64(4). doi: 10.1002/pbc.26270. Epub 2016 Nov 5.


Corrigendum: PI3Kγ is a molecular switch that controls immune suppression.

Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA.

Nature. 2017 Feb 2;542(7639):124. doi: 10.1038/nature21026. Epub 2016 Dec 14. No abstract available.


Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells.

De Henau O, Rausch M, Winkler D, Campesato LF, Liu C, Cymerman DH, Budhu S, Ghosh A, Pink M, Tchaicha J, Douglas M, Tibbitts T, Sharma S, Proctor J, Kosmider N, White K, Stern H, Soglia J, Adams J, Palombella VJ, McGovern K, Kutok JL, Wolchok JD, Merghoub T.

Nature. 2016 Nov 17;539(7629):443-447. doi: 10.1038/nature20554. Epub 2016 Nov 9.


PI3Kγ is a molecular switch that controls immune suppression.

Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA.

Nature. 2016 Nov 17;539(7629):437-442. doi: 10.1038/nature19834. Epub 2016 Sep 19. Erratum in: Nature. 2017 Feb 2;542(7639):124.


An Atypical Splenic B Cell Progenitor Population Supports Antibody Production during Plasmodium Infection in Mice.

Ghosh D, Wikenheiser DJ, Kennedy B, McGovern KE, Stuart JD, Wilson EH, Stumhofer JS.

J Immunol. 2016 Sep 1;197(5):1788-800. doi: 10.4049/jimmunol.1502199. Epub 2016 Jul 22.


GLT-1-Dependent Disruption of CNS Glutamate Homeostasis and Neuronal Function by the Protozoan Parasite Toxoplasma gondii.

David CN, Frias ES, Szu JI, Vieira PA, Hubbard JA, Lovelace J, Michael M, Worth D, McGovern KE, Ethell IM, Stanley BG, Korzus E, Fiacco TA, Binder DK, Wilson EH.

PLoS Pathog. 2016 Jun 9;12(6):e1005643. doi: 10.1371/journal.ppat.1005643. eCollection 2016 Jun.


An examination of neurocognition and symptoms as predictors of post-hospital community tenure in treatment resistant schizophrenia.

Ahmed AO, Murphy CF, Latoussakis V, McGovern KE, English J, Bloch A, Anthony DT, Savitz AJ.

Psychiatry Res. 2016 Feb 28;236:47-52. doi: 10.1016/j.psychres.2016.01.001. Epub 2016 Jan 5.


Perfluoroalkyl and polyfluoroalkyl substances and indicators of immune function in children aged 12-19 y: National Health and Nutrition Examination Survey.

Stein CR, McGovern KJ, Pajak AM, Maglione PJ, Wolff MS.

Pediatr Res. 2016 Feb;79(2):348-57. doi: 10.1038/pr.2015.213. Epub 2015 Oct 22.


Incidence of Adjacent Segment Disease Requiring Reoperation After Lumbar Laminectomy Without Fusion: A Study of 398 Patients.

Bydon M, Macki M, De la Garza-Ramos R, McGovern K, Sciubba DM, Wolinsky JP, Witham TF, Gokaslan ZL, Bydon A.

Neurosurgery. 2016 Feb;78(2):192-9. doi: 10.1227/NEU.0000000000001007.


Environmental phenols and pubertal development in girls.

Wolff MS, Teitelbaum SL, McGovern K, Pinney SM, Windham GC, Galvez M, Pajak A, Rybak M, Calafat AM, Kushi LH, Biro FM; Breast Cancer and Environment Research Program.

Environ Int. 2015 Nov;84:174-80. doi: 10.1016/j.envint.2015.08.008. Epub 2015 Aug 31.


Progress in Small Molecule and Biologic Therapeutics Targeting Ghrelin Signaling.

McGovern KR, Darling JE, Hougland JL.

Mini Rev Med Chem. 2016;16(6):465-80. Review.


Impact of Age on Short-term Outcomes After Lumbar Fusion: An Analysis of 1395 Patients Stratified by Decade Cohorts.

Bydon M, Abt NB, De la Garza-Ramos R, Olorundare IO, McGovern K, Sciubba DM, Gokaslan ZL, Bydon A.

Neurosurgery. 2015 Sep;77(3):347-53; discussion 353-4. doi: 10.1227/NEU.0000000000000852.


Surpassing the Target: How a Recruitment Campaign Transformed the Participant Accrual Trajectory in the Epilepsy Phenome/Genome Project.

McGovern K, Karn CF, Fox K; EPGP Investigators.

Clin Transl Sci. 2015 Oct;8(5):518-25. doi: 10.1111/cts.12307. Epub 2015 Jul 14.


Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia.

Lim Y, Gondek L, Li L, Wang Q, Ma H, Chang E, Huso DL, Foerster S, Marchionni L, McGovern K, Watkins DN, Peacock CD, Levis M, Smith BD, Merchant AA, Small D, Matsui W.

Sci Transl Med. 2015 Jun 10;7(291):291ra96. doi: 10.1126/scitranslmed.aaa5731. Erratum in: Sci Transl Med. 2015 Jul 8;7(295):295er6. Ma, Haley [corrected to Ma, Hayley].


Antitumor activity of a polypyridyl chelating ligand: in vitro and in vivo inhibition of glioma.

David CN, Frias ES, Elix CC, McGovern KE, Walker AM, Eichler JF, Wilson EH.

ASN Neuro. 2015 Jan-Feb;7(1). doi: 10.1177/1759091415572365.


Reproductive and immune effects of chronic corticosterone treatment in male White's treefrogs, Litoria caerulea.

Kaiser K, Devito J, Jones CG, Marentes A, Perez R, Umeh L, Weickum RM, McGovern KE, Wilson EH, Saltzman W.

Conserv Physiol. 2015 May 25;3(1):cov022. doi: 10.1093/conphys/cov022. eCollection 2015.


Effects of anthropogenic noise on endocrine and reproductive function in White's treefrog, Litoria caerulea.

Kaiser K, Devito J, Jones CG, Marentes A, Perez R, Umeh L, Weickum RM, McGovern KE, Wilson EH, Saltzman W.

Conserv Physiol. 2015 Jan 16;3(1):cou061. doi: 10.1093/conphys/cou061. eCollection 2015.


HSP90 inhibition enhances antimitotic drug-induced mitotic arrest and cell death in preclinical models of non-small cell lung cancer.

O'Connell BC, O'Callaghan K, Tillotson B, Douglas M, Hafeez N, West KA, Stern H, Ali JA, Changelian P, Fritz CC, Palombella VJ, McGovern K, Kutok JL.

PLoS One. 2014 Dec 26;9(12):e115228. doi: 10.1371/journal.pone.0115228. eCollection 2014.


Prostate-specific antigen decline during salvage radiation therapy following prostatectomy is associated with reduced biochemical failure.

Kabarriti R, Ohri N, Hannan R, Tishbi N, Baliga S, McGovern KP, Mourad WF, Ghavamian R, Kalnicki S, Guha C, Garg MK.

Pract Radiat Oncol. 2014 Nov-Dec;4(6):409-14. doi: 10.1016/j.prro.2014.01.002. Epub 2014 Feb 22.


Are vibrissae viable sensory structures for prey capture in northern elephant seals, Mirounga angustirostris?

Mcgovern KA, Marshall CD, Davis RW.

Anat Rec (Hoboken). 2015 Apr;298(4):750-60. doi: 10.1002/ar.23061. Epub 2014 Oct 31.


Biomechanical impact of C2 pedicle screw length in an atlantoaxial fusion construct.

Xu R, Bydon M, Macki M, Belkoff SM, Langdale ER, McGovern K, Wolinsky JP, Gokalsan ZL, Bydon A.

Surg Neurol Int. 2014 Aug 28;5(Suppl 7):S343-6. doi: 10.4103/2152-7806.139664. eCollection 2014.


Routine, empathic and compassionate patient care: definitions, development, obstacles, education and beneficiaries.

Post SG, Ng LE, Fischel JE, Bennett M, Bily L, Chandran L, Joyce J, Locicero B, McGovern K, McKeefrey RL, Rodriguez JV, Roess MW.

J Eval Clin Pract. 2014 Dec;20(6):872-80. doi: 10.1111/jep.12243. Epub 2014 Sep 29. Review.


Systems biology of cancer: a challenging expedition for clinical and quantitative biologists.

Korsunsky I, McGovern K, LaGatta T, Olde Loohuis L, Grosso-Applewhite T, Griffeth N, Mishra B.

Front Bioeng Biotechnol. 2014 Aug 19;2:27. doi: 10.3389/fbioe.2014.00027. eCollection 2014.


Concurrent neoadjuvant chemotherapy is an independent risk factor of stroke, all-cause morbidity, and mortality in patients undergoing brain tumor resection.

Abt NB, Bydon M, De la Garza-Ramos R, McGovern K, Olivi A, Huang J, Bydon A.

J Clin Neurosci. 2014 Nov;21(11):1895-900. doi: 10.1016/j.jocn.2014.05.010. Epub 2014 Jul 22.


Gold fiducials are a unique marker for localization in the thoracic spine: a cost comparison with percutaneous vertebroplasty.

Macki M, Bydon M, McGovern K, Abt N, de la Garza-Ramos R, Naff N, Bydon A.

Neurol Res. 2014 Oct;36(10):925-7. doi: 10.1179/1743132814Y.0000000413. Epub 2014 Jun 25.


Dietary predictors of urinary environmental biomarkers in young girls, BCERP, 2004-7.

Mervish N, McGovern KJ, Teitelbaum SL, Pinney SM, Windham GC, Biro FM, Kushi LH, Silva MJ, Ye X, Calafat AM, Wolff MS; BCERP.

Environ Res. 2014 Aug;133:12-9. doi: 10.1016/j.envres.2014.04.040. Epub 2014 Jun 3.


Phthalate exposure and pubertal development in a longitudinal study of US girls.

Wolff MS, Teitelbaum SL, McGovern K, Windham GC, Pinney SM, Galvez M, Calafat AM, Kushi LH, Biro FM; Breast Cancer and Environment Research Program.

Hum Reprod. 2014 Jul;29(7):1558-66. Epub 2014 Apr 29.


Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth.

Campbell VT, Nadesan P, Ali SA, Wang CY, Whetstone H, Poon R, Wei Q, Keilty J, Proctor J, Wang LW, Apte SS, McGovern K, Alman BA, Wunder JS.

Mol Cancer Ther. 2014 May;13(5):1259-69. doi: 10.1158/1535-7163.MCT-13-0731. Epub 2014 Mar 14.


Spontaneous regression of sequestrated lumbar disc herniations: Literature review.

Macki M, Hernandez-Hermann M, Bydon M, Gokaslan A, McGovern K, Bydon A.

Clin Neurol Neurosurg. 2014 May;120:136-41. doi: 10.1016/j.clineuro.2014.02.013. Epub 2014 Feb 25. Review.


Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity.

Peluso MO, Campbell VT, Harari JA, Tibbitts TT, Proctor JL, Whitebread N, Conley JM, White KF, Kutok JL, Read MA, McGovern K, Faia KL.

PLoS One. 2014 Mar 7;9(3):e90534. doi: 10.1371/journal.pone.0090534. eCollection 2014.


Molecular mechanisms underlying beta-arrestin-dependent chemotaxis and actin-cytoskeletal reorganization.

McGovern KW, DeFea KA.

Handb Exp Pharmacol. 2014;219:341-59. doi: 10.1007/978-3-642-41199-1_17.


Dark side illuminated: imaging of Toxoplasma gondii through the decades.

McGovern KE, Wilson EH.

Parasit Vectors. 2013 Nov 22;6(1):334. doi: 10.1186/1756-3305-6-334. Review.


Asthma and physical activity in multiracial girls from three US sites.

Vangeepuram N, McGovern KJ, Teitelbaum S, Galvez MP, Pinney SM, Biro FM, Kushi LH, Wolff MS.

J Asthma. 2014 Mar;51(2):193-9. doi: 10.3109/02770903.2013.853081. Epub 2013 Nov 15.


Involvement and targeted intervention of dysregulated Hedgehog signaling in osteosarcoma.

Lo WW, Wunder JS, Dickson BC, Campbell V, McGovern K, Alman BA, Andrulis IL.

Cancer. 2014 Feb 15;120(4):537-47. doi: 10.1002/cncr.28439. Epub 2013 Oct 21.


The pre-clinical absorption, distribution, metabolism and excretion properties of IPI-926, an orally bioavailable antagonist of the hedgehog signal transduction pathway.

Smith S, Hoyt J, Whitebread N, Manna J, Peluso M, Faia K, Campbell V, Tremblay M, Nair S, Grogan M, Castro A, Campbell M, Ferguson J, Arsenault B, Nevejans J, Carter B, Lee J, Dunbar J, McGovern K, Read M, Adams J, Constan A, Loewen G, Sydor J, Palombella V, Soglia J.

Xenobiotica. 2013 Oct;43(10):875-85. doi: 10.3109/00498254.2013.780671. Epub 2013 Mar 25.


The effects of hyperglycemia and endotoxemia on coagulation parameters in healthy adult horses.

McGovern KF, Lascola KM, Smith SA, Clark-Price SC, Wilkins PA, Schaeffer DJ, Foreman JH.

J Vet Intern Med. 2013 Mar-Apr;27(2):347-53. doi: 10.1111/jvim.12052. Epub 2013 Mar 10.


Associations between neighborhood resources and physical activity in inner-city minority children.

Galvez MP, McGovern K, Knuff C, Resnick S, Brenner B, Teitelbaum SL, Wolff MS.

Acad Pediatr. 2013 Jan-Feb;13(1):20-6. doi: 10.1016/j.acap.2012.09.001.


Role of Chemokines and Trafficking of Immune Cells in Parasitic Infections.

McGovern KE, Wilson EH.

Curr Immunol Rev. 2013;9(3):157-168.


Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors.

Liu T, Nair SJ, Lescarbeau A, Belani J, Peluso S, Conley J, Tillotson B, O'Hearn P, Smith S, Slocum K, West K, Helble J, Douglas M, Bahadoor A, Ali J, McGovern K, Fritz C, Palombella VJ, Wylie A, Castro AC, Tremblay MR.

J Med Chem. 2012 Oct 25;55(20):8859-78. doi: 10.1021/jm3011542. Epub 2012 Oct 12.


Assessment of acute moderate hyperglycemia on traditional and thromboelastometry coagulation parameters in healthy adult horses.

McGovern KF, Lascola KM, Smith SA, Clark-Price SC, McMichael M, Wilkins PA.

J Vet Emerg Crit Care (San Antonio). 2012 Oct;22(5):550-7. doi: 10.1111/j.1476-4431.2012.00792.x. Epub 2012 Aug 29.


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