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Items: 22


LRRC15 Is a Novel Mesenchymal Protein and Stromal Target for Antibody-Drug Conjugates.

Purcell JW, Tanlimco SG, Hickson J, Fox M, Sho M, Durkin L, Uziel T, Powers R, Foster K, McGonigal T, Kumar S, Samayoa J, Zhang D, Palma JP, Mishra S, Hollenbaugh D, Gish K, Morgan-Lappe SE, Hsi ED, Chao DT.

Cancer Res. 2018 Jul 15;78(14):4059-4072. doi: 10.1158/0008-5472.CAN-18-0327. Epub 2018 May 15.


The Volume of Three-Dimensional Cultures of Cancer Cells InVitro Influences Transcriptional Profile Differences and Similarities with Monolayer Cultures and Xenografted Tumors.

Boghaert ER, Lu X, Hessler PE, McGonigal TP, Oleksijew A, Mitten MJ, Foster-Duke K, Hickson JA, Santo VE, Brito C, Uziel T, Vaidya KS.

Neoplasia. 2017 Sep;19(9):695-706. doi: 10.1016/j.neo.2017.06.004. Epub 2017 Aug 5.


Clearance of systemic hematologic tumors by venetoclax (Abt-199) and navitoclax.

Ackler S, Oleksijew A, Chen J, Chyla BJ, Clarin J, Foster K, McGonigal T, Mishra S, Schlessinger S, Smith ML, Tahir SK, Leverson JD, Souers AJ, Boghaert ER, Hickson J.

Pharmacol Res Perspect. 2015 Oct;3(5):e00178. doi: 10.1002/prp2.178. Epub 2015 Sep 1.


Acquired resistance to combination treatment with temozolomide and ABT-888 is mediated by both base excision repair and homologous recombination DNA repair pathways.

Liu X, Han EK, Anderson M, Shi Y, Semizarov D, Wang G, McGonigal T, Roberts L, Lasko L, Palma J, Zhu GD, Penning T, Rosenberg S, Giranda VL, Luo Y, Leverson J, Johnson EF, Shoemaker AR.

Mol Cancer Res. 2009 Oct;7(10):1686-92. doi: 10.1158/1541-7786.MCR-09-0299. Epub 2009 Oct 13.


Characterization of Akt overexpression in MiaPaCa-2 cells: prohibitin is an Akt substrate both in vitro and in cells.

Han EK, Mcgonigal T, Butler C, Giranda VL, Luo Y.

Anticancer Res. 2008 Mar-Apr;28(2A):957-63.


Role of focal adhesion kinase in human cancer: a potential target for drug discovery.

Han EK, McGonigal T.

Anticancer Agents Med Chem. 2007 Nov;7(6):681-4. Review.


ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models.

Donawho CK, Luo Y, Luo Y, Penning TD, Bauch JL, Bouska JJ, Bontcheva-Diaz VD, Cox BF, DeWeese TL, Dillehay LE, Ferguson DC, Ghoreishi-Haack NS, Grimm DR, Guan R, Han EK, Holley-Shanks RR, Hristov B, Idler KB, Jarvis K, Johnson EF, Kleinberg LR, Klinghofer V, Lasko LM, Liu X, Marsh KC, McGonigal TP, Meulbroek JA, Olson AM, Palma JP, Rodriguez LE, Shi Y, Stavropoulos JA, Tsurutani AC, Zhu GD, Rosenberg SH, Giranda VL, Frost DJ.

Clin Cancer Res. 2007 May 1;13(9):2728-37.


Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition.

Han EK, Leverson JD, McGonigal T, Shah OJ, Woods KW, Hunter T, Giranda VL, Luo Y.

Oncogene. 2007 Aug 16;26(38):5655-61. Epub 2007 Mar 5.


Optimal classes of chemotherapeutic agents sensitized by specific small-molecule inhibitors of akt in vitro and in vivo.

Shi Y, Liu X, Han EK, Guan R, Shoemaker AR, Oleksijew A, Woods KW, Fisher JP, Klinghofer V, Lasko L, McGonigal T, Li Q, Rosenberg SH, Giranda VL, Luo Y.

Neoplasia. 2005 Nov;7(11):992-1000.


Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo.

Luo Y, Shoemaker AR, Liu X, Woods KW, Thomas SA, de Jong R, Han EK, Li T, Stoll VS, Powlas JA, Oleksijew A, Mitten MJ, Shi Y, Guan R, McGonigal TP, Klinghofer V, Johnson EF, Leverson JD, Bouska JJ, Mamo M, Smith RA, Gramling-Evans EE, Zinker BA, Mika AK, Nguyen PT, Oltersdorf T, Rosenberg SH, Li Q, Giranda VL.

Mol Cancer Ther. 2005 Jun;4(6):977-86.


Functional analysis of focal adhesion kinase (FAK) reduction by small inhibitory RNAs.

Han EK, Mcgonigal T, Wang J, Giranda VL, Luo Y.

Anticancer Res. 2004 Nov-Dec;24(6):3899-905.


Survivin enhances Aurora-B kinase activity and localizes Aurora-B in human cells.

Chen J, Jin S, Tahir SK, Zhang H, Liu X, Sarthy AV, McGonigal TP, Liu Z, Rosenberg SH, Ng SC.

J Biol Chem. 2003 Jan 3;278(1):486-90. Epub 2002 Nov 4.


Species specificity of amidine-based urokinase inhibitors.

Klinghofer V, Stewart K, McGonigal T, Smith R, Sarthy A, Nienaber V, Butler C, Dorwin S, Richardson P, Weitzberg M, Wendt M, Rockway T, Zhao X, Hulkower KI, Giranda VL.

Biochemistry. 2001 Aug 7;40(31):9125-31.


Domain structure analysis of elongation factor-3 from Saccharomyces cerevisiae by limited proteolysis and differential scanning calorimetry.

Ladror US, Egan DA, Snyder SW, Capobianco JO, Goldman RC, Dorwin SA, Johnson RW, Edalji R, Sarthy AV, McGonigal T, Walter KA, Holzman TF.

Protein Sci. 1998 Dec;7(12):2595-601.


Identification and kinetic analysis of a functional homolog of elongation factor 3, YEF3 in Saccharomyces cerevisiae.

Sarthy AV, McGonigal T, Capobianco JO, Schmidt M, Green SR, Moehle CM, Goldman RC.

Yeast. 1998 Feb;14(3):239-53. Erratum in: Yeast 1998 Jun 15;14(8):792.


Construction of a sorbitol-based vector for expression of heterologous proteins in Saccharomyces cerevisiae.

McGonigal T, Bodelle P, Schopp C, Sarthy AV.

Appl Environ Microbiol. 1998 Feb;64(2):793-4.


High-level overexpression of yeast elongation factor 3 and detailed kinetic analysis using a coupled spectrophotometric assay.

Sarthy AV, McGonigal T, Capobianco JO, Holzman TH, Walter KA, Egan DA, Goldman RC.

Anal Biochem. 1997 Dec 15;254(2):288-90. No abstract available.


Phenotype in Candida albicans of a disruption of the BGL2 gene encoding a 1,3-beta-glucosyltransferase.

Sarthy AV, McGonigal T, Coen M, Frost DJ, Meulbroek JA, Goldman RC.

Microbiology. 1997 Feb;143 ( Pt 2):367-76.


Identification of the gene encoding DNA topoisomerase I from Candida albicans.

Taylor A, Giles K, Sarthy AV, McGonigal T, Fostel J.

FEMS Microbiol Lett. 1996 May 1;138(2-3):113-21.


Construction of a human DNA library in a circular centromere-based yeast plasmid.

McGonigal T, Bodelle P, Schopp C, Sarthy AV.

Gene. 1995 Apr 3;155(2):267-71.


Expression of the gene coding for the major outer capsid protein of SA-11 rotavirus in a baculovirus system.

McGonigal TP, Turon MC, Komar-Hartnett K, Kister SE, Smith RE.

Virus Res. 1992 Apr;23(1-2):135-50.


Clones from the human gene complex coding for salivary proline-rich proteins.

Azen E, Lyons KM, McGonigal T, Barrett NL, Clements LS, Maeda N, Vanin EF, Carlson DM, Smithies O.

Proc Natl Acad Sci U S A. 1984 Sep;81(17):5561-5.

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