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Items: 35


Different monocyte phenotypes result in proresolving macrophages in conjugated linoleic acid-induced attenuated progression and regression of atherosclerosis.

Bruen R, Curley S, Kajani S, Lynch G, O'Reilly ME, Dillon ET, Fitzsimons S, Mthunzi L, McGillicuddy FC, Belton O.

FASEB J. 2019 Jul 5:fj201900922R. doi: 10.1096/fj.201900922R. [Epub ahead of print]


Liraglutide Attenuates Preestablished Atherosclerosis in Apolipoprotein E-Deficient Mice via Regulation of Immune Cell Phenotypes and Proinflammatory Mediators.

Bruen R, Curley S, Kajani S, Lynch G, O'Reilly ME, Dillon ET, Brennan EP, Barry M, Sheehan S, McGillicuddy FC, Belton O.

J Pharmacol Exp Ther. 2019 Sep;370(3):447-458. doi: 10.1124/jpet.119.258343. Epub 2019 Jul 3.


SerpinA3N is a novel hypothalamic gene upregulated by a high-fat diet and leptin in mice.

Sergi D, Campbell FM, Grant C, Morris AC, Bachmair EM, Koch C, McLean FH, Muller A, Hoggard N, de Roos B, Porteiro B, Boekschoten MV, McGillicuddy FC, Kahn D, Nicol P, Benzler J, Mayer CD, Drew JE, Roche HM, Muller M, Nogueiras R, Dieguez C, Tups A, Williams LM.

Genes Nutr. 2018 Nov 29;13:28. doi: 10.1186/s12263-018-0619-1. eCollection 2018.


Nutritionally Derived Metabolic Cues Typical of the Obese Microenvironment Increase Cholesterol Efflux Capacity of Adipose Tissue Macrophages.

O'Reilly ME, Kajani S, Ralston JC, Lenighan YM, Roche HM, McGillicuddy FC.

Mol Nutr Food Res. 2019 Jan;63(2):e1800713. doi: 10.1002/mnfr.201800713. Epub 2018 Nov 20.


Unravelling HDL-Looking beyond the Cholesterol Surface to the Quality Within.

Kajani S, Curley S, McGillicuddy FC.

Int J Mol Sci. 2018 Jul 6;19(7). pii: E1971. doi: 10.3390/ijms19071971. Review.


Personalized Cardio-Metabolic Responses to an Anti-Inflammatory Nutrition Intervention in Obese Adolescents: A Randomized Controlled Crossover Trial.

McMorrow AM, Connaughton RM, Magalhães TR, McGillicuddy FC, Hughes MF, Cheishvili D, Morine MJ, Ennis S, Healy ML, Roche EF, Tremblay RE, Szyf M, Lithander FE, Roche HM.

Mol Nutr Food Res. 2018 May;62(10):e1701008. doi: 10.1002/mnfr.201701008.


Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosis.

Bruen R, Curley S, Kajani S, Crean D, O'Reilly ME, Lucitt MB, Godson CG, McGillicuddy FC, Belton O.

Cardiovasc Diabetol. 2017 Nov 6;16(1):143. doi: 10.1186/s12933-017-0626-3.


Nutritional modulation of metabolic inflammation.

Kirwan AM, Lenighan YM, O'Reilly ME, McGillicuddy FC, Roche HM.

Biochem Soc Trans. 2017 Aug 15;45(4):979-985. doi: 10.1042/BST20160465. Epub 2017 Jul 14. Review.


Total HDL cholesterol efflux capacity in healthy children - Associations with adiposity and dietary intakes of mother and child.

Khalil H, Murrin C, O'Reilly M, Viljoen K, Segurado R, O'Brien J, Somerville R, McGillicuddy F, Kelleher CC.

Nutr Metab Cardiovasc Dis. 2017 Jan;27(1):70-77. doi: 10.1016/j.numecd.2016.10.002. Epub 2016 Oct 12.


A casein hydrolysate protects mice against high fat diet induced hyperglycemia by attenuating NLRP3 inflammasome-mediated inflammation and improving insulin signaling.

Healy NP, Kirwan AM, McArdle MA, Holohan K, Nongonierma AB, Keane D, Kelly S, Celkova L, Lyons CL, McGillicuddy FC, Finucane OM, Murray BA, Kelly PM, Brennan L, FitzGerald RJ, Roche HM.

Mol Nutr Food Res. 2016 Nov;60(11):2421-2432. doi: 10.1002/mnfr.201501054. Epub 2016 Sep 8.


High-Density Lipoprotein Proteomic Composition, and not Efflux Capacity, Reflects Differential Modulation of Reverse Cholesterol Transport by Saturated and Monounsaturated Fat Diets.

O'Reilly M, Dillon E, Guo W, Finucane O, McMorrow A, Murphy A, Lyons C, Jones D, Ryan M, Gibney M, Gibney E, Brennan L, de la Llera Moya M, Reilly MP, Roche HM, McGillicuddy FC.

Circulation. 2016 May 10;133(19):1838-50. doi: 10.1161/CIRCULATIONAHA.115.020278. Epub 2016 Apr 14.


Impact of anti-inflammatory nutrients on obesity-associated metabolic-inflammation from childhood through to adulthood.

Connaughton RM, McMorrow AM, McGillicuddy FC, Lithander FE, Roche HM.

Proc Nutr Soc. 2016 May;75(2):115-24. doi: 10.1017/S0029665116000070. Epub 2016 Mar 3. Review.


Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1β secretion and insulin resistance despite obesity.

Finucane OM, Lyons CL, Murphy AM, Reynolds CM, Klinger R, Healy NP, Cooke AA, Coll RC, McAllan L, Nilaweera KN, O'Reilly ME, Tierney AC, Morine MJ, Alcala-Diaz JF, Lopez-Miranda J, O'Connor DP, O'Neill LA, McGillicuddy FC, Roche HM.

Diabetes. 2015 Jun;64(6):2116-28. doi: 10.2337/db14-1098. Epub 2015 Jan 27.


Macrophage migration inhibitory factor deficiency ameliorates high-fat diet induced insulin resistance in mice with reduced adipose inflammation and hepatic steatosis.

Finucane OM, Reynolds CM, McGillicuddy FC, Harford KA, Morrison M, Baugh J, Roche HM.

PLoS One. 2014 Nov 20;9(11):e113369. doi: 10.1371/journal.pone.0113369. eCollection 2014.


Translational studies of A20 in atherosclerosis and cardiovascular disease.

McGillicuddy FC, Moll HP, Farouk S, Damrauer SM, Ferran C, Reilly MP.

Adv Exp Med Biol. 2014;809:83-101.


Long-term exposure to a high-fat diet results in the development of glucose intolerance and insulin resistance in interleukin-1 receptor I-deficient mice.

McGillicuddy FC, Reynolds CM, Finucane O, Coleman E, Harford KA, Grant C, Sergi D, Williams LM, Mills KH, Roche HM.

Am J Physiol Endocrinol Metab. 2013 Oct 1;305(7):E834-44. doi: 10.1152/ajpendo.00297.2013. Epub 2013 Aug 6.


Insights into the role of macrophage migration inhibitory factor in obesity and insulin resistance.

Finucane OM, Reynolds CM, McGillicuddy FC, Roche HM.

Proc Nutr Soc. 2012 Nov;71(4):622-33. doi: 10.1017/S0029665112000730. Epub 2012 Aug 22. Review.


Network analysis of adipose tissue gene expression highlights altered metabolic and regulatory transcriptomic activity in high-fat-diet-fed IL-1RI knockout mice.

Morine MJ, Toomey S, McGillicuddy FC, Reynolds CM, Power KA, Browne JA, Loscher C, Mills KH, Roche HM.

J Nutr Biochem. 2013 May;24(5):788-95. doi: 10.1016/j.jnutbio.2012.04.012. Epub 2012 Jul 26.


Nutritional status, genetic susceptibility, and insulin resistance--important precedents to atherosclerosis.

McGillicuddy FC, Roche HM.

Mol Nutr Food Res. 2012 Jul;56(7):1173-84. doi: 10.1002/mnfr.201100785. Review.


Lipoxin A4 attenuates adipose inflammation.

Börgeson E, McGillicuddy FC, Harford KA, Corrigan N, Higgins DF, Maderna P, Roche HM, Godson C.

FASEB J. 2012 Oct;26(10):4287-94. doi: 10.1096/fj.12-208249. Epub 2012 Jun 14.


Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance.

Reynolds CM, McGillicuddy FC, Harford KA, Finucane OM, Mills KH, Roche HM.

Mol Nutr Food Res. 2012 Aug;56(8):1212-22. doi: 10.1002/mnfr.201200058. Epub 2012 Jun 15.


Inflammation modulates human HDL composition and function in vivo.

de la Llera Moya M, McGillicuddy FC, Hinkle CC, Byrne M, Joshi MR, Nguyen V, Tabita-Martinez J, Wolfe ML, Badellino K, Pruscino L, Mehta NN, Asztalos BF, Reilly MP.

Atherosclerosis. 2012 Jun;222(2):390-4. doi: 10.1016/j.atherosclerosis.2012.02.032. Epub 2012 Feb 28.


Docosahexaenoic acid attenuates macrophage-induced inflammation and improves insulin sensitivity in adipocytes-specific differential effects between LC n-3 PUFA.

Oliver E, McGillicuddy FC, Harford KA, Reynolds CM, Phillips CM, Ferguson JF, Roche HM.

J Nutr Biochem. 2012 Sep;23(9):1192-200. doi: 10.1016/j.jnutbio.2011.06.014. Epub 2011 Dec 1.


Adipose modulation of high-density lipoprotein cholesterol: implications for obesity, high-density lipoprotein metabolism, and cardiovascular disease.

McGillicuddy FC, Reilly MP, Rader DJ.

Circulation. 2011 Oct 11;124(15):1602-5. doi: 10.1161/CIRCULATIONAHA.111.058453. No abstract available.


Fats, inflammation and insulin resistance: insights to the role of macrophage and T-cell accumulation in adipose tissue.

Harford KA, Reynolds CM, McGillicuddy FC, Roche HM.

Proc Nutr Soc. 2011 Nov;70(4):408-17. doi: 10.1017/S0029665111000565. Epub 2011 Aug 12. Review.


Lack of interleukin-1 receptor I (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis.

McGillicuddy FC, Harford KA, Reynolds CM, Oliver E, Claessens M, Mills KH, Roche HM.

Diabetes. 2011 Jun;60(6):1688-98. doi: 10.2337/db10-1278. Epub 2011 Apr 22.


Adipocyte modulation of high-density lipoprotein cholesterol.

Zhang Y, McGillicuddy FC, Hinkle CC, O'Neill S, Glick JM, Rothblat GH, Reilly MP.

Circulation. 2010 Mar 23;121(11):1347-55. doi: 10.1161/CIRCULATIONAHA.109.897330. Epub 2010 Mar 8.


The role of inflammation and macrophage accumulation in the development of obesity-induced type 2 diabetes mellitus and the possible therapeutic effects of long-chain n-3 PUFA.

Oliver E, McGillicuddy F, Phillips C, Toomey S, Roche HM.

Proc Nutr Soc. 2010 May;69(2):232-43. doi: 10.1017/S0029665110000042. Epub 2010 Feb 17. Review.


Experimental endotoxemia induces adipose inflammation and insulin resistance in humans.

Mehta NN, McGillicuddy FC, Anderson PD, Hinkle CC, Shah R, Pruscino L, Tabita-Martinez J, Sellers KF, Rickels MR, Reilly MP.

Diabetes. 2010 Jan;59(1):172-81. doi: 10.2337/db09-0367. Epub 2009 Sep 30.


Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway.

McGillicuddy FC, Chiquoine EH, Hinkle CC, Kim RJ, Shah R, Roche HM, Smyth EM, Reilly MP.

J Biol Chem. 2009 Nov 13;284(46):31936-44. doi: 10.1074/jbc.M109.061655. Epub 2009 Sep 23.


Gene profiling of human adipose tissue during evoked inflammation in vivo.

Shah R, Lu Y, Hinkle CC, McGillicuddy FC, Kim R, Hannenhalli S, Cappola TP, Heffron S, Wang X, Mehta NN, Putt M, Reilly MP.

Diabetes. 2009 Oct;58(10):2211-9. doi: 10.2337/db09-0256. Epub 2009 Jul 6.


Inflammation impairs reverse cholesterol transport in vivo.

McGillicuddy FC, de la Llera Moya M, Hinkle CC, Joshi MR, Chiquoine EH, Billheimer JT, Rothblat GH, Reilly MP.

Circulation. 2009 Mar 3;119(8):1135-45. doi: 10.1161/CIRCULATIONAHA.108.810721. Epub 2009 Feb 16.


Novel "plum pudding" gels as potential drug-eluting stent coatings: controlled release of fluvastatin.

McGillicuddy FC, Lynch I, Rochev YA, Burke M, Dawson KA, Gallagher WM, Keenan AK.

J Biomed Mater Res A. 2006 Dec 15;79(4):923-33.


TGF-beta1-induced thrombospondin-1 expression through the p38 MAPK pathway is abolished by fluvastatin in human coronary artery smooth muscle cells.

McGillicuddy FC, O'Toole D, Hickey JA, Gallagher WM, Dawson KA, Keenan AK.

Vascul Pharmacol. 2006 Jun;44(6):469-75. Epub 2006 Apr 19.


Extended delivery of the antimitotic agent colchicine from thermoresponsive N-isopropylacrylamide-based copolymer films to human vascular smooth muscle cells.

Wilson SJ, Gorelov AV, Rochev YA, McGillicuddy F, Dawson KA, Gallagher WM, Keenan AK.

J Biomed Mater Res A. 2003 Nov 1;67(2):667-73.


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