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Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration.

Ewing LE, McGill MR, Yee EU, Quick CM, Skinner CM, Kennon-McGill S, Clemens M, Vazquez JH, McCullough SS, Williams DK, Kutanzi KR, Walker LA, ElSohly MA, James LP, Gurley BJ, Koturbash I.

Molecules. 2019 Jun 17;24(12). pii: E2256. doi: 10.3390/molecules24122256.


Expression of drug metabolizing enzymes and transporters in the cochlea: Implications for drug delivery and ototoxicity.

Kennon-McGill S, Clemens MM, McGill MR.

Hear Res. 2019 Aug;379:98-102. doi: 10.1016/j.heares.2019.05.002. Epub 2019 May 15.


Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model.

Ewing LE, Skinner CM, Quick CM, Kennon-McGill S, McGill MR, Walker LA, ElSohly MA, Gurley BJ, Koturbash I.

Molecules. 2019 Apr 30;24(9). pii: E1694. doi: 10.3390/molecules24091694.


Animal models of drug-induced liver injury.

McGill MR, Jaeschke H.

Biochim Biophys Acta Mol Basis Dis. 2019 May 1;1865(5):1031-1039. doi: 10.1016/j.bbadis.2018.08.037. Epub 2018 Sep 3. Review.


Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F₁ Mice.

Gurley BJ, Miousse IR, Nookaew I, Ewing LE, Skinner CM, Jenjaroenpun P, Wongsurawat T, Kennon-McGill S, Avula B, Bae JY, McGill MR, Ussery D, Khan IA, Koturbash I.

Nutrients. 2019 Apr 3;11(4). pii: E776. doi: 10.3390/nu11040776.


Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange.

Kennedy RC, Smith AK, Ropella GEP, McGill MR, Jaeschke H, Hunt CA.

Toxicol Sci. 2019 May 1;169(1):151-166. doi: 10.1093/toxsci/kfz029.


The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling.

Clemens MM, Kennon-McGill S, Apte U, James LP, Finck BN, McGill MR.

Food Chem Toxicol. 2019 Mar;125:279-288. doi: 10.1016/j.fct.2019.01.014. Epub 2019 Jan 14.


Acetaminophen is both bronchodilatory and bronchoprotective in human precision cut lung slice airways.

Kennedy JL, Kurten RC, McCullough S, Panettieri RA, Koziol-White C, Jones SM, Caid K, Gill PS, Roberts D, Jaeschke H, McGill MR, James L.

Xenobiotica. 2019 Sep;49(9):1106-1115. doi: 10.1080/00498254.2018.1536814. Epub 2019 Jan 30.


Carpenter ants use diverse antennae sampling strategies to track odor trails.

Draft RW, McGill MR, Kapoor V, Murthy VN.

J Exp Biol. 2018 Nov 19;221(Pt 22). pii: jeb185124. doi: 10.1242/jeb.185124.


The Problem With Predictive Values: Are We Using the Right Metrics for Preclinical Prediction of Drug Hepatotoxicity?

McGill MR.

Toxicol Sci. 2018 Sep 1;165(1):3-4. doi: 10.1093/toxsci/kfy157. No abstract available.


Biomarkers of drug-induced liver injury: progress and utility in research, medicine, and regulation.

McGill MR, Jaeschke H.

Expert Rev Mol Diagn. 2018 Sep;18(9):797-807. doi: 10.1080/14737159.2018.1508998. Epub 2018 Aug 13. Review.


Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration.

Lutkewitte AJ, Schweitzer GG, Kennon-McGill S, Clemens MM, James LP, Jaeschke H, Finck BN, McGill MR.

Food Chem Toxicol. 2018 May;115:273-283. doi: 10.1016/j.fct.2018.03.014. Epub 2018 Mar 11. No abstract available.



Kennon-McGill S, McGill MR.

J Clin Transl Res. 2018 Jan 15;3(3). pii: 5. doi: 10.18053/jctres.03.201703.005. Epub 2017 Nov 18.


Modulation of O-GlcNAc Levels in the Liver Impacts Acetaminophen-Induced Liver Injury by Affecting Protein Adduct Formation and Glutathione Synthesis.

McGreal SR, Bhushan B, Walesky C, McGill MR, Lebofsky M, Kandel SE, Winefield RD, Jaeschke H, Zachara NE, Zhang Z, Tan EP, Slawson C, Apte U.

Toxicol Sci. 2018 Apr 1;162(2):599-610. doi: 10.1093/toxsci/kfy002.


Increased C-Reactive Protein in Healthy Controls.

McGill MR, Gronowski AM.

Clin Chem. 2018 Jan;64(1):242-243. doi: 10.1373/clinchem.2017.274746. No abstract available.


Extrahepatic toxicity of acetaminophen: critical evaluation of the evidence and proposed mechanisms.

Kennon-McGill S, McGill MR.

J Clin Transl Res. 2017 Nov 18;3(3):297-310. eCollection 2018 Jan 15. Review.


Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity.

Du K, Ramachandran A, McGill MR, Mansouri A, Asselah T, Farhood A, Woolbright BL, Ding WX, Jaeschke H.

Food Chem Toxicol. 2017 Oct;108(Pt A):339-350. doi: 10.1016/j.fct.2017.08.020. Epub 2017 Aug 18.


Professionalism in Residency Training: A Compilation of Desirable Behaviors and a Case-Based Comparison Between Pathologists in Training and Practice.

Gronowski AM, McGill MR, Domen RE.

Acad Pathol. 2016 Sep 16;3:2374289516667509. doi: 10.1177/2374289516667509. eCollection 2016 Jan-Dec.


Erratum to: Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity.

Maes M, McGill MR, da Silva TC, Abels C, Lebofsky M, Weemhoff JL, Tiburcio T, Pereira IVA, Willebrords J, Yanguas SC, Farhood A, Beschin A, Van Ginderachter JA, Penuela S, Jaeschke H, Cogliati B, Vinken M.

Arch Toxicol. 2017 May;91(5):2263-2264. doi: 10.1007/s00204-016-1929-y. No abstract available.


Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice.

Bhushan B, Chavan H, Borude P, Xie Y, Du K, McGill MR, Lebofsky M, Jaeschke H, Krishnamurthy P, Apte U.

Toxicol Sci. 2017 Feb;155(2):363-378. doi: 10.1093/toxsci/kfw213. Epub 2016 Oct 23.


Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity.

Maes M, McGill MR, da Silva TC, Abels C, Lebofsky M, Weemhoff JL, Tiburcio T, Veloso Alves Pereira I, Willebrords J, Crespo Yanguas S, Farhood A, Beschin A, Van Ginderachter JA, Penuela S, Jaeschke H, Cogliati B, Vinken M.

Arch Toxicol. 2017 May;91(5):2245-2261. doi: 10.1007/s00204-016-1885-6. Epub 2016 Nov 8. Erratum in: Arch Toxicol. 2017 May;91(5):2263-2264.


Falsely Elevated Plasma Creatinine Due to an Immunoglobulin M Paraprotein.

McGill MR, Vijayan A, Trulock EP, Witt CA, Kohler GD, Scott MG.

Am J Kidney Dis. 2016 Nov;68(5):789-792. doi: 10.1053/j.ajkd.2016.05.014. Epub 2016 Jul 22.


Caspase Inhibition Prevents Tumor Necrosis Factor-α-Induced Apoptosis and Promotes Necrotic Cell Death in Mouse Hepatocytes in Vivo and in Vitro.

Ni HM, McGill MR, Chao X, Woolbright BL, Jaeschke H, Ding WX.

Am J Pathol. 2016 Oct;186(10):2623-36. doi: 10.1016/j.ajpath.2016.06.009. Epub 2016 Sep 9.


Plasma biomarkers to study mechanisms of liver injury in patients with hypoxic hepatitis.

Weemhoff JL, Woolbright BL, Jenkins RE, McGill MR, Sharpe MR, Olson JC, Antoine DJ, Curry SC, Jaeschke H.

Liver Int. 2017 Mar;37(3):377-384. doi: 10.1111/liv.13202. Epub 2016 Aug 6.


Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice.

Ni HM, McGill MR, Chao X, Du K, Williams JA, Xie Y, Jaeschke H, Ding WX.

J Hepatol. 2016 Aug;65(2):354-62. doi: 10.1016/j.jhep.2016.04.025. Epub 2016 May 2.


Hearing, reactive metabolite formation, and oxidative stress in cochleae after a single acute overdose of acetaminophen: an in vivo study.

McGill MR, Kennon-McGill S, Durham D, Jaeschke H.

Toxicol Mech Methods. 2016 Feb;26(2):104-11. doi: 10.3109/15376516.2015.1122136. Epub 2016 Mar 16.


Involvement of connexin43 in acetaminophen-induced liver injury.

Maes M, McGill MR, da Silva TC, Abels C, Lebofsky M, Maria Monteiro de Araújo C, Tiburcio T, Veloso Alves Pereira I, Willebrords J, Crespo Yanguas S, Farhood A, Beschin A, Van Ginderachter JA, Zaidan Dagli ML, Jaeschke H, Cogliati B, Vinken M.

Biochim Biophys Acta. 2016 Jun;1862(6):1111-21. doi: 10.1016/j.bbadis.2016.02.007. Epub 2016 Feb 18.


A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen.

Michaut A, Le Guillou D, Moreau C, Bucher S, McGill MR, Martinais S, Gicquel T, Morel I, Robin MA, Jaeschke H, Fromenty B.

Toxicol Appl Pharmacol. 2016 Feb 1;292:40-55. doi: 10.1016/j.taap.2015.12.020. Epub 2015 Dec 29.


Connexin32: a mediator of acetaminophen-induced liver injury?

Maes M, McGill MR, da Silva TC, Lebofsky M, Maria Monteiro de Araújo C, Tiburcio T, Veloso Alves Pereira I, Willebrords J, Crespo Yanguas S, Farhood A, Zaidan Dagli ML, Jaeschke H, Cogliati B, Vinken M.

Toxicol Mech Methods. 2016 Feb;26(2):88-96. doi: 10.3109/15376516.2015.1103000. Epub 2016 Jan 7.


Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity.

Xie Y, Woolbright BL, Kos M, McGill MR, Dorko K, Kumer SC, Schmitt TM, Jaeschke H.

J Clin Transl Res. 2015;1(2):100-106. Epub 2015 Sep 30.


Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver.

Hu J, Ramshesh VK, McGill MR, Jaeschke H, Lemasters JJ.

Toxicol Sci. 2016 Mar;150(1):204-15. doi: 10.1093/toxsci/kfv319. Epub 2015 Dec 31.


The past and present of serum aminotransferases and the future of liver injury biomarkers.

McGill MR.

EXCLI J. 2016 Dec 15;15:817-828. doi: 10.17179/excli2016-800. eCollection 2016. Review.


Critical review of resveratrol in xenobiotic-induced hepatotoxicity.

McGill MR, Du K, Weemhoff JL, Jaeschke H.

Food Chem Toxicol. 2015 Dec;86:309-18. doi: 10.1016/j.fct.2015.11.003. Epub 2015 Nov 10. Review.


Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses.

Du K, McGill MR, Xie Y, Jaeschke H.

Food Chem Toxicol. 2015 Dec;86:253-61. doi: 10.1016/j.fct.2015.10.016. Epub 2015 Oct 30.


A direct comparison of methods used to measure oxidized glutathione in biological samples: 2-vinylpyridine and N-ethylmaleimide.

Mcgill MR, Jaeschke H.

Toxicol Mech Methods. 2015;25(8):589-95. doi: 10.3109/15376516.2015.1094844. Epub 2015 Oct 13.


Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes.

Xie Y, McGill MR, Du K, Dorko K, Kumer SC, Schmitt TM, Ding WX, Jaeschke H.

Toxicol Appl Pharmacol. 2015 Dec 1;289(2):213-22. doi: 10.1016/j.taap.2015.09.022. Epub 2015 Sep 30.


Lack of direct cytotoxicity of extracellular ATP against hepatocytes: role in the mechanism of acetaminophen hepatotoxicity.

Xie Y, Woolbright BL, Kos M, McGill MR, Dorko K, Kumer SC, Schmitt TM, Jaeschke H.

J Clin Transl Res. 2015 Sep 30;1(2):1-7. eCollection 2015 Sep 30.


Acetaminophen-induced Liver Injury: from Animal Models to Humans.

Jaeschke H, Xie Y, McGill MR.

J Clin Transl Hepatol. 2014 Sep;2(3):153-61. doi: 10.14218/JCTH.2014.00014. Epub 2014 Sep 15. Review.


Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity.

Du K, Xie Y, McGill MR, Jaeschke H.

Expert Opin Drug Metab Toxicol. 2015;11(11):1769-79. doi: 10.1517/17425255.2015.1071353. Epub 2015 Jul 20. Review.


Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice.

Miyakawa K, Joshi N, Sullivan BP, Albee R, Brandenberger C, Jaeschke H, McGill MR, Scott MA, Ganey PE, Luyendyk JP, Roth RA.

Blood. 2015 Oct 8;126(15):1835-43. doi: 10.1182/blood-2014-09-598656. Epub 2015 Jul 15.


Bile Acid-Induced Toxicity in HepaRG Cells Recapitulates the Response in Primary Human Hepatocytes.

Woolbright BL, McGill MR, Yan H, Jaeschke H.

Basic Clin Pharmacol Toxicol. 2016 Feb;118(2):160-7. doi: 10.1111/bcpt.12449. Epub 2015 Aug 13.


MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury.

McGill MR, Jaeschke H.

J Clin Med. 2015 May 20;4(5):1063-78. doi: 10.3390/jcm4051063. eCollection 2015 May. Review.


Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells.

Xie Y, McGill MR, Cook SF, Sharpe MR, Winefield RD, Wilkins DG, Rollins DE, Jaeschke H.

Xenobiotica. 2015;45(10):921-9. doi: 10.3109/00498254.2015.1026426. Epub 2015 Apr 14.


Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity.

Du K, McGill MR, Xie Y, Bajt ML, Jaeschke H.

Food Chem Toxicol. 2015 Jul;81:62-70. doi: 10.1016/j.fct.2015.04.014. Epub 2015 Apr 9.


Cytochrome P450-derived versus mitochondrial oxidant stress in acetaminophen hepatotoxicity.

Jaeschke H, McGill MR.

Toxicol Lett. 2015 Jun 15;235(3):216-7. doi: 10.1016/j.toxlet.2015.04.002. Epub 2015 Apr 6.


The role of the c-Jun N-terminal kinases 1/2 and receptor-interacting protein kinase 3 in furosemide-induced liver injury.

McGill MR, Du K, Xie Y, Bajt ML, Ding WX, Jaeschke H.

Xenobiotica. 2015 May;45(5):442-9. doi: 10.3109/00498254.2014.986250. Epub 2014 Nov 25.


Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients.

Woolbright BL, McGill MR, Staggs VS, Winefield RD, Gholami P, Olyaee M, Sharpe MR, Curry SC, Lee WM, Jaeschke H; Acute Liver Failure Study Group.

Toxicol Sci. 2014 Dec;142(2):436-44. doi: 10.1093/toxsci/kfu195. Epub 2014 Sep 19.


Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase.

Du K, Williams CD, McGill MR, Jaeschke H.

Toxicol Appl Pharmacol. 2014 Nov 15;281(1):58-66. doi: 10.1016/j.taap.2014.09.002. Epub 2014 Sep 16.


Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis.

Ward J, Kanchagar C, Veksler-Lublinsky I, Lee RC, McGill MR, Jaeschke H, Curry SC, Ambros VR.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12169-74. doi: 10.1073/pnas.1412608111. Epub 2014 Aug 4.


Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome.

McGill MR, Staggs VS, Sharpe MR, Lee WM, Jaeschke H; Acute Liver Failure Study Group.

Hepatology. 2014 Oct;60(4):1336-45. doi: 10.1002/hep.27265. Epub 2014 Aug 25.

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