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Items: 19


NLRP3 inflammasome activation in hepatic stellate cells induces murine liver fibrosis.

Inzaugarat ME, Johnson CD, Holtmann TM, McGeough MD, Trautwein C, Papouchado BG, Schwabe R, Hoffman HM, Wree A, Feldstein AE.

Hepatology. 2018 Sep 4. doi: 10.1002/hep.30252. [Epub ahead of print]


Increased Neutrophil Secretion Induced by NLRP3 Mutation Links the Inflammasome to Azurophilic Granule Exocytosis.

Johnson JL, Ramadass M, Haimovich A, McGeough MD, Zhang J, Hoffman HM, Catz SD.

Front Cell Infect Microbiol. 2017 Dec 11;7:507. doi: 10.3389/fcimb.2017.00507. eCollection 2017.


TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies.

McGeough MD, Wree A, Inzaugarat ME, Haimovich A, Johnson CD, Peña CA, Goldbach-Mansky R, Broderick L, Feldstein AE, Hoffman HM.

J Clin Invest. 2017 Dec 1;127(12):4488-4497. doi: 10.1172/JCI90699. Epub 2017 Nov 13.


NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL-17 and TNF in mice.

Wree A, McGeough MD, Inzaugarat ME, Eguchi A, Schuster S, Johnson CD, Peña CA, Geisler LJ, Papouchado BG, Hoffman HM, Feldstein AE.

Hepatology. 2017 Sep 13. doi: 10.1002/hep.29523. [Epub ahead of print]


Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate.

Miller M, Tam AB, Mueller JL, Rosenthal P, Beppu A, Gordillo R, McGeough MD, Vuong C, Doherty TA, Hoffman HM, Niwa M, Broide DH.

J Immunol. 2017 Apr 15;198(8):3017-3022. doi: 10.4049/jimmunol.1601848. Epub 2017 Mar 8.


GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation.

Das S, Miller M, Beppu AK, Mueller J, McGeough MD, Vuong C, Karta MR, Rosenthal P, Chouiali F, Doherty TA, Kurten RC, Hamid Q, Hoffman HM, Broide DH.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13132-13137. Epub 2016 Oct 31.


NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.

Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M.

Cell. 2016 Feb 25;164(5):896-910. doi: 10.1016/j.cell.2015.12.057.


Tr1 Cells, but Not Foxp3+ Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10-Dependent Mechanism.

Yao Y, Vent-Schmidt J, McGeough MD, Wong M, Hoffman HM, Steiner TS, Levings MK.

J Immunol. 2015 Jul 15;195(2):488-97. doi: 10.4049/jimmunol.1403225. Epub 2015 Jun 8.


Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart.

Toldo S, Mezzaroma E, McGeough MD, Peña CA, Marchetti C, Sonnino C, Van Tassell BW, Salloum FN, Voelkel NF, Hoffman HM, Abbate A.

Cardiovasc Res. 2015 Feb 1;105(2):203-12. doi: 10.1093/cvr/cvu259. Epub 2014 Dec 18.


Mutation of EpCAM leads to intestinal barrier and ion transport dysfunction.

Kozan PA, McGeough MD, Peña CA, Mueller JL, Barrett KE, Marchelletta RR, Sivagnanam M.

J Mol Med (Berl). 2015 May;93(5):535-45. doi: 10.1007/s00109-014-1239-x. Epub 2014 Dec 9.


NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms.

Qu C, Bonar SL, Hickman-Brecks CL, Abu-Amer S, McGeough MD, Peña CA, Broderick L, Yang C, Grimston SK, Kading J, Abu-Amer Y, Novack DV, Hoffman HM, Civitelli R, Mbalaviele G.

FASEB J. 2015 Apr;29(4):1269-79. doi: 10.1096/fj.14-264804. Epub 2014 Dec 4.


NLRP3 inflammasome activation is required for fibrosis development in NAFLD.

Wree A, McGeough MD, Peña CA, Schlattjan M, Li H, Inzaugarat ME, Messer K, Canbay A, Hoffman HM, Feldstein AE.

J Mol Med (Berl). 2014 Oct;92(10):1069-82. doi: 10.1007/s00109-014-1170-1. Epub 2014 May 28.


ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma.

Miller M, Rosenthal P, Beppu A, Mueller JL, Hoffman HM, Tam AB, Doherty TA, McGeough MD, Pena CA, Suzukawa M, Niwa M, Broide DH.

J Immunol. 2014 Apr 15;192(8):3475-87. doi: 10.4049/jimmunol.1303047. Epub 2014 Mar 12.


Functional consequences of EpCam mutation in mice and men.

Mueller JL, McGeough MD, Peña CA, Sivagnanam M.

Am J Physiol Gastrointest Liver Physiol. 2014 Feb 15;306(4):G278-88. doi: 10.1152/ajpgi.00286.2013. Epub 2013 Dec 12.


Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies.

Brydges SD, Broderick L, McGeough MD, Pena CA, Mueller JL, Hoffman HM.

J Clin Invest. 2013 Nov;123(11):4695-705.


NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice.

Wree A, Eguchi A, McGeough MD, Pena CA, Johnson CD, Canbay A, Hoffman HM, Feldstein AE.

Hepatology. 2014 Mar;59(3):898-910. doi: 10.1002/hep.26592. Epub 2014 Jan 30.


Cutting edge: IL-6 is a marker of inflammation with no direct role in inflammasome-mediated mouse models.

McGeough MD, Pena CA, Mueller JL, Pociask DA, Broderick L, Hoffman HM, Brydges SD.

J Immunol. 2012 Sep 15;189(6):2707-11. doi: 10.4049/jimmunol.1101737. Epub 2012 Aug 17.


Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice.

Bonar SL, Brydges SD, Mueller JL, McGeough MD, Pena C, Chen D, Grimston SK, Hickman-Brecks CL, Ravindran S, McAlinden A, Novack DV, Kastner DL, Civitelli R, Hoffman HM, Mbalaviele G.

PLoS One. 2012;7(4):e35979. doi: 10.1371/journal.pone.0035979. Epub 2012 Apr 27.


Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.

Brydges SD, Mueller JL, McGeough MD, Pena CA, Misaghi A, Gandhi C, Putnam CD, Boyle DL, Firestein GS, Horner AA, Soroosh P, Watford WT, O'Shea JJ, Kastner DL, Hoffman HM.

Immunity. 2009 Jun 19;30(6):875-87. doi: 10.1016/j.immuni.2009.05.005. Epub 2009 Jun 4.

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